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What Are the Five Warning Signs of Testicular Cancer? – MedicineNet

By daniellenierenberg

What is testicular cancer?

Testicular cancer arises from the testes (a part of the male reproductive system). The testicles are responsible for the production of male sex hormones and sperm for reproduction. They are located within the scrotum, a loose bag of skin below the penis. Testicular cancer is the most common type of cancer occurring in males in the US between the ages of 15 and 35.

Testicular cancer can be aggressive and grow and spread rapidly. However, this cancer is highly treatable even after it spreads. Hence, the prognosis for men with testicular cancer is good. Studies have shown that the risk of dying from testicular cancer is about1 in 5,000.

How is testicular cancer treated?

The treatment may involve one or a combination of multiple treatment modalities, which depends on the extent of the disease.

The treatment options include

What causes testicular cancer?

The exact cause of testicular cancer is unknown. Some factors increase the risk of testicular cancer, including

What are the warning signs of testicular cancer?

The initial signs and symptoms of testicular cancer include

What are the types of testicular cancer?

Most testicular cancers are germ cell (cells that produce sperm) tumors. There are two main types of testicular cancer, seminomas and nonseminomas.

How is testicular cancer diagnosed?

Medically Reviewed on 8/13/2020

References

Medscape

American Cancer Society

Medline

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Scientists hope to bring Malaysian rhinoceros back from extinction with stem cell technology – National Post

By daniellenierenberg

Efforts to get the two to breed had not worked.

He was the equivalent of a 70-year-old man, so of course you dont expect the sperm to be all that good, said John Payne of the Borneo Rhino Alliance (BORA), who has campaigned for about four decades to save Malaysias rhinos.

It was obvious that, to increase the chances of success, one should get sperm and eggs from the rhinos in Indonesia. But right till today, Indonesia is still not keen on this.

ACROSS THE BORDER

Indonesias environment ministry disputed accusations of cross-border rivalry as a reason why Malaysias rhinos died out, saying talks continue on ways to work with conservationists in the neighboring southeast Asian nation.

Because this is part of diplomatic relations, the implementation must be in accordance with the regulation of each country, said Indra Exploitasia, the ministrys director for biodiversity conservation.

The Malaysian scientists plan to use cells from the dead rhinos to produce sperm and eggs that will yield test-tube babies to be implanted into a living animal or a closely related species, such as the horse.

The plan is similar to one for the African northern white rhinoceros, which number just two. Researchers in that effort reported some success in 2018 in producing embyronic stem cells for the southern white rhino.

But the process is still far from producing a whole new animal, say Thomas Hildebrandt and Cesare Galli, the scientists leading the research.

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To Become a Nerve Cell, Timing Is of the Essence – Technology Networks

By daniellenierenberg

Mitochondria are small organelles that provide the energy critical for each cell in our body, in particular in the high fuel-consuming brain. In this week's edition ofScience, a Belgian team of researchers led by Pierre Vanderhaeghen (VIB-KU Leuven, ULB) finds that mitochondria also regulate a key event during brain development: how neural stem cells become nerve cells. Mitochondria influence this cell fate switch during a precise period that is twice as long in humans compared to mice. The seminal findings highlight an unexpected function for mitochondria that may help explain how humans developed a bigger brain during evolution, and how mitochondrial defects lead to neurodevelopmental diseases.

Our brains are made up of billions of incredibly diverse neurons. They first arise in the developing brain when stem cells stop self-renewing and differentiate into a particular type of neuron. This process, called neurogenesis, is precisely regulated to give rise to the enormous complex structure that is our brain. It is thought that small differences in the way neural stem cells generate neurons are at the origin of the dramatic increase in the size and complexity of our brain.

To gain insight in this complex process, prof. Pierre Vanderhaeghen (VIB-KU Leuven, ULB) and his colleagues examined the mitochondria, small organelles that provide energy in every cell in the body, including the developing brain.

"Diseases caused by defects in mitochondria lead to developmental problems in many organs, in particular the brain," explains Vanderhaeghen, a specialist in stem cell and developmental neurobiology. "We used to think that this was related to the crucial function of mitochondria to provide energy to the cells, but this is only part of the story: recent work in stem cells suggests that mitochondria have a direct influence on organ development. We have tested whether and how this could be the case in the brain."

Ryohei Iwata, a postdoctoral researcher in the Vanderhaeghen lab, developed a new method to watch mitochondria in great detail as the neural stem cells are 'caught in the act' to become neurons. "We found that shortly after stem cells divide, the mitochondria in daughter cells destined to self-renew will fuse, while those in daughter cells that become neurons show high levels of fission instead," says Ryohei Iwata.

But this was not just a coincidence: indeed, the researchers could show that increased mitochondrial fission in fact promotes differentiation to a neuronal fate, while mitochondrial fusion after mitosis redirects daughter cells towards self-renewal.

"We found that the influence of mitochondrial dynamics on cell fate choice is limited to a very specific time window, right after cell division," says Pierre Casimir, a PhD student in Vanderhaeghen's lab. "Interestingly, the restricted time window is twice as long in humans compared to mice."

"Previous findings were primarily focused on fate decision of neural stem cells before they divide, but our data reveal that cell fate can be influenced for a much longer period, even after neural stem cell division," says Vanderhaeghen. This may have interesting implications in the emerging field of cell reprogramming, where scientists try to convert non-neuronal cells directly in neuronal cells for therapeutic purposes for instance.

"Since this period of plasticity is much longer in human cells compared to mouse cells, it is tempting to speculate that it contributes to the increased self-renewal capacity of human progenitor cells, and thus to the uniquely developed brain and cognitive abilities of our species. It is fascinating to think that mitochondria, small organelles that have evolved in cells more than a billion years ago, might have contributed to the recent evolution of the human brain."

Reference:Iwata, R., Casimir, P., & Vanderhaeghen, P. (2020). Mitochondrial dynamics in postmitotic cells regulate neurogenesis. Science, 369(6505), 858862. https://doi.org/10.1126/science.aba9760

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Dior Skincare Ambassador Joanna Czech On Her Self-Care Routine And How To Prevent Maskne – Tatler Malaysia

By daniellenierenberg

Image: Steve Wrubel/Parfums Christian Dior By Chloe Pek August 14, 2020

The beauty expert counts Bella Hadid and Kim Kardashian amongst her clientele

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When it comes to facial massages, celebrity facialist Joanna Czech has that magic touch. Counting Hollywood and runway bigwigs like Bella Hadid, Kim Kardashian, Jennifer Aniston, Cate Blanchett, Kate Winslet, Liam Neeson and more amongst her star-studded list of clients, Joannas skincare treatments are highly coveted internationally.

Now, the skincare expert is adding another credential to her portfoliojoining the House of Dior as a skincare ambassador and lending her expertise in developing the Dior skincare techniques international training.

In an interview via Zoom, Czech told us she had her reservations about joining Dior Skincare at first. I mean, theyre famous for make-up and fashion. I couldnt put my name next to fashion skincareIm very particular about that. Then, I heard about how the Capture Totale range stimulates cell energy, so that changed everything and my skin as well.

Czech, who originally planned to go to medical school in her schooling years, fell in love with skincare when she enrolled in the Aesthetics Institute and never looked back. However, she has remained inquisitive and fascinated with science. This is evident from her holistic approach to beauty, which combines both traditional techniques and cutting-edge technology.

See also: The Best Beauty Launches In August 2020

Adenosine triphosphate (ATP, the main carrier of energy for cellular activities) is responsible for the very first mitosis of cells. It is human physiology that production of ATP drastically drops at around seven years old, and the energy keeps slowing down. So any treatment or product that would stimulate cell energy is fascinating to me.

Culminated from Diors decades-long research into stem cells, the Capture Totale line is infused with a regenerative floral complex of Madagascan longozo, Chinese peony, white lily, and Chinese jasmine, which help to re-energise stem cells rather than replenish them.

Dont believe a product that says it contains stem cells because the stem cells are not alive within the product. Only stem cells that are directly re-injectedand most likely come from your bone marrowworks, Joanna explained, debunking one of the most popular beauty fads in recent years.

With the expert on the line, we took the opportunity to ask our burning questions about maskneand skincare misconceptions.

What is a skincare philosophy that you live by?

Respect, support and protect. This goes for skincare, how we treat ourselves and others.

Your all-time favourite Dior Skincare product and why?

The Capture Totale C.E.L.L. Energy Super Potent Serum because it contains the most concentrated version of the cell energising complex and acetylated hyaluronic acid. It creates hydrated, plump and radiant skin. If you are consistent, you see results in days. My skin has never looked better.

A common skincare mistake many people make?

In my opinion, its using toner. Thats a misconception because still, many people use a toner as the second step of cleansing as opposed to the first step of treating the skin, and this is from my experience of talking with clients.

They put toner or micellar water on a cotton pad and they keep wiping and seeing more make-up. If you see more make-up on your cotton pad, that means you need to go back into washing.

Toner is very often misunderstood or skipped, and it shouldnt be. I cant imagine, for instance, applying a serum on my face without applying toner first. There is no way the efficacy of the product will be the same if you have not applied a toner. Depending on the toner, they offer hydration and sometimes micro-exfoliation, but mainly they are used to maintain the pH of the skin. The optimal pH for our skin is 5.5, and many factors from our diet to lifestyle, and even washing our face can throw the skins pH off the scale, so it's very important to balance it back.

See also: Lancme's Celebrity Make-Up Artist Lisa Eldridge & Neelofa Share 5 Beauty Tips

With face masks becoming part of everyday life, maskne has become a real problem. How can we prevent these breakouts?

When you wear a mask, it creates a micro-climate and we keep breathing carbon dioxide back and forth, so there is not enough of anti-bacterial oxygen getting into the skin. There is sometimes too much moisture happening, so we will get super hydrated initially, and then get quite dehydrated right after. Thats when you will experience eczema and redness.

What I recommend is keeping the skin as clean as possible before wearing the mask, with just a balancing toner, and protecting balm or healing ointments to lubricate areas where the mask could potentially irritate the skin. Very often, its on the nose bridge, as well as on the side and behind the ears.

For less reactivity, I wouldnt go through with the whole routine, but if you have to, I would advise starting your routine earlier so the products are on your skin for at least 30-40 minutes. If you will be stepping out shortly, reduce the routine and skip some steps. But no matter what, never forget about your SPF because the friction of the mask could also get rid of our stratum corneum and create little scabs, causing discolourations.

Then, as soon as you arrive home, take the mask off, wash your face, and again balance your skin with toner and use your serums.

What are your tips for soothing breakouts or eczema caused by wearing masks?

Even with microscopic breakouts, I would continue using any product that is hydrating because sometimes we misunderstand we have a breakout and then we try to use benzoyl peroxide, or everything that is dehydrating. No, your skin would be producing even more sebum. So keep hydrating your skin with soothing ingredients like colostrum and hyaluronic acid.

Your skincare routine?

My morning routine is very brief: cleanser, toner, a serum and then there is moisturiser. For my night time routine, my very first step is getting into the shower when I get home. I begin with massaging my body with my shower gel and silicone gloves under the shower, then I apply products like multi-vitamin oils and sometimes micro-exfoliating toners all over my body.

Then, I go to my face. I usually dont wear any make-up, so I start right away with my cleanser with some massaging movements and I remove it with a linen washcloth, followed by a toner. My favourite way of applying toner is the sponge techniqueinitially, you spread the product on your face, and then you press and release. When you press, your skin microscopically opens and when you release, the skin grasps whatever is on the surface.

After the toner, I use my serum. Ive been using the Capture Totale C.E.L.L. Energy Super Potent Serum since September. If you have weaker areas like forehead lines and nasolabial folds, these are the areas I would concentrate longer on, followed by an eye cream and moisturiser. Thats usually my five-step basic routine.

About twice a week, I do facial masks, one of those quick ones because Im the kind of New Yorker who only has five seconds for myself. But no matter how busy or tired I am at night, I would never forget about my skincare routine. Your skin is 60 per cent more potent to absorb everything during relaxation and rejuvenation time. So if you dont take care of your skin at night, you might as well forget doing anything in the morning. Twenty-five per cent of our immune system is within our skin, and we can improve that percentage of our health with products chosen for your skin condition and consistent skincare.

See also: Sulwhasoo's Ginseng To Achieve Skin As Flawless As South Korean Superstar Song Hye Kyo's

You work with many notable clientswhats the most common skincare problem celebrities deal with and treatments that they request for?

Celebrities have exactly the same problems as we do. The only one little difference is that celebrities tend to wear more make-up and more often than some of us, usually under the heat of theatrical or film lights, so they need a lot of hydration and rebalancing. Ive been called to the movie set many times to help soothe their skin with algae masks, or any cooling and hydrating treatments.

Their needs are equal to ours. They want to work on their facial contours and ensure their skin is as evenly textured as possible so their makeup looks perfect, so I would offer some mild exfoliation, perhaps micro-currents for targeted muscle stimulation, and maybe manual massaging to stimulate blood flow to create the sort of rosy healthy oxygenated looking skin. Many people call it a red carpet facial but I call them ordinary facial because every woman wants the samesmooth hydrated skin with nice cheekbones, beautiful jawlines, and thats what really works.

See also: Beauty Talk With Aznita Azman, Founder Of Nita Cosmetics

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Back from the dead? Stem cells give hope for revival of Malaysia’s extinct rhinos – The Jakarta Post – Jakarta Post

By daniellenierenberg

Some skin, eggs and tissue samples are all that remain of Malaysia's last rhino, Iman, who died last November after years of failed breeding attempts.

Now scientists are pinning their hopes on experimental stem cell technology to bring back the Malaysian variant of the Sumatran rhinoceros, making use of cells from Iman and two other dead rhinos.

"I'm very confident," molecular biologist Muhammad Lokman Md Isa told Reuters in his laboratory at the International Islamic University of Malaysia.

"If everything is functioning, works well and everybody supports us, it's not impossible."

The smallest among the world's rhinos, the Sumatran species was declared extinct in the wild in Malaysia in 2015. Once it had roamed across Asia, but hunting and forest clearance reduced its numbers to just 80 in neighboringIndonesia.

Iman, 25, died in a nature reserve on Borneo island, following massive blood loss caused by uterine tumors, within six months of the death of Malaysia's last male rhino, Tam.

Efforts to get the two to breed had not worked.

"He was the equivalent of a 70-year-old man, so of course you don't expect the sperm to be all that good," said John Payne of the Borneo Rhino Alliance (BORA), who has campaigned for about four decades to save Malaysia's rhinos.

"It was obvious that, to increase the chances of success, one should get sperm and eggs from the rhinos inIndonesia. But right till today,Indonesiais still not keen on this."

Across the border

Indonesia's environment ministry disputed accusations of cross-border rivalry as a reason why Malaysia's rhinos died out, saying talks continue on ways to work with conservationists in the neighboring southeast Asian nation.

"Because this is part of diplomatic relations, the implementation must be in accordance with the regulation of each country," said Indra Exploitasia, the ministry's director for biodiversity conservation.

The Malaysian scientists plan to use cells from the dead rhinos to produce sperm and eggs that will yield test-tube babies to be implanted into a living animal or a closely related species, such as the horse.

The plan is similar to one for the African northern white rhinoceros, which number just two. Researchers in that effort reported some success in 2018 in producing embryonic stem cells for the southern white rhino.

But the process is still far from producing a whole new animal, say Thomas Hildebrandt and Cesare Galli, the scientists leading the research.

And even if it worked, the animals' lack of genetic diversity could pose a threat to long-term survival, Galli told Reuters.

Indonesian scientist Arief Boediono is among those helping in Malaysia, hoping success will provide lessons to help his country's rhinos.

"It may take five, 10, 20 years, I don't know," Arief added. "But there has already been some success involving lab rats in Japan, so that means there is a chance."

Japanese researchers have grown teeth and organs such as pancreas and kidneys using embryonic stem cells from rats and mice in efforts to grow replacement human organs.

For now, however, Iman's hide will be stuffed and put on display alongside Tam in a Borneo museum.

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Skin Disorders: Pictures, symptoms, causes and help – TODAY – TODAY

By daniellenierenberg

Is it acne, a rash or maybe something more serious? Skin disorders can vary in both symptoms and severity. Some skin conditions are minor, some are serious but treatable, and others, like skin cancer, can be life-threatening. Here are 18 common (and a few less common) skin conditions with photos to help you ID them. Remember to always reach out to your physician for a proper diagnosis and treatment.

Acne | Actinic keratosis | Basal cell carcinoma | Blisters | Carbuncle | Cellulitis | Chicken pox | Cold sores | Contact dermatitis | Eczema | Hives | Latex allergy | Lupus | Measles | Melanoma | Psoriasis | Rosacea | Squamous cell carcinoma

Suffering from acne? Youre not alone. Acne is the most common condition dermatologists treat 40 to 50 million Americans struggle with acne at any given time.

Acne can show up almost anywhere on the skin as blackheads, papules and pustules or pimples, cysts and nodules

Acne starts when dead skin cells dont shed properly and clog your pores.

Some acne can be treated with over-the-counter products, while others require professional help, including prescription medication and treatments.

Read more about acne and how to treat it.

These precancerous lesions often appear as rough spots on the skin. Actinic keratosis is common, but if left untreated it can turn into squamous cell carcinoma.

The appearance of actinic keratosis can vary from bumps that look like pimples or acne to rough lesions that are red, pink or gray.

When cells in the skin called keratinocytes are damaged by UV rays, it can cause actinic keratosis.

While not always necessary, treatments may include removal of the actinic keratosis with liquid nitrogen, chemical peels, scraping or other therapies.

Read more about actinic keratosis and how to treat it.

Basal cell carcinoma is the most common type of skin cancer. It affects approximately 2.6 million people in the U.S. each year. Do you know how to spot it?

Basal cell carcinoma is much more common in people who have light skin. Symptoms tend to be the same color as the skin or pink. Its important to look for any changes in your skin.

Exposure from ultraviolet rays (UV) from the sun or indoor tanning is a primary cause of basal cell carcinoma.

Your dermatologist may be able to remove a basal cell carcinoma tumor when doing a biopsy. Sometimes a Mohs surgery is recommended.

Read more about basal cell carcinoma and how to spot it.

A common skin condition, most people develop blisters once in a while.

Blisters are small, painful sacs of fluid.

Blisters can be caused by friction, such as by a shoe rubbing against the skin, or by sunburns, heat or skin diseases.

Blisters tend to heal on their own, but a blister can be drained if its too painful.

Read more about blisters and how to treat them.

Sometimes confused with a spider bite, a carbuncle is a group of boils that stem from an infection of the skin and are connected to each other.

Red, tender bumps, or boils, that contain pus are signs of a carbuncle. Carbuncles can eventually rupture, and pus will leak out of them.

A bacterial infection, such as Staphylococcus aureus, is often the cause of a carbuncle.

If a carbuncle is small, you may be able to treat it at home with warm compresses and bandages. Otherwise, your dermatologist can make an incision to drain the pus.

Read more about carbuncles and how to treat them.

Cellulitis is an infection of the skin in which the skin becomes red and swollen. It typically occurs after you get a cut or wound.

When you have cellulitis, an area of your skin often on one of your legs becomes red, swollen, warm and possibly painful.

Cellulitis can be caused by two different types of bacteria: streptococcus (aka strep) or staphylococcus (aka staph).

Antibiotics like penicillin, cephalosporin or erythromycin are normally used to treat cellulitis.

Read more about cellulitis and how to treat it.

Also called varicella, this highly contagious disease mostly strikes children.

A fever may precede it, but the unique chicken pox rash appears on the skin with itchy blisters that look like lots of little dew drops.

The varicella-zoster virus (VZV) causes chicken pox as well as shingles. Its unlikely to get chicken pox if youve had the chicken pox vaccine.

The best treatment for chicken pox is prevention through vaccination. An early case of chicken pox may be treated with antiviral drugs. Other remedies can be used to ease symptoms.

Read more about chicken pox and how to treat it.

Trending stories,celebrity news and all the best of TODAY.

Also known as fever blisters, cold sores are blisters, or clusters of blisters, that appear on your lips or near your mouth.

Symptoms of cold sores can vary. The sores may start with a tingling, burning or other sensation, then break open and scab over.

Cold sores are caused by the herpes simplex virus. Outbreaks are triggered by stress, fatigue, illness and other factors.

Read more about cold sores and how to treat them.

Almost everyone gets contact dermatitis at some point. There are two main types of contact dermatitis allergic and irritant. Both trigger a rash.

Symptoms of allergic contact dermatitis may include itching, rash, dryness and other symptoms. Cracked, itchy, chapped skin with sores may be signs of irritant contact dermatitis.

Contact dermatitis is caused by something that touches your skin like poison ivy, nickel, fragrances, latex or other irritants and triggers a rash.

The best treatment for contact dermatitis is to avoid whatever it is that triggers your rash. Beyond that, your dermatologist may also recommend antihistamine pills, moisturizers or topical steroids.

Read more about contact dermatitis and how to treat it.

Eczema is a condition that causes red, itchy patches on the skin. It often starts at a young age often people with eczema get it when they're babies.

Eczema is almost always itchy, but otherwise symptoms can vary from person to person. Skin infected with eczema can be dry, dark, scaly, swollen or oozing.

Eczema may be caused by an overactive immune system, but its not entirely clear what causes the condition.

There is no cure for eczema, but symptoms can be managed with medications and other therapies.

Read more about eczema and how to treat it

The onset of hives can be mysterious, and though hives usually go away in less than 24 hours, new ones can repeatedly appear.

Hives appear on the skin as slightly swollen, raised pink or red patches. You may have one hive, a group of hives that may be separate or connected together.

Its difficult to pinpoint the cause of hives, but there are many triggers that can cause hives, from insect bites and allergic reactions to medication, stress and heat.

The go-to treatment for hives is usually antihistamines.

Read more about hives and how to treat them.

People with an allergy to latex are allergic to a protein found in the sap of the Brazilian rubber tree.

Different symptoms appear with different types of latex allergies. One type causes a rash on the skin; another can cause anaphylaxis, which can result in a swelling of the airways and difficulty breathing.

When your immune system reacts as though latex is a harmful substance, it causes an allergic reaction to latex.

Since theres no cure for latex allergies, your best bet is to avoid coming into contact with latex.

Read more about latex allergy and how to treat it.

An autoimmune disease that causes pain and inflammation, lupus can affect your skin, as well as your kidneys, heart, joints and lungs.

A red butterfly-shaped rash that appears on the nose and cheeks is one common sign of lupus, but symptoms of lupus will vary, depending on the type of lupus you have.

There are a number of factors that may play a role in whether you develop rosacea, but experts dont know for certain what causes the skin condition.

There is no cure for rosacea, but the condition can be managed to help keep symptoms from worsening.

Read more about lupus and how to treat it.

Also known as rubeola, measles is a contagious and potentially deadly disease that usually strikes children.

Beyond the signifying red, spotted rash, measles may also be accompanied by a fever, cough, runny nose and other symptoms.

A virus that infects the respiratory tract and spreads throughout the body causes measles. Its one of the most contagious diseases.

The best treatment is prevention through a vaccine. Otherwise, high doses of vitamin A, bed rest and medications to reduce pain and fever may help.

Read more about measles and how to treat it.

Its one of the less common skin cancers, but melanoma is the most dangerous because it can easily spread to other parts of your body.

Melanoma tumors tend to be black or brown, but can sometimes be pink, tan or white. Anyone can get melanoma, but people with light skin are at greater risk.

UV light exposure from ultraviolet rays from the sun or indoor tanning causes most melanomas.

Treatments depend on how advanced the melanoma is and where the tumor is located. It may include surgery, radiation, chemotherapy or other therapies.

Read more about melanoma and how to treat it.

Psoriasis affects more than 8 million people in the U.S. It typically starts in the teen years or early 20s, though it can occur at any age.

When you have psoriasis, your body makes new skin cells quickly, and the cells typically build up in thick, scaly patches on the skin called plaques.

There are a number of factors that may contribute to causing psoriasis. The immune system and genetics may play a role. Certain triggers can also cause the onset of psoriasis and psoriasis flare-ups.

Psoriasis doesnt have a cure, there are medications and treatments that can help manage the condition.

Read more about psoriasis and how to treat it.

This common inflammatory skin condition causes redness of the face.

In addition to causing facial redness, if rosacea is not treated, it can cause visible blood vessels, breakouts like acne and other symptoms.

There are a number of factors that may play a role in whether you develop rosacea, but experts dont know for certain what causes the skin condition.

There is no cure for rosacea, but the condition can be managed to help keep symptoms from worsening.

Read more about rosacea and how to treat it.

Also known as cutaneous squamous cell carcinoma, this cancer develops when the squamous cells in the top layer of your skin grow out of control.

Though its linked with exposure to ultraviolet rays, squamous cell carcinoma can crop up in areas that dont get much sun. Watch out for rough, scaly patches, sores that dont heal or anything else that looks suspicious.

Squamous cell carcinoma is mainly caused by UV rays from the sun or indoor tanning.

Treatments for squamous cell carcinoma may include surgery, radiation or other therapies. Catching it early is key.

Read more about squamous cell carcinoma and how to treat it.

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IN CASE YOU MISSED ITSchedule of Reuters features from this week – Reuters

By daniellenierenberg

Aug 13 (Reuters) - Every week, Reuters journalists produce scores of multimedia features and human-interest stories from around the world.

Below are some engaging stories selected by our editors, as well as explanatory context and background on world headlines. For a full schedule of news and events, please go to our editorial calendar on Reuters Connect here

Baby George, born amid Beirut blast, is light in the darkness

BEIRUT, Aug 12 - Stepping into the delivery room where his wife Emmanuelle was about to give birth, Edmond Khnaisser meant to capture their sons first moments on camera. Instead, he recorded the instant the biggest blast in Lebanons history sent windows crashing onto the hospital bed. (LEBANON-SECURITY/BLAST-BABY (TV, PIX), moved, 401 words)

Squeegee selfies: Tel Aviv tower-washer is rising TikTok star

TEL AVIV, Aug 11 - Twirling to hip hop over chasms of steel and glass, soapy squeegee in one hand and a smartphone in the other, Noa Toledo is an Israeli social media star who aims to encourage other women to take on her traditionally male-dominated job. (ISRAEL-SOCIALMEDIA/WINDOW WASHER (TV, PIX), moved, 155 words)

From carats to peanuts: how a pandemic upended the global diamond industry

JOHANNESBURG/MUMBAI, Aug 12 - As the coronavirus pandemic shuttered mines from Lesotho to Canada and disrupted supply chains, Rajen Patel swapped diamond polishing for peanut farming. (HEALTH-CORONAVIRUS/DIAMONDS (PIX, GRAPHICS), by Helen Reid, Tanisha Heiberg and Rajendra Jadhav, 828 words)

Raphael did a nose-job in self-portrait, face reconstruction suggests

ROME, Aug 11 - Raphael probably didnt like his nose, and replaced it with an idealised version in his famous self-portrait. (ARTS-ITALY/RAPHAEL (PIX, TV), by Philip Pullella, 399 words)

Back from the dead? Stem cells give hope for revival of Malaysias extinct rhinos

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IN CASE YOU MISSED ITSchedule of Reuters features from this week - Reuters

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Back From the Dead? Stem Cells Give Hope for Revival of Malaysia’s Extinct Rhinos – The New York Times

By daniellenierenberg

KUANTAN, Malaysia Some skin, eggs and tissue samples are all that remain of Malaysia's last rhino, Iman, who died last November after years of failed breeding attempts.

Now scientists are pinning their hopes on experimental stem cell technology to bring back the Malaysian variant of the Sumatran rhinoceros, making use of cells from Iman and two other dead rhinos.

"I'm very confident," molecular biologist Muhammad Lokman Md Isa told Reuters in his laboratory at the International Islamic University of Malaysia.

"If everything is functioning, works well and everybody supports us, it's not impossible."

The smallest among the world's rhinos, the Sumatran species was declared extinct in the wild in Malaysia in 2015. Once it had roamed across Asia, but hunting and forest clearance reduced its numbers to just 80 in neighbouring Indonesia.

Iman, 25, died in a nature reserve on Borneo island, following massive blood loss caused by uterine tumours, within six months of the death of Malaysia's last male rhino, Tam.

Efforts to get the two to breed had not worked.

"He was the equivalent of a 70-year-old man, so of course you don't expect the sperm to be all that good," said John Payne of the Borneo Rhino Alliance (BORA), who has campaigned for about four decades to save Malaysia's rhinos.

"It was obvious that, to increase the chances of success, one should get sperm and eggs from the rhinos in Indonesia. But right till today, Indonesia is still not keen on this."

ACROSS THE BORDER

Indonesia's environment ministry disputed accusations of cross-border rivalry as a reason why Malaysia's rhinos died out, saying talks continue on ways to work with conservationists in the neighbouring southeast Asian nation.

"Because this is part of diplomatic relations, the implementation must be in accordance with the regulation of each country," said Indra Exploitasia, the ministry's director for biodiversity conservation.

The Malaysian scientists plan to use cells from the dead rhinos to produce sperm and eggs that will yield test-tube babies to be implanted into a living animal or a closely related species, such as the horse.

The plan is similar to one for the African northern white rhinoceros, which number just two. Researchers in that effort reported some success in 2018 in producing embyronic stem cells for the southern white rhino.

But the process is still far from producing a whole new animal, say Thomas Hildebrandt and Cesare Galli, the scientists leading the research.

And even if it worked, the animals' lack of genetic diversity could pose a threat to long-term survival, Galli told Reuters.

Indonesian scientist Arief Boediono is among those helping in Malaysia, hoping success will provide lessons to help his country's rhinos.

"It may take five, 10, 20 years, I don't know," Arief added. "But there has already been some success involving lab rats in Japan, so that means there is a chance."

Japanese researchers have grown teeth and organs such as pancreas and kidneys using embryonic stem cells from rats and mice in efforts to grow replacement human organs.

For now, however, Iman's hide will be stuffed and put on display alongside Tam in a Borneo museum.

(Editing by Matthew Tostevin and Clarence Fernandez)

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Beauty & Wellness Awards 2020: New Kids on the Block – Prestige Online

By daniellenierenberg

After months of reviewing close to 300 beauty products and wellness facilities, and tallying, here are the best skincare products of this year, and lest we forget, your top pick! And so without further ado, here are the Beauty & Wellness Awards winners.

As technology continues to advance and discoveries are made each day,we do our part in dipping our toe in the proverbial pool of beauty toexplore the latest and greatest. Embracing the new is part of our job asinvestigative beauty aficionados, and as we dig through the recentdebuts, weve found some newbies that have found a permanent spot onour top shelf that we highly recommend checking out.

1

Best Face Cream: First Aid Beauty Ultra Repair Cream

For even the most sensitive skin, FAB delivers animpressive amount of hydration without anyirritation. The luscious whipped-cream texturespreads easily over the face, yet still holds wellenough for make-up to sit over nicely.

Ultra Repair Cream

HK$249/170g; HK$109/56.7G

2

Best Hydrating Serum: Skin Need 100% Hyaluronic Acid B5

The ultimate water magnet, thisserum locks in all the hydration youneed. Its easily absorbed, so yourskin feels fresh and clean without atrace of stickiness. The heavy doseof hyaluronic acid binds and trapsmoisture to the skin.

100% Hyaluronic Acid B5

HK$598

3

Best Reparative Formula: Wildsmith Skin Active Repair Radiance Polisher

Exfoliate to your hearts content and skinsneed the gentle grains of walnut shell androsehip-seed powder sloughs away deadskin cells and polishes the skins surface. Mixthe desired amount with any facial cleanserto create your very own scrub.

Skin Active Repair Radiance Polisher

HK$254

4

Best Body Cream: Augustinus Bader The Body Cream

A fresh launch from world-leadingstem cell and biomedical pioneerand scientist, Professor AugustinusBader, The Body Cream is officiallythe newest must-have item in bodyand skin care. Powered by thebrands patented Trigger FactorComplex (TFC8), this cellularrenewal cream reawakens dormantstem cells and results in firmer,toned skin with a reduction incellulite and stretch marks.

5

Readers Choice: Drunk Elephant F-balm

Electrolytes pump us full of hydration. And if its good to ingest. Why wouldnt it be topically? This waterfacial masque hydratant nourishes and repairs parched skin while you sleep. Its cooling effects are especially appreciated this season.

All of the Drunk Elephant products are naturally formulated and cater directly to your skins health. Oi Tak Kan, Prestige Reader

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Going On At The Greenville Library – WSPA 7News

By daniellenierenberg

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Scientists Create Hair-Bearing Human Skin from Pluripotent …

By daniellenierenberg

A team of researchers from several U.S. institutions has created an organoid culture system that generates complex skin from human pluripotent stem cells.

A hair-bearing skin organoid. Image credit: Indiana University School of Medicine.

This is the first study to show that human hair can be grown completely from stem cells in a dish, which has been a goal of the skin biology community for decades, said lead author Dr. Karl Koehler, from Harvard Medical School and Boston Childrens Hospital.

Through the 3D culture technique developed in past studies, Dr. Koehler and colleagues incubated human stem cells for about 150 days in a skin organoid.

Weve developed a new cooking recipe for generating human skin that produces hair follicles after about 70 days in culture, Dr. Koehler explained.

When the hair follicles grow, the roots extend outward radially. Its a bizarre-looking structure, appearing almost like a deep-sea creature with tentacles coming out from it.

After the incubation period, researchers tested whether skin organoids could integrate on the skin of nude mice. More than half of the organoids they grafted on the mice grew human hair follicles.

The skin organoid developed from culture is akin to fetal facial skin and hair, he said.

The teams experiments show that organoid generated hairy skin can integrate into mouse skin, which suggests potential applications in skin and facial reconstruction.

This could be a huge innovation, providing a potentially unlimited source of soft tissue and hair follicles for reconstructive surgeries, said first author Dr. Jiyoon Lee, also from Harvard Medical School and Boston Childrens Hospital.

Skin regeneration is of great interest for treating patients, added co-author Dr. Taha Shipchandler, from the Indiana University School of Medicine.

If we can harness this growth into a medium, and easily apply it to patients, it would change the way we treat many injuries or reconstructions. This would have a profound effect on the medical field.

The results were published in the journal Nature.

_____

J. Lee et al. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature, published online June 3, 2020; doi: 10.1038/s41586-020-2352-3

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How Close Are We To Making Babies from Bone Marrow? – Discover Magazine

By daniellenierenberg

In 2007, a group of researchers reported a startling discovery: They had created sperm-like cells out of stem cells taken from the bone marrow of human men. Two years later, however, the study was retracted due to charges of plagiarism. Thirteen years later, the ability to create functional human sperm out of stem cells remains elusive.

Scientists have been trying to figure out how to create functioning human gametes eggs and sperm from stem cells for 20 or 30 years, says Vittorio Sebastiano, a stem cell biologist at Stanford University whose research focuses on reproductive biology. Doing so would help people struggling with infertility have children and help scientists unlock the secrets of human development. Since 2007, scientists have made considerable progress on this front, creating healthy mouse pups from stem cell-generated gametes and even immature human egg cells. But there is still a long road ahead before scientists will be able to convert skin or bone marrow into babies.

We are trying to really find ways to efficiently, robustly generate germ cells that can be, in the short term, used to understand the biology of these concepts, but in the long term [used to be] able to restore fertility, says Sebastiano.

When the first baby conceived via in vitro fertilization (IVF) was born in 1978, it was a major step forward for reproductive science and a precursor to the stem cell research conducted by Sebastiano and others today, he says. But IVF is not an option for every individual or couple trying to have a biological child, including those who are born without gametes or who receive aggressive cancer treatments at a young age. This scientific technique would offer these individuals a new shot at reproduction.

The next major step came in the 2000s, with the creation of induced pluripotent stem cells (iPSCs). These cells are taken from blood or skin cells and reprogrammed to behave like embryonic cells, which have the ability to develop into any type of cell in the body. Since then, researchers have been trying to figure out how to turn these embryonic-like cells into functional sperm and eggs.

A colony of induced pluripotent stem cells used to treat the rare genetic disorder Fanconi anemia. (Credit: Juan Carlos Izpisua Belmonte, Salk Institute for Biological Studies)

Part of what has made this work so challenging is that scientists havent been able to fully grasp what happens in a human embryo during normal development, says Sebastiano. Scientists understand this process in mice because the rodents are easy to study in the lab. But ethical restrictions and technical factors (like having access to the embryos at just the right point in time) make this phenomenon hard to study in people, he says.

Despite the roadblocks, scientists have made significant progress in the last 10 years. In 2012, a group of researchers in Japan created fertile mouse eggs from iPSCs and used those eggs to breed healthy mouse pups. In [the] mouse, the whole circle has already been completed, says Sebastiano. Now it has been shown by a couple of groups in the UK and in Japan that you can generate embryonic-like cells from mice and then you can actually push these cells to become eggs or sperm, fully functional.

In 2018, the same group of Japanese scientists made another major breakthrough. Using human blood cells and the pluripotent stem cell technique, they managed to produce immature human eggs.

Similar efforts to create sperm are not as far along, says Sebastiano. Several efforts over the years have purported to create sperm-like cells, including the 2007 blood marrow study. A much-heralded study published in 2014 also made major news, but Sebastiano says the development of the cells in that study didnt go far beyond the earliest stages of differentiation.

But, we are actively working on it, says Sebastiano. Probably in the next few years we will be able to generate fully functional sperm and fully functional oocytes. Then, the question will be how do scientists test the quality of these gametes, he says.

The only way to fully assess the quality and functionality of a sperm or egg is to use it to, well, try to fertilize another gamete and produce a baby. Thats why this work has to be approached with the utmost care, says Sebastiano. He hypothesizes that once scientists have developed techniques that they think produce mature human oocytes and sperm, the next step will be testing these techniques in primates. That way, researchers can follow the entire life of individual animals produced from this technique to see if any unexpected problems develop, he says.

Sebastiano has no doubt that one day, these stem cells could help individuals struggling with infertility to produce healthy children. This, along with a fascination with biological development, is what drives Sebastianos work. There are also, of course, significant ethical considerations that have to be carefully considered. This technique has the potential to affect human life on a generational level, he notes. And many people also raise concerns about other future consequences, like the ability to create designer babies or produce offspring from hairs stolen from unsuspecting celebrities. Bioethics experts have written about the need to start working through the medical and legal issues around this technique now, before it is viable.

There is a need actually to develop this, but since we are really dealing with a very unique cell type we need to be cautious, says Sebastiano.

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The NIU BODY Rebrand: millennials have grown up and so has their skin care – CosmeticsDesign.com USA

By daniellenierenberg

This rebrand symbolizes our growth as a company and an opportunity to show our customers that we understand and are responding to their evolving skincare needs, Connie Lo, Three Ships Co-Founder, tells the press.

We invite anyone, adds Lo,interested in a more revitalized complexion to try our products and embark on their journey to better skin.

Connie Lo and Laura Burget founded NIU Body in early 2017 as an unpretentious, clean, and affordable skin care brand for their fellow millennials. We aspire to be an approachable option without the fancy fluff, at affordable prices so everyone can enjoy everything green beauty has to offer. Our products are simple in both design and formulation, explained Burget in her 2018 Indie Beauty Profile.

And those core brand qualities havent changed now that NIU Body is Three Ships: While our look has changed, says Burget in a press release shared with Cosmetics Design, we remain meticulous in our approach to sourcing sustainable ingredients and creating formulations that provide tangible benefits.

Our philosophy, she says,has and always will be to be the change we want to see in the beauty industry: natural, effective and affordable skincare with a conscience.

As with any thorough rebrand, the change from NIU Body to Three Ships is about more than just a new name. As the brand explains in a recent LinkedIn update, It really was a culmination of how we felt about our years-long journey discovering affordable skincare ingredients that actually worked for us. The destination always seems further than it appears, but as we journey towards it, we start to see the full picture. Three Ships is about the journey to better skin.

The brand has new packaging and labeling, based primarily on consumer feedback. And now the brands portfolio is full of skin care product names that highlight key ingredients and benefits, such as Clarify Tea Tree + MCT Cleansing Oil, Hydrate 49% Almond Oil Serum, and Awake Rose Hydrosol Toner.

In conjunction with the rebranding, Three Ships also launched a new day cream. The Radiance Grape Stem Cell + Squalene Day Cream is, according to the brands press release, a highly-requested product formulated with revolutionary grape stem cells to protect from UV damage throughout the day and fight photo-aging. Hydrating prickly pear and argan oils along with natural squalene lock in moisture leaving skin soft and radiant.

Radiance is made for all skin types to help even and balance skin tone. It's also packaged in an airless pump top jar, which prevents air exposure and helps protect the cream, increasing the shelf life naturally, notes the release.

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The best anti-aging skin care products to use in your 40s – TODAY

By daniellenierenberg

For most of my life, Ive credited my good skin to two products: a gentle cleanser and a powerful sunscreen. But something happened when I hit my 40s I noticed my skin no longer glowed like it used to and it always seemed to look and feel dry. When I noticed a few sunspots on the top of my right cheek, I realized it was time to elevate my morning and evening beauty routines.

Fine lines, dryness, sunspots and a loss of firmness are all things women begin to deal with in their 40s, says Dr. Mona Gohara, associate clinical professor of dermatology at Yale School of Medicine. Plummeting estrogen levels directly affect collagen production, skin thickness and hydration, so its important to develop an anti-aging skin care program, and stick with that program, during this decade.

With so many anti-aging products on the market boasting ingredients youd never thought youd put on your face (acids! oils!), it can be hard to figure out where to start.

So we reached out to top dermatologists across the country to help simplify the process. Everyone we spoke to listed sunscreen as the most important topical to keep forty-something skin looking great, followed by the appropriate cleanser, anti-ager, moisturizer and exfoliator.

Below, you'll find a quick guide to what youll need when it comes to choosing the right ingredients for your face, because as Gohara stressed, At this age, prevention not just correction should still be your goal.

When shopping for a sunscreen in your 40s, experts note you should be looking for the words zinc oxide, titanium dioxide and iron oxide on the label.

Zinc oxide and titanium dioxide protect against both UVA and UVB rays, while iron oxide guards against skin-damaging blue light from computer and cell phone screens, notes Gohara. Look for an SPF of 30 or higher and slather on half a teaspoon on your face daily, including your ears and neck, before applying makeup. If you drive, be sure to protect your hands, as UVA rays can penetrate glass, resulting in sunspots.

EltaMD UV Facial Broad-Spectrum SPF 30+, despite having zinc oxide, doesnt leave your skin with a whiteish tint. It's also formulated with hyaluronic acid, which can help keep your skin hydrated and firm.

Supergoop! Unseen Sunscreen SPF 40 is oil-free, goes on clear and works as a makeup primer to control shine. The vegan formula should be applied as the last step in your skin care regimen before you apply makeup, at least 15 minutes before you step out into the sun.

Gohara recommends keeping this brush-on SPF powder in your glove compartment. With SPF 50, the water-resistant formula provides both protection and sheer tinted coverage.

In your 40s, derms recommend using a cleanser containing ceramides, glycerin, and vitamin E.

Ceramides are lipids that help retain moisture, glycerin is a humectant that pulls water from the deepest layers of the skin, while vitamin E also adds moisture, says Dr. Martha Viera, volunteer faculty at the University of Miami Department of Dermatology. Before cleansing, wash your hands thoroughly to avoid dirt or bacteria from touching your skin, and splash your face with lukewarm water prior to application to activate the cleansing ingredients. Start and end your day by washing with a quarter-sized amount of cleanser, applying it in a circular motion over your face and neck.

Viera likes La Roche-Posay Toleriane Hydrating Gentle Cleanser because its designed to balance the skins pH levels, protecting the skins sensitive barrier. It is formulated to cleanse the skin without stripping it of moisture thanks to ingredients such as glycerin and niacinamide.

Bioderma Sensibio Foaming Gel has a soothing gel-cream texture that turns to foam when activated. The gentle formula works to remove makeup while also hydrating the skin.

Dove White Beauty Bar with Deep Moisture is great for sensitive skin as it combines cleansing ingredients with a dose of moisturizing cream. It is suitable for sensitive skin and gentle enough to use on both your face and body.

Youll need two anti-aging products in your 40s: a morning serum that contains moisture-drawing hyaluronic acid and antioxidants, and a night serum that includes peptides and retinol (retinol should be applied at night as it can make your skin sensitive to the sun).

Be sure to layer your anti-ager under your moisturizer and consider a serum which, thanks to their small molecular makeup, absorbs quickly and deeply, says Dr. Arisa Ortiz, director of laser and cosmetic dermatology at the University of California at San Diego. Antioxidants like vitamin C, E, B5, and resveratrol attach themselves to free radicals, preventing the free radicals from latching onto and damaging healthy skin cells, while retinoids and peptides exfoliate dead skin while stimulating collagen and softening lines.

Obagi Professional-C Serum contains ascorbic acid, a vitamin C derivative that softens the look of pigmentation and encourages collagen growth. It can be applied to the face, neck and chest in the mornings and followed with sunscreen.

Dr. Ortiz likes Rodan + Fields Intensive Renewing Serum because its lightweight, absorbs easily and has the highest levels of vitamin A for a nonprescription product. The serums are held in small capsules that you can open to smooth all over your skin.

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This dermatologist-approved pick is suitable for normal, sensitive and dry skin. The formula works to not only visibly brighten the skin but also reduce the appearance of fine lines and wrinkles.

To tackle dry skin in your 40s, Gohora recommends looking for ingredients that help boost and maintain moisture, including niacinamide, ceramides, glycerin and hyaluronic acid.

To be most effective, apply your moisturizer after your anti-aging serum. Dot your cheeks, forehead, chin and nose, and then rub in a circular upward motion both morning and night, notes Dr. Paul Jarrod Frank, clinical assistant professor of dermatology at The Icahn School of Medicine at Mount Sinai Hospital and author of "The Pro-Aging Playbook."

This moisturizer comes in a soothing light gel-cream formula and uses hyaluronic acid to fortify the lipid barrier to prevent dryness. It can be applied twice daily after a serum is applied to the skin.

Pause Collagen Boosting Moisturizer contains skin-conditioning fatty acids and B vitamins that work to promote healthy skin. The formula features the brand's "Pause Complex," which combines vitamins, antioxidants and peptides that help boost collagen production.

Dr. Frank likes Caudalie Vinoperfect Brightening Moisturizer, a lightweight gel that contains niacinamide and hyaluronic acid for a boost of hydration. It can be applied in the mornings to the face and neck in order to brighten and moisturize the skin.

Acids in exfoliators help remove layers of dead skin cells to promote cell turnover, clear pores and reduce pigmentation. Look for words such as glycolic, lactic, mandelic or salicylic acid on the label.

Apply a dime-sized amount of facial exfoliator two to three times a week at night, Jarrod told us. Just dont overdo it too much exfoliation can rob skin of the fatty acids that protect the skin barrier.

This treatment addresses skin care concerns by exfoliating, purifying and smoothing the skin. Depending on your skin type, it can be used up to three times a week to improve the appearance of your complexion.

Dr. Frank likes Drunk Elephant T.L.C. Sukari Babyfacial, which has an eye-popping 25% glycolic and lactic acid blend to smooth and brighten skin. Since the formula uses clean ingredients, it is fragrance-free and won't leave the skin feeling irritated.

A derivative of salicylic acid can be found in Lancme Renergie Lift Multi-Action Ultra Milk Peel, a leave-on exfoliator that you apply after cleansing and before your moisturizer. The milky consistency feels smooth on the skin and should be applied with a cotton round.

Dermalogica Daily Microfoliant contains salicylic acid and foams up into a paste when activated with water. The formula can be applied daily to the skin to slough off dead skin cells and even out your complexion.

Although it is a bit of a splurge, this daily serum uses rich ingredients such as mandelic and lactic acid to unclog pores, even skin texture, reduce the appearance of fine lines and more. It can be applied to the face and neck to reveal brighter skin over time.

Bonus products: Our experts noted theres no harm incorporating a neck or eye cream into your routine in your 40s.

Look for targeted ingredients in a neck cream, such as tetrapeptides to promote collagen formation, antioxidant algae extract to protect against free radicals, glucosamine to stimulate hyaluronic acid and improve hydration while decreasing wrinkles, and omega-3 fatty acids to add moisture.

Apply a dime-size amount in the morning and evening, working your way up the neck to the jawline until the product is evenly distributed and absorbed, notes Gohara. Neck creams tend to be thicker than traditional moisturizers, so allow more time for them to absorb and be sure to follow up with a sunscreen in the morning.

Viera likes Revision Nectifirm Advanced, which uses peptides to smooth dry skin. Other ingredients such as lingonberry extract work with the skin's natural microbiome to provide soothing results.

Prai Ageless Throat & Dcolletage Creme has shea butter and hyaluronic acid to plump lines and effectively smooth the skin. For best results, the brand recommends applying the moisturizer twice daily to target areas.

Suzanne Somers Organics Neck Firming Crme contains tetrapeptides to support collagen and elastin growth. The formula is packed with skin-boosting ingredients such as hyaluronic acid and Swiss apple stem cells that help to combat signs of aging.

This cream can be applied twice daily in upward motions to hydrate and revitalize the skin. The formula is quick-absorbing, so it won't leave the skin feeling oily or greasy.

Look for ingredients like caffeine to reduce puffiness and dark circles, niacinamide and hyaluronic acid to plump fine lines, and arginine, growth factors, and retinol to boost collagen production.

Apply a pea-sized amount twice daily by gently patting the cream on with your ring finger, Viera said. Be sure to use any eye products containing retinoids at night to avoid sun sensitivity.

Dr. Viera likes Neocutis Lumire Illuminating Eye Cream, a lightweight cream that contains antioxidants to protect against environmental damage. In addition to its protective qualities, it can also be used to reduce the appearance of puffiness and dark circles.

RoC Retinol Correxion Eye Cream uses a derivative of vitamin A to accelerate the removal of dead skin cells, leaving you with visibly brighter skin. It targets concerns such as crow's feet, under-eye wrinkles, deep wrinkles and fine lines.

Skinbetter Science Interfuse Eye Treatment Cream contains caffeine to reduce puffiness and vitamin C to brighten the under-eye area. It is packed with humectants to help lock in moisture and promote healthy skin.

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The best anti-aging skin care products to use in your 40s - TODAY

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40 Hot Weather Hacks: The lazy girls’ hair and beauty product guide to summer – Metro.co.uk

By daniellenierenberg

(Picture; Nuthing)

Lets face it, the past few months have been stressful enough were due a break. And frankly summer should be off-season for anything high-maintenance.

Whether you are WFH in August or actually managing a getaway, right now we are all looking for no-fuss makeup, hassle-free hair and stress-free style.

Heres what can help you look and feel your best, with as little effort as possible:

Lots has been written about the importance of Vitamin D in recent months and although were (hopefully) getting sunshine about now it important to keep levels high.

Myprotein makes a convenient spray in both Vitamin D3 and B12 that ensure everyone gets the essential micronutrients and vitamins that we might miss if were in front of a laptop.

Vitamin D3 Spray, 8.99, MyProtein

This award-winning collagen drink supplement is packed with the highest concentration of marine collagen on the market. Its also infused with vitamin C, which works with the collagen to enhance skin rejuvenation and tissue renewal.

A fuss-free and easy addition to your beauty regime, users say that their skin feels softer, more hydrated and firmer.

Comes in 14 ready-mixed 10ml sachets; can be added to hot or cold drinks.

Collagen Drink Supplement For Women, 32.99, Absolute Collagen

Too tired to make your own? These are insta-healthy meals. Purition is 100% whole food shakes, are made from crushed nuts, seeds, fruits and vegetables and come in ordinary or vegan recipe. All are gluten-free and low in sugar.

Flavours include superfood ingredients such as turmeric and beetroot.

Original Discovery Box, 13.50, Purition

Epsom salts have long been hailed by wellness experts for instantly de-bloating and helping with water retention.

These from Westlab do even more. Mixed with essential oils, the Alchemy range helps draw fluid and toxins from the body and can soothe tired, aching, overworked muscles and revive body and mind.

Plus they smell great.

Westlabs Recover Epsom Salts White Willow & Eucalyptus, 5.99, Amazon

A body hack that can help you lose around 5-7 lbs in 5 days and it is actually good for you.

Developed at the Longevity Institute of the University of Southern California (USC) and under the sponsorship of the National Institute for Aging and the National Institute of Health, this five day programme tricks your body into thinking its fasting, and while you get the health benefits, you can continue eating.

Each days complete nutrition arrives in 5 small boxes (one for each day) that include plant-based energy bars, soups, snacks, drinks, and supplements, all carefully designed to nourish your body and promote positive changes in metabolic markers, cellular rejuvenation, reduced inflammation, and healthy aging

ProLon Fasting Mimicking Diet, 200, ProLon

These brand new sauna blankets are built with layers of infrared heating and toxin-free fabrics that lets you feel like youre in a spa without ever leaving home.

You just roll it out on a heatproof surface like your bed and use a handheld controller to begin heating it up. The blanket uses far-infrared heat that makers promise can help detoxify the body, rejuvenate skin, reduce stress, burn calories and give you that relaxed, stress-busting feeling a sauna does.

Benefits also include better blood flow, sleep and of course, there is the calorie burn (who doesnt love a workout you can do lying down watching Netflix?). 30 mins to an 1 hour per session recommended.

Infrared Sauna Blanket, 374, MiHigh UK

Dr Galyna Selezneva, Londons top Body Doctor, gets asked every day about cellulite. If a visit to her or another expert practitioner is not on your summer agenda, she advises to drink more water and move more but the most important thing? Dry Brushing!

Calling it, one of the most underrated and effective ways to beat cellulite, Dr Galyna advises just a few minutes a day, is enough to see results. It improves lymphatic drainage, and fluid retention and lessens cellulite. Results are instant and lasting.

Dr Galyna Selezneva, Rita Rakus Clinic

A sustainable and organic brand created by Danish born US based, make-up artist Kirsten Kjaer Weis, these are the brands hero cream blushes together with a complementary highlighter shade which gives an instant glow.

Minimalist and sleek, the shades work together to create the ultimate bronze and flushed duo for light to medium skin tones and blush and highlight for deeper skin tones.

Kjaer Weis Flush and Glow Duo, 41, Content Beauty Wellbeing

Is lockdown face a real thing?

If youve picked up a bit of puff during all of this, this wonder cream can have you looking sleek and sharp on your zoom call in no time.

Tighter skin, instantly, minus the toxins of injectables. Beloved by cheekbone superior girls like Gwyneth Paltrow, Sienna Miller and Victoria Beckham, its packed with plant extracts and high actives and relies on neuropeptides (naturally derived from algae) to smooth skin. Regularly named as a best natural alternative to Botox by beauty editors.

V-Tox, 105, 99, Linda Meredith

Only sold online, this is a great way to cheat a tan.

Giving your face an instant, natural sun-kissed glow, its packed with ingredients that illuminate, hydrate and perfect the skin.

It comes with a Face Mist and handy Face Lifter Brush that makes it go on really evenly and without staining your hands.

The Bronze & Sculpt Duo, 55.00 Amanda Harrington

The golden glow you love with none of the fuss. Free of odours, orange tones and streaks it gives a great sun-kissed complexion but also sun protection.

Blended with organic sunscreens, it has SPF 50 UVA protection and combines natural gradual technology and instant tanning without clogging pores, allowing the skin to breathe.

Tancream All in One Self Tan, Bronzer and SPF50, Ideal World TV

Tired of scrubbing off old spray tan? Looking to get rid of bronze streaks, while you relax?

This new bath bomb from Lusso Tan is the worlds first tan-removing bath bomb, just relax in a bath filled with essential-oil infused water and watch your tan dissolve before your eyes!

Full of skin-loving ingredients, the Lusso Tan Bath Bomb removes tan in a matter of minutes, while repairing and protecting the skin at the same time. The longer you soak, the better the tan-removing results.

Summer Meadow Bath Bomb, 8.50, Lusso Tan

Specifically designed for the delicate eye area, these little beauties work to stop eyes from looking tired, no matter how little sleep youre getting.

Stick under the eye for around 15 minutes and notice immediate results.

Filled with antioxidant-rich flower extract serum that feels cool to the skin and aims to smooth the look of fine lines and wrinkles, the pack contains 5 x 2 eye pads.

Rose Blossom Glow Hydro-Gel Eye Pads 5 x 2 29.90, Eclat Skin London

Instantly glam up with these beauties.

With eyelash extensions having been on hold because of Covid, award-winning Dollbaby London has come up with a way to boost your lashes that is easy, effective and mess-free.

The UKs first 2-in-1 eyeliner and lash adhesive, the Dollbaby Duo Pen works with any strip (non magnetic) lashes. Simply line the eye with two coats like a regular eyeliner, apply your lashes immediately on top of the liner (no drying time required) and go!

Unlike other eyelash glues, theres drying time and its not sticky or messy. And the pens ultra-fine tip is easy to apply. Vegan and cruelty-free, it comes in black or clear for a more natural look.

To remove, simply peel lashes off and remove eyeliner with normal makeup remover. Will give you approx 30-40 applications

Duo Pen, 19.75, Doll Baby London

Why go to a salon when you can give yourself a 5-minute facial in your own bathroom?

A fantastic do-it-yourself facial peel, skin looks clear, clean and smooth instantly. Made with with dead-cell sloughing glycolic acids, powerful pomegranate enzymes, gentle bamboo scrub grains, purifying salicylic acid and anti-free-radical stem cells from raspberries.

Fruitizyme Five Minute Facial, Beauty Pie Members 10.26, Beauty Pie

Pretty summer dresses can also mean painful, sweaty and chafing thighs in the hot summer sunshine.

Smoovall is a skin contact spray that leaves an invisible protective layer that prevents the soreness and irritation caused by friction (chafing).

Its a non toxic spray and unlike the common roller balms and powders, is non-greasy and invisible.

Skin contact spray, 14.99, Smoovall

A super affordable summer essentials kit packed with everything you need beauty-wise.

New from GlossyBox, it includes everything from an ultra gentle facial peel, a jet lag recovery mask, a coco shimmer body mist, lip balm, nail polish, dry shampoo body cream, tangle teezer and lip balm.

Summer Essentials, (valued over 95, but 30 for subscribers and 35 for non-subscribers), Glossy Box

No time to social distance at a salon? Why not pedi at home?

This 7-day peel sock is the bomb. Just pull these on like socks, tape them around your ankles, wait an hour, wash, and 7 days and some very impressive exfoliation later, youll have feet so soft youll want to show them off.

Ingredients include glycolic and lactic acids, natural fruit extracts of grapefruit, orange and lemon, plus sweet almond and coconut extracts.

Dr Glycolic Soft Feet 7-Day Peel Socks, 3.92 Beauty Pie

This one is a game changer.

Remove & Chill is the first of its kind: an innovative, waterless, acetone-free removal cream that dissolves nail polish, nourishes nails and actually smells good. Its a nail polish remover cream, enriched with hydrating essential oils that removes nail polish in 3 minutes.

Its also travel friendly.

Remove & Chill Nail Polish Eraser Cream, 14.25, Beauty Mart

Want freedom from a hot blow dryer this summer? Who doesnt?

Celebrity stylist Edward James has created a signature treatment that offers smoothness without the hot air. Not to be confused with a Brazilian blow dry, which is made for thicker, stronger Brazilian hair, this one is gentler and suits finer hair.

An ammonia-free glossing oil adds shine and moisture followed by Edwards secret formula a smoothing keratin applied to the frizziest part of the hair with a paint brush.

Its 100, takes 15 minutes, contains no formaldehyde and is heaven in humidity. It lasts for up to 6 weeks, ensuring you will never resemble Monica from Friends even in the hottest days of summer.

British Blow Dry, 100, Edward James London

This is a great dry shampoo that cleans hair and lets you go longer between washes.

It uses Living Proofs triple cleaning technology to absorb and remove dirt, oil and sweat you just leave for 30 seconds and let the cleansing begin.

A time-release fragrances helps hair smell clean- a great way to wash less often protecting your fresh head of colour after your long-awaited salon appointment!

Living Proof Dry Shampoo, 19.99, Living Proof

These seamless clip-ins are amazing. Instantly change and update your look with no effort at all.

They are comfortable and lay flat on the scalp which means no irritating bits poking through your perfect coif.

Their silicone band technology fuses and bonds every single strand of hair at the top of each weft which means there is less shedding and tangling too.

14in Seamless Clip In Human Hair Extensions, 95, Foxy Locks

This 100% vegan friendly, cruelty-free brand makes waxing fun (well, as fun as it can be).

Enriched with things like apricot extract to soothe and moisturise the skin, plus Vitamin E for its antioxidants and anti-ageing effects, the body hair removal jelly is fuss-free and works fast in just 5-10 minutes.

For use on body hair of all lengths. Suitable for sensitive skin Available in 3 scents Strawberry & Watermelon, Pineapple & Coconut and Blueberry & Passionfruit.

Pink Shimmer Hair Removal Jelly, 9.99, Nuthing

Hair takes a beating in the summer and this new range of snazzy hair products are kind to both hair and the environment.

Promising no sulfates, parabens, silicones, or even gluten, the range is vegan and cruelty-free with 100% recyclable sugarcane bottles. They are also affordable and great on hair.

The rescue mask is a summer stand out ideal for colour treated hair, it seals cuticles and repairs split ends and it also has UV protection and a pollution barrier. Ingredients include coconut & yuzu scent, sugar beet extract, and vegetable derived conditioners.

Azure by PFB Rescue & Repair Mask, 10.99, Boots

If your eyebrows are an untamed as theyve ever been enter a summer must-have. This painless eyebrow trimmer looks like a stylish pen and trims eyebrows at the touch of a button.

A precision-engineered shaper, this nifty gadget has a tiny and super-accurate micro-precision trimming head, encased in 18 karat gold plate.

JML Finishing Touch Flawless Brows, 19.97, Amazon

Banish those unwanted hairs once and for all.

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Coronavirus Drug and Treatment Tracker – The New York Times

By daniellenierenberg

The Covid-19 pandemic is one of the greatest challenges modern medicine has ever faced. Doctors and scientists are scrambling to find treatments and drugs that can save the lives of infected people and perhaps even prevent them from getting sick in the first place.

Below is an updated list of 20 of the most-talked-about treatments for the coronavirus. While some are accumulating evidence that theyre effective, most are still at early stages of research. We also included a warning about a few that are just bunk.

We are following 20 coronavirus treatments for effectiveness and safety:

Tentative or

mixed evidence

We are following 20 coronavirus treatments

for effectiveness and safety:

Tentative or

mixed evidence

We are following 20 coronavirus treatments

for effectiveness and safety:

There is no cure yet for Covid-19. And even the most promising treatments to date only help certain groups of patients and await validation from further trials. The F.D.A. has not fully licensed any treatment specifically for the coronavirus. Although it has granted emergency use authorization to some treatments, their effectiveness against Covid-19 has yet to be demonstrated in large-scale, randomized clinical trials.

This list provides a snapshot of the latest research on the coronavirus, but does not constitute medical endorsements. Always consult your doctor about treatments for Covid-19.

New additions and recent updates:

Added ivermectin, a drug typically used against parasitic worms that is being increasingly prescribed in Latin America. Aug. 10

Updated descriptions for several treatments. Aug. 10

We will update and expand the list as new evidence emerges. For details on evaluating treatments, see the N.I.H. Covid-19 Treatment Guidelines. For the current status of vaccine development, see our Coronavirus Vaccine Tracker.

WIDELY USED: These treatments have been used widely by doctors and nurses to treat patients hospitalized for diseases that affect the respiratory system, including Covid-19.

PROMISING EVIDENCE: Early evidence from studies on patients suggests effectiveness, but more research is needed. This category includes treatments that have shown improvements in morbidity, mortality and recovery in at least one randomized controlled trial, in which some people get a treatment and others get a placebo.

TENTATIVE OR MIXED EVIDENCE: Some treatments show promising results in cells or animals, which need to be confirmed in people. Others have yielded encouraging results in retrospective studies in humans, which look at existing datasets rather than starting a new trial. Some treatments have produced different results in different experiments, raising the need for larger, more rigorously designed studies to clear up the confusion.

NOT PROMISING: Early evidence suggests that these treatments do not work.

PSEUDOSCIENCE OR FRAUD: These are not treatments that researchers have ever considered using for Covid-19. Experts have warned against trying them, because they do not help against the disease and can instead be dangerous. Some people have even been arrested for their false promises of a Covid-19 cure.

EVIDENCE IN CELLS, ANIMALS or HUMANS: These labels indicate where the evidence for a treatment comes from. Researchers often start out with experiments on cells and then move onto animals. Many of those animal experiments often fail; if they dont, researchers may consider moving on to research on humans, such as retrospective studies or randomized clinical trials. In some cases, scientists are testing out treatments that were developed for other diseases, allowing them to move directly to human trials for Covid-19.

All treatmentsWidely usedPromisingTentative or mixedNot promisingPseudoscience

Antivirals can stop viruses such as H.I.V. and hepatitis C from hijacking our cells. Scientists are searching for antivirals that work against the new coronavirus.

PROMISING EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSEMERGENCY USE AUTHORIZATIONRemdesivirRemdesivir, made by Gilead Sciences, was the first drug to get emergency authorization from the F.D.A. for use on Covid-19. It stops viruses from replicating by inserting itself into new viral genes. Remdesivir was originally tested as an antiviral against Ebola and Hepatitis C, only to deliver lackluster results. But preliminary data from trials that began this spring suggested the drug can reduce the recovery time of people hospitalized with Covid-19 from 15 to 11 days. (The study defined recovery as either discharge from the hospital or hospitalization for infection-control purposes only.) These early results did not show any effect on mortality, though retrospective data released in July hints that the drug might reduce death rates among those who are very ill.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSFavipiravirOriginally designed to beat back influenza, favipiravir blocks a viruss ability to copy its genetic material. A small study in March indicated the drug might help purge the coronavirus from the airway, but results from larger, well-designed clinical trials are still pending.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSMK-4482Another antiviral originally designed to fight the flu, MK-4482 (previously known as EIDD-2801) has had promising results against the new coronavirus in studies in cells and on animals. Merck, which has been running clinical trials on the drug this summer, has announced it will launch a large Phase III trial in September.Updated Aug. 6

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS Recombinant ACE-2To enter cells, the coronavirus must first unlock them a feat it accomplishes by latching onto a human protein called ACE-2. Scientists have created artificial ACE-2 proteins which might be able to act as decoys, luring the coronavirus away from vulnerable cells. Recombinant ACE-2 proteins have shown promising results in experiments on cells, but not yet in animals or people.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS AND HUMANS IvermectinFor decades, ivermectin has served as a potent drug to treat parasitic worms. Doctors use it against river blindness and other diseases, while veterinarians give dogs a different formulation to cure heartworm. Studies on cells have suggested ivermectin might also kill viruses. But scientists have yet to find evidence in animal studies or human trials that it can treat viral diseases. As a result, Ivermectin is not approved to use as an antiviral.

In April, Australian researchers reported that the drug blocked coronaviruses in cell cultures, but they used a dosage that was so high it might have dangerous side effects in people. The FDA immediately issued a warning against taking pet medications to treat or prevent Covid-19. These animal drugs can cause serious harm in people, the agency warned.

Since then a number of clinical trials have been launched to see if a safe dose of ivermectin can fight Covid-19. In Singapore, for example, the National University Hospital is running a 5,000-person trial to see if it can prevent people from getting infected. As of now, theres no firm evidence that it works. Nevertheless ivermectin is being prescribed increasingly often in Latin America, much to the distress of disease experts.Updated Aug. 10

NOT PROMISING EVIDENCE IN CELLS AND HUMANS Lopinavir and ritonavirTwenty years ago, the F.D.A. approved this combination of drugs to treat H.I.V. Recently, researchers tried them out on the new coronavirus and found that they stopped the virus from replicating. But clinical trials in patients proved disappointing. In early July, the World Health Organization suspended trials on patients hospitalized for Covid-19. They didnt rule out studies to see if the drugs could help patients not sick enough to be hospitalized, or to prevent people exposed to the new coronavirus from falling ill. The drug could also still have a role to play in certain combination treatments.

NOT PROMISING EVIDENCE IN CELLS, ANIMALS AND HUMANSHydroxychloroquine and chloroquineGerman chemists synthesized chloroquine in the 1930s as a drug against malaria. A less toxic version, called hydroxychloroquine, was invented in 1946, and later was approved for other diseases such as lupus and rheumatoid arthritis. At the start of the Covid-19 pandemic, researchers discovered that both drugs could stop the coronavirus from replicating in cells.

Since then, theyve had a tumultuous ride. A few small studies on patients offered some hope that hydroxychloroquine could treat Covid-19. The World Health Organization launched a randomized clinical trial in March to see if it was indeed safe and effective for Covid-19, as did Novartis and a number of universities. Meanwhile, President Trump repeatedly promoted hydroxychloroquine at press conferences, touting it as a game changer, and even took it himself. The F.D.A. temporarily granted hydroxychloroquine emergency authorization for use in Covid-19 patients which a whistleblower later claimed was the result of political pressure. In the wake of the drugs newfound publicity, demand spiked, resulting in shortages for people who rely on hydroxychloroquine as a treatment for other diseases.

But more detailed studies proved disappointing. A study on monkeys found that hydroxychloroquine didnt prevent the animals from getting infected and didnt clear the virus once they got sick. Randomized clinical trials found that hydroxychloroquine didnt help people with Covid-19 get better or prevent healthy people from contracting the coronavirus. Another randomized clinical trial found that giving hydroxychloroquine to people right after being diagnosed with Covid-19 didnt reduce the severity of their disease. (One large-scale study that concluded the drug was harmful as well was later retracted.) The World Health Organization, the National Institutes of Health and Novartis have since halted trials investigating hydroxychloroquine as a treatment for Covid-19, and the F.D.A. revoked its emergency approval. The F.D.A. now warns that the drug can cause a host of serious side effects to the heart and other organs when used to treat Covid-19.

In July, researchers at Henry Ford hospital in Detroit published a study finding that hydroxychloroquine was associated with a reduction in mortality in Covid-19 patients. President Trump praised the study on Twitter, but experts raised doubts about it. The study was not a randomized controlled trial, in which some people got a placebo instead of hydroxychloroquine. The studys results might not be due to the drug killing the virus. Instead, doctors may have given the drug to people who were less sick, and thus more likely to recover anyway.

Despite negative results, a number of hydroxychloroquine trials have continued, although most are small, testing a few dozen or a few hundred patients. A recent analysis by STAT and Applied XL found more than 180 ongoing clinical trials testing hydroxychloroquine or chloroquine, for treating or preventing Covid-19. Although its clear the drugs are no panacea, its theoretically possible they could provide some benefit in combination with other treatments, or when given in early stages of the disease. Only well-designed trials can determine if thats the case.Updated Aug. 10

Most people who get Covid-19 successfully fight off the virus with a strong immune response. Drugs might help people who cant mount an adequate defense.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS AND HUMANS Convalescent plasmaA century ago, doctors filtered plasma from the blood of recovered flu patients. So-called convalescent plasma, rich with antibodies, helped people sick with flu fight their illness. Now researchers are trying out this strategy on Covid-19. In May, the F.D.A. designated convalescent plasma an investigational product. That means that despite not yet being shown as safe and effective, plasma can be used in clinical trials and given to some patients who are seriously ill with Covid-19. Tens of thousands of patients in the U.S. have received plasma through a program launched by the Mayo Clinic and the federal government.

The Trump administration has praised convalescent plasma, despite the lack of evidence yet that it works. The first wave of trials have been small and the results have been mixed. Large randomized clinical trials are underway, but theyve struggled to enroll enough participants, some of whom worry they will receive a placebo instead of the treatment itself.

Experts say that its vital to complete these trials to determine if convalescent plasma is safe and effective. If these trials are successful, it could serve as an important stopgap measure until more potent therapies become widely available.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSMonoclonal antibodiesConvalescent plasma from people who recover from Covid-19 contains a mix of different antibodies. Some of the molecules can attack the coronavirus, but many are directed at other pathogens. Researchers have sifted through this slurry to find the most potent antibodies against Covid-19. They have then manufactured synthetic copies of these molecules, known as monoclonal antibodies. Researchers have begun investigating them as a treatment for Covid-19, either individually or in cocktails.

Monoclonal antibodies were first developed as a therapy in the 1970s, and since then the F.D.A. has approved them for 79 diseases, ranging from cancer to AIDS. Since the start of the pandemic, researchers have found dozens of monoclonal antibodies that show promise against Covid-19 in preclinical studies on cells and animals. Companies like Eli Lilly and Regeneron recently began clinical trials studying monoclonal antibodies. Several other firms, as well as teams at universities, are slated to enter the race soon as well.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSInterferonsInterferons are molecules our cells naturally produce in response to viruses. They have profound effects on the immune system, rousing it to attack the invaders, while also reining it in to avoid damaging the bodys own tissues. Injecting synthetic interferons is now a standard treatment for a number of immune disorders. Rebif, for example, is prescribed for multiple sclerosis.

As part of its strategy to attack our bodies, the coronavirus appears to tamp down interferon. That finding has encouraged researchers to see whether a boost of interferon might help people weather Covid-19, particularly early in infection. Early studies, including experiments in cells and mice, have yielded encouraging results that have led to clinical trials.

An open-label study in China suggested that the molecules could help prevent healthy people from getting infected. On July 20, the British pharmaceutical company Synairgen announced that an inhaled form of interferon called SNG001 lowered the risk of severe Covid-19 in infected patients in a small clinical trial. The full data have not yet been released to the public, or published in a scientific journal. On August 6, the National Institute of Allergy and Infectious Diseases launched a Phase III trial on a combination of Rebif and the antiviral remdesivir, with results expected by fall 2020.Updated Aug. 10

The most severe symptoms of Covid-19 are the result of the immune systems overreaction to the virus. Scientists are testing drugs that can rein in its attack.

PROMISING EVIDENCE EVIDENCE IN HUMANS DexamethasoneThis cheap and widely available steroid blunts many types of immune responses. Doctors have long used it to treat allergies, asthma and inflammation. In June, it became the first drug shown to reduce Covid-19 deaths. That study of more than 6,000 people, which in July was published in the New England Journal of Medicine, found that dexamethasone reduced deaths by one-third in patients on ventilators, and by one-fifth in patients on oxygen. It may be less likely to help and may even harm patients who are at an earlier stage of Covid-19 infections, however. In its Covid-19 treatment guidelines, the National Institutes of Health recommends only using dexamethasone in patients with COVID-19 who are on a ventilator or are receiving supplemental oxygen.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS Cytokine InhibitorsThe body produces signaling molecules called cytokines to fight off diseases. But manufactured in excess, cytokines can trigger the immune system to wildly overreact to infections, in a process sometimes called a cytokine storm. Researchers have created a number of drugs to halt cytokine storms, and they have proven effective against arthritis and other inflammatory disorders. Some turn off the supply of molecules that launch the production of the cytokines themselves. Others block the receptors on immune cells to which cytokines would normally bind. A few block the cellular messages they send. Depending on how the drugs are formulated, they can block one cytokine at a time, or muffle signals from several at once.

Against the coronavirus, several of these drugs have offered modest help in some trials, but faltered in others. Drug companies Regeneron and Roche drug both recently announced that two drugs called sarilumab and tocilizumab, which both target the cytokine IL-6, did not appear to benefit patients in Phase 3 clinical trials. Many other trials remain underway, several of which combine cytokine inhibitors with other treatments.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS EMERGENCY USE AUTHORIZATIONBlood filtration systemsThe F.D.A. has granted emergency use authorization to several devices that filter cytokines from the blood in an attempt to cool cytokine storms. One machine, called Cytosorb, can reportedly purify a patients entire blood supply about 70 times in a 24-hour period. A small study in March suggested that Cytosorb had helped dozens of severely ill Covid-19 patients in Europe and China, but it was not a randomized clinical trial that could conclusively demonstrate it was effective. A number of studies on blood filtration systems are underway, but experts caution that these devices carry some risks. For example, such filters could remove beneficial components of blood as well, such as vitamins or medications.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS Stem cellsCertain kinds of stem cells can secrete anti-inflammatory molecules. Over the years, researchers have tried to use them as a treatment for cytokine storms, and now dozens of clinical trials are under way to see if they can help patients with Covid-19. But these stem cell treatments havent worked well in the past, and its not clear yet if theyll work against the coronavirus.

Doctors and nurses often administer other supportive treatments to help patients with Covid-19.

WIDELY USEDProne positioningThe simple act of flipping Covid-19 patients onto their bellies opens up the lungs. The maneuver has become commonplace in hospitals around the world since the start of the pandemic. It might help some individuals avoid the need for ventilators entirely. The treatments benefits continue to be tested in a range of clinical trials.

WIDELY USEDEMERGENCY USE AUTHORIZATIONVentilators and other respiratory support devicesDevices that help people breathe are an essential tool in the fight against deadly respiratory illnesses. Some patients do well if they get an extra supply of oxygen through the nose or via a mask connected to an oxygen machine. Patients in severe respiratory distress may need to have a ventilator breathe for them until their lungs heal. Doctors are divided about how long to treat patients with noninvasive oxygen before deciding whether or not they need a ventilator. Not all Covid-19 patients who go on ventilators survive, but the devices are thought to be lifesaving in many cases.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS AnticoagulantsThe coronavirus can invade cells in the lining of blood vessels, leading to tiny clots that can cause strokes and other serious harm. Anticoagulants are commonly used for other conditions, such as heart disease, to slow the formation of clots, and doctors sometimes use them on patients with Covid-19 who have clots. Many clinical trials teasing out this relationship are now underway. Some of these trials are looking at whether giving anticoagulants before any sign of clotting is beneficial.

False claims about Covid-19 cures abound. The F.D.A. maintains a list of more than 80 fraudulent Covid-19 products, and the W.H.O. debunks many myths about the disease.

WARNING: DO NOT DO THISDrinking or injecting bleach and disinfectantsIn April, President Trump suggested that disinfectants such as alcohol or bleach might be effective against the coronavirus if directly injected into the body. His comments were immediately refuted by health professionals and researchers around the world as well as the makers of Lysol and Clorox. Ingesting disinfectant would not only be ineffective against the virus, but also hazardous possibly even deadly. In July, Federal prosecutors charged four Florida men with marketing bleach as a cure for COVID-19.

WARNING: NO EVIDENCEUV lightPresident Trump also speculated about hitting the body with ultraviolet or just very powerful light. Researchers have used UV light to sterilize surfaces, including killing viruses, in carefully managed laboratories. But UV light would not be able to purge the virus from within a sick persons body. This kind of radiation can also damage the skin. Most skin cancers are a result of exposure to the UV rays naturally present in sunlight.

WARNING: NO EVIDENCESilverThe F.D.A. has threatened legal action against a host of people claiming silver-based products are safe and effective against Covid-19 including televangelist Jim Bakker and InfoWars host Alex Jones. Several metals do have natural antimicrobial properties. But products made from them have not been shown to prevent or treat the coronavirus.

Note: After additional discussions with experts we have adjusted several labels on the tracker. The Strong evidence label has been removed until further research identifies treatments that consistently benefit groups of patients infected by the coronavirus. In its place, Promising evidence will be used for drugs such as remdesivir and dexamethasone that have shown promise in at least one randomized controlled trial, and Widely used for treatments such as proning and ventilators that are often used with severely ill patients, including those with Covid-19. And we may reintroduce the Ineffective label when ongoing clinical trials repeatedly end with disappointing results.

Sources: National Library of Medicine; National Institutes of Health; William Amarquaye, University of South Florida; Paul Bieniasz, Rockefeller University; Jeremy Faust, Brigham & Womens Hospital; Matt Frieman, University of Maryland School of Medicine; Noah Haber, Stanford University; Swapnil Hiremath, University of Ottawa; Akiko Iwaskai, Yale University; Paul Knoepfler, University of California, Davis; Elena Massarotti, Brigham and Womens Hospital; John Moore and Douglas Nixon, Weill Cornell Medical College; Erica Ollman Saphire, La Jolla Institute for Immunology; Regina Rabinovich, Harvard T.H. Chan School of Public Health; Ilan Schwartz, University of Alberta; Phyllis Tien, University of California, San Francisco.

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Coronavirus Drug and Treatment Tracker - The New York Times

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Why Silicon Valley Execs Are Investing Billions to Stay Young – Robb Report

By daniellenierenberg

Entrepreneur Dave Aspreys end-of-life plans are quite simple, really, even if some of his ambitions sound laughably optimistic to most of us.I want to die at a time and by a method of my own choosing, and keep doing awesome things until that day, he tells me. I dont think its outrageous to believe Ill make it to 180 years old. And if I run out of energy, itll just be because I did too much cool shit for my own good.

Asprey is strolling across his lush property in British Columbia, holding up his phone and pointing out the specimens in this years garden as we chat over Zoom in the midst of the global pandemic. Hes protecting his skin from the sun with a goofy Outdoor Research hat and wearing a long string of beads that he says are each over a hundred years old, from cultures around the world.

Asprey, 48, is the founder of the Bulletproof wellness empire and a vocal champion of the movement to extend human life expectancy beyond 100 years. Hes made millions by experimenting on his own body and packaging his home-brewed discoveries into books, a podcast, consulting services and consumer products (you may have even tried his butter-laced coffee). Asprey, who was a web-security executive before he became the Bulletproof Executive, is just one of a cadre of tech elite who have begun directing their attentionand truckloads of moneytoward the problem of life extension. Jeff Bezos, Peter Thiel, Sergey Brin, Larry Ellisonname a Silicon Valley A-lister and he or she is likely funding longevity research, experimenting with anti-aging interventions or both. These are the masters of the universe who see no reason they cant take the tech industrys optimization obsession and apply it to the ultimate challenge: conquering death itself.

And their efforts appear to be paying off: Thanks to a recent explosion of advances in longevity medicine, Aspreys vision of living healthfully into his second century might not be so crazy. In fact, for people in middle age right now, a handful of therapies in clinical trials have the potential, for the first time in human history, to radically transform what old age looks like. If the life extensionists are right, a person whos 40 today might reasonably expect to still be downhill skiing, running a 10K or playing singles tennis at 100.

Dave AspreyDave Asprey

If you do anti-aging right, Asprey insists, youll have a level of resilience and energy to fight what comes your way. If you get Covid-19, youre less likely to become very sick. The idea is that at a cellular level, youre making yourself very hard to kill.

The most extreme of the controversial interventions Asprey has undergone involved having stem cells extracted from his own bone marrow and fat and then injected into hundreds of locations on his body. Into every joint, between every vertebra and into my cerebrospinal fluid, face and sex organs, he tells me cheerfully. For what I spent on that, I could have bought a really nicely appointed Tesla.

He trots up a flight of stairs to his home office, which sits above a million-dollar lab filled with health gadgets, such as a cryochamber, a hypoxic trainer and an AI-enabled stationary bike. For a wealthy person, investing in your body should be a major part of your Im rich strategy, he explains. Personally, I think you should be spending at least 2 to 3 percent of your net worth on health and longevity. Get a personal chef who can cook you the right food. Its not that hard.

It might be an exaggeration to say BioViva CEO Liz Parrish believes death is optional, but for her, Aspreys goal of living to 180 shows a distinct lack of ambition. If you can reach homeostasis in the body, Parrish says, where its regenerating itself just a little bit faster than its degrading, then what do you die of? An accident or natural disaster, probably. Theres no expiration date at 90 or 100 years old.

Tall, blond and fit, Parrish cuts a strikingly youthful figure at 49one that might convince you to order whatever shes having. But, like Asprey, she has received criticism from the longevity research community for becoming patient zero in her own experimental drug trial, aimed at halting aging at the cellular level. In 2015, Parrish underwent telomerase and follistatin gene therapies in Bogota, Colombia. The procedures involved receiving around a hundred injections of a cocktail of genes and a virus modified to deliver those new genes into her bodys cells. The objective was to prevent age-related muscle loss and lengthen her telomeres: the caps at the end of our chromosomes. Scientists have identified their unraveling as not only a marker of aging but also a potential cause of age-related decline.

Liz ParrishLiz Parrish

Parrish told the media about her clandestine experiment and has published periodic updates on her condition in the five years since, and she reports that she has indeed increased her muscle mass and lengthened her telomeres. Parrishs punk-rock approach stems from her conviction that the medical-research communityboth the Food and Drug Administration (FDA) and researchers who arent business-mindedis moving too slowly, with too much red tape, when it comes to advancing aging therapeutics. But gene therapy is a relatively new area of medicine that brings with it a host of new risks, including cancer, severe immune reactions and infections caused by the viral vector used to deliver the drug.

Parrish downplays such worries. There may be risks, she tells Robb Report. But the known risk is that youre 100 percent likely to die. So you have to decide for yourself if the potential benefit outweighs that.

Humans have always aspired to find the fountain of youth, so people might be skeptical about the fact that anti-aging technologies are working now, says British investor and businessman Jim Mellon. But the fact is that this is finally happening, and we need to seize the moment. Mellon cofounded Juvenescence, a three-year-old pharmaceutical company thats investing in multiple technologies simultaneously to increase the odds of bringing winning products to market.

Mellon, 63, has made his fortune betting on well-timed investment opportunities, and he predicts that a new stock-market mania for life extension is just around the corner. This is like the internet dial-up phase of longevity biotech, he enthuses. If youd invested in the internet in the very early days, youd be one of the richest people on the planet. Were at that stage now, so the opportunity for investors is huge. According to a report by Bank of America Merrill Lynch, hes not wrong: The market for technologies to increase human life span is projected to grow sixfold to $610 billion in just the next five years.

When I talk to Mellon in the late spring, hes sequestered on the rugged coast of the Isle of Man, a tiny spit of land in the Irish Sea. Despite being what he describes as imprisoned there for 15 weeksand countingduring the Covid-19 shutdown, hes jovial and chatty and wants to make it clear that his interest in life extension is much more than financial. Working to extend life is an ethical cause, he says. If we can help people to live healthfully until the end of life, well transform the world completely. Well reduce a huge amount of pressure on failing health-care systems, and well have to reimagine pension and life insurance. This should be the number-one tick in anyones investment portfolio.

If youd like to get on board with this social-impact view of longevity, it helps to understand the trajectory of aging today. In Americas most affluent neighborhoods, the average life span is about 88 years. (Meanwhile, in this countrys poorest, it hovers around a meager 66 because of a raft of inequalities, such as diet, stress, smoking, pollution and health care.) For most people, health starts gradually diminishing in the last 15 years of life with the onset of chronic conditions, including arthritis, neurodegeneration and diabetes. If we could eliminate such diseases of aging, experts say, the US could save an estimated $7.1 trillion in health-care costs over the next 50 years. (Quite where all these sprightly centenarians might live on this already densely populated planet remains to be seen.)

Jim MellonEric Verdin

One of Mellons bets is on a class of drugs called senolytics, which destroy senescent cells: the so-called zombie cells that, for complex reasons, stop dividing as we age. Senescent cells harm the body by secreting compounds that cause inflammation in surrounding tissues. Many age-related conditionsarthritis, diabetes, Alzheimers, cancerhave an inflammatory component, and studies suggest that a buildup of senescent cells is a large part of the problem.

A number of biotech start-ups are devel- oping drugs that target cell senescence, but the furthest along is Unity Biotechnology, a company in South San Francisco that has three drugs in clinical trials to address aging conditions, starting with osteoar- thritis of the knee. Unity raised more than $200 million from such big names as Thiel and Bezos, who chipped in through their investment firms, before going public in 2018. Since then, Mellon has also bought a small stake.

The holy grail of senolytics will be the development of a preventive therapy to wipe out senescent cells in the body before they cause conditions of aging, theoretically extending life span. In June, a team from Sloan Kettering published new breakthrough research showing that CAR T cellstypically used for precision cancer therapycan also be used to target and kill senescent cells. Prescription senolytics for anti-aging therapy are still years away, but unsurprisingly, theres an audience of longevity enthusiasts who want to access such anti-aging miracles yesterdayand no shortage of FDA-unapproved ways to chase after them. For instance, after a few studies examined the senolytic effects of a chemotherapy drug called dasatinib, the website FightAging.org published a step-by-step guide to senolytic self-experimentation using chemotherapeutics.

It doesnt take a Ph.D. in biochemistry to guess that taking off-label chemo drugs might come with harmful side effects, but that hasnt stopped a zealous group of body-hackers from trying it themselves and chronicling their efforts online. The internet is littered with novice longevity adviceand sketchy anti-aging companies eager to separate the hopeful and desperate from their money, like the company that charges $8,000 for transfusions of plasma from the blood of teenagers and early-twentysomethings (yes, just like Gavin Belson on HBOs Silicon Valley). Many of these are at best ineffective and at worst deadly, since the same cellular systems that fuel growth in young people might cause cancer when tipped into overdrive. Imagine the tragic irony of paying tens of thousands for a therapy that promises to help you live longer but actually causes the cancer that kills you.

Adobe

Beyond the obvious red flags of repurposed chemo drugs and the bloodletting of teens, it can be difficult for a layperson to separate the world-changing longevity breakthroughs from the terrible ideas. Enter one of the worlds leading experts on longevity to help make sense of things.

Eric Verdin, 63, is president and CEO of the Buck Institute, a globally renowned center for aging research just outside San Francisco in Marin County. Verdin is bullish on the promise of living healthfully to at least 100. Today. But 180? Dont count on it. My prediction, based on everything we know today, is that getting to 120 is about the best we can do for the foreseeable future. Ill bet my house were not going to see anyone live to 180 for another 200 years, if ever, he says. But making everyone a healthy centenarian, this is something we can do today. And thats something to be excited about.

Verdins own lab at the Buck Institute studies the aging immune system and how its affected by lifestyle factors, such as nutrition and exercise. Informed by this research, Verdin follows a time-restricted diet in which he eats all of his meals in an eight-to-nine-hour window (similar to the Buchinger Wilhelmi process) and gets plenty of exercise mountain biking in Marins steep hills. The good news is that over 90 percent of what causes diseases of aging is environmental, and that means its within your control, he says.

But he emphasizes that responsible management of your health comes with limits, like avoiding experimental therapies. A group of people have decided to try some expensive and dangerous interventions, but there is zero evidence that any of these are going to help them live longer, he says. The problem, according to Verdin, is that the results of aging interventions in mouse trials can look very promising but rarely translate to success in humans. Theres a huge delta between the health of a stressed lab mouse and an optimally healthy mouse, Verdin says. So when you treat lab mice with longevity therapeutics, you see an outsized result that doesnt at all guarantee the same result in humans.

On the other hand, Verdin tells Robb Report, there are definitely new protocols worth getting excited about. Take, for instance, rapalogs, a class of drugs that interact with a protein called mTOR, which serves as a linchpin for multiple critical biological processes, including cell growth and metabolism. Rapalog drugs tamp down mTOR, possibly preventing age-related diseases such as diabetes, stroke and some cancers. The drug rapamycin, the most heavily studied formula, was approved in the US in 1999 to help prevent organ-transplant rejection. Last year the medical journal Aging published a rapturous opinion piece by oncologist Mikhail Blagosklonny in which he made the case that rapamycinin small or intermittent dosesis effective as a preventive treatment to ward off diseases of aging, and that, in the elderly, not taking rapamycin may be even more dangerous than smoking.

Eric VerdinJim Hughes Photography

Later this year, a biotech firm called resTORbio, which was spun out of the Swiss-based Big Pharma company Novartis in 2017, is expected to seek FDA approval for its rapalog RTB101, which clinical trials have shown to slow age-related decline of the immune system and improve immune response in elderly people by more than 20 percent, a key factor in protecting vulnerable aging populations from disease. (It is currently in trials on elderly patients with Covid-19.) This is the furthest-along program of anything in the aging field, Joan Mannick, cofounder and chief medical officer of resTORbio, told MIT Technology Review last year. If health authorities approve this drug well have a product for people to prevent age-related diseases. Not just in our lifetime, but in, you know, a few years.

One of the many effects of rapamycin is that it mimics the mechanisms of calorie restriction. As Verdins lab and others have shown, fasting provides a number of anti-aging benefits, including insulin regulation, reduced inflammation and, to put it colloquially, clearing out the gunky by-products of metabolismpart of the reason Twitter CEO Jack Dorsey and other tech titans eat just a few meals per week. For lesser mortals, fasting is extremely hard to commit to and not much fun, hence the huge interest in calorie-restriction mimetics like rapamycin, which provide all the benefits without the downer not-eating part.

Of all the calorie-restriction mimetics, the one sparking the most excitement among longevity researchers is already on the market: metformin, a decades-old diabetes drug. Metformin became a part of the Silicon Valley health regimen several years ago after an epidemiological study showed that Type 2 diabetics who took the drug lived longer than non-diabetics who didnt. Just about everyone in the longevity industry takes metformin, Verdin tells me. He takes it himself, and nearly everybody I interviewed is taking or has taken it, too.

In April, Nir Barzilai, the renowned endocrinologist who spearheaded research on the anti-aging properties of metformin, announced in an opinion piece he co-authored in the journal Cell Metabolism that his lab is launching a large clinical trial to investigate the anti-aging effects of the drug on non-diabetic populations. Barzilais goal is to prove to the FDA that aging itselfrather than conditions associated with it, like Alzheimers and arthritiscan be targeted as a disease. If Barzilai is successful and the FDA approves aging as a treatment indication, the process of bringing longevity therapies to market would accelerate rapidly.

Just as the FDA was able to move faster to bring Covid-19 therapies to market this year, we will reach a tipping point when public opinion pushes the FDA to approve aging as an indication, and the longevity-research field will make leaps as a result, Mellon says. He has contributed funding to Barzilais metformin research, which he believes will be instrumental in proving that there are compounds that can extend human life across the board.

The fact of the matter is that the US has the best regulatory system for new drug development in the world, Mellon says. Were in the first era ever when humans can be bioengineered to live longer. And in 10 years, well have solutions that are even better than today. Just wait, its coming.

Liz Parrish

Jim Mellon

Diet:Vegetarian.Mindfulness practice:Nightly meditation.

Exercise regimen:30 minutes of cardio and 10 minutes of weights,five days a week.

Anti-aging Rx:Regenerative gene therapies. Im certain most peoplewill take them in the next couple decades.

180th-birthday wish:Solving another critical issue.

Sleep routine:7.5 hours plus a 30-minute nap; in bed by 9 p.m.

Vitamins/supplements/ prescription meds:Vitamins D and B12, metformin.

Exercise regimen:Walk or run minimum 10,000 steps a day;weights three times week.

Anti-aging Rx:Green tea.

100th-birthday wish:Another 25 years.

Dave Asprey

Jim Hughes Photography

180th-birthday wish:Either a cruise to Mars or a 1970 Mustang Fastback,which by then will be 210 years old!

Sleep Routine:Avoid: coffee after 2 p.m., heavy workouts after 6 p.m.,alcohol during the week and heavy eating in the evening.

Vitamins/supplements:Vitamin D, omega fatty acids, NMN, citrus bioflavonoidcomplex, fiber supplement, prebiotic supplement.

Diet:Fasting-mimicking diet once every four to six months;roughly 16:8 intermittent fasting at other times.

Mindfulness practice:Daily meditation.

Anti-aging Rx:I love cooking and eating, so I do not restrict foodon the weekend. Happiness with friends and family is thesurest path to longevity.

100th-birthday wish:A bike tour across the US, from coast to coast.

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Cosmetic Skin Care Market -Product Overview and Scope, Opportunities, Market Volume, Competitive Landscape, Possible Challenges and Forecast to 2026 -…

By daniellenierenberg

As Cosmetic Skin Care market document has precise and accurate analysis of market trends, future developments, market segments and competitive analysis which suits the needs of all sizes of businesses in the Cosmetic Skin Care industry. This market research report involves a key data and information about the market, emerging trends, product usage, motivating factors for customers and competitors, restraints, brand positioning, and customer behaviour, which is of utmost importance when it comes to achieving a success in the competitive marketplace. A winning Cosmetic Skin Care market report encompasses many vital parameters about market analysis which can be used for the business.

A detailed market study and analysis of trends in consumer and supply chain dynamics cited in this Cosmetic Skin Care market analysis report helps businesses draw the strategies about sales, marketing, and promotion. Company profiles of the key market competitors are analysed with respect to company snapshot, geographical presence, product portfolio, and recent developments. The report also helps to know about the types of consumers, their response and views about particular products, and their thoughts for the step up of a product. Company profiles covered in this Cosmetic Skin Care report can be quite useful for making At present, the market is developing its presence and some of the Global Cosmetic Skin Care Market key players Involved in the study are LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics.

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026.

Complete study compiled with over 100+ pages, list of tables & figures, profiling 10+ companies. Ask for Sample @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-cosmetic-skin-care-market&SR

Global Cosmetic Skin Care Market Dynamics:

Market Drivers:

Increasing spending on personal care acts as a market driver

Rising prevalence for natural active ingredients based cosmetic among population will also drive the market growth

Growing demand for sun protection products will propel the growth of this market

Market Restraints:

High cost of the skin care products will restrain the market growth

Strict government rules associated with the less usage of antioxidants will also hamper the market growth

Emerging competition in the cosmetic skin care products is another factor impeding the market growth

Important Features of the Global Cosmetic Skin Care Market Report:

1) What all companies are currently profiled in the report?

List of players that are currently profiled in the report- LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics.

** List of companies mentioned may vary in the final report subject to Name Change / Merger etc.

2) What all regional segmentation covered? Can specific country of interest be added?

Currently, research report gives special attention and focus on following regions:

North America, Europe, Asia-Pacific etc.

** One country of specific interest can be included at no added cost. For inclusion of more regional segment quote may vary.

3) Can inclusion of additional Segmentation / Market breakdown is possible?

Yes, inclusion of additional segmentation / Market breakdown is possible subject to data availability and difficulty of survey. However a detailed requirement needs to be shared with our research before giving final confirmation to client.

** Depending upon the requirement the deliverable time and quote will vary.

Global Cosmetic Skin Care Market Segmentation:

By Product: Anti-Aging Cosmetic Products, Skin Whitening Cosmetic Products, Sensitive Skin Care Products, Anti-Acne Products, Dry Skin Care Products, Warts Removal Products, Infant Skin Care Products, Anti-Scars Solution Products, Mole Removal Products, Multi Utility Products

By Application: Flakiness Reduction, Stem Cells Protection against UV, Rehydrate the skins surface, Minimize wrinkles, Increase the viscosity of Aqueous, Others

By Gender: Men, Women

Check Complete Report Details of Cosmetic Skin Care Market @ https://www.databridgemarketresearch.com/toc/?dbmr=global-cosmetic-skin-care-market&SR

The Cosmetic Skin Care Market report provides insights on the following pointers:

Major Key Contents Covered in Cosmetic Skin Care Market:

This Cosmetic Skin Care Market Research/analysis Report Contains Answers to your following Questions

Note TheCOVID-19 (coronavirus) pandemic is impacting society and the overall economy across the world. The impact of this pandemic is growing day by day as well as affecting the supply chain. The COVID-19 crisis is creating uncertainty in the stock market, massive slowing of supply chain, falling business confidence, and increasing panic among the customer segments. The overall effect of the pandemic is impacting the production process of several industries. This report onMarket provides the analysis on impact on COVID-19 on various business segments and country markets. The reports also showcase market trends and forecast, factoring theimpact of COVID-19 Situation.

Thanks for reading this article; you can also get individual chapter wise section or region wise report versions like North America, Europe, or Asia Etc.

About Data Bridge Market Research:

An absolute way to forecast what future holds is to comprehend the trend today!

Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process. Data bridge is an aftermath of sheer wisdom and experience which was formulated and framed in the year 2015 in Pune.

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Cosmetic Skin Care Market -Product Overview and Scope, Opportunities, Market Volume, Competitive Landscape, Possible Challenges and Forecast to 2026 -...

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15 Best Face Moisturizers With SPF 2020 – Moisturizer With Sunscreen – Women’s Health

By daniellenierenberg

Since sunscreen should be applied every dayyes, every daywhy not consolidate steps by using a sunscreen/moisturizer hybrid? The hydrating formulas give you the benefits of sun protection without the white, streaky aftermath. Plus, it makes it that much easier to apply (aka no more excuses about forgetting to put on sunscreen). Look for moisturizing ingredients like hyaluronic acid, ceramides, or niacinamide that give your skin a drink without leaving it greasy.

And if you're still in the camp of "my skin doesn't get burned," that's not an excuse to skip daily SPF. According to The Skin Cancer Foundation, "no matter your skin type, UV radiation from the sun and other sources can cause dangerous, lasting damage to your skin." Sunscreen isn't just about protecting your skin from a sunburn; it also reduces your risk of developing squamous cell carcinoma (the second most common type of skin cancer) by about 40 percent (again, according to The Skin Cancer Foundation) and lowers your melanoma risk by 50 percent. And if it's aging you're worried about, it has your skin covered there too as it prevents wrinkles, sagging, and age spots as well.

Ghostly white cast turning you off? Say hello to tinted sunscreen! (Keep reading for some favorites.)

To get all these benefits of SPF, you have to make sure you're wearing it correctly: Just remember, you need at least a nickel-size drop of sunscreen or SPF moisturizer to cover your face every morning," says Mona Gohara, MD, dermatologist and Women's Health advisory board member.

Here are the 15 best moisturizers with SPF that you won't mind applying every. Single. Day.

You would never know this natural sunscreen houses a whopping 20% zinc oxide thanks to the blendable tint. (Read: You will not mind applying this every day.) You'll also get antioxidant protection thanks to algae and sunflower sprout extract.

This oil-free, lightweight moisturizer blends right in so fast you'll forget if you even applied it. And if you don't want to listen to WH about wearing sunscreen, maybe you'll take a page out of Rihanna's book: You gotta protect your skin from the sun no matter what your skin color is" she says on the Fenty site. "If you have discoloration, guess what, you can get that from the sun. I think a lot of people with darker skin tones think because theyre not burning that they dont need SPF but we can still get sun damage."

Fenty Skin HYDRA VIZOR INVISIBLE MOISTURIZER SPF 30

Whether you have oily skin or you just prefer a lighter consistency, this lotion will be your new fave. It soaks into skin quickly and is basically weightless after it's been appliedyou might even forget you have it onmaking it ideal for layering. Plus, it's non-comedogenic so acne-prone folks won't have to worry.

Simple Skincare, Protecting Light Moisturizer, SPF 15

Made by Black women for Black women, you can trust that this sunscreen/moisturizer hybrid isn't going to leave any white streaks behind. Avocado, jojoba, and sunflower oil all contribute to the rich, hydrating texture that sinks in without clogging pores or leading to breakouts.

Black Girl Sunscreen SPF 30

$18.99

If you're prone to an oily T-zone, this hydrating sunscreen is for you. Ceramides and niacinamide nourish your skin without making it feel greasy, and the mineral SPF ingredients (it contains both titanium dioxide and zinc oxide) keep you sun safe.

CeraVe Hydrating Sunscreen SPF 50 Face

Moisturizing gold standard hyaluronic acid is paired alongside coconut oil and aloe vera for a refreshing and hydrating formula. And thanks to the tint (there's four shades to choose from), it'll even out your complexion too.

Suntegrity 5-in-1 Tinted Moisturizing Face Sunscreen

Most derms recommend a combination of sunscreen and an antioxidant product (to fight aging free radical damage from UV exposure) for the best daily protection. This lightweight lotion has it all in one. It hydrates, has SPF 30, and contains a combination of blackberry extract and vitamins C and E for an antioxidant boost.

Aveeno Absolutely Ageless Daily Moisturizer SPF 30

Hate the feeling of thick, greasy sunscreen? Meet the complete opposite. This gel sunscreen hydrates (thanks to hyaluronic acid, glycerin, and vitamin E) and protects (thanks to a combo of proven chemical sunscreen ingredients) all while feeling like nothing on your skin.

Neutrogena Hydro Boost Water Gel Lotion SPF 50

This triple threat corrects redness, moisturizes, and protects your skin from UV damage. Centella asiatica (an herb native to Asia) is the hero ingredient that works to protect the skin from environmental stress that can lead to irritated, inflamed skin. While the cream goes on green, it quickly turns into a neutral shade to blend into your skin tone for a more even complexion.

Cicapair Tiger Grass Color Correcting Treatment SPF 30

$18.00

Yes, this is a moisturizer with sunscreen, but if you couldn't tell from the name, it's also packed with plant stem cells (they actually make up 15.5 percent of the formula) that fight free radicals to prevent collagen breakdown, promote firmer looking skin, and help smooth fine lines.

Plant Stem Cell Day Cream SPF 30

$75.00

Ever feel like your sunscreen is leaving your skin looking like an oil slick? Meet your new SPF BFF. Not only does it protect your skin from UVA (what causes aging) and UVB (what causes your skin to burn) rays, it also claims to minimize pores by 54 percent and keeps your skin matte for up to 10 hours.

Oil and Pore Control Mattifier Broad Spectrum SPF 45 PA++++

The combo of chemical sun protection ingredients (avobenzone, homosalate, and octisalate) in this nourishing cream provide your skin safety from UVA and UVB rays. It also contains cerium, a mineral that protects from the blue of your computer screen, television, and phone. So, you're double protected.

Supergoop! Superscreen Daily Moisturizer Broad Spectrum SPF 40 PA+++

Think of this moisturizer with sunscreen like a cup of coffee for your skin. While it protects and nourishes, it also boosts your skin's energy from actual coffee beans (the caffeine is also an anti-irritant). Because who couldn't use a extra jolt in the morning?

Origins Ginzing SPF 40 Energy-Boosting Tinted Moisturizer

Extra oily skin types, meet the moisturizer-SPF face cream that will not leave you looking like a greaseball. It has a whipped texture that absorbs in seconds and leaves a velvety smooth finish that looks great under makeup.

Olay Total Effects Whip Face Moisturizer SPF 25

If you're starting to see hyperpigmentation, then you need to up your SPF game. Stat with a brightening product like L'Oral's. This sunscreen lotion contains SPF 30 to stop new dark spots from forming and a combination of glycolic acid, vitamin C, and retinol to treat any existing discoloration.

L'Oral Paris RevitaLift Bright Reveal Brightening Day Moisturizer SPF 30

$19.98

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15 Best Face Moisturizers With SPF 2020 - Moisturizer With Sunscreen - Women's Health

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Could induced pluripotent stem cells be the breakthrough genetics has been waiting for? – The New Economy

By daniellenierenberg

Embryonic stem cells. The ethical issues associated with stem cell research could be resolved through the use of induced pluripotent stem cells, which are derived from fully committed and differentiated cells of the adult body

The almost miraculous benefits that stem cells may one day deliver have long been speculated on. Capable of becoming different types of cells, they offer huge promise in terms of transplant and regenerative medicine. It is, however, also a medical field that urges caution one that must constantly battle exaggeration. If stem cells do in fact hold the potential to reverse the ageing process, for example, then such breakthroughs remain many years away.

Recently, though, the field has had cause for excitement. In 2006, Japanese researcher Shinya Yamanaka discovered that mature cells could be reprogrammed to become pluripotent, meaning they can give rise to any cell type of the body. In 2012, the discovery of these induced pluripotent stem cells (iPSCs) saw Yamanaka and British biologist John Gurdon awarded the Nobel Prize in Physiology or Medicine. Since then, there has been much talk regarding the potential iPSCs possess, not only for the world of medicine, but for society more generally, too.

A big stepHistorically, one of the major hurdles preventing further research into stem cells has been an ethical one. Until the discovery of iPSCs, embryonic stem cells (ESCs) represented the predominant area of research, with cells being taken from preimplantation human embryos. This process, however, involves the destruction of the embryo and, therefore, prevents the development of human life. Due to differences in opinion over when life is said to begin during embryonic development, stem cell researchers face an ethical quandary.

The promise of significant health benefits and new revenue streams has led some clinics to offer unproven stem cell treatments to individuals

With iPSCs, though, no such dilemmas exist. IPSCs are almost identical to ESCs but are derived from fully committed and differentiated cells of the adult body, such as a skin cell. Like ESCs, iPSCs are pluripotent and, as they are stem cells, can self-renew and differentiate, remaining indefinitely propagated and retaining the ability to give rise to any human cell type over time.

One important distinction to make is that both ESCs and iPSCs do not exist in nature, Vittorio Sebastiano, Assistant Professor (Research) of Obstetrics and Gynaecology (Reproductive and Stem Cell Biology) at Stanford Universitys Institute for Stem Cell Biology and Regenerative Medicine, told The New Economy. They are both beautiful laboratory artefacts. This means that at any stage of development, you cannot find ESCs or iPSCs in the developing embryo, foetus or even in the postnatal or adult body. Both ESCs and iPSCs can only be established and propagated in the test tube.

The reason neither ESCs nor iPSCs can be found in the body is that they harbour the potential to be very dangerous. As Sebastiano explained, these cells could spontaneously differentiate into tumorigenic masses because of their intrinsic ability to give rise to any cell type of the body. Over many years of research, scientists have learned how to isolate parts of the embryo (in the case of ESCs) and apply certain culture conditions that can lock cells in their proliferative and stem conditions. The same is true for iPSCs.

To create iPSCs, scientists take adult cells and exogenously provide a cocktail of embryonic factors, known as Yamanaka factors, for a period of two to three weeks. If the expression of such factors is sustained for long enough, they can reset the programme of the adult cells and establish an embryonic-like programme.

Turning back the clockThere is already a significant body of research dedicated to how stem cells can be used to treat disease. For example, mesenchymal stem cells (usually taken from adult bone marrow) have been deployed to treat bone fractures or as treatments for autoimmune diseases. It is hoped that iPSCs could hold the key for many more treatments.

Global stem cell market:25.5%Expected compound annual growth rate (2018-24)$467bnExpected market value (2024)

IPSCs are currently utilised to model diseases in vitro for drug screening and to develop therapies that one day will be implemented in people, Sebastiano explained. Given their ability to differentiate into any cell type, iPSCs can be used to differentiate into, for example, neurons or cardiac cells, and study specific diseases. In addition, once differentiated they can be used to test drugs on the relevant cell type. Some groups and companies are developing platforms for cell therapy, and I am personally involved in two projects that will soon reach the clinical stage.

Perhaps the most exciting prospects draw on iPSCs regenerative properties. Over time, cells age for a variety of reasons namely, increased oxidative stress, inflammation and exposure to pollutants or sunlight, among others. All these inputs lead to an accumulation of epigenetic mistakes those that relate to gene expression rather than an alteration of the genetic code itself in the cells, which, over time, results in the aberrant expression of genes, dysfunctionality at different levels, reduced mitochondrial activity, senescence and more besides. Although the epigenetic changes that occur with time may not be the primary cause of ageing, the epigenetic landscape ultimately affects and controls cell functionality.

What we have shown is that, if instead of being expressed for two weeks we express the reprogramming factors for a very short time, then we see that the cells rejuvenate without changing their identity, Sebastiano said. In other words, if you take a skin cell and express the reprogramming genes for two to four days, what you get is a younger skin cell.

By reprogramming a cell into an iPSC, you end up with an embryonic-like cell the reprogramming erases any epigenetic errors. If expressed long enough, it erases the epigenetic information of cell identity, leaving embryonic-like cells that are also young.

Slow and steadyAs with any scientific advancement, financial matters are key. According to Market Research Engine, the global stem cell market is expected to grow at a compound annual growth rate of 25.5 percent between 2018 and 2024, eventually reaching a market value of $467bn. The emergence of iPSCs has played a significant role in shaping these predictions, with major bioscience players, such as Australias Mesoblast and the US Celgene, working on treatments involving this particular type of stem cell.

The business potential around stem cell research is huge, Sebastiano told The New Economy. [Particularly] when it comes to developing cell banks for which we have detailed genetic information and, for example, studying how different drugs are toxic or not on certain genetic backgrounds, or when specific susceptibility mutations are present.

Unfortunately, even as the business cases for iPSC treatments increase, a certain degree of caution must be maintained. The promise of significant health benefits and new revenue streams has led some clinics to offer unproven stem cell treatments to individuals. There have been numerous reports of complications emerging, including the formation of a tumour following experimental stem cell treatment in one particular patient, as recorded in the Canadian Medical Association Journal last year. Such failures risk setting the field back years.

The challenge for researchers now will be one of balance. The potential of iPSCs is huge both in terms of medical progress and business development but can easily be undermined by misuse. Medical advancements, particularly ones as profound as those associated with iPSCs, simply cannot be rushed.

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Could induced pluripotent stem cells be the breakthrough genetics has been waiting for? - The New Economy

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