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What I learnt from checking in to the ‘Immunity Hotel’ – Telegraph.co.uk

By daniellenierenberg

There isnt a third person in our marriage but there is a rival. My husband is passionate about a family-run fasting clinic in Uberlingen, overlooking Lake Constance, Germany. He goes alone twice a year and was there at the beginning of lockdown. He happily remained there for six weeks unable to get home. Buchinger Wilhelmi was founded seventy years ago by Otto Buchinger, a medical officer in the navy who cured himself of paralysis caused by rheumatic fever by fasting for 19 days in 1918. Now one of the worlds leading therapeutic fasting centres, Buchinger is run by Ottos great-grandson, Leonard Wilhelmi.

The German government demanded that the clinic remain open during lockdown, concerned that hospital over-crowding would necessitate patients being moved there. This proved unnecessary. But after Easter, having taken the requisite health and hygiene precautions, they encouraged guests. They are currently full with a completely different clientele, according to owner, Raimund Wilhelmi (Ottos grandson.) Normally, two-thirds of our guests are repeat guests. Now, fifty percent have come for the first time and they are much younger. There is a significant difference in the demographic because people are waking up to a new awareness about health as Covid affects everybody. His son, Leonard, adds: The medical community agree that the main causes in violent reactions to Covid are diabetes, high blood pressure and being over-weight. We have been treating these conditions for decades and our goal is now to equip people with a better immune system to fight Covid.

The minute my husband heard about their new immune-boosting programme, he signed us up for atwo weeks' holiday in August. This was an extravagance at a cost of over two thousand pounds a person. Health is our most valuable commodity, he reassured me. After an hour in this sleek minimalist medical centre, my sixteen-year-old daughter burst into tears. All her boarding school issues were ignited. My inner rebel similarly baulked at the first 24 hours that we had to spend eating in our rooms, until the results of our Covid tests, taken on arrival, came through. (Thankfully they were negative or we would have been quarantined in our rooms for our entire stay.)

There was something convict-like about dining on trays in our monastically simple rooms. Thank goodness the clinic do not advise couples share rooms 80 per centof guests go alone so we each had our own room. As Andrew was doing the full ten-day fast of 250 liquid calories a day, which I couldnt stomach(I was on 800 solid calories a day and Daisy, 1800,) a shared room would have destroyed our marriage. Not because Andrew had an enema on the bed every other day but because his preternatural joy freaked us out. His pious enthusiasm for the regime initially made us hate it. Until we were fully institutionalised, (or as Daisy said indoctrinated) the stricture wore us out.

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Stem Cells Market is Expected to Thrive at Impressive CAGR by 2025 – Scientect

By daniellenierenberg

This report studies the Stem Cells market size (value and volume) by players, regions, product types and end industries, history data 2013-2017 and forecast data 2018-2025; This report also studies the global market competition landscape, market drivers and trends, opportunities and challenges, risks and entry barriers, sales channels, distributors and Porters Five Forces Analysis.

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Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources: Embryos formed during the blastocyst phase of embryological development (embryonic stem cells) and Adult tissue (adult stem cells).

Both types are generally characterized by their potency, or potential to differentiate into different cell types (such as skin, muscle, bone, etc.).

Stem Cells market, by technology, is Cell Acquisition, Cell Production, Cryopreservation, Expansion, and Sub-Culture. Stem Cell Therapy in China is not mature, so in this report we mainly cover Stem Cell Banking market.

Stem Cells market, by technology, is Cell Acquisition, Cell Production, Cryopreservation, Expansion, and Sub-Culture. Stem Cell Therapy in China is not mature, so in this report we mainly cover Stem Cell Banking market.

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Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Stem Cells in these regions, from 2013 to 2025, covering

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Turkey etc.)

Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)

South America (Brazil etc.)

Middle East and Africa (Egypt and GCC Countries)

The various contributors involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers. The key manufacturers in this market include

CCBC

Vcanbio

Boyalife

Beikebiotech

By the product type, the market is primarily split into

Umbilical Cord Blood Stem Cell

Embryonic Stem Cell

Adult Stem Cell

Other

By the end users/application, this report covers the following segments

Diseases Therapy

Healthcare

We can also provide the customized separate regional or country-level reports, for the following regions:

North America

United States

Canada

Mexico

Asia-Pacific

China

India

Japan

South Korea

Australia

Indonesia

Singapore

Malaysia

Philippines

Thailand

Vietnam

Rest of Asia-Pacific

Europe

Germany

France

UK

Italy

Spain

Russia

Rest of Europe

Central & South America

Brazil

Rest of Central & South America

Middle East & Africa

GCC Countries

Turkey

Egypt

South Africa

Rest of Middle East & Africa

The study objectives of this report are:

To study and analyze the global Stem Cells market size (value & volume) by company, key regions/countries, products and application, history data from 2013 to 2017, and forecast to 2025.

To understand the structure of Stem Cells market by identifying its various subsegments.

To share detailed information about the key factors influencing the growth of the market (growth potential, opportunities, drivers, industry-specific challenges and risks).

Focuses on the key global Stem Cells manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years.

To analyze the Stem Cells with respect to individual growth trends, future prospects, and their contribution to the total market.

To project the value and volume of Stem Cells submarkets, with respect to key regions (along with their respective key countries).

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.

To strategically profile the key players and comprehensively analyze their growth strategies.

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Precision Business Insights is one of the leading market research and management consulting firm, run by a group of seasoned and highly dynamic market research professionals with a strong zeal to offer high-quality insights. We at Precision Business Insights are passionate about market research and love to do the things in an innovative way. Our team is a big asset for us and great differentiating factor. Our company motto is to address client requirements in the best possible way and want to be a part of our client success. We have a large pool of industry experts and consultants served a wide array of clients across different verticals. Relentless quest and continuous endeavor enable us to make new strides in market research and business consulting arena.

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Here are some must-try beauty products for $25 or less (and a couple splurges) – Commercial Appeal

By daniellenierenberg

Jean Chen Smith, Correspondent for Memphis Commercial Appeal Published 6:01 a.m. CT Aug. 28, 2020 | Updated 11:26 a.m. CT Aug. 28, 2020

Lily Lolo's Lip Gloss Set offers two colors perfect for day or night.(Photo: Lily Lolo)

You dont have to spend a ton of money on beauty products that are safe, effective and easy to use.With so many options in the marketplace today, it's easy to get lost among the offerings.

Here are someof our favoritebeauty finds under $25.

Beauty Society, an American skincare and cosmetics company that specializes in affordable products, was named one of 2019s top eco-friendly skincare companies because of itsrefilling and biodegradable packaging practices. Its matte liquid lipsticks ($22) are smudge free and long lasting. The unique formula prevents color from bleeding, which makes for fewer applications.

Details: beautysociety.com

Actsyl-3 ($25)is a fast-absorbing, non-greasy, formulated serum designed to improve follicle thickness and stimulate hair stem cells. The Actsyl-3 serum contains Redensyl (3%) and Capixyl (2%) two ingredients proven to help regrow hair. Key peptides also help to strengthen hair roots and improve scalp health all without affecting hormones.

Details: actsyl.com

Trinny Londons Eye2Eye / Eyeshade ($24) is a collection of flattering shades that function as both eyeshadows and eyeliners. Rich in pigment, moisturizing and easy to use, these glide on smoothly, allowing you to smudge, smoke or line your eyes. The company also carries a full line of accessories such as The Elizabeth ($20), which is a bright yellow bag for storing your makeup essentials.Fifteen percent of the proceeds for every The Elizabeth sold go to The Princes Trust, which supports the Change A Girl's Life Campaign, an initiative of Women Supporting Women.

Details: trinnylondon.com

Wonderskin Wonder Blading Lip Gloss ($22.50) delivers draw-dropping shine that makes lips look plump without a sticky or tacky feel. The high-lacquer finish can last for hours and works great over any of the companys coordinating Peel & Reveal Lip Colors.

Details: wonderskin.com

Crabtree & Evelyn's Petal Power Lip Scrub ($18) helps to cleanse and hydrate your lips using shea butter and coconut oil.It is gentle enough to use daily and great for exfoliating the dead skin from dry, chapped lips.

Details: crabtree-evelyn.com

Facial Works Sea Mist Calming Cucumber Toning Mist ($24) is the perfect travel companion.This is a soothing and calming toner providing antioxidant benefits from CleanSea Complex and is packed with Sea Whip, an anti-inflammatory ingredient from the Caribbean Sea. This 1-ounce bottle is travel-sized, so you can bring it with you anywhere. A full-size bottle is also available.

Details: thefacialworks.com

Beautycounter Countersun Mineral Sunscreen Stick will keep you protected.(Photo: Beautycounter)

Refresh and renew with Beautycounters Citrus Mimosa Body Wash ($25), a gentle and moisturizing cleanser that energizes with a citrus scent. Certified vegan and cruelty-free, this will leave your skin feeling soft, clean and hydrated.Dont forget the sunscreen!The Countersun Mineral Sunscreen Stick SPF 30C ($21) comes in a convenient stick form with plenty of protection. Water-resistant and formulated with non-nano zinc and California poppy, the SPF 30 formula provides an effective shield from UVA and UVB rays, while moisturizing with cocoa butter, without leaving a white residue on your skin. Best of all, it is reef-friendly and water-resistant for up to 80 minutes.

Details: beautycounter.com

These Purifying Facial Towelettes From Rooted Beauty will keep you refreshed.(Photo: Rooted Beauty)

On the Grove Collaborative website, you can find affordable beauty products that adhere to the highest standards.The site prioritizes products made with sustainable, plant-based ingredients that arent tested on animals. Each brand must meet strict guidelines regarding safety, ethics, environmental impact and animal welfare. Purifying Facial Towelettes ($6.95) from Rooted Beauty will keep you refreshed throughout the day. They remove dirt, oiland makeup with free-radical-fighting white tea, calming calendula and the R7 complex, which contains antioxidant-rich roots.Throw Lily Lolos Lip Gloss Set ($25) into your bag the colors are perfect for both day and night.

Details: grove.co/roven

Sjal Skincare's Balans is a gentle pore cleanser.(Photo: Sjal Skincare)

Sjal Skincare Balans ($75) is a lightweight deep pore cleanser that hydrates, detoxifies and protects the skin. This powerhouse cleaner contains potent ingredients such as pearl extract for brightening, African whitewood extract and fig leaf extract, a natural barrier to protect the skin against water loss.

Details: sjalskincare.com/products/balans

Westmore Beauty-Skin Conditioning Exfoliator ($39) is a creamy exfoliator packed with moisturizing ingredients like shea butter and squalene. The oil-free formula contains gentle exfoliating beads to instantly smooth away dirt and dry skin, making your skin feel soft and silky. Fragrance-free and made without the use of parabens, sulfates or phthalates, this is something you will want to put on your skin.

Details:westmorebeauty.com

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Cells Reach Out and Touch, Providing Evidence of Foresight and Design – Discovery Institute

By daniellenierenberg

Photo: Cichlid fish, by Russell D. Fernald and Sabrina S. Burmeister / CC BY (https://creativecommons.org/licenses/by/2.5).

Anarticle yesterdayforEvolution Newsabout allostery showed how an individual protein or RNA can send information to its distant domains. Information sharing can also occur between chains of molecules arranged in a signaling cascade, where each one triggers action in the next. This is a bit more like the Rube Goldberg technique, except that in cells, it is much more logical and reliable. Here are new examples ofmechanosensing(the ability to sense a touch) andmechanotransduction(the ability to pass on touch information). A paper onbioRxivexplains, Cells sense the physical properties of their environment, translate them into biochemical signals and adapt their behaviour accordingly.

One such system is the MAPK/ERK pathway that all eukaryotic cells use to get information from the cell surface into the nucleus. A diagram onWikipedias page makes it clear that many individual factors take part. Once the EGFR receptor triggers ERK on the cells exterior membrane, a signaling cascade begins with at least 16 cofactors and proteins transporting the information to the cell nucleus, which responds by transcribing code proteins or enzymes. ERK signals can also spread throughout the cytoplasm, leading to a variety of responses depending on the nature of the triggering molecule.

Now, Japanese scientists have noticed a further response in neighboring cells. When one cells ERK pathway is triggered, that cell shrinks. Neighboring cells sense the change and respond by shrinking themselves, causing a chain reaction.Researchers at Kyoto Universitylikened this to how crowds do The Wave at sporting arenas, passing collective motion throughout the stadium.

Cells are tightly connected and packed together, so when one starts contracting from ERK activation, it pulls in its neighbors, elaborates [Tsuyoshi] Hirashima. This then caused surrounding cells to extend, activating their ERK, resulting in contractions thatlead to a kind of tug-of-war propagating into colony movement.[Emphasis added.]

The response involves both chemical and mechanical factors. Our work clearly shows that the ERK-mediatedmechano-chemical feedback systemgenerates complicated multicellular patterns, the lead author comments.

Another touch-sensitive mechanism is the so-called Hedgehog (Hh) pathway, so named because defects in its function cause fruit fly embryos to look like the spiny animals. Hedgehog pathways are often associated with the primary cilium, an organelle that sticks out like an antenna from the cell membrane and senses its environment. When triggered, it also causes a cascade of reactions inside the cell.

Craig Albertson, a researcher at theUniversity of Massachusetts, Amherstwas curious why cichlid fish can evolve so quickly to environmental changes, including changing the shapes and densities of bone in their jaws. This capacity for phenotypic plasticity is not evolution of a Darwinian kind, but rather a programmed response to environmental cues.

Albertson works with a system cichlid fishes known throughout the scientific world as champions of phenotypic plasticity thatcan alter, in a single season, jawbone hardness or shape to match feeding conditions.They are also well known for their rapid evolution and diversity in jaw shapes, which hasenabled cichlids to adapt to many different food sources, including algae, plankton, fish, snails and even the scales of other fishes.

Albertson speculated that this capacity for rapid response to environmental cues might be associated with the Hedgehog signaling pathway. By tuning the amount of Hh signal, his research team discovered that more bone was deposited, or vice versa.

Albertson, explains, Bone cells in these fish are innatelysensitive to differentmechanical environments. But we were able to play with this system using a single molecular switch you turn up the Hh signal and the cells become more sensitive to the environment, or you turn the molecular sensor down and the cells become almost deaf to the environment.

Like ERK, the Hedgehog signaling pathway involves numerous factors that interact in chain reactions. And it is triggered by a mechano-sensor on the cell, the primary cilium.

An important clue came as Albertson learned more about how this molecular pathway works. He explains, There isa well-known mechano-sensor on most cells, including those that make the skeleton, called the primary cilium. Cells that lack this organelle are unable to sense or respond to environmental input, includingmechanical load.It turns out that several key protein components of the Hedgehog pathway are physically associated with this structure, making it an obvious candidate for an environmentally sensitive signal.

The team believes this kind of response to environmental cues could be responsible for other kinds of rapid evolution in other animals. The Hh signal has also been shown to regulate plasticity inbeetle horns, so there may be something special that positions it to be anenvironmental sensor across tissues and animals, Albertson says. This is not Darwinism; it is pre-programmed response using molecular machines capable of sensing touch.

How does skin stretch when a body grows? The answers may rely on mechanosensitive factors.Nature News and Views said recently, Stretching the skin of mice reveals thatmechanical strain is communicated by a subpopulation of stem cellsthat proliferate and promote mechanical resistance,and so generate extra skin.

One of the most remarkable examples of touch communication was announced this month inNature. Researchers at theUniversity of Montrealconfirmed the existence of nanotubes that grow out of cell membranes and reach across comparatively large distances to touch other cells, affect their behaviors, and even share organelles with them. They found these nanotubes in the retinas of mice, and believe they are responsible for controlling blood flow in the capillaries.

For the first time, we have identifieda communication structure between cellsthat is required to coordinate blood supply in the living retina, said Dr. Adriana Di Polo, a neuroscience professor at Universit de Montral and holder of a Canada Research Chair in glaucoma and age-related neurodegeneration, who supervised the study.

We already knew that activated retinal areas receive more blood than non-activated ones, she said, butuntil now no one understood how this essential blood delivery was finely regulated.

These nanotubes tunnel through the mass of retinal cells to distant capillaries, where they contact pericytes, cells that have the ability to control the amount of blood passing through a single capillary simply by squeezing and releasing it. This touch communication allows a retinal cell to tell the capillary it needs more blood or less blood.

Using a microscopy technique to visualize vascular changes in living mice, we showed that pericytes project very thin tubes, calledinter-pericyte tunnelling nanotubes, tocommunicate with other pericytes located in distant capillaries, said Alarcon-Martinez. Through these nanotubes,the pericytes can talk to each other to deliver blood where it is most needed.

Video micrographs show that even mitochondria can be passed down these nanotubes. The paper inNaturesays:

Here we identify nanotube-like processes that connect two bona fide pericytes on separate capillary systems, forming a functional network in the mouse retina, which we named interpericyte tunnelling nanotubes (IP-TNTs). We provide evidence that these (i) have an open-ended proximal side and a closed-ended terminal (end-foot) that connects with distal pericyte processes via gap junctions, (ii)carry organelles including mitochondria, which can travelalong these processes, and (iii) serve as a conduit for intercellular Ca2+waves, thusmediating communication between pericytes.

The cells literally reach out and touch other pericytes bound to other capillaries, and hand off signals and organelles. This gives the retinal cells, dependent on a steady supply of oxygen and nutrients, a way to fine-tune their own blood supply. The gap junctions act like filters: Small particles, such as ions, can pass through this junction, but larger objects, such as organelles, cannot. Tunneling nanotubes had been noted between cells in a petri dish before, but a companion article onNature News and Viewscalls this the firstin vivoevidence for the existence of a type of TNT-like protrusion. Maybe it wont be the first for long. The research teams headline calls them, Nanotubes in the eye that help us see.

These are just some of the ways that cells respond to mechanical forces. The chains of reactions can be very elaborate and irreducibly complex. But first, they have to be triggered by well-designed mechanosensors that can feel a factor in the environment and then pass along that information to downstream processes that can do something about it. Undoubtedly many more examples of mechanosensing and mechanotransduction remain to be discovered. Its hard to conceive of any of these systems arising piecemeal by accumulated mistakes (mutations).

Instead, they appear as systems of coordinated parts that were planned to adapt to changes, providing robustness. It is exciting to ponder how such pre-programmed responses to environmental cues could trigger rapid adaptations, giving rise to some of the spectacular variations seen in birds, beetles, fish, and other organisms. Prematurely attributed to Darwinian processes, these examples of phenotypic plasticity actually show foresight and design.

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Demand for Medical Skin Care Products Market Driven by Shifting Consumer Perceptions and Growing Awareness – Scientect

By daniellenierenberg

Medical skin care products are used for beautifying or to address some other skin care problems. The cosmetic industry is booming and skin care forms a very huge part of this industry. The aesthetic appearance is so important that people spend a lot on skin care products and treatment. People being more technologically aware of the various new skin care products trending in the market. In addition to the aesthetic application, the medical skin care products are also used to address issues such as acne, pimples or scars.

Medical Skin Care Products Market: Drivers and Restraints

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

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Medical Skin Care Products Market: Segmentation

On the basis of product type the medical skin care products market can be segmented as:

On the basis of application, the medical skin care products market can be segment as:

On the basis of distribution channel, the medical skin care products market can be segment as:

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Medical Skin Care Products Market: Overview

Medical skin care products are used to address basic skin problems ranging from acne to scars. There are various advancements in the ingredients used to offer skin care products to the consumers. For instance, the use of hyaluronic acid and retinoids is the latest development in the industry. The anti-aging creams are at the forefront as the help treating issues such as wrinkles, scars, acne, and sun damage. Another, product in demand is the probiotic skincare which include lactobacillus and bifidobacterium.

Medical Skin Care Products Market: Region-wise Outlook

In terms of geography, medical skin care products market has been divided into five regions including North- America, Asia- Pacific, Middle-East & Africa, Latin America and Europe. North America dominated the global medical skin care products market as international players are acquiring domestic companies to make their hold strong in the U.S. LOral is accelerating its U.S. market by signing a definitive agreement with Valeant Pharmaceuticals International Inc. to acquire CeraVe, AcneFree and Ambi skin-care brands for US$ 1.3 billion. The acquisition is expected LOreal to get hold of the brands in the price-accessible segment. Asia Pacific is expected to be the fastest growing region owing to the increasing disposable income and rising awareness towards the skin care products.

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Medical Skin Care Products Market: Key Market Participants

Some of the medical skin care products market participants are Avon Products Inc., Beiersdorf AG, Colgate-Palmolive Company, Kao Corporation, LOral S.A., Procter & Gamble, Shiseido Company, The Estee Lauder Companies Inc., Unilever PLC, Revlon, Clinique Laboratories, llc., Murad, LLC., SkinCeuticals, RMS Beauty, J.R. Watkins and 100% PURE.

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Demand for Medical Skin Care Products Market Driven by Shifting Consumer Perceptions and Growing Awareness - Scientect

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Foetal cells are used to make the Oxford coronavirus vaccine. But they came from a foetus in 1973 – ABC News

By daniellenierenberg

Religious leaders have raised ethical doubts over one of Australia's primary coronavirus vaccine hopes because scientists have used foetal cells in its development.

Developers at Oxford University and pharmaceutical firm AstraZeneca are using cell lines from an electively aborted foetus in the vaccine candidate, with Anglican, Catholic and Greek Orthodox leaders questioning the practice.

But using foetal cells in vaccine development isn't new and the Catholic Church has previously expressed qualified support for the use of vaccines derived from these cells under certain circumstances.

We spoke to Bill Lott, a virologist at QUT's Institute of Health and biomedical innovation, to understand the role of foetal cells in vaccine development.

The foetal cells used in vaccine development are derived from a small number of foetuses which were legally terminated decades ago.

The Oxford vaccine uses HEK (human embryonic kidney) 293 cell lines, obtained from a female foetus in the Netherlands in 1973.

"We're using tissues that were from foetuses that were aborted 40, 50, 60 years ago," Dr Lott said.

"It doesn't require newly aborted foetuses."

While living human cells can only divide around 50 times, those foetal cells have been genetically modified so they can divide an infinite number of times.

"That's why we can use the cells that we harvested [decades ago] today," Dr Lott said.

"They're not the actual original cells, they've been immortalised and then propagated over the decades."

This means we'll never need to replace specimens used in development.

"Just by analogy, buying ivory is illegal [because] if you create a market for ivory, then it creates the demand to kill more elephants," Dr Lott said.

"In this case, that's not happening because these foetuses were aborted 60 years ago, 50 years ago, and using these immortalised tissues now is not going to create a need to go and get new ones."

In fact, scientists would prefer to keep using HEK 293 cell lines because they have been repeatedly tried and tested in a laboratory setting and found to be safe.

"When you're making a vaccine you require safety testing," Dr Lott said.

"If we went back and used a different cell type, you're throwing an unknown into the consideration.

"So that will severely slow down your ability to make these things.

"Using HEK 293, we've used it for decades and we know that it's safe."

This week, Australia's Deputy Chief Medical Officer Nick Coatsworth pointed out the use of foetal cells had been a "reality" in past vaccine development.

"The reality for vaccines is that they need cell cultures in order for us to grow them," he said.

"The human cell is a really important part of their development.

"There are strong ethical regulations surrounding the use of any type of human cell, particularly foetal human cells.

"This is a very professional, highly powered research unit at Oxford University.

"I think we can have every faith that the way they have manufactured the vaccine has been against the highest of ethical standards internationally."

Breaking down the latest news and research to understand how the world is living through an epidemic, this is the ABC's Coronacast podcast.

So, how do foetal cells help with vaccine development? Dr Lott explained they operate like a "vaccine factory".

First, scientists need to develop the vaccine candidate and then combine it with an adenovirus vector.

An adenovirus is a particular type of common virus that causes illnesses like bronchitis, pneumonia and a sore throat.

For instance, when you get a cold, you may be infected with an adenovirus, a coronavirus or a rhinovirus.

A vector is an organism that spreads infection by moving pathogens from one host to another.

So an adenovirus vector? "That's an adenovirus that has been sort of emptied out and then you put a different kind of genome in there to make protein," Dr Lott said.

The next step is to put the vaccine/adenovirus vector combination into a big vat of foetal cells.

"The viral vector infects these HEK 293 cells really, really efficiently," Dr Lott said.

"One reason why you use the HEK 293 is because you get essentially 100 per cent infection with the adenoviral vector.

"And what it does is it turns the HEK 293 cells into a vaccine factory."

What do we mean by "vaccine factory"? Dr Lott explains foetal cells begin producing "tons and tons of that modified adenovirus" which they then "spit out into the liquid bit of the cells" called the cell culture media.

"[The foetal cells] start cranking out this massive amount of modified adenovirus, and then you purify those things away from the cell tissue," he said.

"You pull the [cell] media off, and it's just going to be full of the vaccine and essentially no tissue.

"And that's what your vaccine is."

The foetal cells will operate as this "vaccine factory" regardless of whether the vaccine is effective or not so the next step generally involves animal and then human trials of varying scale.

Inherent in the whole process is stripping away the conditioned cell media, where the foetal cells are contained.

The head of the World Health Organization has warned we may never get a silver bullet for COVID-19. What could that future look like in Australia?

That means a successful vaccine developed using foetal cells will have no remnants of those cells in the final product.

"You purify the vaccine away from the cells that they were grown in, and then you destroy all the cells," Dr Lott said.

"So then you're going to take that liquid and you'll purify it some more, but there are not going to be any [foetal] cells in there.

"There's nothing left when it becomes the vaccine that gets delivered."

Foetal tissue has been used with innovative effect in various strands of medical research.

The difference is some of those processes require fresh foetal cells not the "immortalised" cells vaccine developers can use.

"The vaccine work is pretty straightforward," Dr Lott said.

"But cancer research, the research into the mechanisms of various things cystic fibrosis, haemophilia, rheumatoid arthritis that all required fresh foetal tissue."

Scientists studying Zika virus used foetal cells to discover that the virus crossed the placental membrane and caused brain damage in unborn foetuses.

"[That research] brought out a whole raft of therapies and protections for unborn foetuses [and] "saved a lot of lives, including [the lives of] unborn foetuses," Dr Lott said.

Foetal cell lines have been used in the development of various vaccines, including for chicken pox, Ebola, polio, rubella, shingles, Hepatitis A, and rabies.

Foetal tissue has also facilitated breakthroughs in the treatment of various medical issues including cystic fibrosis, haemophilia, IVF, Parkinson's and Alzheimer's diseases, AIDS, and spinal cord injuries.

Scientists have many different methodologies for developing vaccines and there are a variety of reasons why foetal cells aren't always used.

Billions are being poured into the race to find a coronavirus vaccine, with the winner owning a powerful political tool. During the last pandemic an Australian company got there first.

"Some of them don't use it because of ethical issues," Dr Lott said.

"Some of them don't use it because they're not using an adenovirus [vector], so they don't really need the HEK 293.

"And there are other [development] strategies.

"There's an mRNA strategy that's very popular.

"So some of them don't require it."

The development of a coronavirus vaccine was time critical because of the virus' devastating public health and economic impacts, Dr Lott said.

Therefore, it was important for scientists to diversify their methodologies in order to develop a vaccine as quickly as possible.

Both stem cells and foetal cells are critical to innovations in medical research but what's the difference between the two?

Dr Lott explains stem cells are basically the earliest iteration of a foetal cell before the cell differentiates itself into, for example, a hair cell, liver cell, eye cell or skin cells.

"A stem cell is simply a cell that can turn into a different cell types," Dr Lott said.

"That first embryonic stem cell can eventually turn into any kind of cell in your body.

"So you've got embryonic stem cells, and then you've got adult stem cells, and in between are the foetal stem cells [which] are partially differentiated.

"So foetal cells contain not only stem cells some of the foetal cells have already differentiated into their final cell type."

In 2005 and again in 2017, the Catholic Church expressed qualified support for the use of foetal-cell-derived vaccines but only if there was no available alternative.

A 2005 "moral reflection" issued by Pope Benedict XVI specifically addressed the issue.

"As regards the diseases against which there are no alternative vaccines which are available and ethically acceptable, it is right to abstain from using these vaccines if it can be done without causing children, and indirectly the population as a whole, to undergo significant risks to their health," the Pope wrote.

"However, if the latter are exposed to considerable dangers to their health, vaccines with moral problems pertaining to them may also be used on a temporary basis.

"We find a proportional reason, in order to accept the use of these vaccines in the presence of the danger of favouring the spread of the pathological agent."

In 2017, the life ethics arm of the Catholic Church issued a statement that: Catholic parents could vaccinate their children with a "clear conscience" that "the use of such vaccines does not signify some sort of cooperation in voluntary abortion".

Earlier this year and in the context of the coronavirus vaccine race, John Di Camillo, an ethicist with the National Catholic Bioethics Center, confirmed: "One is allowed to make use of [vaccine derived from foetal tissue] where there's a serious threat to the health or life of the individual, or of the greater population.

"This does not amount to a strictobligationto use it, but it certainly can be a legitimate choice in conscience if theres that serious reason, and there's no other reasonable alternative."

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Nurse working on Covid-19 frontline had ‘virus symptoms’ that turned out to be leukaemia – iNews

By daniellenierenberg

When nurse Neri Pucci suddenly felt ill during a hospital shift his first thought was that hed picked up Covid-19.

Working long shifts on an A&E ward, the 28-year-oldpresumed being exposed to patients with the virus was the reason he was suffering a fever, night sweats, a cough, a sore throat, breathlessness and a headache.

But several tests for coronavirus were negative and blood analysis showed his white blood cells had sky rocketed.

Medics quickly determined he had acute lymphoblastic leukaemia, a cancer that progresses quickly and aggressively and requires immediate treatment.

And so instead of finishing the shift he was due to work, the Italian, who has worked for the NHS for five years, was kept in hospital as an in-patient.

Hes been undergoing gruelling chemotherapy over the last 12 weeks and remains isolated in a room with restricted visitors.

Because Neri took a career break and returned as temporary staff, he is not entitled to NHS sick pay. His colleague has set up a GoFundMe appeal to support him which has so far raised more than 9,400.

Ive had a lot of love and support from family, friends, colleagues and people around the world, its fantastic, said Neri.

Neri has worked at Londons The Royal Free Hospital A&E since 2014 and last year, for a change of scene, took a post as a nurse on a cruise ship. He returned to the hospital in June and took ill after just six weeks.

I knew my colleagues were struggling during the pandemic and I felt I should come back and help, he said. Wearing full PPE for a 12-hour shift is quite exhausting, it makes you hot and sweaty. I had seen patients who had Covid, and of course took all precautions. So when I got ill I thought it must be the virus. I felt dizzy, short of breath and my heart was racing and then my knees went purple.

It was a lot to take in when they said it was leukaemia and I needed to stay in hospital.

Acute lymphoblastic leukaemia is rare, with around 790 people diagnosed with the condition each year in the UK, according to the NHS. Most cases develop in children, teenagers and young adults.

The disease is caused by a genetic mutation in the stem cells, although why this happens is not yet fully understood but there are certain risk factors.

Symptoms of acute lymphoblastic leukaemia

The disease usually starts slowly before rapidly becoming severe. Symptoms listed by the NHS are pale skin, feeling tired and breathless, repeated infections over a short time, unusual and frequent bleeding, such as bleeding gums or nosebleeds, high temperature and night sweats.

Sufferers can also get bone and joint pain, easily bruised skin, swollen lymph nodes, tummy pain) caused by a swollen liver or spleen, unintentional weight loss and a purple skin rash.

In some cases, the affected cells can spread from your bloodstream into your central nervous system. This can cause neurological symptoms, including headaches, seizures or fits, being sick, blurred vision and dizziness.

Neri was transferred to University College Hospital and his parents left their home town of Florence to stay in London to support their only child.

He has suffered side effects from the chemotherapy including nausea, fatigue, numb fingers and headaches and says hes found isolation difficult.

Im extremely vulnerable to infections and even more so with Covid around, he said. Im in a side room and there is strict visitation.Im allowed one visitor a week for just two hours, so that means only my mum can come one week and then my dad the next. Its very hard. The nurses have been so kind and I feel very well looked after.

Neri is now waiting on a bone marrow transplant, which will leave him immunocompromised for months. He will likely need at least a year off work, depending on how soon he has the procedure.

His friend who set up the fundraising appeal, Miguel Montenegro, wrote: The funds we raise will be used to support his accommodations costs and bills so that he can carry on focusing on his recovery and can remain in the country to obtain the best care possible.

He is looking forward to getting better as soon as possible as he wishes to return to work promptly and continue providing people with the best care he is capable of.

Do you have a real life story? Email claudia.tanner@inews.co.uk.

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The Truth About Cosmetic Treatments was a startling and sad documentary – iNews

By daniellenierenberg

According to a young Mancunian woman festooned with eyeliner, tattoos and pumped-up lips, a major motivation for having cosmetic treatments is to make yourself look more like Kylie Jenner and the Kardashians. Big lips, square jaw, tiny waist, big bum, big boobs now its become commercial enough that we can get it, she explained.

This may not be an aspiration shared by everyone but you might expect that the people who provide these appearance-altering procedures would be subject to strict regulation. Not so, as medical journalist Michael Mosley was horrified to discover in the startling documentary, The Truth about Cosmetic Treatments. You dont need a licence or even any training to start injecting somebodys face with fillers, despite the risks of disfiguring infections or blindness.

The rush for self-renovation has been accelerated by social media and the way that established treatments, such as face-lifts and nose jobs, requiring full-scale surgery, are being replaced by less invasive techniques.

Teaming up with blogger Mehreen Baig, Mosley explored the freaky world of lip and nose fillers, microneedling and botox, and bravely volunteered to have his own crows feet blitzed by a gadget which, as its operator enthused, melts the skin instantaneously. Once the rawness and swelling on his face had subsided, Mosley was disgruntled to find that it hadnt made much difference.

Other customers were left similarly deflated. Julie, whose fractionated CO2 laser treatment left her face covered in tatters of dead skin, enjoyed some improved skin elasticity, but tests revealed no noticeable dermatological changes. The only treatment that seemed to have a significant effect was the stem-cell facelift undergone by Kim, who paid 6,000 for the privilege of having the cells injected into her cheekbones. She was delighted with her smoother, younger-looking face.

Mosley had assembled a panel of punters to look at before and after photos and assess whether the treatments had made the contestants look more attractive. They lost their personality, one man said. As dermatologist Tamara Griffiths warned, then, its a case of buyer beware.

THEARTSDESK.COM

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Cytovia Therapeutics and NYSCF Announce Filing of Provisional Patent for iPSC-Derived NK Cells to Produce Unlimited On-Demand NK and CAR-NK Cells for…

By daniellenierenberg

NEW YORK, Aug. 25, 2020 (GLOBE NEWSWIRE) -- Cytovia Therapeutics, an emerging biopharmaceutical company and the New York Stem Cell Foundation (NYSCF) Research institute today announced the filing of a provisional patent application with the U.S. Patent & Trademark Office (USPTO) for the differentiation of Natural Killer (NK) cells from induced pluripotent stem cells (iPSCs). The NYSCF Research Institute is a pioneer and acknowledged leader in stem cell technology, having developed the NYSCF Global Stem Cell Array, the premier automated robotic platform for reprogramming skin or blood into induced pluripotent stem cells (iPSCs) and differentiating them into disease-relevant cell types.

Cytovia and NYSCF are also collaborating on the process development of Good Manufacturing Practices (GMP) of iPSC NK and CAR-NK cells with the potential to file additional patents on the engineering, expansion and GMP manufacturing processes of iPSC NK cells to treat cancer.

Dr. Daniel Teper, CEO of Cytovia commented, This first patent application filing on iPSC-NK cells is an important milestone for Cytovia, positioning us as a pioneer in this emerging field. The use of iPSC-NK cells constitutes a transformational approach to cancer treatment, enabling the use of precision cell therapy for many patients. Cytovia plans to initiate first clinical trials with iPSC NK-cells in 2021.

Susan L Solomon, Chief Executive Officer of NYSCF added, We are delighted by the progress made by the NYSCF and Cytovia team in the differentiation and expansion of NK cells from an iPSC source. These iPSC-NK cells can be genetically modified to create iPSC-CAR-NK cells. In the coming months, the collaboration will focus on developing a standardized GMP process to support Cytovias iPSC-NK and iPSC-CAR NK therapeutic candidates for cancer.

ABOUT CAR NK CELL THERAPYChimeric Antigen Receptors (CAR) are fusion proteins that combine an extracellular antigen recognition domain with an intracellular co-stimulatory signaling domain. Natural Killer (NK) cells are modified genetically to allow insertion of a CAR. CAR-NK cell therapy has demonstrated initial clinical relevance without the limitations of CAR-T, such as Cytokine Release Syndrome, neurotoxicity or Graft vs Host Disease (GVHD). Induced Pluripotent Stem Cells (iPSC) - derived CAR-NKs are naturally allogeneic, available off-the-shelf and may be able to be administered on an outpatient basis. Recent innovative developments with the iPSC, an innovative technology, allow large quantities of homogeneous genetically modified CAR NK cells to be produced from a master cell bank, and thus hold promise to expand access of cell therapy for many patients.

ABOUTTHE NEW YORK STEM CELL FOUNDATION RESEARCH INSTITUTE The New York Stem Cell Foundation (NYSCF) Research Institute is an independent non-profit organization accelerating cures and better treatments for patients through stem cell research. The NYSCF global community includes over 190 researchers at leading institutions worldwide, including the NYSCF Druckenmiller Fellows, the NYSCF Robertson Investigators, the NYSCF Robertson Stem Cell Prize Recipients, and NYSCF Research Institute scientists and engineers. The NYSCF Research Institute is an acknowledged world leader in stem cell research and in the development of pioneering stem cell technologies, including the NYSCF Global Stem Cell Array, which is used to create cell lines for laboratories around the globe. In 2019, NYSCF launched the Womens Reproductive Cancers Initiative, which aims to shift paradigms in the way these cancers are studied and treated, in collaboration with leading cancer experts across the globe. NYSCF focuses on translational research in an accelerator model designed to overcome barriers that slow discovery and replace silos with collaboration. For more information, visitwww.nyscf.org

ABOUT CYTOVIA THERAPEUTICS, INCCytovia Therapeutics Inc is an emerging biotechnology company that aims to accelerate patient access to transformational immunotherapies, addressing several of the most challenging unmet medical needs in cancer and severe acute infectious diseases. Cytovia focuses on Natural Killer (NK) cell biology and is leveraging multiple advanced patented technologies, including an induced pluripotent stem cell (iPSC) platform for CAR (Chimeric Antigen Receptors) NK cell therapy, next-generation precision gene-editing to enhance targeting of NK cells, and NK engager multi-functional antibodies. Our initial product portfolio focuses on both hematological malignancies such as multiple myeloma and solid tumors including hepatocellular carcinoma and glioblastoma. The company partners with the University of California San Francisco (UCSF), the New York Stem Cell Foundation (NYSCF), the Hebrew University of Jerusalem, and CytoImmune Therapeutics. Learn more atwww.cytoviatx.com

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Cytovia Therapeutics and NYSCF Announce Filing of Provisional Patent for iPSC-Derived NK Cells to Produce Unlimited On-Demand NK and CAR-NK Cells for...

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Autologous Cell Therapy Market Along With Covid-19 Impact Analysis and Business Opportunities Outlook 2027 – Scientect

By daniellenierenberg

Transparency Market Research (TMR)has published a new report titled, Autologous cell therapy Market Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 20192027. According to the report, the globalautologous cell therapy marketwas valued atUS$ 7.5 Bnin2018and is projected to expand at a CAGR of18.1%from2019to2027.

Get PDF Sample Copy of Report: (Including TOC, List of Tables & Figures, Chart) :https://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=715

Overview

Rise in Prevalence of Neurological Disorders & Cancer and Others to Drive Market

REQUEST FOR COVID19 IMPACT ANALYSIS https://www.transparencymarketresearch.com/sample/sample.php?flag=covid19&rep_id=715

Bone Marrow Segment to Dominate Market

Neurology Segment to be Highly Lucrative Segment

Hospitals Segment to be Highly Lucrative Segment

North America to Dominate Global Market

Competitive Landscape

Read our Case study at :https://www.transparencymarketresearch.com/casestudies/innovative-medical-device-manufacturing-start-up

The global autologous cell therapy market has been segmented as follows:

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Autologous Cell Therapy Market Along With Covid-19 Impact Analysis and Business Opportunities Outlook 2027 - Scientect

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The Science of Survival: Evolving Research in Advanced Non-Small Cell Lung Cancer – Reuters

By daniellenierenberg

Despite significant progress in treating cancer in recent years, the need for further improvements has persisted particularly for some of the most challenging forms of the disease, such as lung cancer. Lung cancer is one of the most common cancers, and is the leading cause of cancer death in both men and women.

The majority of lung cancer cases are non-small cell lung cancer (NSCLC), a complex disease that can affect each patient differently. Most cases of NSCLC are not diagnosed until the disease is advanced meaning it has metastasized or spread which can make it more challenging to treat.

The impact of lung cancer, and advanced NSCLC in particular, continues to be felt across our communities, explained Andrea Ferris, president and chairman of LUNGevity Foundation. While every persons experience with the disease is unique, many patients hope they can retain a sense of normalcy in their lives and are seeking more treatment options that offer a chance at a longer life.

Research Driving New Progress for Certain Patients

Researchers have accelerated their pursuit of new and differentiated approaches that address this critical unmet need, focusing on options that may offer patients a chance at a longer life. One area of research that has shown potential is combining treatments, such as immunotherapies, for certain patients with previously untreated advanced disease.

Hossein Borghaei, D.O., chief of thoracic medical oncology at Fox Chase Cancer Center in Philadelphia explains, Progress in treating advanced lung cancer has led to more options for patients with newly diagnosed advanced NSCLC. Some of the most recent developments in the field of immunotherapy are particularly exciting.

One example is the U.S. Food and Drug Administrations approval of the first and only dual immunotherapy approach for newly diagnosed patients. Opdivo (nivolumab) is a prescription medicine used in combination with Yervoy (ipilimumab) for adults with advanced stage NSCLC that has spread to other parts of your body (metastatic) and tests positive for PD-L1 and do not have an abnormal EGFR or ALK gene.

Opdivo can cause problems that can sometimes become serious or life threatening and can lead to death. Serious side effects may include lung problems (pneumonitis); intestinal problems (colitis) that can lead to tears or holes in your intestine; liver problems (hepatitis); hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas); kidney problems, including nephritis and kidney failure; skin problems; inflammation of the brain (encephalitis); problems in other organs; and severe infusion reactions; and complications of stem-cell transplant that uses donor stem cells (allogeneic). Additional serious side effects of Yervoy alone include: nerve problems that can lead to paralysis; eye problems; and complications of stem-cell transplant that uses donor stem cells (allogeneic). Please see Important Facts about side effects for Opdivo and Yervoy below.

Opdivo and Yervoy work with your immune system to help fight cancer in two ways. Yervoy stimulates the kind of cells that help fight cancer, while Opdivo may help these cells to find and fight the cancer cells again. While doing so, Opdivo and Yervoy can also affect healthy cells. These problems can sometimes become serious or life threatening and can lead to death. These problems may happen anytime during treatment or even after treatment has ended. Some of these problems may happen more often when Opdivo is used in combination with Yervoy.

Clinical Trial Findings: A Chance to Live Longer

Opdivo + Yervoy was studied in a clinical trial and compared to platinum-based chemotherapy among certain patients with previously untreated, advanced NSCLC that tested positive for PD-L1.

In the trial, 396 patients received Opdivo + Yervoy and 397 patients received platinum-based chemotherapy. Patients who were treated with Opdivo + Yervoy lived longer than those treated with platinum-based chemotherapy:

In the trial, 396 patients received Opdivo + Yervoy and 397 patients received platinum-based chemotherapy. Patients who were treated with Opdivo + Yervoy lived longer than those treated with platinum-based chemotherapy:

An additional analysis showed:

The data supporting this dual immunotherapy approach are encouraging, particularly as one third of the patients who responded to treatment with Opdivo + Yervoy were still alive at three years, said Dr. Borghaei. Further, Opdivo + Yervoy offers a non-chemotherapy option, which can be important to some patients.

The most common side effects of Opdivo, when used in combination with Yervoy, include: feeling tired; diarrhea; rash; itching; nausea; pain in muscles, bones, and joints; fever; cough; decreased appetite; vomiting; stomach-area (abdominal) pain; shortness of breath; upper respiratory tract infection; headache; low thyroid hormone levels (hypothyroidism); decreased weight; and dizziness. Please see Important Facts about side effects for Opdivo and Yervoy below.

Evolving Outlooks and Adapting Support for Patients

Facing a lung cancer diagnosis and beginning treatment can be life-altering in many ways and todays unique environment as a result of the coronavirus has brought about additional considerations for patients, caregivers and the broader healthcare community, with telemedicine and other forms of remote support playing an increasingly vital role.

Patients should know there are resources available and ways to stay connected, even during times when maintaining physical distance from others is important, said Ferris. We have transformed many of our patient support and education offerings into virtual formats, which we are updating frequently to provide the most recent information and reach and connect as many people as possible.

Dr. Borghaei also urges patients to reach out to their doctor or care team to learn about and take advantage of available remote support offerings. Advances in cancer research are still happening every day, with Opdivo + Yervoy being one example. Its as important as ever that people diagnosed with lung cancer speak with their doctor to fully understand their treatment options. While how we deliver care might look different now in some ways, our commitment to helping patients live longer hasnt changed.

To learn more about Opdivo + Yervoy, please visit http://www.Opdivo.com.

INDICATION

OPDIVO (nivolumab) is a prescription medicine used in combination with YERVOY (ipilimumab) as a first treatment for adults with a type of advanced stage lung cancer (called non-small cell lung cancer) when your lung cancer has spread to other parts of your body (metastatic) and your tumors are positive for PD-L1, but do not have an abnormal EGFR or ALK gene.

It is not known if OPDIVO is safe and effective in children younger than 18 years of age.

OPDIVO (10 mg/mL) and YERVOY (5 mg/mL) are injections for intravenous (IV) use.

ImportantSafetyInformationforOPDIVO(nivolumab) + YERVOY (ipilimumab)

OPDIVO is a medicine that may treat certain cancers by working with your immune system. OPDIVO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. Some of these problems may happen more often when OPDIVO is used in combination with YERVOY.

YERVOY can cause serious side effects in many parts of your body which can lead to death. These problems may happen anytime during treatment with YERVOY or after you have completed treatment.

Serious side effects may include:Lung problems (pneumonitis). Symptoms of pneumonitis may include: new or worsening cough; chest pain; and shortness of breath. Intestinal problems (colitis) that can lead to tears or holes in your intestine. Signs and symptoms of colitis may include: diarrhea (loose stools) or more bowel movements than usual; blood in your stools or dark, tarry, sticky stools; and severe stomach area (abdomen) pain or tenderness. Liver problems (hepatitis). Signs and symptoms of hepatitis may include: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); drowsiness; dark urine (tea colored); bleeding or bruising more easily than normal; feeling less hungry than usual; and decreased energy.Hormone gland problems (especially the thyroid, pituitary, adrenal glands, and pancreas). Signs and symptoms that your hormone glands are not working properly may include: headaches that will not go away or unusual headaches; extreme tiredness; weight gain or weight loss; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness; hair loss; feeling cold; constipation; voice gets deeper; and excessive thirst or lots of urine. Kidney problems, including nephritis and kidney failure.Signs of kidney problems may include: decrease in the amount of urine; blood in your urine; swelling in your ankles; and loss of appetite. Skin problems.Signs of these problems may include: rash; itching; skin blistering; and ulcers in the mouth or other mucous membranes. Inflammation of the brain (encephalitis). Signs and symptoms of encephalitis may include: headache; fever; tiredness or weakness; confusion; memory problems; sleepiness; seeing or hearing things that are not really there (hallucinations); seizures; and stiff neck. Problems in other organs. Signs of these problems may include: changes in eyesight; severe or persistent muscle or joint pains; severe muscle weakness; and chest pain.

Additional serious side effects observed during a separate study of YERVOY alone include: Nerve problems that can lead to paralysis. Symptoms of nerve problems may include: unusual weakness of legs, arms, or face; and numbness or tingling in hands or feet. Eye problems.Symptoms may include: blurry vision, double vision, or other vision problems; and eye pain or redness.

Get medical help immediatelyif you develop any of these symptoms or they get worse. It may keep these problems from becoming more serious. Your healthcare team will check you for side effects during treatment and may treat you with corticosteroid or hormone replacement medicines. If you have a serious side effect, your healthcare team may also need to delay or completely stop your treatment.

OPDIVO and OPDIVO + YERVOY can cause serious side effects, including: Severe infusion reactions. Tell your doctor or nurse right away if you get these symptoms during an infusion: chills or shaking; itching or rash; flushing; difficulty breathing; dizziness; fever; and feeling like passing out.Graft-versus-host disease, a complication that can happen after receiving a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic), may be severe, and can lead to death, if you receive YERVOY either before or after transplant. Your healthcare provider will monitor you for the following signs and symptoms: skin rash, liver inflammation, stomach-area (abdominal) pain, and diarrhea.

Pregnancy and Nursing: Tell your healthcare provider if you are pregnant or plan to become pregnant. OPDIVO and YERVOY can harm your unborn baby. If you are a female who is able to become pregnant, your healthcare provider should do a pregnancy test before you start receiving OPDIVO. Females who are able to become pregnant should use an effective method of birth control duringtreatmentand for at least 5 months after the last dose. Talk to your healthcare provider about birth control methods that you can use during this time. Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment. You or your healthcare provider should contact Bristol Myers Squibb at 1-800-721-5072 as soon as you become aware of the pregnancy. Pregnancy Safety Surveillance Study: Females who become pregnant during treatment with YERVOY are encouraged to enroll in a Pregnancy Safety Surveillance Study. The purpose of this study is to collect information about the health of you and your baby. You or your healthcare provider can enroll in the Pregnancy Safety Surveillance Study by calling 1-844-593-7869. Before receiving treatment, tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if either treatment passes into your breast milk. Do not breastfeed during treatment and for 5 months after the last dose.

Tell your healthcare provider about: Your health problems or concerns if you: have immune system problems such as autoimmune disease, Crohns disease, ulcerative colitis, lupus, or sarcoidosis; have had an organ transplant; have lung or breathing problems; have liver problems; or have any other medical conditions. All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of OPDIVO, when used in combination with YERVOY, include: feeling tired; diarrhea; rash; itching; nausea; pain in muscles, bones, and joints; fever; cough; decreased appetite; vomiting; stomach-area (abdominal) pain; shortness of breath; upper respiratory tract infection;headache; low thyroid hormone levels (hypothyroidism); decreased weight; and dizziness.

These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatchor call 1-800-FDA-1088.

Please see U.S. Full Prescribing Information and Medication Guide forOPDIVO and YERVOY.

2020 Bristol-Myers Squibb Company.

OPDIVO and YERVOY are registered trademarks of Bristol-Myers Squibb Company.

7356US2001251-01 08/20

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The Science of Survival: Evolving Research in Advanced Non-Small Cell Lung Cancer - Reuters

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7 Derm-Approved Tips To Even Your Skin Tone (You’ll Seriously Glow!) – mindbodygreen.com

By daniellenierenberg

Much like vitamin C, retinol (or retinoids, retinoic acid, or Retin-A), is a favorite ingredient for skin care professionals thanks to its renowned efficacy. It also works to help even skin tone twofold.

First up: Retinol spurs collagen production: "Retinol binds to retinoid receptors within skin cells," says board-certified dermatologist Joshua Zeichner, M.D. This "activates genes that upregulate collagen production."

Second, it also increases cell turnover at the cellular level. "Besides stimulating production of new collagen, retinol enhances cell turnover," says Zeichner. "This means it sheds dead and damaged cells that make the skin look dull." And while retinol thickens the lower layers of the skin, he says, it thins out the top layer (the stratum corneum), which creates a dewy glow.

Retinol, however, tends to have less tolerability, although modern formulas are usually more gentle and sophisticated. Adding one to your routine usually takes an adjustment period where the skin may experience peeling, flaking, redness, and dryness. Some with highly sensitive skin are never fully able to tolerate the ingredient, while others will do so quickly.

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Your Ultimate Guide to Shopping Some of the Best Mary Kay Products – Yahoo Canada Shine On

By daniellenierenberg

From Good Housekeeping

Mary Kay, the mega-famous beauty company founded in 1963 by entrepreneur Mary Kay Ash, has earned its stripes with its devoted fan base thanks, in part, to its effective formulas. Not only does the company known for its iconic pink Cadillacs invest millions in research and testing, but the brand has at least 1,500 patents.

Three particular areas where the brand shines are anti-aging products, moisturizing formulas, and bold cosmetics. Below were sharing the products in those categories that any MK devotee will tell you is a must-shop, whether youre looking to expand your collection or start a stash from scratch.

If youre battling dryness, genetics, the weather, and even soaking too long in a hot bath can be to blame. But regardless of the cause ask your derm what they think the culprit is for you these three wonders will come to the rescue with hydrating ingredients like glycerin, shea butter, and squalane. And the clincher? The brands high-tech formulations will help your skin stay hydrated.

Mary Kay Hydrogel Eye Patches, pk./30 pairs, $40

These pretty pink patches are the perfect slip-on fix any time your eyes could use a moisture boost. According to an independent consumer study of 157 people, these patches, loaded with the humectant glycerin, boosted skin hydration upon application. Translation: youll see the effects right away. They leave the delicate eyelid skin feeling cool and soothed, and can help reduce the look of puffiness and dullness.

Mary Kay White Tea & Citrus Satin Body Whipped Shea Crme, $22

This cream is luxe. Loaded with shea and mango butter and sunflower and apricot kernel oil, it feels unbelievably smooth and creamy and, based on biophysical testing, was proven to moisturize for 24 hours. The light, energizing scent? Thats just a bonus.

Mary Kay Naturally Nourishing Oil, $48

We love this oil not only for the hydrators it contains (squalane, sweet almond oil, sesame oil, and olive oil) but what it doesnt (parabens and synthetic dyes and fragrances). Glide it on your face, elbows, cuticles, the ends of your hair, or wherever you need an extra dose of moisture for instant relief.

Turning back the clock is all about lifting and firming to blur and soften lines while protecting the skin from collagen-depleting damage. And this is an area where MKs science-backed, award-winning family of anti-aging products shines. Read on for some of the stand-outs in the range.

Mary Kay TimeWise Miracle Set 3D, $110

If youre looking for an all-in-one skin-perfecting system, well, here you go. This set (which comes in normal/dry and combination/oily versions) contains a cleanser, SPF day cream, night cream, and eye cream, all packed with encapsulated resveratrol, vitamin B3, and peptides to both treat existing signs of aging and protect the skin against free radicals that can cause further signs of aging. And the combination is effective in a 12-week independent clinical study, participants found that there was a visible improvement of multiple signs of aging in just four weeks, with more results coming after prolonged use.

Mary Kay TimeWise Repair Lifting Bio-Cellulose Mask, $70 (pack of four)

Use this Korean beauty-inspired sheet mask just once for 20 to 30 minutes to help boost the radiance of your complexion. Use it twice weekly for 14 days and youll get visibly firmer and more lifted skin, according to clinical trials. You can address your thank you note to the blend of oat kernel extract, orchid extract, and skin-conditioning sodium hyaluronate and the plant-based bio-cellulose material that helps all that goodness absorb into the skin.

Mary Kay TimeWise Repair Volu-Firm Advanced Lifting Serum, $70

The serum was formulated to enhance what the brand dubbed the triangle of youth, meaning full cheeks, a defined jawline, and a taut neck. If the ingredients sound fancy peptides, plant stem cells derived from gotu kola, and alpinia galanga leaf and schisandra extracts thats because they are. They were specifically chosen to support your skins hyaluronic acid, elastin, and collagen levels, which are required for the firm, bouncy skin associated with youth.

Getting all done-up doesnt have to be a big production. By choosing the right high-performing products, you can make a major impact with a just few must-haves. Thats why weve selected these three Mary Kay products as your makeup MVPs they work. Theres a pigment-packed liquid shadow, a high-shine lip gloss, and a volumizing mascara, each clocking in under $20.

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Mary Kay Unlimited Lip Gloss, $16

With a shine thats out of this world and a formula thats intensely moisturizing (due to patent-pending technology), this brand new non-sticky gloss is a statement lip in the making. Oh, and it comes in 14 shades and three finishes (cream, pearl, and shimmer), so theres one to fit every mood.

Mary Kay Ultimate Mascara, $15

Ultimate, indeed. When you want LASHES in all caps, this is the mascara to reach for. This ultra-thickening, smooth formula manages to give major volume without flaking, smudging, or clumping. Its also ophthalmologist-tested to ensure that its suitable for contact lens wearers and people with sensitive eyes, so everyone can swipe safely.

Mary Kay Liquid Eye Shadow, $14

All four of the light-catching celestial-inspired shades (Pink Starlight, Light Beam, Purple Nova, and Meteor Shower) of this creamy shadow are packed with pigment for a rich pop of color, but they feel weightless on your lids. Even better: The formula is blendable, so you can sweep on with the doe foot applicator and sheer out with your finger when youre going for a more subdued look.

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Global Dermal Regeneration Matrix Device Market to Witness Stellar CAGR During the Forecast Period – The News Brok

By daniellenierenberg

Skin is the largest organ of the human body. It is composed of three layers: epidermis-the outermost layer; dermis-contains sweat glands, hair follicles and connective tissue and hypodermis-made up of fat and connective tissue. The main functions of the skin includes protection, sensation and regulation. The skin acts as a barrier and provides protection against harmful chemicals, radiation, microorganism and changing environmental conditions. It also helps regulate body temperature and maintain fluid balance. Skin is an extensive network of nerve cells and contains various receptors to detect changes in the environment such as touch, pain, heat and cold. Damage to skin due to burn or trauma can disrupt all the vital functions performed by the skin.

To remain ahead of your competitors, request for a sample[emailprotected]https://www.persistencemarketresearch.com/samples/12166

Currently, topical antibiotics, skin grafting, wound dressings and tissue-engineered substitutes are available in the market that are used to treat skin-related disorders. A skin graft can be done by natural substitute such as amniotic membrane, potato peel or artificial material that includes synthetic polymer sheet, polymer foam or spray. These substitute helps in the healing process. Skin regeneration refers to the regrowth of the damaged skin from the remaining tissue. Stem cell therapy has a vital application in skin regeneration.

Dermal regeneration matrix device provides an appropriate environment that is necessary for the proliferation and differentiation of skin cells. It helps in triggering the bodys own repair mechanism by cell signaling, that drive the matrix environment in wound healing process. Dermal regeneration matrix device is used to treat skin burns and is also finds application in reconstructive surgery for contractures (scars). The dermal regeneration matrix device is placed over the damaged skin which provides an environment for regeneration of new skin and tissue. The matrix is made of cow collagen, silicone and shark cartilage.

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In 1996, the U.S. Food and Drug Administration (FDA) first approved integra dermal regeneration matrix device for treatment of burn injuries. In 2002, dermal regeneration matrix device was approved for use in reconstructive surgery for burn scars. About 30 million people in the U.S. are suffering from diabetes, of which 15% experience a diabetic foot ulcer in their lifetime. In January 2016, FDA approved the use of dermal regeneration matrix for treatment of chronic diabetic foot ulcers (DFU). The usage of dermal regeneration matrix device is expected to expand the growth of dermal regeneration matrix device owing to increase usage in chronic foot ulcer.

Technological advancement and continued research in the development of artificial skin promises to bring more products to the marketplace. Increasing adoption of the device and long-term benefits associated with its application are some of the factors expected to fuel growth of the global dermal regeneration matrix device market over the forecast period. However, less awareness among the consumers and high cost of device are some of the key factors that could hamper growth of the market.

The global dermal regeneration matrix device is segmented on the basis of source, application, end user and geography.

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On the basis of source, the global dermal regeneration matrix device market is segmented into cow collagen, silicone and shark cartilage. On the basis of end user, the global dermal regeneration matrix device market is segmented into hospitals and dermatology centers. The hospital segment is expected to contribute significantly to the total market in terms of market share. According to World Health Organization, over 265,000 deaths are caused due to burns each year. The majority of the burn cases occur in low and middle-income countries. Injuries such as traffic collisions, falls, burns, drowning, poisoning and others are expected to kills around five million people worldwide. Thus, the demand for dermal regeneration growth matrix is expected to be high in the low and middle-income countries over the forecast period.

On the basis of region, the global dermal regeneration matrix device market is segmented into five key regions: North America, Latin America, Europe, Asia Pacific and Middle East & Africa.

Some of the major players in the global dermal regeneration matrix device market include

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How to choose the right eye cream to target your skin concerns – Lifestyle Asia

By daniellenierenberg

Not all eye creams are made the same. Heres how to choose the best one for everything youre looking to fix.

Picture this: Youve been staying up late from all the Netflix bingeing and it shows with the heavy eye bags youre carrying under your peepers. You slap on some eye cream thats gotten rave reviews online, only to find that it doesnt help reduce those bags at all. What gives?

The key here is to read the fine print: Specifically, the ingredients list. No, were not asking you to check out which ingredients you might be sensitive to. In fact, the key ingredients in your eye cream actually play a big factor in determining which eye care woes youd like to solve.

Allow us to elucidate.

Fine lines and crows feet around the eye area are, unfortunately, where the first signs of ageing appear. Chalk it up to the skin around the eye area being the thinnest. It also doesnt help that youre probably tugging and pulling at your eyes more than you should putting on contact lenses, drawing your eyeliner, and even the act of removing your eye makeup contributes to this.

If you want to alleviate or diminish fine lines around the eye area, youll want to pick an eye cream that has retinol or peptides, as well as hyaluronic acid in it.

Retinol, as you may already know, is a super ingredient perfect for anti-ageing. The Vitamin A derivative helps increase collagen production and cell turnover rate, though have a bad rap of sensitising skin and making it susceptible to irritation (especially if youve just started using it). Peptides are arguably less invasive, and also do the job of helping your skin create collagen, though some researchers say its effects are much milder. As for hyaluronic acid, it helps plump skin with hydration, which will help fill out those wrinkles.

There are many reasons why you have dark eye circles. It could be hereditary or an underlying health condition both of which you should probably consult a doctor about. But if your dark eye circles stem from a bad lifestyle and lack of sleep, we might be able to help you out. The best eye cream you need to look out for should contain Vitamin C, niacinamide, liquorice, kojic acid, or retinol.

Vitamin C is an antioxidant, and having it in your skincare will help protect skin cells from free radicals caused by UV exposure. In eye creams, Vitamin C will hinder melanin production while lightening pigmentation and brown spots. Your dark eye circles will eventually be evened out with a more radiant outlook. Niacinamide is typically great for blemishes as it controls sebum production in the skin. It also works to reduce hyper-pigmentation and bolsters your skins ceramide production, meaning it helps even out and protect the skins barrier function. In eye creams, this hero ingredient will help improve uneven skin tone.

For those who want a plant-derivative option, liquorice or liquorice root is a popular all-natural option to lighten skin that has gone through sun damage. Thanks to the Glabridin compound in liquorice, any eye cream with this ingredient will also have UV-blocking enzymes to protect against future damages. Similarly, kojic acid also helps to lighten sun-damaged skin, as well as age spots and scars.

Are puffy eyes the bane of your existence? Do people always give you a concerned look and ask if youve been crying? Weve got the solution for you. The best eye cream you can get to remedy this problem is one that contains caffeine.

Caffeine, as you already know, is a diuretic, which increases the excretion of water from bodies. Most eye creams that have caffeine in it claims to help awaken your eyes, but what it actually does is to relieve water retention from your eyes, a common cause of puffiness. It also helps with certain types of dark eye circles by reducing the build-up of blood which causes the dark discolouration under your eyes. For that all-important de-puffing function, youll want to look for ingredients that target skin elasticity and water retention.

(Header image credit: Hadi Safari/Unsplash)

This article was first published on Lifestyle Asia Kuala Lumpur.

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CRISPR cows could boost sustainable meat production, but regulations, wary consumers stand in the way – Genetic Literacy Project

By daniellenierenberg

When Ralph Fisher,a Texas cattle rancher, set eyes on one of the worlds first cloned calves in August 1999, he didnt care what the scientists said: He knew it was his old Brahman bull, Chance, born again. About a year earlier, veterinarians at Texas A&M extracted DNA from one of Chances moles and used the sample to create a genetic double. Chance didnt live to meet his second self, but when the calf was born, Fisher christened him Second Chance, convinced he was the same animal.

Scientists cautioned Fisher that clones are more like twins than carbon copies: The two may act or even look different from one another. But as far as Fisher was concerned, Second Chance was Chance. Not only did they look identical from a certain distance, they behaved the same way as well. They ate with the same odd mannerisms; laid in the same spot in the yard. But in 2003, Second Chance attacked Fisher and tried to gore him with his horns. About 18 months later, the bull tossed Fisher into the air like an inconvenience and rammed him into the fence. Despite 80 stitches and a torn scrotum, Fisher resisted the idea that Second Chance was unlike his tame namesake,telling the radio program This American Life that I forgive him, you know?

In the two decades since Second Chance marked a genetic engineering milestone, cattle have secured a place on the front lines of biotechnology research. Today, scientists around the world are using cutting-edge technologies, fromsubcutaneous biosensorstospecialized food supplements, in an effort to improve safety and efficiency within the$385 billion global cattle meat industry. Beyond boosting profits, their efforts are driven by an imminent climate crisis, in which cattle play a significant role, and growing concern for livestock welfare among consumers.

Gene editing stands out as the most revolutionary of these technologies. Although gene-edited cattle have yet to be granted approval for human consumption, researchers say tools like Crispr-Cas9 could let them improve on conventional breeding practices and create cows that are healthier, meatier, and less detrimental to the environment. Cows are also beinggiven genesfrom the human immune system to create antibodies in the fight against Covid-19. (The genes of non-bovine livestock such as pigs and goats, meanwhile, have been hacked togrow transplantable human organsandproduce cancer drugs in their milk.)

But some experts worry biotech cattle may never make it out of the barn. For one thing, theres the optics issue: Gene editing tends to grab headlines for its role in controversial research and biotech blunders. Crispr-Cas9 is often celebrated for its potential to alter the blueprint of life, but that enormous promise can become a liability in the hands of rogue and unscrupulous researchers, tempting regulatory agencies to toughen restrictions on the technologys use. And its unclear how eager the public will be to buy beef from gene-edited animals. So the question isnt just if the technology will work in developing supercharged cattle, but whether consumers and regulators will support it.

Cattle are catalysts for climate change. Livestockaccount for an estimated 14.5 percent of greenhouse gas emissions from human activities, of which cattle are responsible for about two thirds, according to the United Nations Food and Agriculture Organization (FAO). One simple way to address the issue is to eat less meat. But meat consumption is expected to increasealong with global population and average income. A 2012reportby the FAO projected that meat production will increase by 76 percent by 2050, as beef consumption increases by 1.2 percent annually. And the United States isprojected to set a recordfor beef production in 2021, according to the Department of Agriculture.

For Alison Van Eenennaam, an animal geneticist at the University of California, Davis, part of the answer is creating more efficient cattle that rely on fewer resources. According to Van Eenennaam, the number of dairy cows in the United Statesdecreasedfrom around 25 million in the 1940s to around 9 million in 2007, while milk production has increased by nearly 60 percent. Van Eenennaam credits this boost in productivity to conventional selective breeding.

You dont need to be a rocket scientist or even a mathematician to figure out that the environmental footprint or the greenhouse gases associated with a glass of milk today is about one-third of that associated with a glass of milk in the 1940s, she says. Anything you can do to accelerate the rate of conventional breeding is going to reduce the environmental footprint of a glass of milk or a pound of meat.

Modern gene-editing tools may fuel that acceleration. By making precise cuts to DNA, geneticists insert or remove naturally occurring genes associated with specific traits. Some experts insist that gene editing has the potential to spark a new food revolution.

Jon Oatley, a reproductive biologist at Washington State University, wants to use Crispr-Cas9 to fine tune the genetic code of rugged, disease-resistant, and heat-tolerant bulls that have been bred to thrive on the open range. By disabling a gene called NANOS2, he says he aims to eliminate the capacity for a bull to make his own sperm, turning the recipient into a surrogate for sperm-producing stem cells from more productive prized stock. These surrogate sires, equipped with sperm from prize bulls, would then be released into range herds that are often genetically isolated and difficult to access, and the premium genes would then be transmitted to their offspring.

Furthermore, surrogate sires would enable ranchers to introduce desired traits without having to wrangle their herd into one place for artificial insemination, says Oatley. He envisions the gene-edited bulls serving herds in tropical regions like Brazil, the worldslargestbeef exporter and home to around 200 million of the approximately 1.5 billion head of cattle on Earth.

Brazils herds are dominated by Nelore, a hardy breed that lacks the carcass and meat quality of breeds like Angus but can withstand high heat and humidity. Put an Angus bull on a tropical pasture and hes probably going to last maybe a month before he succumbs to the environment, says Oatley, while a Nelore bull carrying Angus sperm would have no problem with the climate.

The goal, according to Oatley, is to introduce genes from beefier bulls into these less efficient herds, increasing their productivity and decreasing their overall impact on the environment. We have shrinking resources, he says, and need new, innovative strategies for making those limited resources last.

Oatley has demonstrated his technique in mice but faces challenges with livestock. For starters, disabling NANOS2 does not definitively prevent the surrogate bull from producing some of its own sperm. And while Oatley has shown he can transplant sperm-producing cells into surrogate livestock, researchers have not yet published evidence showing that the surrogatesproduceenough quality sperm to support natural fertilization. How many cells will you need to make this bull actually fertile? asks Ina Dobrinski, a reproductive biologist at the University of Calgary who helped pioneer germ cell transplantation in large animals.

But Oatleys greatest challenge may be one shared with others in the bioengineered cattle industry: overcoming regulatory restrictions and societal suspicion. Surrogate sires would be classified as gene-edited animals by the Food and Drug Administration, meaning theyd face a rigorous approval process before their offspring could be sold for human consumption. But Oatley maintains that if his method is successful, the sperm itself would not be gene-edited, nor would the resulting offspring. The only gene-edited specimens would be the surrogate sires, which act like vessels in which the elite sperm travel.

Even so, says Dobrinski, Thats a very detailed difference and Im not sure how that will work with regulatory and consumer acceptance.

In fact, American attitudes towards gene editing have been generally positive when the modification is in the interest of animal welfare. Many dairy farmers prefer hornless cows horns can inflict damage when wielded by 1,500-pound animals so they often burn them off in apainful processusing corrosive chemicals and scalding irons. Ina study published last yearin the journal PLOS One, researchers found that most Americans are willing to consume food products from cows genetically modified to be hornless.

Still, experts say several high-profile gene-editing failures in livestock andhumansin recent years may lead consumers to consider new biotechnologies to be dangerous and unwieldy.

In 2014, a Minnesota startup called Recombinetics, a company with which Van Eenennaams lab has collaborated, created a pair of cross-bred Holstein bulls using the gene-editing tool TALENs, a precursor to Crispr-Cas9, making cuts to the bovine DNA and altering the genes to prevent the bulls from growing horns. Holstein cattle, which almost always carry horned genes, are highly productive dairy cows, so using conventional breeding to introduce hornless genes from less productive breeds can compromise the Holsteins productivity. Gene editing offered a chance to introduce only the genes Recombinetics wanted. Their hope was to use this experiment to prove that milk from the bulls female progeny was nutritionally equivalent to milk from non-edited stock. Such results could inform future efforts to make Holsteins hornless but no less productive.

The experiment seemed to work. In 2015, Buri and Spotigy were born. Over the next few years, the breakthrough received widespread media coverage, and when Buris hornless descendant graced thecover of Wired magazine in April 2019, it did so as the ostensible face of the livestock industrys future.

But early last year, a bioinformatician at the FDA ran a test on Buris genome and discovered an unexpected sliver of genetic code that didnt belong. Traces of bacterial DNA called a plasmid, which Recombinetics used to edit the bulls genome, had stayed behind in the editing process, carrying genes linked to antibiotic resistance in bacteria. After the agency publishedits findings, the media reaction was swift and fierce: FDA finds a surprise in gene-edited cattle: antibiotic-resistant, non-bovine DNA,readone headline. Part cow, part bacterium?readanother.

Recombinetics has since insisted that the leftover plasmid DNA was likely harmless and stressed that this sort of genetic slipup is not uncommon.

Is there any risk with the plasmid? I would say theres none, says Tad Sonstegard, president and CEO of Acceligen, a Recombinetics subsidiary. We eat plasmids all the time, and were filled with microorganisms in our body that have plasmids. In hindsight, Sonstegard says his teams only mistake was not properly screening for the plasmid to begin with.

While the presence of antibiotic-resistant plasmid genes in beef probably does not pose a direct threat to consumers, according to Jennifer Kuzma, a professor of science and technology policy and co-director of the Genetic Engineering and Society Center at North Carolina State University, it does raise the possible risk of introducing antibiotic-resistant genes into the microflora of peoples digestive systems. Although unlikely, organisms in the gut could integrate those genes into their own DNA and, as a result, proliferate antibiotic resistance, making it more difficult to fight off bacterial diseases.

The lesson that I think is learned there is that science is never 100 percent certain, and that when youre doing a risk assessment, having some humility in your technology product is important, because you never know what youre going to discover further down the road, she says. In the case of Recombinetics. I dont think there was any ill intent on the part of the researchers, but sometimes being very optimistic about your technology and enthusiastic about it causes you to have blinders on when it comes to risk assessment.

The FDA eventually clarified its results, insisting that the study was meant only to publicize the presence of the plasmid, not to suggest the bacterial DNA was necessarily dangerous. Nonetheless, the damage was done. As a result of the blunder,a plan was quashedforRecombinetics to raise an experimental herd in Brazil.

Backlash to the FDA study exposed a fundamental disagreement between the agency and livestock biotechnologists. Scientists like Van Eenennaam, who in 2017 received a $500,000 grant from the Department of Agriculture to study Buris progeny, disagree with the FDAs strict regulatory approach to gene-edited animals. Typical GMOs aretransgenic, meaning they have genes from multiple different species, but modern gene-editing techniques allow scientists to stay roughly within the confines of conventional breeding, adding and removing traits that naturally occur within the species.

That said, gene editing is not yet free from errors and sometimes intended changes result in unintended alterations, notes Heather Lombardi, division director of animal bioengineering and cellular therapies at the FDAs Center for Veterinary Medicine. For that reason, the FDA remains cautious.

Theres a lot out there that I think is still unknown in terms of unintended consequences associated with using genome-editing technology, says Lombardi. Were just trying to get an understanding of what the potential impact is, if any, on safety.

Bhanu Telugu, an animal scientist at the University of Maryland and president and chief science officer at the agriculture technology startup RenOVAte Biosciences, worries that biotech companies willmigrate their experimentsto countries with looser regulatory environments. Perhaps more pressingly, he says strict regulation requiring long and expensive approval processes may incentivize these companies to work only on traits that are most profitable, rather than those that may have the greatest benefit for livestock and society, such as animal well-being and the environment.

What company would be willing to spend $20 million on potentially alleviating heat stress at this point? he asks.

On a windywinter afternoon, Raluca Mateescu leaned against a fence post at the University of Floridas Beef Teaching Unit while a Brahman heifer sniffed inquisitively at the air and reached out its tongue in search of unseen food. Since 2017, Mateescu, an animal geneticist at the university, has been part of a team studying heat and humidity tolerance in breeds like Brahman and Brangus (a mix between Brahman and Angus cattle). Her aim is to identify the genetic markers that contribute to a breeds climate resilience, markers that might lead to more precise breeding and gene-editing practices.

In the South, Mateescu says, heat and humidity are a major problem. That poses a stress to the animals because theyre selected for intense production to produce milk or grow fast and produce a lot of muscle and fat.

Like Nelore cattle in South America, Brahman are well-suited for tropical and subtropical climates, but their high tolerance for heat and humidity comes at the cost of lower meat quality than other breeds. Mateescu and her team have examined skin biopsies and found that relatively large sweat glands allow Brahman to better regulate their internal body temperature. With funding from the USDAs National Institute of Food and Agriculture, the researchers now plan to identify specific genetic markers that correlate with tolerance to tropical conditions.

If were selecting for animals that produce more without having a way to cool off, were going to run into trouble, she says.

There are other avenues in biotechnology beyond gene editing that may help reduce the cattle industrys footprint. Although still early in their development,lab-cultured meatsmay someday undermine todays beef producers by offering consumers an affordable alternative to the conventionally grown product, without the animal welfare and environmental concerns that arise from eating beef harvested from a carcass.

Other biotech techniques hope to improve the beef industry without displacing it. In Switzerland, scientists at a startup called Mootral areexperimenting with a garlic-based food supplementdesigned to alter the bovine digestive makeup to reduce the amount of methane they emit. Studies have shown the product to reduce methane emissions by about 20 percent in meat cattle, according to The New York Times.

In order to adhere to the Paris climate agreement, Mootrals owner, Thomas Hafner, believes demand will grow as governments require methane reductions from their livestock producers. We are working from the assumption that down the line every cow will be regulated to be on a methane reducer, he told The New York Times.

Meanwhile, a farm science research institute in New Zealand, AgResearch, hopes to target methane production at its source by eliminating methanogens, the microbes thought to be responsible for producing the greenhouse gas in ruminants. The AgResearch team isattempting to developa vaccine to alter the cattle guts microbial composition, according to the BBC.

Genomic testing may also allow cattle producers to see what genes calves carry before theyre born, according to Mateescu, enabling producers to make smarter breeding decisions and select for the most desirable traits, whether it be heat tolerance, disease resistance, or carcass weight.

Despite all these efforts, questions remain as to whether biotech can ever dramatically reduce the industrys emissions or afford humane treatment to captive animals in resource-intensive operations. To many of the industrys critics, including environmental and animal rights activists, the very nature of the practice of rearing livestock for human consumption erodes the noble goal of sustainable food production. Rather than revamp the industry, these critics suggest alternatives such as meat-free diets to fulfill our need for protein. Indeed,data suggestsmany young consumers are already incorporating plant-based meats into their meals.

Ultimately, though, climate change may be the most pressing issue facing the cattle industry, according to Telugu of the University of Maryland, which received a grant from the Bill and Melinda Gates Foundation to improve productivity and adaptability in African cattle. We cannot breed our way out of this, he says.

Dyllan Furness is a Florida-based science and technology journalist. His work has appeared in Quartz, OneZero, and PBS, among other outlets. Follow him on Twitter @dyllonline

This article was originally published at Undark and has been republished here with permission. Follow Undark on Twitter @undarkmag

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Cosmetic Skin Care Market Increasing Demand, Industry Share with Industry Study Pandemic Impact Product Overview and Scope, Opportunities, Market…

By daniellenierenberg

Cosmetic Skin Care market research report is generated with a nice blend of industry insight, talent solutions, practical solutions and use of technology to advance user experience. The key research methodology used in this Cosmetic Skin Care market document by DBMR research team is data triangulation which involves data mining, analysis of the impact of data variables on the market, and primary (industry expert) validation. Nowadays, businesses get highly benefited with the different segments covered in the Cosmetic Skin Care market research report which provides better market insights to them with which they can drive the business into right direction.

An influential Cosmetic Skin Care market report analyses key factors of the market that gives precise and accurate data and information which is useful for the business. The scope of this Cosmetic Skin Care market report extends from market scenarios to comparative pricing between major players, cost and profit of the specified Cosmetic Skin Care market regions. The data collected to structure this Cosmetic Skin Care market document is based on the data collection modules with large sample sizes. The market data is analysed and forecasted using well established Cosmetic Skin Care market statistical and coherent models. No stone is left unturned while preparing this Cosmetic Skin Care market research report.

some of the Global Cosmetic Skin Care Market key players Involved in the study are LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics.

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026.

Complete study compiled with over 100+ pages, list of tables & figures, profiling 10+ companies. Ask for Sample @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-cosmetic-skin-care-market&SR

Keep yourself up-to-date with latest Cosmetic Skin Care market trends and changing dynamics due to COVID Impact and Economic Slowdown globally. Maintain a competitive edge by sizing up with available business opportunity in Cosmetic Skin Care Market various segments and emerging territory.

**Moreover, it will also include the opportunities available in micro markets for stakeholders to invest, detailed analysis of competitive landscape and product services of key players**

Why Data Bridge Cosmetic Skin Care Market Research?

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Technically acclaimed Analysts with complete industry know how Robust research methodology followed by our publishers to arrive at market estimates, Focus on technology trends, Extensive repository of market research reports to meet our clients needs.

Customers Satisfaction:Our expert team will assist with all your research needs and customize the report.

Inimitable Expertise:Analysts will provide deep insights about the reports Global major countries (United States, Canada, Germany, France, UK, Italy, Russia, Spain, China, Japan, Korea, India, Australia, New Zealand, Southeast Asia, Middle East, Africa, Mexico, Brazil, C. America, Chile, Peru, Colombia) market size (sales, revenue and growth rate) of Cosmetic Skin Care industry

Global Cosmetic Skin Care Market: Regional Analysis

Asia Pacific: China, Japan, India, and Rest of Asia Pacific

Europe: Germany, the UK, France, and Rest of Europe

North America: The US, Mexico, and Canada

Latin America: Brazil and Rest of Latin America

Middle East & Africa: GCC Countries and Rest of Middle East & Africa

By Product: Anti-Aging Cosmetic Products, Skin Whitening Cosmetic Products, Sensitive Skin Care Products, Anti-Acne Products, Dry Skin Care Products, Warts Removal Products, Infant Skin Care Products, Anti-Scars Solution Products, Mole Removal Products, Multi Utility Products

By Application: Flakiness Reduction, Stem Cells Protection against UV, Rehydrate the skins surface, Minimize wrinkles, Increase the viscosity of Aqueous, Others

By Gender: Men, Women

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Major factors covered in the report:

**Global Cosmetic Skin Care Market summary

**Economic Impact on the Industry

** Cosmetic Skin Care Market Competition in terms of Manufacturers

**Production, Revenue (Value) by geographical segmentation

**Production, Revenue (Value), Price Trend by Type

** Cosmetic Skin Care Market Analysis by Application

**Cost Investigation

**Industrial Chain, Raw material sourcing strategy and Downstream Buyers

**Marketing Strategy comprehension, Distributors and Traders

**Study on Market Research Factors

**Global Cosmetic Skin Care Market Forecast

How Research Study of DBMR helps clients in their decision making:

**Creating strategies for new product development

**Supporting & Adjust Investment/business decisions

**Benchmark and judge own competitiveness

**Aiding in the business planning process

**Serving as a credible, independent check on company internal forecasts

**Supporting acquisition strategies

Below is the TOC of the report:

Executive Summary

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Cosmetic Skin Care Market Increasing Demand, Industry Share with Industry Study Pandemic Impact Product Overview and Scope, Opportunities, Market...

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US FDA-approved ointment found to treat, kill viral infections including Covid-19 – ETHealthworld.com

By daniellenierenberg

Washington: A US pharma company has successfully tested a Food and Drug Administration-approved over the counter ointment as the first line of defence against the deadly coronavirus that has so far killed over eight lakh people globally.

Scientists associated with the project said the FDA-registered non-prescription over the counter (OTC) ointment has been proven to prevent, treat and kill viral infections including coronavirus.

As per the lab report states, no infectious virus was detected after 30 seconds of T3X treatment, the pharma company said in a statement.

This is a big deal. It is the type of protection a lot of people have been hoping for and could be a first line of defence against the COVID virus. It is a powerful and effective layer of prevention, Huber said.

He was speaking after the company released the results of an independent laboratory evaluation of a topical medical formulation that mitigates coronavirus from entering the body through the nasal passages, thereby significantly reducing the likelihood of people becoming infected with the virus.

A recent study by the Massachusetts Institute of Technology (MIT) concluded that people contract COVID-19 and other viruses primarily through the nose. However, virus may still enter a body through the mouth and the eyes.

T3X is an FDA registered, over-the-counter formulation, which means that no prescription is needed. It is easy to use and can be self-administered without the assistance of medical personnel or technicians, the company said.

The research concludes that APT T3X effectively neutralises viral infectivity within seconds. The anti-viral efficacy supports the topical intranasal use of APT T3X to decrease the viral load of exposure.

Under the conditions tested, APT T3X displays a 99.9% virucidal activity against human coronavirus NL63, the company said.

The testing was performed over two months, in May and June. All definitive anti-viral assays were performed in triplicate, it said.

The product was initially developed eight years ago for resistant-bacterial infections, but its formulation additionally provides powerful anti-fungal and anti-viral therapies. It has no documented side effects. However, patients diagnosed with Lyme disease should be aware of a potential Herx reaction shortly after use, the company said.

A total of 22,864,873 people have contracted coronavirus globally so far, according to the Johns Hopkins University's COVID resource centre.

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US FDA-approved ointment found to treat, kill viral infections including Covid-19 - ETHealthworld.com

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Best Anti Aging Advances to ComeHow We’ll Soon Be Looking Younger – The Kit

By daniellenierenberg

On April 15, 2002, the FDA approved a temporary treatment for wrinkles that would revolutionize aging. All of a sudden, you could waltz into a derms office and get your frown lines ironed out faster than it would take to iron an actual shirt. It was called botulinum toxin,Botox for short.

Eighteen years later, a few units of Botox every three months has become the norm for millions around the world (more than seven million yearly in the U.S. alone). Now, if someone had told your grandparents, or even your parents, 20 years ago that people would be getting their foreheads frozen to look younger, they likely would have scoffed at the idea. So just imagine what other wild fixes could be coming to a medi-spa near you.

Its exciting to think about how the next 10 years will look, says Dr. Rohan Bissoondath, medical director of Calgarys Preventous Cosmetic Medicine clinic. With lifespan increasing, people are routinely going to be living into their hundreds, so we want to look great as well. From magic pills to creams that mimic injections, we take a look at the incredible innovations on the horizon.

The best products worth your time, money and energy get beauty news and more delivered to your inbox with our daily newsletter.

The way science is progressing, facelifts are set to become obsolete, says Dr. Lisa Kellett of Torontos DLK on Avenue. I think that the gold standard will eventually be finding ways to regenerate and kick-start our own collagen instead of doing a facelift. Kellett is already trying out cutting-edge technology to accomplish this, such as a laser that delivers growth factors right in the dermis to regenerate tissue. Its pretty snazzy stuff, but she anticipates even greater advances in coming years. I think well be able to use stem cells in conjunction with technology to regenerate collagenI think thats what well be doing one day.

Botox in a cream? This has been in the pipeline for a while, says Bissoondath. The challenge is getting the molecules to penetrate the skin so that they can act on the muscle. Maybe on crows feet because its a thinner area, thinner muscles; that may be an area where we see some utility for it, but its still out there. Topical Botox had some success in trials, but scientists still have kinks to work out. In the meantime, a Botox cream might be beneficial even if it doesnt reach muscles, says Bissoondath. I see the potential for having it in a cream and applying it to the whole face, not necessarily affecting facial expressions, but giving an improved glow and better skin quality.

If you want to smooth, you get Botox. If you want to brighten, you get IPL. If you want to tighten, you get Thermage. But what if there was a treatment that did it all? I think thats the future of aging, says Kellett, who is just about to launch such a treatment at her clinic. Marketed as the next generation of laser and light-based platform technology, Ethera is a multiple modality device that can tackle everything from dark spots and skin laxity to textural issues and wrinkles. It means that when patients come in, theyre not just doing one thing, says the doc. Instead, in the same appointment, shes able to address a variety of concerns with a single machine.

Okay, this is very cool. Something I think is possible is a pill to replace exercise, says Bissoondath, who adds that this could be developed in the not so distant future. With the advances were making in understanding the functions of our body down to the cellular level and intracellular level, and understanding how our mitochondria actually ages, were looking at ways now where we can manipulate that from a pill perspective. The pill wouldnt deliver all the benefits of physical activity, such as the positive impact on our mood, but it would replicate its effects on our body. It wont take the place of walking around outside and soaking up natureit cant do the mental part of it. But as far as the physiologic, biochemical part of it, were really understanding that better and making big strides. Its exciting.

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Induced Pluripotent Stem Cells Market Size Is Anticipated To Reach US$ 17200 Mn at a CAGR of 7% By 2026, Owing to Increasing Number of Product…

By daniellenierenberg

The healthcare industry has been focusing on excessive research and development in the last couple of decades to ensure that the need to address issues related to the availability of drugs and treatments for certain chronic diseases is effectively met. Healthcare researchers and scientists at the Li Ka Shing Faculty of Medicine of the Hong Kong University have successfully demonstrated the utilization of human induced pluripotent stem cells or hiPSCs from the skin cells of the patient for testing therapeutic drugs.

The success of this research suggests that scientists have crossed one more hurdle towards using stem cells in precision medicine for the treatment of patients suffering from sporadic hereditary diseases. iPSCs are the new generation approach towards the prevention and treatment of diseases that takes into account patients on an individual basis considering their genetic makeup, lifestyle, and environment. Along with the capacity to transform into different body cell types and same genetic composition of the donors, hiPSCs have surfaced as a promising cell source to screen and test drugs.

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In the present research, hiPSC was synthesized from patients suffering from a rare form of hereditary cardiomyopathy owing to the mutations in Lamin A/C related cardiomyopathy in their distinct families. The affected individuals suffer from sudden death, stroke, and heart failure at a very young age. As on date, there is no exact treatment available for this condition.

This team in Hong Kong tested a drug named PTC124 to suppress specific genetic mutations in other genetic diseases into the iPSC transformed heart muscle cells. While this technology is being considered as a breakthrough in clinical stem cell research, the team at Hong Kong University is collaborating with drug companies regarding its clinical application.

The unique properties of iPS cells provides extensive potential to several biopharmaceutical applications. iPSCs are also used in toxicology testing, high throughput, disease modeling, and target identification. This type of stem cell has the potential to transform drug discovery by offering physiologically relevant cells for tool discovery, compound identification, and target validation.

A new report by Persistence Market Research (PMR) states that the globalinduced pluripotent stem or iPS cell marketis expected to witness a strong CAGR of 7.0% from 2018 to 2026. In 2017, the market was worth US$ 1,254.0 Mn and is expected to reach US$ 2,299.5 Mn by the end of the forecast period in 2026.

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Customization to be the Key Focus of Market Players

Due to the evolving needs of the research community, the demand for specialized cell lines have increased to a certain point where most vendors offering these products cannot depend solely on sales from catalog products. The quality of the products and lead time can determine the choices while requesting custom solutions at the same time. Companies usually focus on establishing a strong distribution network for enabling products to reach customers from the manufacturing units in a short time period.

Entry of Multiple Small Players to be Witnessed in the Coming Years

Several leading players have their presence in the global market; however, many specialized products and services are provided by small and regional vendors. By targeting their marketing strategies towards research institutes and small biotechnology companies, these new players have swiftly established their presence in the market.

Report Highlights:

Explore Extensive Coverage of PMR`sLife Sciences & Transformational HealthLandscape

Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics andmarket research methodologyto help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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Induced Pluripotent Stem Cells Market Size Is Anticipated To Reach US$ 17200 Mn at a CAGR of 7% By 2026, Owing to Increasing Number of Product...

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