JUPITER, Fla., Jan. 31, 2012 /PRNewswire/ -- BioRestorative Therapies, Inc. (OTCQB: BRTX) ("BRT") today announced that it has entered into a License Agreement with Regenerative Sciences, LLC ("RS") with respect to certain stem cell-related technology and clinical treatment procedures developed by RS. The treatment is an advanced stem cell injection procedure that may offer relief from lower back pain, buttock and leg pain, or numbness and tingling in the legs or feet as a result of bulging and herniated discs.

To date, over 40 procedures have been performed on patients. It is a minimally invasive out-patient procedure, and objective MRI data and patient outcomes for this novel injection procedure show positive results with limited patient downtime. BRT intends to utilize the existing treatment and outcome data, as well as further research, to prepare for clinical trials in the United States.

Pursuant to the agreement, BRT will obtain an exclusive license to utilize or sub-license a certain medical device for the administration of specific cells and/or cell products to the precise locations within the damaged disc and/or spine (and other parts of the body, if applicable) and an exclusive license to utilize or sublicense a certain method for culturing cells for use in repairing damaged areas. The agreement contemplates a closing of the license grant in March 2012, subject to the fulfillment of certain conditions. 

Mark Weinreb, Chairman and CEO of BRT, said, "This possible alternative to back surgery represents a large market for BRT once it begins offering the procedure to patients who might be facing spinal fusions or back surgery (which often times is unsuccessful). By delivering a particular cell population using a proprietary medical device that inserts a specialized needle into the disc and injects cells for repair and re-population, BRT hopes to revolutionize how degenerative disc disease will be treated." 

About BioRestorative Therapies, Inc.
BioRestorative Therapies, Inc.'s goal is to become a medical center of excellence using cell and tissue protocols, primarily involving a patient's own (autologous) adult stem cells (non-embryonic), allowing patients to undergo cellular-based treatments. In June 2011, the Company launched a technology that involves the use of a brown fat cell-based therapeutic/aesthetic program, known as the ThermoStem™ Program.  The ThermoStem™ Program will focus on treatments for obesity, weight loss, diabetes, hypertension, other metabolic disorders and cardiac deficiencies and will involve the study of stem cells, several genes, proteins and/or mechanisms that are related to these diseases and disorders.  As more and more cellular therapies become standard of care, the Company believes its strength will be its focus on the unity of medical and scientific explanations for clinical procedures and outcomes for future personal medical applications.  The Company also plans to offer and sell facial creams and products under the Stem Pearls™ brand.

This press release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events or results to differ materially from those projected in the forward-looking statements as a result of various factors and other risks, including those set forth in the Company's Form 10, as amended, filed with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and the Company undertakes no obligation to update such statements.

CONTACT:  Mark Weinreb, CEO, Tel: (561) 904-6070, Fax: (561) 429-5684

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BioRestorative Therapies Signs License Agreement for Stem Cell Disc/Spine Procedure

06-10-2011 17:25 A doctor becomes patient and gives his testimony on stem cell treatment he received to overcome heart failure.

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Stem Cell Treatment for Heart Failure - Video

Of all the body’s organs, the human heart is probably the one most primed for performance and efficiency. Decade after decade, it continues to pump blood around our bodies. However, this performance optimisation comes at a high price: over the course of evolution, almost all of the body’s own regeneration mechanisms in the heart have become deactivated. As a result, a heart attack is a very serious event for patients; dead cardiac cells are irretrievably lost. The consequence of this is a permanent deterioration in the heart’s pumping power and in the patient’s quality of life.

In their attempt to develop a treatment for the repair of cardiac tissue, scientists are pursuing the aim of growing replacement tissue in the laboratory, which could then be used to produce replacement patches for the repair of damaged cardiac muscle. The reconstruction of a three-dimensional structure poses a challenge here. Experiments have already been carried out with many different materials that could provide a scaffold substance for the loading of cardiac muscle cells.

“Whether natural or artificial in origin, all of the tested fibres had serious disadvantages,” says Felix Engel, Research Group Leader at the Max Planck Institute for Heart and Lung Research in Bad Nauheim. “They were either too brittle, were attacked by the immune system or did not enable the heart muscle cells to adhere correctly to the fibres.” However, the scientists have now found a possible solution in Kharagpur, India.

At the university there, coin-sized disks are being produced from the cocoon of the tasar silkworm (Antheraea mylitta). According to Chinmoy Patra, an Indian scientist who now works in Engel’s laboratory, the fibre produced by the tasar silkworm displays several advantages over the other substances tested. “The surface has protein structures that facilitate the adhesion of heart muscle cells. It’s also coarser than other silk fibres.” This is the reason why the muscle cells grow well on it and can form a three-dimensional tissue structure. “The communication between the cells was intact and they beat synchronously over a period of 20 days, just like real heart muscle,” says Engel.

Despite these promising results, clinical application of the fibre is not currently on the agenda. “Unlike in our study, which we carried out using rat cells, the problem of obtaining sufficient human cardiac cells as starting material has not yet been solved,” says Engel. It is thought that the patient’s own stem cells could be used as starting material to avoid triggering an immune reaction. However, exactly how the conversion of the stem cells into cardiac muscle cells works remains a mystery.

More information: Chinmoy Patra, Sarmistha Talukdar, Tatyana Novoyatleva, Siva R. Velagala, Christian Mühlfeld, Banani Kundu, Subhas C. Kundu, Felix B. Engel
Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering, Biomaterials, Advance Online Publication Januar 10, 2012

Provided by Max-Planck-Gesellschaft (news : web)

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Scientists use silk from the tasar silkworm as a scaffold for heart tissue

27-01-2012 21:30 TORONTO - Doctors have performed Ontario's first cardiac stem cell transplant using cells from the patient's own bone marrow.

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Cardiac Stem Cell Transplant - Video

08-11-2011 12:57 Human pluripotent stem cell derived cardiomyocytes (cardiac tissue) grown on an "air-liquid-interface" culture system to produce "microheart" OrganDots™. These OrganDots™, a core technology supporting VistaGen's drug rescue programs, are used to evaluate the positive ("efficacy") and negative ("toxicity") of drugs and drug candidates on the electrical functions and beating rates of the microhearts.

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VistaGen's Cardiac OrganDots(TM) Produced for Drug Rescue - Video

21-06-2010 19:24 This video goes into Severe Heart Disease and shows how adult stem cells can improve the clinical condition.. More information can be found at http://www.vescell.com . The world's first and still leading heart stem cell company.

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Adult Stem Cells Used To Rebuild Heart Tissue Video.mp4 - Video

24-12-2011 14:49 bboy force back in action AKA captain boogiedown lives!! the DOUBLE BLIND STUDY of adult stem cell research extracted from bone marrow has worked a miracle! Witness the miracle. see part 1

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bboy force the stem cell miracle man part 2 of 2 witness the magic - Video

18-11-2011 05:34 UCL Lunch Hour Lecture: Prometheus and I: building new body parts from stem cells Professor Martin Birchall (UCL Ear Institute) Prometheus created life from clay, and within many biologists and surgeons there is a primal desire to do the same from the materials at hand, in an effort to stave off death and disease. Organ transplantation has been one Promethean solution, but a lack of donor organs, ethical and other issues limits the stretch of this technology

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Prometheus and I: building new body parts from stem cells (15 Nov 2011) - Video

CIRM has funded a $5.5 million Disease Team to develop a follow on clinical trial that uses a patient's own heart stem cells to regenerate scarred tissue damaged by a heart attack. The team is led by Eduardo Marban, MD, PhD, Director of the Cedars-Sinai Heart Institute. Marban presented the team's latest progress at the December 8th, 2011 CIRM Governing Board meeting

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Stem Cell Clinical Trial for Heart Failure: Eduardo Marban - CIRM Spotlight on Disease - Video

MP3 http://www.4shared.com Guests: Anthony F. Sanchez, Christian Wilde Regenerative Medicine: In the first half of Tuesday's show, researcher Christian Wilde talked about the emerging field of regenerative medicine, and how scientists are actually building replacement body parts with stem cells. He announced that Dr.

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Coast To Coast AM - 15.11.2011 - 4/4 - Regenerative Medicine/Dulce Base - Video

Coast to Coast AM Regenerative Medicine/ Dulce Base Date: 11-15-11 Host: George Noory Guests: Anthony F. Sanchez, Christian Wilde News segment guests: Nick Begich, Dr. Robert Manning [Quick Info] First Half: Researcher Christian Wilde talks about the emerging field of regenerative medicine; scientists are actually building replacement body parts with stem cells.

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C2CAM - 2011.11.15 - Dulce Base - Regenerative Medicine - Video

http://www.arthritistreatmentcenter.com Stem cells effective in healing damage from heart attacks.

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Stem Cells Heal Heart Attack Damage. - Video

Coast to Coast AM Regenerative Medicine/ Dulce Base Date: 11-15-11 Host: George Noory Guests: Anthony F. Sanchez, Christian Wilde News segment guests: Nick Begich, Dr. Robert Manning [Quick Info] First Half: Researcher Christian Wilde talks about the emerging field of regenerative medicine; scientists are actually building replacement body parts with stem cells.

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C2CAM - 2011.11.15 - Dulce Base - Regenerative Medicine - Info - Video

orlive.uwhealth.org Researcher, Dr. Timothy Kamp, discusses the depth and breadth of stem cell research at the UW. Dr

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Latest Update on Stem Cell Research at UW - Dr. Timothy Kamp - Video

DOWNLOAD LINK: adf.ly (CLICK ON "REGULAR DOWNLOAD" BUTTON FOR FREE DOWNLOAD) FOLLOW ON TWITTER: twitter.com SUBSCRIBE TO MY YOUTUBE CHANNEL: http://www.youtube.com REGISTER FOR HOTFILE ACCOUNT: hotfile.com REGISTER FOR FILESERVE ACCOUNT: http://www.fileserve.com http://www.coasttocoastam.com Date: 11-15-11 Host: George Noory Guests: Anthony F. Sanchez, Christian Wilde In the first half, researcher Christian Wilde talked about the emerging field of regenerative medicine, and how scientists are actually building replacement body parts with stem cells.

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Coast To Coast AM: Regenerative Medicine / Dulce Base 11-15-2011 Download Link - Video

The cells shown are beating cardiomyocytes derived from human induced pluripotent stem cells.

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Beating Cardiomyocytes in Cell Culture - Video

Mark Sussman, PhD, interviews Piero Anversa, MD, FAHA and Roberto Bolli, MD on the results of the SCIPIO trial at the American Heart Association's Scientific Sessions 2011.

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SCIPIO: Cardiac stem cells and postinfarction heart failure - Video

A synchronously beating monolayer of cardiomyocytes (heart cells) derived from induced pluripotent stem cells.

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Beating iCell® Cardiomyocytes - Video

Human pluripotent stem cell derived cardiomyocytes (cardiac tissue), produced and grown with proprietary processes, self-organizing to form large 3-dimensional tissues visible to the unaided eye. The interaction and role of the cardiomyocytes, and other heart-related cells that differentiate in these cultures in the formation of stable functional adult cardiac tissues, are being studied.

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VistaGen's Stem Cell Derived Cardiomyocytes - Video

Promoting an excellent show! http://www.coasttocoastam.com Author and researcher Christian Wilde reported on alternative approaches to treating heart disease. In the third hour, he was joined by holistic expert Gabriel Cousens, MD, and raw food authority David Wolfe. Wilde noted that turmeric has been shown to have strong anti-inflammatory properties in the body, and the arteries in particular.

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Stem Cell Research