Understanding Chronic Myeloid Leukemia: Causes, Symptoms, and Treatment  Everyday Health

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Understanding Chronic Myeloid Leukemia: Causes, Symptoms, and Treatment - Everyday Health

7 medical breakthroughs that gave us hope in 2023  National Geographic

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Mansour bin Zayed witnesses inauguration of ADSCC Bone Marrow Transplant & Cellular Therapy Congress 2023  ZAWYA

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Mansour bin Zayed witnesses inauguration of ADSCC Bone Marrow Transplant & Cellular Therapy Congress 2023 - ZAWYA

ADSCC Bone Marrow Transplant and Cellular Therapy Congress 2023 to take place in Abu Dhabi  ZAWYA

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ADSCC Bone Marrow Transplant and Cellular Therapy Congress 2023 to take place in Abu Dhabi - ZAWYA

Orchard Therapeutics Reports First Quarter 2023 Financial Results and Announces Initiation of Rolling Submission for Biologics License Application of OTL-200 for Metachromatic Leukodystrophy to U.S. FDA  Marketscreener.com

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Orchard Therapeutics Reports First Quarter 2023 Financial Results and Announces Initiation of Rolling Submission for Biologics License Application of...

Family of 7-month-old in need of bone marrow transplant hosting donor registration event  CBS Pittsburgh

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Family of 7-month-old in need of bone marrow transplant hosting donor registration event - CBS Pittsburgh

Anika Continues to Expand Addressable Market for Tactoset Injectable Bone Substitute with Additional 510(k) Clearance from FDA  Marketscreener.com

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Anika Continues to Expand Addressable Market for Tactoset Injectable Bone Substitute with Additional 510(k) Clearance from FDA - Marketscreener.com

MorphoSys Completes Enrollment of Phase 3 MANIFEST-2 Study of Pelabresib in Myelofibrosis with Topline Results Expected by End of 2023  Marketscreener.com

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MorphoSys Completes Enrollment of Phase 3 MANIFEST-2 Study of Pelabresib in Myelofibrosis with Topline Results Expected by End of 2023 -...

VOR BIOPHARMA INC. Management's Discussion and Analysis of Financial Condition and Results of Operations (form 10-K)  Marketscreener.com

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BioRestorative Therapies to Seek FDA Approval to Expand the Clinical Application of BRTX-100  Marketscreener.com

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BioSenic delivers a new post-hoc analysis of its Phase III JTA-004 trial on knee osteo-arthritis with positive action on the most severely affected patient population  Marketscreener.com

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BioSenic delivers a new post-hoc analysis of its Phase III JTA-004 trial on knee osteo-arthritis with positive action on the most severely affected...

JASPER THERAPEUTICS, INC. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS (form 10-K)  Marketscreener.com

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For a range of unmet medical needs, India offers a fantastic opportunity to push cell and gene therapies: B ..  ETHealthWorld

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For a range of unmet medical needs, India offers a fantastic opportunity to push cell and gene therapies: B .. - ETHealthWorld

NGM BIOPHARMACEUTICALS INC Management's Discussion and Analysis of Financial Condition and Results of Operations. (form 10-K)  Marketscreener.com

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Bone health: Tips to keep your bones healthy

Protecting your bone health is easier than you think. Understand how diet, physical activity and other lifestyle factors can affect your bone mass.

Bones play many roles in the body providing structure, protecting organs, anchoring muscles and storing calcium. While it's important to build strong and healthy bones during childhood and adolescence, you can take steps during adulthood to protect bone health, too.

Your bones are continuously changing new bone is made and old bone is broken down. When you're young, your body makes new bone faster than it breaks down old bone, and your bone mass increases. Most people reach their peak bone mass around age 30. After that, bone remodeling continues, but you lose slightly more bone mass than you gain.

How likely you are to develop osteoporosis a condition that causes bones to become weak and brittle depends on how much bone mass you attain by the time you reach age 30 and how rapidly you lose it after that. The higher your peak bone mass, the more bone you have "in the bank" and the less likely you are to develop osteoporosis as you age.

A number of factors can affect bone health. For example:

You can take a few simple steps to prevent or slow bone loss. For example:

Include plenty of calcium in your diet. For adults ages 19 to 50 and men ages 51 to 70, the Recommended Dietary Allowance (RDA) is 1,000 milligrams (mg) of calcium a day. The recommendation increases to 1,200 mg a day for women age 51 and older and for men age 71 and older.

Good sources of calcium include dairy products, almonds, broccoli, kale, canned salmon with bones, sardines and soy products, such as tofu. If you find it difficult to get enough calcium from your diet, ask your doctor about supplements.

Pay attention to vitamin D. Your body needs vitamin D to absorb calcium. For adults ages 19 to 70, the RDA of vitamin D is 600 international units (IUs) a day. The recommendation increases to 800 IUs a day for adults age 71 and older.

Good sources of vitamin D include oily fish, such as salmon, trout, whitefish and tuna. Additionally, mushrooms, eggs and fortified foods, such as milk and cereals, are good sources of vitamin D. Sunlight also contributes to the body's production of vitamin D. If you're worried about getting enough vitamin D, ask your doctor about supplements.

If you're concerned about your bone health or your risk factors for osteoporosis, including a recent bone fracture, consult your doctor. He or she might recommend a bone density test. The results will help your doctor gauge your bone density and determine your rate of bone loss. By evaluating this information and your risk factors, your doctor can assess whether you might be a candidate for medication to help slow bone loss.

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Karina Hernandez, a nurse, mother and wife of a military officer, was diagnosed with cancer.

SAN ANTONIO A bone marrow registry was held Sunday for the wife of an Air Force Major stationed here in San Antonio.

Karina Hernandez, a nurse at BAMC, mother and wife of a military officer, was diagnosed with a rare bone marrow cancer called Myelofibrosis back in 2017 while pregnant.

She had severe pain in her side that wouldn't go away. Testing revealed that not only was she pregnant, she had an enlarged spleen due to Myelofibrosis.

We spoke with her awesome husband, Major Jesse Hernandez on Sunday about the challenges they have faced.

"Her cancer has progressed to the point where she know requires a bone marrow transplant in order to save her life," said Major Hernandez. "So today we're running a bone marrow registry drive with the goal to find a match for my wife and maybe for other patients who are facing the same need."

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There are over 18,000 patients that could benefit from healthy bone marrow and it could save their life.

"Karina continues to work at BAMC caring for other people, all while battling cancer," said Major Hernandez. "She has been on chemo medications the whole time and this is my opportunity to try and help her and hopefully find someone who is a match to help her."

Her friends and family all say Karina cares more about getting people to sign up for the registry to help others.

She is concerned that - It's not just for herself, it's for how many other people can be helped by this, said Dora Lopez, one of the drives organizers.

Unfortunately, Hispanics do not commonly sign themselves up as donors, said her family. So it has been difficult to try and find a match for her.

"The chances of a Caucasian patient finding a matches is 79% Hispanics is a 48% chance and African Americans is only a 29% chance," said Be The Match Recruitment Coordinator Melinda Dixon.

A bone marrow registry in her honor was held Sunday at St. Anthony Mary Claret Catholic Church located at 6150 Roft Road from 7 a.m. to 7 p.m.

If you missed the drive, you can still sign up for the registry by following this link or by texting Cure4Karina to 61474.

You must be at least 18 years old to register. You will not be asked to donate right away, only to swab the inside of your cheeks to send in so your DNA can be added to the national registry. if it is a match for a patient, a donation could save a life.

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Bone marrow drive held for military wife with cancer

Overview

Bone cancer can begin in any bone in the body, but it most commonly affects the pelvis or the long bones in the arms and legs. Bone cancer is rare, making up less than 1 percent of all cancers. In fact, noncancerous bone tumors are much more common than cancerous ones.

The term "bone cancer" doesn't include cancers that begin elsewhere in the body and spread (metastasize) to the bone. Instead, those cancers are named for where they began, such as breast cancer that has metastasized to the bone.

Some types of bone cancer occur primarily in children, while others affect mostly adults. Surgical removal is the most common treatment, but chemotherapy and radiation therapy also may be utilized. The decision to use surgery, chemotherapy or radiation therapy is based on the type of bone cancer being treated.

Signs and symptoms of bone cancer include:

Make an appointment with your doctor if you or your child develops bone pain that:

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The cause of most bone cancers is unknown. A small number of bone cancers have been linked to hereditary factors, while others are related to previous radiation exposure.

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Osteosarcoma, the most common type of bone cancer, often starts in the long bones the legs or the arms but it can occur in any bone.

Bone cancers are broken down into separate types based on the type of cell where the cancer began. The most common types of bone cancer include:

It's not clear what causes bone cancer, but doctors have found certain factors are associated with an increased risk, including:

Bone cancer care at Mayo Clinic

March 22, 2022

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Top Questions

What is bone made of?

The two principal components of bone are collagen and calcium phosphate, which distinguish it from other hard tissues such as chitin, enamel, and shell.

What are the major functions of bone tissue?

Bone tissue makes up the individual bones of the skeletons of vertebrates. The other roles of bone include structural support for the mechanical action of soft tissues, protection of soft organs and tissues, provision of a protective site for specialized tissues such as the blood-forming system (bone marrow), and a mineral reservoir.

Do bones contain calcium?

Bone contains 99 percent of the calcium in the body and can behave as an adequate buffer for maintaining a constant level of freely moving calcium in soft tissues, extracellular fluid, and blood.

Why is calcium important for bone health?

The mechanical strength of bone is proportional to its mineral content. The Food and Nutrition Board of the U.S. National Academy of Sciences has recommended 1,0001,300 mg of calcium daily for adults and 7001,300 mg for children.

How does vitamin D deficiency affect bones in humans?

A deficiency in vitamin D results in poor mineralization of the bones of the skeleton, causing rickets in children and osteomalacia in adults.

Summary

bone, rigid body tissue consisting of cells embedded in an abundant hard intercellular material. The two principal components of this material, collagen and calcium phosphate, distinguish bone from such other hard tissues as chitin, enamel, and shell. Bone tissue makes up the individual bones of the human skeletal system and the skeletons of other vertebrates.

The functions of bone include (1) structural support for the mechanical action of soft tissues, such as the contraction of muscles and the expansion of lungs, (2) protection of soft organs and tissues, as by the skull, (3) provision of a protective site for specialized tissues such as the blood-forming system (bone marrow), and (4) a mineral reservoir, whereby the endocrine system regulates the level of calcium and phosphate in the circulating body fluids.

Bone is found only in vertebrates, and, among modern vertebrates, it is found only in bony fish and higher classes. Although ancestors of the cyclostomes and elasmobranchs had armoured headcases, which served largely a protective function and appear to have been true bone, modern cyclostomes have only an endoskeleton, or inner skeleton, of noncalcified cartilage and elasmobranchs a skeleton of calcified cartilage. Although a rigid endoskeleton performs obvious body supportive functions for land-living vertebrates, it is doubtful that bone offered any such mechanical advantage to the teleost (bony fish) in which it first appeared, for in a supporting aquatic environment great structural rigidity is not essential for maintaining body configuration. The sharks and rays are superb examples of mechanical engineering efficiency, and their perseverance from the Devonian Period attests to the suitability of their nonbony endoskeleton.

In modern vertebrates, true bone is found only in animals capable of controlling the osmotic and ionic composition of their internal fluid environment. Marine invertebrates exhibit interstitial fluid compositions essentially the same as that of the surrounding seawater. Early signs of regulability are seen in cyclostomes and elasmobranchs, but only at or above the level of true bone fishes does the composition of the internal body fluids become constant. The mechanisms involved in this regulation are numerous and complex and include both the kidney and the gills. Fresh and marine waters provide abundant calcium but only traces of phosphate; because relatively high levels of phosphate are characteristic of the body fluids of higher vertebrates, it seems likely that a large, readily available internal phosphate reservoir would confer significant independence of external environment on bony vertebrates. With the emergence of terrestrial forms, the availability of calcium regulation became equally significant. Along with the kidney and the various component glands of the endocrine system, bone has contributed to development of internal fluid homeostasisthe maintenance of a constant chemical composition. This was a necessary step for the emergence of terrestrial vertebrates. Furthermore, out of the buoyancy of water, structural rigidity of bone afforded mechanical advantages that are the most obvious features of the modern vertebrate skeleton.

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Bone | Definition, Anatomy, & Composition | Britannica

often attributive

1

: one of the hard parts of the skeleton of a vertebrate

: any of various hard animal substances or structures (such as baleen or ivory) akin to or resembling bone

: the hard largely calcareous connective tissue of which the adult skeleton of most vertebrates is chiefly composed

2

3

bones plural

: the basic design or framework (as of a play or novel)

5

bones plural : thin bars of bone, ivory, or wood held in pairs between the fingers and used to produce musical rhythms

: a strip of material (such as whalebone or steel) used to stiffen a garment (such as a corset)

6

transitive verb

1

2

: to provide (a garment) with stays

3

: to rub (something, such as a boot or a baseball bat) with something hard (such as a piece of bone) in order to smooth the surface

4

US, vulgar slang : to have sexual intercourse with (someone)

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Bone Definition & Meaning - Merriam-Webster

To understand osteoporosis, it is important to learn about bone. Made mostly of collagen, bone is living, growing tissue. Collagen is a protein that provides a soft framework, and calcium phosphate is a mineral that adds strength and hardens the framework. This combination of collagen and calcium makes bone strong and flexible enough to withstand stress. More than 99 percent of the body's calcium is contained in the bones and teeth. The remaining 1 percent is found in the blood.

Two types of bone are found in the bodycortical and trabecular. Cortical bone is dense and compact. It forms the outer layer of the bone. Trabecular bone makes up the inner layer of the bone and has a spongy, honeycomb-like structure.

Think of bone as a bank account where you deposit and withdraw bone tissue. During childhood and the teenage years, new bone is added to the skeleton faster than old bone is removed. As a result, bones become larger, heavier, and denser. For most people, bone formation continues at a faster pace than removal until bone mass peaks during the third decade of life.

After age 20, bone withdrawals can begin to exceed deposits. For many people, this bone loss can be prevented by continuing to get calcium, vitamin D, and exercise and by avoiding tobacco and excessive alcohol use. Osteoporosis develops when bone removal occurs too quickly, replacement occurs too slowly, or both. You are more likely to develop osteoporosis if you did not reach your maximum peak bone mass during your bone-building years.

Women are more likely than men to develop osteoporosis. This is because women generally have smaller, thinner bones than men have and because women can lose bone tissue rapidly in the first 4 to 8 years after menopause because of the sharp decline in production of the hormone estrogen. Produced by the ovaries, estrogen has been shown to have a protective effect on bone. Women usually go through menopause between age 45 and 55. After menopause, bone loss in women greatly exceeds that in men. However, by age 65, women and men tend to lose bone tissue at the same rate. Although men do not undergo the equivalent of menopause, production of the male hormone testosterone may decrease, and this can lead to increased bone loss and a greater risk of developing osteoporosis.

Osteoporosis is preventable for many people. Prevention is important because although there are treatments for osteoporosis, a cure has not yet been found. A comprehensive program that can help prevent osteoporosis includes:

The National Institutes of Health Osteoporosis and Related Bone Diseases ~National Resource Center acknowledges the assistance of theNational Osteoporosis Foundation in the preparation of this publication.

For updates and for any questions about any medications you are taking, please contact

U.S. Food and Drug AdministrationToll Free: 888-INFO-FDA (888-463-6332)Website: https://www.fda.gov

For additional information on specific medications, visit Drugs@FDA at https://www.accessdata.fda.gov/scripts/cder/daf. Drugs@FDA is a searchable catalog of FDA-approved drug products.

NIH Pub. No. 18-7876

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What Is Bone? | NIH Osteoporosis and Related Bone Diseases National ...