Victoria Gray's recovery from sickle cell disease, which had caused her painful seizures, came in a year of breakthroughs in one of the hottest areas of medical research -- gene therapy.

Picture: Supplied.

WASHINGTON, United States - In the summer, a mother in Nashville with a seemingly incurable genetic disorder finally found an end to her suffering -- by editing her genome.

Victoria Gray's recovery from sickle cell disease, which had caused her painful seizures, came in a year of breakthroughs in one of the hottest areas of medical research -- gene therapy.

"I have hoped for a cure since I was about 11," the 34-year-old told AFP in an email.

"Since I received the new cells, I have been able to enjoy more time with my family without worrying about pain or an out-of-the-blue emergency."

Over several weeks, Gray's blood was drawn so doctors could get to the cause of her illness -- stem cells from her bone marrow that were making deformed red blood cells.

The stem cells were sent to a Scottish laboratory, where their DNA was modified using Crispr/Cas9 -- pronounced "Crisper" -- a new tool informally known as molecular "scissors."

The genetically edited cells were transfused back into Gray's veins and bone marrow. A month later, she was producing normal blood cells.

Medics warn that caution is necessary but, theoretically, she has been cured.

"This is one patient. This is early results. We need to see how it works out in other patients," said her doctor, Haydar Frangoul, at the Sarah Cannon Research Institute in Nashville.

"But these results are really exciting."

In Germany, a 19-year-old woman was treated with a similar method for a different blood disease, beta-thalassemia. She had previously needed 16 blood transfusions per year.

Nine months later, she is completely free of that burden.

For decades, the DNA of living organisms such as corn and salmon has been modified.

But Crispr, invented in 2012, made gene editing more widely accessible. It is much simpler than preceding technology, cheaper and easy to use in small labs.

The technique has given new impetus to the perennial debate over the wisdom of humanity manipulating life itself.

"It's all developing very quickly," said French geneticist Emmanuelle Charpentier, one of Crispr's inventors and the cofounder of Crispr Therapeutics, the biotech company conducting the clinical trials involving Gray and the German patient.

CURES

Crispr is the latest breakthrough in a year of great strides in gene therapy, a medical adventure started three decades ago when the first TV telethons were raising money for children with muscular dystrophy.

Scientists practising the technique insert a normal gene into cells containing a defective gene.

It does the work the original could not -- such as making normal red blood cells, in Victoria's case, or making tumour-killing super white blood cells for a cancer patient.

Crispr goes even further: instead of adding a gene, the tool edits the genome itself.

After decades of research and clinical trials on a genetic fix to genetic disorders, 2019 saw a historic milestone: approval to bring to market the first gene therapies for a neuromuscular disease in the US and a blood disease in the European Union.

They join several other gene therapies -- bringing the total to eight -- approved in recent years to treat certain cancers and inherited blindness.

Serge Braun, the scientific director of the French Muscular Dystrophy Association, sees 2019 as a turning point that will lead to a medical revolution.

"Twenty-five, 30 years, that's the time it had to take," he told AFP from Paris.

"It took a generation for gene therapy to become a reality. Now, it's only going to go faster."

Just outside Washington, at the National Institutes of Health (NIH), researchers are also celebrating a "breakthrough period."

"We have hit an inflection point," said Carrie Wolinetz, NIH's associate director for science policy.

These therapies are exorbitantly expensive, however, costing up to $2 million -- meaning patients face gruelling negotiations with their insurance companies.

They also involve a complex regimen of procedures that are only available in wealthy countries.

Gray spent months in the hospital getting blood drawn, undergoing chemotherapy, having edited stem cells reintroduced via transfusion -- and fighting a general infection.

"You cannot do this in a community hospital close to home," said her doctor.

However, the number of approved gene therapies will increase to about 40 by 2022, according to MIT researchers.

They will mostly target cancers and diseases that affect muscles, the eyes and the nervous system.

**BIOTERRORISM **

Another problem with Crispr is that its relative simplicity has triggered the imaginations of rogue practitioners who don't necessarily share the medical ethics of Western medicine.

Last year in China, scientist He Jiankui triggered an international scandal -- and his ex-communication from the scientific community -- when he used Crispr to create what he called the first gene-edited humans.

The biophysicist said he had altered the DNA of human embryos that became twin girls Lulu and Nana.

His goal was to create a mutation that would prevent the girls from contracting HIV, even though there was no specific reason to put them through the process.

"That technology is not safe," said Kiran Musunuru, a genetics professor at the University of Pennsylvania, explaining that the Crispr "scissors" often cut next to the targeted gene, causing unexpected mutations.

"It's very easy to do if you don't care about the consequences," Musunuru added.

Despite the ethical pitfalls, restraint seems mainly to have prevailed so far.

The community is keeping a close eye on Russia, where biologist Denis Rebrikov has said he wants to use Crispr to help deaf parents have children without the disability.

There is also the temptation to genetically edit entire animal species -- malaria-causing mosquitoes in Burkina Faso or mice hosting ticks that carry Lyme disease in the US.

The researchers in charge of those projects are advancing carefully, however, fully aware of the unpredictability of chain reactions on the ecosystem.

Charpentier doesn't believe in the more dystopian scenarios predicted for gene therapy, including American "biohackers" injecting themselves with Crispr technology bought online.

"Not everyone is a biologist or scientist," she said.

And the possibility of military hijacking to create soldier-killing viruses or bacteria that would ravage enemies' crops?

Charpentier thinks that technology generally tends to be used for the better.

"I'm a bacteriologist -- we've been talking about bioterrorism for years," she said. "Nothing has ever happened."

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2019: The year gene therapy came of age - Eyewitness News

Bone Marrow Stem Cells Comments Off on 2019: The year gene therapy came of age – Eyewitness News | December 28th, 2019

NEW ORLEANS Nancy Van Den Akker went through a difficult time.

Compressed discs caused pain shooting down her leg. In May, she had surgery to fix that. Then there was another problem.

"Was about ready to start physical therapy when apparently some of the stitches in the side opened up. I had kind of these gaping holes there," said Nancy Van Den Akker.

It's harder for diabetics like Nancy to heal, so even with standard wound medicine the incision stayed open for three months. Then Tulane reconstructive plastic surgeon Dr. Abigail Chaffin asked Nancy to try new technology.

"What we're talking about today is living tissue. These are donated placentas from healthy mothers, undergoing planned C-sections, that give consent to donate tissue that would otherwise be discarded," explained Dr. Abigail Chaffin, a reconstructive plastic surgeon specializing in wound medicine who is the Medical Director of the MedCentris Wound Healing Institute at Tulane.

The tissue comes in many sizes. Dr. Chaffin spreads it out over the wound, then it's bandaged for a week. The tissue bathes the wound in growth factors and stem cells helping regenerate your own tissue, faster.

"These can be used for many different type of wounds, from diabetic ulcers, venous ulcers, non-healing surgical wounds, over any area of the body," said Dr. Chaffin.

This can keep people out of the operating room with anesthesia and from having a painful skin graft that leaves a big scar. It can also help prevent infection and limb amputation. She even used it successfully before surgery on a young patient whose wound did not heal for 10 years.

Nancy healed in four weeks with the treatment.

"It's all healed up. I don't even feel it. Within just a couple of weeks, I was able to start physical therapy," said Nancy Van Den Akker.

Every time someone is finished with the treatment the medical team rings a big bell hanging in the center.

Now that her medical team has declared Nancy healed, she can't wait to take the senior dog she rescued out for walks again.

Here are more before and after pictures:

The MedCentris Wound Healing Institute is doing a study at Tulane on the effectiveness of the new technology.

It's for any child or adult who has an open wound for at least four weeks.It is through your insurance and co-pay.

For more call 504-399-3605 or toll free, 1-855-HEAL-DAT.

Get breaking news from your neighborhood delivered directly to you by downloading the new FREE WWL-TV News app now in theIOS App StoreorGoogle Play.

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New technology being used to heal serious wounds - WWLTV.com

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This undated screen grab shows the cell-division of two fertilized human embryos during the first 24 hours of embryonic development following IVF treatment at a private clinic in London. ( Jim Dyson/Getty Images )

LOS ANGELES - Some of the scientific advancements of the 2010s have been truly mind-blowing, and perhaps none more so than the leaps and bounds weve made in the realm of reproduction.

This was not only the decade in which the first three-parent baby was born, it was the era when a rogue scientist chose to make edits to a set of twin girls DNA, making real the long-imagined scenario of genetically altering human beings while simultaneously thrusting the deeply complicated ethical discussions surrounding this practice into the limelight.

These are the five most life-altering breakthroughs in reproduction from the past decade.

In 2018, Chinese biophysics researcher He Jiankui announced that he had used the gene-editing tool CRISPR to modify the genes of two twin girls before birth. He and his team said that their goal was to make the girls immune to infection by HIV through the elimination of a gene called CCR5.

When the news broke, many mainstream scientists criticized the attempt, calling it too unsafe to try. Where some people saw the potential for a new kind of medical treatment capable of eradicating genetic disease, others saw a window into a dystopian future filled with designer babies and framed by a new kind of eugenics.

At the time, Dr. Kiran Musunuru, a University of Pennsylvania gene-editing expert, said Hes work was unconscionable... an experiment on human beings that is not morally or ethically defensible.

Other experts believe Hes work could propel the field of gene editing forward.

The twins, known as Lulu and Nana, have continued to make headlines since their birth. The gene modification that He claims to have carried out may have caused some unintended mutations in other parts of the genome, which could have unpredictable consequences for their health long term something many scientists who argue against Hes work cite as a reason to hold off on using gene-editing technology on humans.

Only time will tell what will happen to Lulu and Nana and if the edits to their DNA ultimately help or hurt them, but their story pushed the topic of human gene-editing and the ethics surrounding it to the forefront of the global scientific community.

In 2016, a technique called mitochondrial transfer was used successfully for the first time to create a three-parent baby grown from a fathers sperm, a mothers cell nucleus and a third donors egg that had the nucleus removed.

This technique was developed to prevent the transmission of certain genetic disorders through the mothers mitochondria. The majority of a three-parent babys DNA would come from his parents in the form of nuclear DNA, and only a small portion would come from the donor in the form of mitochondrial DNA.

A team led by physician John Zhang at the New Hope Fertility Center in New York City facilitated the birth of the first three-parent baby in April 2016.

Using human pluripotent stem cells, researchers were able to make the precursors of human sperm or eggs. In other words, they reprogrammed skin and blood stem cells to become an early-state version of what would eventually become either sperm or an egg.

"The creation of primordial germ cells is one of the earliest events during early mammalian development," Dr. Naoko Irie, first author of the paper from the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge told Science Daily. "It's a stage we've managed to recreate using stem cells from mice and rats, but until now few researches have done this systematically using human stem cells. It has highlighted important differences between embryo development in humans and rodents that may mean findings in mice and rats may not be directly extrapolated to humans."

A 2018 study showed that gene editing can allow two same-sex mice to conceive pups, and two female mice were able to successfully create healthy pups that then went on to reproduce themselves.

A team of researchers at the Chinese Academy of Sciences in Beijing, led by developmental biologist Qi Zhou, were able to use gene editing to produce 29 living mice from two females, seven of which went on to have their own pups. They were able to produce 12 pups from two male parents, but those offspring were not able to live more than two days.Whether or not the method can one day be used in same-sex human reproduction is still up for debate.

For the first time ever, Chinese scientists were able to clone two primates using the technique that produced Dolly the sheep, the first mammal to be cloned from an adult somatic cell via nuclear transfer.

The two cloned female macaques were named Zhong Zhong and Hua Hua, and their successful birth opened up the possibility of using the same cloning method to one day clone humans.

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What a time to be alive: Reproductive breakthroughs of the 2010s that changed life as we know it - FOX 11 Los Angeles

Skin Stem Cells Comments Off on What a time to be alive: Reproductive breakthroughs of the 2010s that changed life as we know it – FOX 11 Los Angeles | December 28th, 2019

Ginger and carrot are powerhouses of nutrition. They are endowed with essential nutrients like vitamins A and C, beta carotene, folate, so on and so forth. While carrot is a good option for people with type 2 diabetes, ginger has long been used in the traditional Indian medicines like Ayurveda and naturopathy to treat a host of ailments like cough and cold, inflammation, nausea, etc. So, sipping a glass of ginger carrot juice every day is a great idea for more reasons than one. Here, we share with you, the most crucial health benefits of ginger carrot juice.

White blood cells are essential components of your immune system. They are formed out of your bone marrow stem cells with the help of vitamin A. Carrot ginger juice is the storehouse of this nutrient. So, have a glass of this drink every day even if you dont like the taste. Smart tip: Add a few oranges to your glass of carrot orange juice.

Loaded with vitamin C, this detox drink is a natural crusader against cancer. This vitamin reduces your risk of breast and stomach cancers. Additionally, gingerol, a chemical component of ginger, can be useful in taming ovarian cancer cells, suggests a study published in the European Journal of Pharmacology. These components also strengthen your fight against colon cancer cells, finds the same study.

Carrot ginger juice is rich in vitamins C and E. Both play a very significant role in ensuring a healthy skin tone and texture. Vitamin C helps in the synthesis of collagen, a protein that gives your skin its structure, strength and elasticity. It also heals skin wounds. Vitamin E, on the other hand, protects your skin against the harsh UV rays of the sun. Rich in antioxidants, this vitamin also regulates the inflammation levels of your skin.

This is a super easy recipe which doesnt take more than 10 minutes for preparation.

Prep time: 10 minutesServes: 1

8 medium-sized carrots, washed, peeled and tops cut off8 medium-sized oranges, peeled and deveined1 3-inch knob of fresh ginger, peeled

Simply run all the ingredients in a juicer, pour the juice in a glass and serve.

Published : December 27, 2019 3:33 pm

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Warm up to that glass of carrot ginger juice: It boosts your immune function - TheHealthSite

Skin Stem Cells Comments Off on Warm up to that glass of carrot ginger juice: It boosts your immune function – TheHealthSite | December 28th, 2019

NewsScienceThis was the decade designer babies went from concept to feasibility

Saturday, 28th December 2019, 7:02 am

Gene editing

This was the decade when designer babies went from science fiction to fact as a Chinese scientist, He Jiankui, made the shock announcement in December 2018 that the worlds first genetically modified children had been born. He was working illegally and he was widely condemned for not waiting until regulations had been put into place.

But the move showed just how rapidly the Crispr-Cas9 gene-editing technique likened to a find and replace command wasadvancing.

Embryonic and pluripotent Stem Cellresearch

This potentially revolutionary field of medicine has developed to the point where treatments are just around the corner.

Embryonic, or pluripotent, stem cells have extraordinary medical potential because they can develop into any one of the 220 or so mature, specialised cells of the body from insulin-making pancreatic cells to the nerve cells of the brain. In 2018, scientists restored the vision of two UK patients with age-related macular degeneration by inserting a patch of embryonic stem cells into their eyes. The research team hopes an affordable, off-the-shelf therapy could be available to NHS patients within five years.

Treatments for spinal cord injury, heart failure, diabetes, Parkinsons disease and lung cancer are also in advanced trials.

Higgs Boson

Gravitational waves

Scientific history was made in December 2016 as gravitational ripples in the fabric of spacetime, first predicted by Albert Einstein 100 years earlier, were detected, opening new vistas into the dark side of the universe. Physicists around the world confirmed they had detected unambiguous signals of gravitational waves emanating from the collision of two black holes 1.3 billion light years away.

The observations not only confirmed Einsteins general theory of relativity; they also provided the first direct detection of black holes colliding.

Black holes

Neanderthals

The Neanderthals may have been extinct for thousands of years, but in 2010, geneticists mapped their genome using DNA extracted from ancient bones. This led to a startling discovery: our ancestors interbred with other species after they migrated out of Africa.

So in the UK, most of us have a small percentage of Neanderthal genes in our DNA.

Excerpt from:
From gene editing to black holes and the Neanderthals, here's the biggest advances in science over the past decade - inews

Spinal Cord Stem Cells Comments Off on From gene editing to black holes and the Neanderthals, here’s the biggest advances in science over the past decade – inews | December 28th, 2019

WASHINGTON: In the summer, a mother in Nashville with a seemingly incurable genetic disorder finally found an end to her suffering - by editing her genome.Victoria Gray's recovery from sickle cell disease, which had caused her painful seizures, came in a year of breakthroughs in one of the hottest areas of medical research - gene therapy.'; var randomNumber = Math.random(); var isIndia = (window.geoinfo && window.geoinfo.CountryCode === 'IN') && (window.location.href.indexOf('outsideindia') === -1 ); console.log(isIndia && randomNumber "I have hoped for a cure since I was about 11," the 34-year-old told AFP in an email.

"Since I received the new cells, I have been able to enjoy more time with my family without worrying about pain or an out-of-the-blue emergency."

Over several weeks, Gray's blood was drawn so doctors could get to the cause of her illness - stem cells from her bone marrow that were making deformed red blood cells.

The stem cells were sent to a Scottish laboratory, where their DNA was modified using Crispr/Cas9 - pronounced "Crisper" -- a new tool informally known as molecular "scissors."

The genetically edited cells were transfused back into Gray's veins and bone marrow. A month later, she was producing normal blood cells.

Medics warn that caution is necessary but, theoretically, she has been cured.

"This is one patient. This is early results. We need to see how it works out in other patients," said her doctor, Haydar Frangoul, at the Sarah Cannon Research Institute in Nashville.

"But these results are really exciting."

In Germany, a 19-year-old woman was treated with a similar method for a different blood disease, beta thalassemia. She had previously needed 16 blood transfusions per year.

Nine months later, she is completely free of that burden.

For decades, the DNA of living organisms such as corn and salmon has been modified.

But Crispr, invented in 2012, made gene editing more widely accessible. It is much simpler than preceding technology, cheaper and easy to use in small labs.

The technique has given new impetus to the perennial debate over the wisdom of humanity manipulating life itself.

"It's all developing very quickly," said French geneticist Emmanuelle Charpentier, one of Crispr's inventors and the cofounder of Crispr Therapeutics, the biotech company conducting the clinical trials involving Gray and the German patient.

Crispr is the latest breakthrough in a year of great strides in gene therapy, a medical adventure started three decades ago, when the first TV telethons were raising money for children with muscular dystrophy.

Scientists practising the technique insert a normal gene into cells containing a defective gene.

It does the work the original could not -- such as making normal red blood cells, in Victoria's case, or making tumor-killing super white blood cells for a cancer patient.

Crispr goes even further: instead of adding a gene, the tool edits the genome itself.

After decades of research and clinical trials on a genetic fix to genetic disorders, 2019 saw a historic milestone: approval to bring to market the first gene therapies for a neuromuscular disease in the US and a blood disease in the European Union.

They join several other gene therapies - bringing the total to eight - approved in recent years to treat certain cancers and an inherited blindness.

Serge Braun, the scientific director of the French Muscular Dystrophy Association, sees 2019 as a turning point that will lead to a medical revolution.

"Twenty-five, 30 years, that's the time it had to take," he told AFP from Paris.

"It took a generation for gene therapy to become a reality. Now, it's only going to go faster."

Just outside Washington, at the National Institutes of Health (NIH), researchers are also celebrating a "breakthrough period."

"We have hit an inflection point," said Carrie Wolinetz, NIH's associate director for science policy.

These therapies are exorbitantly expensive, however, costing up to $2 million - meaning patients face grueling negotiations with their insurance companies.

They also involve a complex regimen of procedures that are only available in wealthy countries.

Gray spent months in hospital getting blood drawn, undergoing chemotherapy, having edited stem cells reintroduced via transfusion - and fighting a general infection.

"You cannot do this in a community hospital close to home," said her doctor.

However, the number of approved gene therapies will increase to about 40 by 2022, according to MIT researchers.

They will mostly target cancers and diseases that affect muscles, the eyes and the nervous system.

Another problem with Crispr is that its relative simplicity has triggered the imaginations of rogue practitioners who don't necessarily share the medical ethics of Western medicine.

Last year in China, scientist He Jiankui triggered an international scandal - and his excommunication from the scientific community - when he used Crispr to create what he called the first gene-edited humans.

The biophysicist said he had altered the DNA of human embryos that became twin girls Lulu and Nana.

His goal was to create a mutation that would prevent the girls from contracting HIV, even though there was no specific reason to put them through the process.

"That technology is not safe," said Kiran Musunuru, a genetics professor at the University of Pennsylvania, explaining that the Crispr "scissors" often cut next to the targeted gene, causing unexpected mutations.

"It's very easy to do if you don't care about the consequences," Musunuru added.

Despite the ethical pitfalls, restraint seems mainly to have prevailed so far.

The community is keeping a close eye on Russia, where biologist Denis Rebrikov has said he wants to use Crispr to help deaf parents have children without the disability.

There is also the temptation to genetically edit entire animal species - malaria-causing mosquitoes in Burkina Faso or mice hosting ticks that carry Lyme disease in the US.

The researchers in charge of those projects are advancing carefully, however, fully aware of the unpredictability of chain reactions on the ecosystem.

Charpentier doesn't believe in the more dystopian scenarios predicted for gene therapy, including American "biohackers" injecting themselves with Crispr technology bought online.

View original post here:
2019: the year gene therapy came of age - Times of India

Bone Marrow Stem Cells Comments Off on 2019: the year gene therapy came of age – Times of India | December 27th, 2019

Freeze thaw chambers are also called refrigerated humidity chambers. Freeze thaw chamber is used for applications which require temperature cycling down below freezing. Principle of freeze thaw cycle is used in cryopreservation technique. Cryopreservation is the process of preserving living cells and tissues at cryogenic temperature, which lead to suspended metabolic activity of cells in liquid nitrogen. Principle of freeze thaw cycle is nowadays used as treatment method for cancer, as freezing temperature is used in cryosurgery for local tissue destruction.

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Freezing and thawing cause cell death due to ice crystal formation, osmotic shock, and membrane damage. Advanced freeze thaw chambers are available in the market with new features, such as, epoxy coating to avoid corrosion, better condenser and evaporator, capillary tube system, CFC-free polyurethane foam for insulation, broad temperature range from -20 C to 60 C, and long service life designs.

Rise in understanding about the physical and chemical properties of freeze and thaw cycle, advancement in the field of mechanics, and flexibility to stimulate a broad range of conditions are some of the factors driving the growth of the freeze thaw chambers market. However, expensive maintenance and stringent regulatory standards are anticipated to hamper the growth of the market during the forecast period. Customized freeze thaw chambers are the ones which can be modified based on the requirement of the end-user. Introduction of customized freeze thaw instruments is likely to boost the growth of the freeze thaw chambers market during the forecast period.

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On the basis of application area, the global freeze thaw chambers market can be segmented into biopharmaceutical development, molecular biology and biochemistry, medical application, and others. Medical application can be further divided into cryopreserved products and others. Cryopreserved products can be further classified into blood transfusion, bone marrow transplantation, artificial insemination, in vitro fertilization (IVF), stem cell and organ, and others.

The biopharmaceutical development segment is propelling the growth of the freeze thaw chambers market as freezing is one of the processing steps in drug development that ensures the stability and quality of drugs, while freeze thaw chambers provide stability to drug substances. Freeze thaw chambers are also used for ASTM material testing. The cryopreserved products segment is expected to drive the growth of the freeze thaw chambers market during the forecast period due to increase in awareness about the importance and function of stem cell and tissue engineering. Advancement in organ transplantation technology is also another important factor contributing to the growth of stem cell and organ cryopreservation. Freeze thaw chambers are extensively used to transfer cryopreserved products to the end-user for applications, such as, blood transfusion, bone marrow transplantation, artificial insemination, and in vitro fertilization (IVF).

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Based on end-user, the global freeze thaw chambers market can be segmented into biopharmaceutical companies, pathology and research laboratories, hospitals, and stem cell and blood banks. The pathology and research laboratories segment is boosting the growth of the freeze thaw chambers market as these chambers are required for research applications which require very low freezing temperature. Biopharmaceutical companies is another growing segment of the freeze thaw chambers market. Freeze thaw chambers maximize productivity and reduce production cost by providing flexibility to drug substances.

In terms of region, the global freeze thaw chambers market can be categorized into North America, Europe, Asia Pacific, Lain America, and Middle East & Africa. North America is the leading market for freeze thaw chambers in the world due to extensive funding support from the government for research activities in the region. Europe is another leading market for freeze thaw chambers market owing to extensive research in the field of biochemistry and molecular biology in the region. The freeze thaw chambers market in Asia Pacific is expected to grow significantly during the forecast period due to rise in awareness in the region regarding medical applications involving cryopreservation process, such as, umbilical cord, stem cell, and blood sample.

Key players operating in the global freeze thaw chambers market are Darwin Chambers, Newtronic Lifecare Equipments Pvt. Ltd., Caron Products and Services, Inc, BIONICS SCIENTIFIC TECHNOLOGIES (P) LTD., Santorius, Feutron Klimasimulation GmBH., LR Environmental Equipment Co.Inc., and Dycometal.

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Freeze Thaw Chambers Market Poised to Expand at a Robust Pace by 2026 - Market Research Sheets

Bone Marrow Stem Cells Comments Off on Freeze Thaw Chambers Market Poised to Expand at a Robust Pace by 2026 – Market Research Sheets | December 27th, 2019

Global Hematopoietic Stem Cell Transplantation (HSCT) Market 2019 by key players, regions, type, and application, forecast to 2025. The Report contains a forecast of 2019 and ending 2025 with a host of metrics like supply-demand ratio, Hematopoietic Stem Cell Transplantation (HSCT) market frequency, dominant players of Hematopoietic Stem Cell Transplantation (HSCT) market, driving factors, restraints, and challenges. The report also contains market revenue, sales, Hematopoietic Stem Cell Transplantation (HSCT) production and manufacturing cost that could help you get a better view of the market. The report focuses on the key global Hematopoietic Stem Cell Transplantation (HSCT) manufacturers, to define, describe and analyze the sales volume, value, market competition landscape, market share, SWOT analysis and development plans in future years.

The report provides information on trends and developments and focuses on market capacities, technologies, and the changing structure of the Hematopoietic Stem Cell Transplantation (HSCT) Market. The new entrants in the Hematopoietic Stem Cell Transplantation (HSCT) Market are finding it hard to compete with the international dealer based on quality and reliability.

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Major Players included in this report are as follows Regen Biopharma IncChina Cord Blood CorpCBR Systems IncEscape Therapeutics IncCryo-Save AGLonza Group LtdPluristem Therapeutics IncViaCord I

Hematopoietic Stem Cell Transplantation (HSCT) Market can be segmented into Product Types as AllogeneicAutologous

Hematopoietic Stem Cell Transplantation (HSCT) Market can be segmented into Applications as Peripheral Blood Stem Cells Transplant (PBSCT)Bone Marrow Transplant (BMT)Cord Blood Transplant (CBT)

Hematopoietic Stem Cell Transplantation (HSCT) Market: Regional analysis includes:Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)Europe (Turkey, Germany, Russia UK, Italy, France, etc.)North America (United States, Mexico, and Canada.)South America (Brazil etc.)The Middle East and Africa (GCC Countries and Egypt.)

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The huge assortment of tables, graphs, diagrams, and charts obtained in this market research report generates a strong niche for an in-depth analysis of the ongoing trends in the Hematopoietic Stem Cell Transplantation (HSCT) market. Further, the report revises the market share held by the key players and forecast their development in the upcoming years. The report also looks at the latest developments and advancement among the key players in the market such as mergers, partnerships, and achievements.

In short, the Global Hematopoietic Stem Cell Transplantation (HSCT) Market report offers a one-stop solution to all the key players covering various aspects of the industry like growth statistics, development history, industry share, Hematopoietic Stem Cell Transplantation (HSCT) market presence, potential buyers, consumption forecast, data sources, and beneficial conclusion.

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Global Hematopoietic Stem Cell Transplantation (HSCT) Market 2019 Industry Key Players, Trends, Sales, Supply, Demand, Analysis & Forecast to 2025...

Bone Marrow Stem Cells Comments Off on Global Hematopoietic Stem Cell Transplantation (HSCT) Market 2019 Industry Key Players, Trends, Sales, Supply, Demand, Analysis & Forecast to 2025… | December 27th, 2019

The report covers the forecast and analysis of the gene therapy market on a global and regional level. The study provides historical data from 2015 to 2018 along with a forecast from 2019 to 2027 based on revenue (USD Million). The study includes drivers and restraints of the gene therapy market along with the impact they have on the demand over the forecast period. Additionally, the report includes the study of opportunities available in the gene therapy market on a global level.

In order to give the users of this report a comprehensive view of the gene therapy market, we have included a competitive landscape and an analysis of Porters Five Forces model for the market. The study encompasses a market attractiveness analysis, wherein all the segments are bench marked based on their market size, growth rate, and general attractiveness.

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The report provides company market share analysis to give a broader overview of the key players in the market. In addition, the report also covers key strategic developments of the market including acquisitions & mergers, new service launches, agreements, partnerships, collaborations & joint ventures, research & development, and regional expansion of major participants involved in the market on a global and regional basis.

The study provides a decisive view of the gene therapy market by segmenting the market based on the type, vector type, therapy area, and regions. All the segments have been analyzed based on present and future trends and the market is estimated from 2019 to 2027. The regional segmentation includes the current and forecast demand for North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa.

Gene therapy is utilized for treating neurodegenerative disorders like Alzheimer, amyotrophic lateral sclerosis, and spinal muscular atrophy. Gene therapy is one of the key treatment kinds that will propel the market growth over the forecast period. Moreover, gene therapy also finds lucrative applications in precision medicine. In addition to this, a rise in the occurrence of cancer is prompting the demand to treat the disease through gene therapy.

Based on the type, the market can be segregated into Germ Line Gene Therapy and Somatic Gene Therapy. In terms of vector type, the gene therapy industry can be divided into Viral Vectors, Non-Viral Vectors, and Human Artificial Chromosome. On the basis of therapy area, the market for gene therapy can be classified into Cancer, Neurological Diseases, Infectious Diseases, Genetic Disorders, Rheumatoid Arthritis, and Others.

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The key players included in this market are Advanced Cell & Gene Therapy, Audentes Therapeutics, Benitec Biopharma, Biogen, Blubird Bio, Inc., Bristol-Myers Squibb Company, CHIESI Farmaceutici SPA, Eurofins Scientific, Geneta Science, Genzyme Corporation, Gilead, GlaxoSmithKline PLC, Human Stem Cells institute, Novartis AG, Orchard Therapeutics, Pfizer Inc., Sangamo therapeutics, Spark therapeutics, and Voyager Therapeutics.

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Kenneth Research is a reselling agency providing market research solutions in different verticals such as Automotive and Transportation, Chemicals and Materials, Healthcare, Food & Beverage and Consumer Packaged Goods, Semiconductors, Electronics & ICT, Packaging, and Others. Our portfolio includes set of market research insights such as market sizing and market forecasting, market share analysis and key positioning of the players (manufacturers, deals and distributors, etc), understanding the competitive landscape and their business at a ground level and many more. Our research experts deliver the offerings efficiently and effectively within a stipulated time. The market study provided by Kenneth Research helps the Industry veterans/investors to think and to act wisely in their overall strategy formulation

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Gene Therapy Market 2019-2027 / Trends, Growth, Opportunities And Top Key - Market Research Sheets

Cardiac Stem Cells Comments Off on Gene Therapy Market 2019-2027 / Trends, Growth, Opportunities And Top Key – Market Research Sheets | December 27th, 2019

University of Houston's C.T. Bauer College of Business has received its second largest donation to benefit its entrepreneurship program.

The Cyvia and Melvyn Wolff Center for Entrepreneurship, which was recently ranked the top undergraduate entrepreneurship program in the country, received the $13 million gift from its namesake foundation The Cyvia and Melvyn Wolff Family Foundation and the state of Texas is expected to match an additional $2 million, bringing the total impact to $15 million.

"Our family is deeply committed to the ideals of entrepreneurship," says Cyvia Wolff in a news release. "Our business personified everything that it means to be an entrepreneur. The skills, the thinking, the mindset are fundamental to success for business leaders today and in the future. On behalf of my late husband, we are truly honored to ensure the entrepreneurial legacy not only endures but remains accessible for students. We are truly honored to be part of this program and university."

The money will be used to create three endowments for the program. The Dave Cook Leadership Endowment, named for the center's director, Dave Cook, will be created and funded with $7 million of the donation to support leadership within the organization. For $4 million, the center will create the Wolff Legacy Endowment, which aims to increase students involved in the center, as well as the companies coming out of the program. The last $2 million will be used to create the Cyvia and Melvyn Wolff Endowed Chair(s)/Professorship(s) in Entrepreneurship. This initiative will support research and community outreach.

"We are passionate about entrepreneurship and how it can forever change students' lives," says Bauer Dean Paul A. Pavlou in the release. "We seek to further promote entrepreneurship as a university-wide, even citywide effort, by collaborating within and across the university in a multitude of areas, such as technology, health care, arts and sports."

The program was created in the mid '90s and was later renamed after Cyvia and Melvyn Wolff in 2007, and has seen great success over the past decade. In that time, Wolff students have created 1,270 businesses, with identified funding of just over $268 million. According to the release, the program has been ranked in the top two spots of the Princeton Review's top undergraduate entrepreneurship programs for nine of the past 12 years.

"Entrepreneurship is crucial for the future of our country, as well as our city and state," says UH President Renu Khator in the release. "We are proud to be at the forefront of work around entrepreneurial training and research. The uniqueness of our program has and continues to make it the model program. This extraordinary gift ensures our leadership in this space will continue and will support the creation of businesses, change communities and impact our students' lives."

At UH, 2,500 students take at least one entrepreneurship course a year, and more than 700 students complete certificate programs.

"What we are doing is transformative in the lives of students, mentors and stakeholders in a way that elevates everyone towards excellence," Cook, who was named the director of the program in 2017, says in the release. "The impact of this gift allows us to remain the leader and to move forward with confidence, purpose and permanence."

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3 innovative research projects coming out of the University of Houston - InnovationMap

Cardiac Stem Cells Comments Off on 3 innovative research projects coming out of the University of Houston – InnovationMap | December 27th, 2019

Stem Cell Assay Market: Snapshot

Stem cell assay refers to the procedure of measuring the potency of antineoplastic drugs, on the basis of their capability of retarding the growth of human tumor cells. The assay consists of qualitative or quantitative analysis or testing of affected tissues and tumors, wherein their toxicity, impurity, and other aspects are studied.

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With the growing number of successful stem cell therapy treatment cases, the global market for stem cell assays will gain substantial momentum. A number of research and development projects are lending a hand to the growth of the market. For instance, the University of Washingtons Institute for Stem Cell and Regenerative Medicine (ISCRM) has attempted to manipulate stem cells to heal eye, kidney, and heart injuries. A number of diseases such as Alzheimers, spinal cord injury, Parkinsons, diabetes, stroke, retinal disease, cancer, rheumatoid arthritis, and neurological diseases can be successfully treated via stem cell therapy. Therefore, stem cell assays will exhibit growing demand.

Another key development in the stem cell assay market is the development of innovative stem cell therapies. In April 2017, for instance, the first participant in an innovative clinical trial at the University of Wisconsin School of Medicine and Public Health was successfully treated with stem cell therapy. CardiAMP, the investigational therapy, has been designed to direct a large dose of the patients own bone-marrow cells to the point of cardiac injury, stimulating the natural healing response of the body.

Newer areas of application in medicine are being explored constantly. Consequently, stem cell assays are likely to play a key role in the formulation of treatments of a number of diseases.

Global Stem Cell Assay Market: Overview

The increasing investment in research and development of novel therapeutics owing to the rising incidence of chronic diseases has led to immense growth in the global stem cell assay market. In the next couple of years, the market is expected to spawn into a multi-billion dollar industry as healthcare sector and governments around the world increase their research spending.

The report analyzes the prevalent opportunities for the markets growth and those that companies should capitalize in the near future to strengthen their position in the market. It presents insights into the growth drivers and lists down the major restraints. Additionally, the report gauges the effect of Porters five forces on the overall stem cell assay market.

Global Stem Cell Assay Market: Key Market Segments

For the purpose of the study, the report segments the global stem cell assay market based on various parameters. For instance, in terms of assay type, the market can be segmented into isolation and purification, viability, cell identification, differentiation, proliferation, apoptosis, and function. By kit, the market can be bifurcated into human embryonic stem cell kits and adult stem cell kits. Based on instruments, flow cytometer, cell imaging systems, automated cell counter, and micro electrode arrays could be the key market segments.

In terms of application, the market can be segmented into drug discovery and development, clinical research, and regenerative medicine and therapy. The growth witnessed across the aforementioned application segments will be influenced by the increasing incidence of chronic ailments which will translate into the rising demand for regenerative medicines. Finally, based on end users, research institutes and industry research constitute the key market segments.

The report includes a detailed assessment of the various factors influencing the markets expansion across its key segments. The ones holding the most lucrative prospects are analyzed, and the factors restraining its trajectory across key segments are also discussed at length.

Global Stem Cell Assay Market: Regional Analysis

Regionally, the market is expected to witness heightened demand in the developed countries across Europe and North America. The increasing incidence of chronic ailments and the subsequently expanding patient population are the chief drivers of the stem cell assay market in North America. Besides this, the market is also expected to witness lucrative opportunities in Asia Pacific and Rest of the World.

Global Stem Cell Assay Market: Vendor Landscape

A major inclusion in the report is the detailed assessment of the markets vendor landscape. For the purpose of the study the report therefore profiles some of the leading players having influence on the overall market dynamics. It also conducts SWOT analysis to study the strengths and weaknesses of the companies profiled and identify threats and opportunities that these enterprises are forecast to witness over the course of the reports forecast period.

Some of the most prominent enterprises operating in the global stem cell assay market are Bio-Rad Laboratories, Inc (U.S.), Thermo Fisher Scientific Inc. (U.S.), GE Healthcare (U.K.), Hemogenix Inc. (U.S.), Promega Corporation (U.S.), Bio-Techne Corporation (U.S.), Merck KGaA (Germany), STEMCELL Technologies Inc. (CA), Cell Biolabs, Inc. (U.S.), and Cellular Dynamics International, Inc. (U.S.).

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Stem Cell Assay Market Predicted to Accelerate the Growth by 2017-2025 - News Cast Report

Cardiac Stem Cells Comments Off on Stem Cell Assay Market Predicted to Accelerate the Growth by 2017-2025 – News Cast Report | December 27th, 2019

Incorporating a facial massage tool into your daily beauty routine might just be the fast-track way to get flawless skin and now, you dont need to be a professional to own one. The following beauty tools for hair, skin, and foot are the perfect winter season must-haves for that product lover who wants flawless, uplifted and natural glow in their skin.

Roller

This elegant tool provides gentle yet effective massages for the eye, face, neck and body areas. It is naturally cool to touch, immediately soothing your skin and depuffing areas prone to water retention like the under-eye area. With regular and continued use, your skin will glow and look younger every time. The gentle rolling motion eases tension knots in your facial muscles and anxieties away.

Derma Roller for hair growth

Just like the skin on our face, the scalp also loses collagen as we age, resulting in slow hair growth and dormant hair follicles. Derma Roller brings blood flow and nutrients to the scalp and induces new stem cells that support hair growth. Derma Roller is a safe and promising tool in hair stimulation and also is useful to treat hair loss.

Paraffin Socks for crack heels

A special, intensive and easy-to-use foot treatment mask that features a sock type design that envelopes the whole foot. The innovative rejuvenating formula guarantees deep and intensive regeneration and hydration of dry patches on hands, feet, and heels. It intensively smoothens out and firms the skin, lubricates and gently warms up, as well as improve the condition of the skin.

Face massager

A Face Massager through micro-vibration gives your facial muscles the right amount of stimulation in order to get a firming effect to improve the skin. It can also reduce wrinkles around eyes, lips, forehead, and neck, and instantly reshape the face contour to reveal your youthful look and energy! It can beautify your skin, only using it for 2 3 minutes per day.

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Face tools to get perfect winter glow - The Statesman

Skin Stem Cells Comments Off on Face tools to get perfect winter glow – The Statesman | December 27th, 2019

Dec 23, 2019 05:03 AM EST

Origami's new role in the field of science and technology has definitely taken a turn for the better in the recent decade. Better known as origami engineering, the practice is used to reduce structures or maximize space and function.

Origami engineering has made great strides in the medical field in particular. The same principles used in origami, when applied to medical devices, allows implants to be folded to minuscule sizes and then unfolded to its actual size. The reverse is also applicable, where like toothpaste tubes, can be fully de-compressed.

Folding techniques could transform flat objects with wrinkles to increase resilience, shock-absorbance, strength, or rigidity. Origami provides a unique insight into how single pieces could sustainably be packaged without cutting, welding, or riveting, allowing for cheaper manufacturing costs and easier assembly.

The utility of origami engineering has captured the attention of people such as Rebecca Taylor, assistant professor at Carnegie Mellon University's Department of Mechanical Engineering. Taylor specializes in microfabrication and biomechanics, a study that has helped her fabricate microscale sensors to reliably assess cardiomyocytes derived from stem cells. A natural inclination to similar practice, Dr. Taylor has developed an origami-based DNA synthetic cardiac contractile protein, which allowed her to observe merging mechanics in multiprotein, acto-myosinc contractile systems.

As a professor, Taylor expands on the utilization of DNA origami in medicine. This technique (also referred to by Dr. Taylor as "bottom-up manufacturing"), allows improvement in nanomanufacturing and nanomechanics of multiprotein systems, paving the way for heart stents that could unfold in a very precise location.

The problem, however, is on how to deploy these structures in a 100% fault-free way. To illustrate this, a common problem that impedes the creation of pop-up tents that could self-assemble at the press of the button is when the folds of the tent get stuck during the folding process on occasion.

Understandably, this raises some concern among those who are keen to use self-folding nanomachines in medicine.

So this is where origami comes in.

According to University of Chicago scientists, the limits of self-folding structures could be intrinsic in that so-called "sticking points" seem to be unavoidable.

Previously thought possible to engineer around, the researchers observed the capacity of foldable structures by creating mathematical models. During the experiment, the team had designed structures capable of self-folding, such as paper origami and nanobots, and creating creases in them beforehand. The result was that when more pre-creases were added to the folds, the more branches in the next folding process could form and the more likely the self-folding mechanism is to get stuck.

Origami engineering is a relatively new innovation. Its application is vast and can be of use to not only technology but to medicine as well. The development of the field itself, then, needs to pick up at a faster pace in order to cater to the intelligent design of foldable structures and materials. But while there are creases in the field that needs to be smoothed out, the greater promise of origami engineering has brought about several research papers in its wake.

RELATED ARTICLE: Swallowed a Battery? Ingestible Origami Robot Made from Pig Gut Can Remove It,Stop Stomach Bleeding

2018 NatureWorldNews.com All rights reserved. Do not reproduce without permission.

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The Art of Origami is Now A Key Tool That Helps Doctors Save Lives - Nature World News

Cardiac Stem Cells Comments Off on The Art of Origami is Now A Key Tool That Helps Doctors Save Lives – Nature World News | December 25th, 2019

A research team from the University of Houston has found a way to use the stem cells found in fat and guide it to become a pacemaker-like cell, according to a new study.

We are reprogramming the cardiac progenitor cell and guiding it to become a conducting cell of the heart to conduct electrical current, said study co-author Bradley McConnell, associate professor of pharmacology, in a press release

The team, publishing the study in the Journal of Molecular and Cellular Cardiology, worked on converting adipogenic mesenchymal stem cells, which reside within fat cells, into cardia progenitor cells. The ensuing cardiac progenitor cells can be programmed to aid heartbeats as a sinoatrial node (SAN), which is part of the electrical cardiac conduction system.

The researchers used what they called a standard screening strategy to test for reprogramming factors for converting human cardiac progenitor cells into pacemaker-like cells. According to their study results, the authors observed expressions of many pacemaker-specific genes, including CX30.2, KCNN4, HCN4, HCN3, HCN1, and SCN3b. The authors wrote that SHOX2, HCN2, and TBX5 (SHT5) combinations of transcription factors were much better candidate(s) in driving cardiac progenitor cells into pacemaker-like cells than other combinations and single transcription factors.

Results of this study show that the SHT5 combination of transcription factors can reprogram CPCs into Pacemaker-like cells, they wrote in their conclusion. SHT5 may be used as a potential stem cell therapy for sick sinus syndrome (SSS) and for other cardiac conduction diseases.

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The Next Generation of Biologic Pacemakers? New Discovery in Stem Cells from Fat Creates Another Alternative Treatment - DocWire News

Cardiac Stem Cells Comments Off on The Next Generation of Biologic Pacemakers? New Discovery in Stem Cells from Fat Creates Another Alternative Treatment – DocWire News | December 25th, 2019

HUNTINGTON Serucell Corporation, a cosmeceutical company based in Huntington, has developed the worlds only dual-cell technology to create and produce anti-aging skincare products, and they did it in Huntington.

Serucell KFS Cellular Protein Complex Serum is made start to finish at Serucells laboratory on the south side of Huntington.

This has been one of the best kept secrets in West Virginia, said Cortland Bohacek, executive chairman and a co-founder of Serucell Corporation.

The company soft launch was in September 2018 at The Greenbrier Spas. The Official online launch was April 2019 and is getting exposure with some well known sellers like Neiman Marcus, local dermatologist and plastic surgeons offices and several other retail locations from New York to California. It is also sold online at serucell.com.

One person that has tried the product is Jennifer Wheeler, who is also a Huntington City Council member.

As a consumer I have an appreciation of the quality of the product and the results Ive seen using it, she said. It has been transformative for my skin and seems like its success will be transformative for our city as well.

She said Serucell and the people behind it are impressive on every level.

In my role on council, Im especially grateful for the companys conscious effort to stay and grow in our city, Wheeler said.

A one-ounce bottle of the serum costs $225. The recommended usage is twice per day and it will last on average of about six weeks.

Serucells active ingredient is called KFS (Keratinocyte Fibroblast Serum), which is made up of more than 1,500 naturally derived super proteins, collagens, peptides and signaling factors that support optimal communication within the cellular makeup of your skin.

This is the first and only dual-cell technology that optimizes hydration and harnesses the power of both keratinocytes and fibroblasts, two essential contributors to maintaining healthy skin by supporting natural rejuvenation of aging skin from the inside out, said Jennifer Hessel, president and CEO of the company.

When applied to the skin, KFS helps boost the skins natural ability to support new collagen and elastin, strengthen the connection and layer of support between the upper and lower layers of your skin. The result, over time is firmer, plumper and smoother skin, according to Hessel.

Why it works so naturally with your skin is because it is natural, Hessel said. These proteins play an important role in strengthening the bond between the layers of your skin, and thats where the re-boot happens.

KFS is the creation of Dr. Walter Neto, Serucells chief science officer and co-founder of the company. Neto is both a physician and a research scientist, specializing in the field of regenerative medicine with an emphasis on skin healing and repair.

Neto said Serucells technology unlocks the key to how our cells communicate and harnesses the signaling power actions to produce the thousands of bioactive proteins necessary to support the skins natural rejuvenation.

Originally from Brazil, Neto studied at Saint Matthews University and completed his clinical training in England. His clinical research on stem-cell cancer therapies, bone and tissue engineering and wound and burn healing led to his discovery in cell-to-cell communication, and ultimately the creation of Serucells KFS Cellular Protein Complex Serum.

Neto received multiple patents for the production method of Serucell KFS Serum.

Neto lives in Huntington with his wife and four golden retrievers.

Neto works alongside his longtime friend, Dr. Brett Jarrell.

I have known Brett since I was 18 years old, Neto said.

Jarrell practices emergency medicine in Ashland, Kentucky, and oversees all aspects of quality control for Serucell. He received his bachelors degree in biology from Wittenberg University, his masters degree in biology from Marshall University and his medical degree from the Marshall University School of Medicine. Jarrell completed his residency at West Virginia University and is board certified by the American Board of Emergency Medicine.

Jarrell has served as a clinical instructor of emergency medicine at the Marshall School of Medicine, president of the West Virginia chapter of the American College of Emergency Medicine and he has published a number of peer-reviewed journal articles on stroke research.

Jarrell also lives in Huntington.

Another co-founder of the company is Dr. Tom McClellan.

McClellan is Serucells chief medical officer and director of research and is a well-respected plastic and reconstructive surgeon with a private practice, McClellan Plastic Surgery, in Morgantown.

McClellan completed his plastic and reconstructive surgery training at the world-renowned Lahey Clinic Foundation, a Harvard Medical School and Tufts Medical School affiliate in Boston, Massachusetts. While in Boston, he worked at Lahey Medical Center, Brigham and Womens Hospital, as well as at the Boston Childrens Hospital. McClellan is board certified by the American Board of Plastic Surgery.

In addition to his practice and role at Serucell, McClellan utilizes his surgical skills through pro bono work with InterplastWV, a non-profit group that provides comprehensive reconstructive surgery to the developing world. He has participated in surgical missions to Haiti, Peru and the Bahamas.

McClellan lives in Morgantown with his family.

All three doctors here have strong connections to West Virginia and we didnt want to leave, Neto said. We all want to give back to West Virginia, so that is the main reason we have our business here in Huntington.

We are building a company we believe can make a difference in the community, Hessel added. Our goal is to grow Serucell and build our brand right here in Huntington. There is a pool of untapped talent here in Huntington. When we expand our business here, we can provide another reason for young people to be able to stay and grow their careers, whether it is in science, operations or manufacturing. The team is a pretty excited to make an impact in the community where it all started.

Hessel decline to give sales numbers, but said the business has been growing each year since the product was introduced. She also declined to give the number of employees at the facility, but did say it has sales representatives across the country.

For more information, visit serucell.com.

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Local firm adds a new wrinkle to anti-aging products - Williamson Daily News

Skin Stem Cells Comments Off on Local firm adds a new wrinkle to anti-aging products – Williamson Daily News | December 25th, 2019

Sickle cell disease is a genetic condition in which red blood cells, which should be circular, adopt a crescent shape and are sticky and rigidALAMY

The first patients to receive gene-editing treatments for inherited blood diseases will enter the new year free of agonising symptoms.

The experiments suggest that altering DNA could treat sickle cell disease (SCD) and beta thalassemia, conditions both caused by faulty genes that hamper the bloods ability to carry oxygen.

The companies behind the trials said that a patient in the US with SCD had been well since July. A thalassemia patient in Germany had been free of symptoms for nine months. Previously she had 16 blood transfusions a year.

British patients could be offered similar experimental therapies next year. The treatment for both conditions involved a high-precision gene-editing tool called Crispr-Cas9. It was used to alter the DNA of some of the cells of Victoria

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Sickle cell patient is pain free after geneediting trial altered her DNA - The Times

Bone Marrow Stem Cells Comments Off on Sickle cell patient is pain free after geneediting trial altered her DNA – The Times | December 25th, 2019

Almost 30 reindeer live on pastureland on the outskirts of Calgary where Jeff Biernaskie is among the researchers trying to determine if their unique healing abilities can be applied to human skin.

Todd Korol/The Globe and Mail

Kyle Hynes is 27. He likes kayaking, fishing and hiking with his dogs around the Rocky Mountains. He is a project manager at a helicopter company and talks with his hands when he gets excited.

He believes reindeer may hold the secret to making his life even better.

When Mr. Hynes was 5, he survived a house fire that left him with scars over 80 per cent of his body and forced him to endure years of surgeries.

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I do love my scars now, he said. But if I could get rid of my scars, I would be the happiest guy alive.

Mammals scar when serious skin wounds heal. Reindeer, however, are among the few exceptions to the rule, with the velvet on their antlers, specifically, healing flawlessly. Scientists at the University of Calgary believe human skin has the potential to heal with the same reindeer magic.

Almost 30 of the creatures live on pastureland on the outskirts of Calgary. Jeff Biernaskie is among the researchers experimenting on the animals. He is a cell biologist and neurobiologist by training focused on tissue regeneration. His team is trying to figure out how to make human skin respond to injury the way reindeer velvet does. The research has the potential restore both the appearance and function of skin for people such as Mr. Hynes.

Jeff Biernaskie is a cell biologist researching how reindeer velvet heals.

Todd Korol/The Globe and Mail

Reindeer sport velvet on their antlers for three to four months a year. The oily brown fuzz protects the antlers as they grow back each year. Reindeer both male and female depend on antlers for scrounging up food under the snow and for protection from predators. Males also show off their racks in mating season.

Dr. Biernaskie originally wanted to isolate the cells that might be responsible for antler growth, long thought to be stem cells that reside in two bony structures, called pedicles, on either side of the skull. Using anesthetic, his team removed small pieces of skin in order to access the pedicle and noticed that the wounds healed without scarring. Then they made more purposeful wounds and found the velvet regenerated seamlessly. By way of comparison, the scientists inflicted identical wounds elsewhere on the reindeers bodies and noted that the animals scarred at those sample sites.

When mammals are wounded, skin cells around the injury and the immune system rush to seal the site as quickly as possible to prevent infection. The natural response to injury, Dr. Biernaskie believes, is regenerative, but those signals are overwhelmed by scar-forming ones in the race to close the wound.

This, however, does not apply to embryonic cells, which are strictly regenerative. Fetal humans, Dr. Biernaskie says, heal perfectly. He says the cells that make up reindeer velvet exhibit genetic properties similar to those in embryonic cells. So if his team can activate regenerative genes and suppress those that form scars, humans may be able to regrow damaged tissue without flaws.

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It is almost like a circuit breaker," Dr. Biernaskie said. You have some that need to be turned on and others that need to be turned off.

Drugs, administered topically or intravenously, may be able to flip the switch, and Dr. Biernaskies lab is experimenting on mice.

His team has been working on the reindeer project for about five years and expects to reveal its findings next year. (The animals are known as caribou in North America and reindeer in Europe. The Calgary herd comes from European stock, so Dr. Biernaskie is sticking with reindeer in casual conversation. Also, its Christmas.)

Scars can be psychologically and physically disabling. Scars on joints, for example, limit mobility.

That becomes a massive burden on our economy, on our health-care system, but also on their quality of life, Dr. Biernaskie said.

Five years ago, the Calgary Firefighters Burn Treatment Society donated $1-million its largest single charitable contribution to support Dr. Biernaskies work. It put up another $1-million this year after his teams progress exceeded expectations.

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Mr. Hynes recognizes that science moves slowly but remains optimistic that he may benefit from Calgarys reindeer.

I live life to the fullest, but when I see this research come out, I get really excited to know that [there is] a possibility it could work for me, he said. [And] for other children who do get burns, theres something there that might cure them.

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How reindeer might help deliver the gift of scar-free healing to humans - The Globe and Mail

Skin Stem Cells Comments Off on How reindeer might help deliver the gift of scar-free healing to humans – The Globe and Mail | December 24th, 2019

Last Christmas a student received what he says was the best Christmas present ever the chance to save a strangers life with a stem cell donation.

This Christmas, the student found out the patient who received his donation was successful, and that the patient was recovering well.

In December last year, Will Briant, 23, from Kennington, received an email that informed him he had come up as a potential match for a blood cancer patient in desperate need of a stem cell transplant.

Will said: Just a week before Christmas, I got the best Christmas present ever. I was told that I was the best match for the patient, and I would be donating early in the new year.

I was so excited. When you sign up you know that its such a tiny chance that youll be found as the best match for someone, so to actually be chosen felt really exciting.

Also, because it was just before Christmas, it felt quite exciting to know that the patient would find out that they had a match just in time for Christmas.

At the beginning of this year Will donated his stem cells at The London Clinic.

Will said: For four days before the donation I had a course of G-CSF injections to increase the number of stem cells I was producing.

This caused mild flu-like symptoms. I just felt a bit tired and achy really.

The whole way through I kept thinking about the recipient and how in this context I was absolutely delighted to have mild flu-like symptoms.

It was quite strange to be doing it for real, after talking to so many potential donors when I volunteered with Marrow at university.

Will initially joined the Anthony Nolan stem cell register in 2014.

His girlfriend, who volunteered with Edinburgh Universitys Blood, Bone Marrow and Transplant Society, which is part of blood cancer charity Anthony Nolans student volunteer network, called Marrow, suggested that he sign up.

Will said: My girlfriend, Libby, told me this amazing statistic that a quarter of all stem cell donors sign up through Marrow at university, so I couldnt not join.

If it wasnt for Marrow and for Libby, I wouldnt have become a donor and given someone hope of a second chance of life just before Christmas.

Following his donation Will then went back to his studies and his job, barely giving a second thought to what hed just done.

Will recently received a letter from the hospital to say that the donation had been successful and the donor recipient was recovering well.

Will said: It was honestly the best letter Ive ever received. It was especially powerful because it really hit home that not only had I given him a second chance of life, but also I had given his wife, his children, his grandchildren and his friends more precious time with him.

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Of all blood cancers, leukaemia and lymphoma are among the most curable.

However, many people, including doctors, still believe the disease leads to immediate death.

This is no longer true today as they are not fatal.

With optimal treatment, the majority of patients go into remission and are considered cured.

These two cancers have been more extensively studied than other forms of cancer, due to the ease in obtaining samples from blood, bone marrow or lymph nodes, spurring the advent of novel targeted therapies for a cure, says consultant haematologist Dr Ng Soo Chin.

Most blood cancers start in the bone marrow, where blood is produced.

Bone marrow contains stem cells, which mature and develop into red blood cells, white blood cells or platelets.

In most blood cancers, normal cell development is interrupted by the uncontrolled growth of an abnormal type of a particular blood cell.

These abnormal blood cells, which are cancerous, prevent your blood from performing many of its functions, like fighting off infections or preventing serious bleeding.

Leukaemia or white blood is classified into acute and chronic disease, which is then divided further into subtypes: acute lymphocytic leukaemia, acute myeloid leukaemia, chronic lymphocytic leukaemia (CLL) and chronic myeloid leukaemia (CML).

The presentation between acute and chronic leukaemia differs.

The acute person will tell you he was well a week ago and is now down with symptoms such as lethargy, anaemia and recurrent infection.

Suddenly, he may look pale, so we check his blood count for any abnormalities. A bone marrow exam will further confirm whether it is acute.

With chronic leukaemia, the patient can be unwell for a couple of months.

We are increasingly picking up cases early because of blood test availability.

The survival rate has improved tremendously for acute leukaemia, with more than 50% fully cured because bone marrow transplants are easily available in the country.

For CLL and CML, 95% of patients are alive at the 10-year mark, says Dr Ng.

Generally, chronic leukaemia patients belong to the older age group (50 years and above), but acute leukaemia can occur in all ages.

Leukaemia symptoms are often vague and not specific, so its easy to overlook them as they may resemble symptoms of the flu and other common illnesses.

In fact, chronic leukaemia may initially produce no symptoms and can go unnoticed or undiagnosed for years.

Lymphomas, a type of blood cancer that begins in a subset of white blood cells called lymphocytes, can be classified into Hodgkins and non-Hodgkins.

The main difference between Hodgkins and non-Hodgkins lymphoma is the specific lymphocyte each involves.

Lymphocytes are an integral part of your immune system, which protects you from germs.

Five-year survival rates are high with Hodgkins lymphoma at 86% and non-Hodgkins lymphoma at 70%.

You can beat the disease even if it is detected at a late stage.

Multiple myeloma, which is the third kind of blood cancer, forms in a type of white blood cell called a plasma cell.

Patients often complain of bone pain, and unfortunately, this type of cancer has no cure.

Blood cancers typically involve abnormal white blood cells and can affect paople of all ages, depending on the type of cancer. 123rf.com

Fear of treatment

Chemotherapy is a much dreaded word among cancer patients.

But with advances in medicine, newer chemotherapy-free treatments are now available.

Dr Ng says, Traditionally, cancer is treated via surgery or radiation the layman says we fry and poison them, which is not far from the truth!

Radiation means burning the cancerous area, but a lot of times, the cancer can also be present elsewhere, so there is limitation to this treatment.

With chemotherapy, we use cytotoxic (cell-killing) drugs they go in and knock off both cancer and normal cells.

The short-term effects include vomiting, hair loss, appetite loss and weight loss.

But as doctors, we are looking at a different perspective. We are more worried about white cells dropping (neutropenia) because the patient can pick up an infection that can potentially kill him.

Neutropenia is a condition that results when the body does not have enough neutrophils, a type of white blood cell that is an essential first line of defence against infections.

Thats one risk of chemotherapy, although we can now improve neutropenia by giving a growth factor injection.

But for certain cancers, we need to step up the drugs.

He adds: We are scared of neutropenia, but patients are more concerned about bodily changes.

The older ones get upset over losing hair because they cannot take it when others ask them what has happened to their hair.

Young people are not as concerned with hair loss because it can be trendy.

We understand that chemotherapy is less than pleasant and strong doses can impair fertility in young patients, especially women.

Despite current technology, only one-third of patients are successful in freezing their eggs.

What he is concerned about is that chemotherapy can actually increase the patients risk of getting another cancer, especially blood cancer.

It can happen the day after! says Dr Ng.

Most experts believe chemotherapy damages stem cells, so if youre unlucky, you might get acute myeloid leukaemia after undergoing chemotherapy for breast cancer.

Its just like crossing the road there is always a risk of being knocked down.

All our cells have a biological clock and there is an orderly exchange of old and new cells.

But with blood cancers such as leukaemia, there is a clone of abnormal cells.

Cancer cells have an advantage over normal cells because they can survive longer.

Chemotherapy is still needed to treat most acute blood cancers, although if the mutation is known, targeted therapies can be applied.

For chronic blood cancers, there is no need for chemotherapy. Oral drugs are enough to combat the disease.

Eventually, many patients are able to wean off the drugs.

As we may be aware, immunotherapy is the buzzword in cancer treatment today.

Also called biologic therapy, it is a type of cancer treatment that boosts the bodys natural defences to fight cancer.

It uses substances made by the body or in a laboratory to improve or restore immune system function.

One of the latest treatment modalities is the CAR T-cell therapy, a form of immunotherapy that uses specially altered T cells a part of the immune system to fight cancer.

A sample of a patients T cells are collected from the blood, then modified to produce special structures called chimeric antigen receptors (CARs) on their surface.

When these CAR T-cells are reinfused into the patient, the new receptors enable them to latch onto a specific antigen on the patients tumour cells and kill the cells.

At the moment, this intravenous therapy is available in the United States and hasnt reached our shores yet. It has to be properly regulated first, says Dr Ng.

A volunteer is having his head shaved to donate hair to make wigs for cancer patients in this filepic. Hair loss is one of the side effects of chemotherapy that affect patients the most.

Following natural remedies

The consultant haematologist errs on the side of caution when patients ask about natural cancer remedies, or the dos and donts during treatment.

We always believe there should be a scientific approach to the problem.

If patients are doing okay while undergoing treatment and there is no weight loss, I tell them to go ahead and do what they always do.

However, just be particular about food hygiene, as there is a chance you may get food poisoning.

If youre undergoing chemotherapy, then youll land yourself in hospital, and if your luck is bad, you may even land up in the ICU (intensive care unit).

So make sure the food is cooked and not left overnight to reduce your chances of infection.

Eat a balanced diet, he advises.

When it comes to exercise, he says to work out within your limit.

Instead of pushing the body and running marathons or climbing mountains, go for walks.

Dr Ng says, Life should go on, but be sensible.

Dont go to crowded places because you may pick up an infection, but dont be withdrawn either. All humans need social interaction.

With the billion-dollar dietary supplements industry, companies are constantly trying to lure customers into buying their products.

A lot of supplements are just glorified vitamins in different packaging.

The more expensive they are, the more people will buy them, thinking they are good.

There are people with good intentions, but unfortunately, there are also a lot of scammers out there that is life.

For the amount you spend on supplements, why not keep the money aside and go for a trip once your treatment is over? he suggests.

Often, the late diagnosis is due to preference for alternative treatment.

These alternative treatments are like fashion shows, after some time, they go out of trend.

For me, youre wasting valuable time because cancer is not your friend.

Yes, chemotherapy is tough, but with the latest chemo-free regimen, patients are more willing to come forward.

The earlier it is treated, the higher your chances of recovering, he says.

To share his 30-odd years of knowledge and experience in the field, Dr Ng has written his third book titled Understanding Blood Disorders.

Intended for patients, caregivers and healthcare professionals, proceeds from the sales of the 270-page book will go to the newly set-up Faith Hope Love Hospice Care Malaysia in Petaling Jaya, Selangor.

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The Galloping Ghosts are looking beyond the scoreboard to help classmate Juwan Adams battle pediatric cancer.

Khalis Whiting and her Abington girls basketball teammates have a different perspective this holiday season. A perspective that changed when through Kisses for Kyle they were put in touch with two area families who have a child battling pediatric cancer.

One George Hamlin is a student in Upper Dublin High School. The other, Juwan Adams, is a senior at Abington. Both families were on the receiving end of gifts and gift cards at the Abington-Upper Moreland game last week. It is the 10th annual giving back game since coach Dan Marsh initiated the project.

It was an amazing experience, said Whiting, the Ghosts sophomore point guard. I was not familiar with the families, but I have seen (Adams) a few times in school, but I never really knew the story until this came up and I researched him.

He has a powerful story, and hes such a strong young man to be going through this. Every time I see him in the hallways, hes always smiling and so positive. So you know give it to his family.

Adams, who has been battling Hodgkins Lymphoma since April of 2016, is in need of a match for an allogeneic stem cell transplant.

Right now, he is out of options, his mother, Andrea Adams, said. We know for sure that an allo stem cell transplant will cure him, but unfortunately, in order to do that, we need a donor.

We have tested everyone in our family, and no one is a full match, so were relying on the Be the Match registry to locate a donor. Sadly, for minorities theres a very slim chance to actually find a full 10-out-of-10 match because we dont have enough minorities on the registry.

Hes had almost every treatment available for Hodgkins, including an auto stem cell transplant, which is where he gave himself his own cells in February of 2017. He was in remission for about a year, and unfortunately, in May of this year, we found out the cancer is back, and its been spreading consistently since May.

Despite missing more than half of the last three-and-a-half years of school, Juwan maintains a 4.25 GPA and is a member of the National Honor Society.

Abington School District has been really great with accommodating him, giving him tutors, and whenever hes an in-patient, he does hospital school, Andrea said.

Juwan is the drum captain and lieutenant of Abingtons marching band, and since September is Pediatric Cancer Awareness month, for the past four years, the marching band has worn gold ribbons on their uniforms.

Since his diagnosis in eighth grade, Juwan has been active in pediatric cancer awareness events, and for the past four years, he has held toy and book drives that he presents to the children at CHOP on his birthday in July.

Last week, Juwan and his family were on the receiving end.

It was great because Juwan never wants gifts, Andrea said. Having a child with cancer, financially its tough, especially now that we have only have one person working fulltime, and that lifted a tremendous burden, and it was so unexpected.

To have him honored by his school and his peers, he was super excited about it, and he really appreciated it because a lot of kids (battling cancer) have to give up school, or their friends tend to abandon them.

I want to thank the team and the Abington students because it is very easy to turn your back on kids that are going through these things. These kids have really rallied around him. This is one of the reasons he fights so hard to be in school. He sometimes sneaks to school because he feels the love from his school and his peers. That was one thing he definitely wanted to do to finish his senior year with his class. They have really rallied around him, and this kind of thing gives him the extra push he needs to keep fighting.

Statistics say Juwan has a 23 percent chance of finding a perfect match, but the Abington senior has been proactive.

When they told him the odds of finding his match, he said he had to do something about it, Andrea said. He set a goal to register a thousand people on the national registry, half of those being minorities.

We have gone around holding bone marrow drives. Hes now an ambassador for Be the Match, and hes been an ambassador for CHOP for about two years.

Juwan is inviting everyone to join his fight.

"People are starting to wake up and realize kids with cancer more and more are dying each day, and if they have a chance to do something, they should take every step they can," Juwan said earlier this fall. It's been hard sometimes, but I have my friends and family to support me.

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Abington working toward big win - Sports - The Intelligencer

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