Successfully treated stem cell therapy patients hailing from around the globe share their pictures and comments. Happy Holidays from the XCell-Center to all of them and to our growing list of satisfied patients and supporters

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XCell-Center Stem Cell Therapy Christmas Video 2010

stemcell.md How many times have you seen a patient interview his or her doctor?

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Bone Marrow Stem Cell Applications

This dynamic session introduced participants to several very current areas of skin research including skin stem cells, cellular senescence, latest ingredients and technology for skin rejuvenation.

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E'shee HBA Global Expo 2011, NYC. Skin Care Anti-Aging Symposium

Explorer : How to Build a Beating Heart : MON FEB 7 10p et/pt : channel.nationalgeographic.com A simple idea backed by stem cell research allows victims of severe burns to heal in merely days.

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The Skin Gun

Amazing Discovery - A new stem cell spray gun to heal burn victims.

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The Skin Gun stem cell research

After extensive research into the power of skin stem cells to reverse aging, a new cosmetic has been born. “Signals,™” this new concept will change your perception of skin care from the genes in your body to the surface of your skin. We took the stem cells from a healthy 19-year old and created a powerful new cosmetic to restore your skin to its youthful, vibrant beauty

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A Major Breakthrough in Skin Care and Nutrition

A 41-site clinical trial, testing the restorative effect that adult bone marrow stem cells have on damaged or injured myocardium in heart attack patients, is being led at Wake Forest Baptist by Sanjay Gandhi, MD.

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Adult Stem Cells May Target and Repair Heart Attack Damage

HD Movie made for: bonemarrowdonor.wordpress.com Clip showing both methods of bone marrow [or Hematopoietic Stem Cells - HSC] transplantation. The movie was made in Poland, but I've added professional English subs, so that You can watch it too... follow me! twitter.com

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Bone marrow transplantation HD, ENG subtitles

just a quick word about how they r going to take the bone marrow cells

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Bone Marrow Stem Cells

Harvard men's health watch is telling everyone how dangerous vitamin supplements are. Unfortunately they are not kidding!

Please know that although we have our references to try to refute these statements, your patient's families will be hearing this stuff.

While it was once hoped that supplements of folic acid could help reduce colon cancer, new research has shown that taking more than the minimum daily requirement would be harmful. Simon says other studies underscore the downside to dietary supplements, which are unregulated in the United States. "The most striking example is beta carotene, which we used to be very hopeful about, but actually increases the risk of lung cancer in smokers. Vitamin E increases the risk of second head-neck cancers in people who have been successfully treated for a first malignancy. Read more...

Immunice for Immune Support

Today Celsense, Inc. and the University of Pittsburgh Cancer Center announced that the FDA has authorized the use of the Cell Sense imaging reagent for use in a phase I clinical trial of a dendritic cell caccine to treat colorectal cancer patients.

This is the first FDA authorization of the use of Cell Sense in patients. Cell Sense is a novel perfluorocarbon tracer agent used to safely and efficiently label cells ex vivo without the use of transfection agents. Labeled cells are then transplanted into the patient enabling researchers and clinicians to non-invasively track the administration and migration of therapeutic cells using MRI. Applications include tracking cells in immunotherapy or regenerative medicine as well as the diagnosis of inflammatory sites by tracking selected populations of immune cells.

Cell Sense has been studied extensively in preclinical testing with many different human cell types including human cells in animals. For instance, in 2009 a paper was published in Informa's Cytotherapy, in which Celsense’s novel perfluorocarbon tracer agent (product “Cell Sense”) was used to label human DCs ex vivo for the purpose of tracking the cells in vivo post-transplant by 19F MRI. The paper provided an assessment of the technology and demonstrated that human DCs were effectively labeled without significant impact on cell viability, phenotype or function. Furthermore, the labeled dendritic cells were clearly detected in vivo by 19F MRI in a model system, with the labeled cells being shown to migrate selectively towards draining lymph node regions within 18 hours after transplant.

Many investigators looking at various ways to label cells to enable in vivo imaging have expressed concern that the FDA would delay the regulatory progress of their therapeutic candidates if an imaging modality was introduced.

This concern is based on numerous reports of MRI contrast reagents, such as the commonly investigated USPIO (ultrasmall superparamagnet iron oxide), deleteriously affecting the cells (see recent paper in Cell Transplantation).

"We believe that the authorization of this IND will alleviate such concerns and lower the barriers for adoption. The agency’s tangible support for bringing new technologies to bear in the translation of cell-based therapeutics is very encouraging,” s Charlie O'Hanlon, President and CEO of Celsense.

While there have been approved uses of imaging reagents (e.g., Feridex, etc) with cell therapies in other countries (e.g. Isreal), I believe this may be the first FDA-sanctioned use of a particle-based imaging label with a cell-based therapy. Other approaches to cellular imaging include nuclear imaging reagents and genetically modifying cells with reporter genes such as those provided by CellSight Technologies.

Imaging labels are capable of providing investigators with data demonstrating where the cells go, at what volumes, and for how long they stay at the target location.

The industry has been keen to see these kinds of technologies clinically employed but different cell-based labels have created their own technical, clinical, and/or regulatory hurdles. I'm hopeful that Celsense and others like them are now ushering us into a new era where we will eventually be able to use various technologies to monitor and collect valuable data concerning cells after they have been administered as a therapy to a patients.

Additional resources on the topic of imaging for cell therapies:

CIRM recently hosted a webinar - "CIRM/RMC Webinar: Imaging Technology for Cellular Therapies. One of the speakers, Dr. Shahriar Yaghoubi from CellSight Technologies, provides an overview of cell therapy imaging with emphasis on PET. Click hear for the archived playback.

A very interesting article posted today on Harvard's StemBook website. "In-vivo Stem Cell Imaging - Regulatory Challenges and Advances". Nice overview intel from J. Bulte and a snapshot into E. Wirth's (of Geron) perspective re: stem cell imaging.

A new book from CRC Press edited by Dara Kraitchman and Joe Wu will be out soon. It gathers together different methods for comparison. The issue will remain the sensitivity of the methods to track few cells. "Stem Cell Labeling for Delivery and Tracking Using Non-Invasive Imaging".

MRI contrast agents can change stem cell proliferation

There s also a very informative discussion thread on the topic in the Cell Therapy Industry group on LinkedIn.

http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com

From medicine to science

When I was about 3 or 4 years old, I got very sick. I stayed in bed for many weeks and every day a nurse would come to give me a penicillin shot. The pain from shots turned into fear, in time fear turned into a plan for revenge. When I got better I demanded to have my own syringe and cruelly treated all teddy bears and dolls. If they didn’t look sick I made them sick, just to perform surgeries, sew wounds and give shots. I even offered my service to family members; unfortunately, they stubbornly kept on being healthy.

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