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International Stem Cell Corporation Engages Leading Immunogeneticists to Advance its Industry-first, Immune-matched Stem Cells

By Dr. Matthew Watson

International Stem Cell Corporation (OTCBB:ISCO), http://www.intlstemcell.com, today added two world-leading immunogeneticists to its scientific advisory board. They and ISCO scientists will study the immune-matching properties of ISCO's human parthenogenetic stem cell (hpSC) technology and the potential for each hpSC-derived therapeutic cell to be an immune-match for millions of people.

Dr. Hans-Dieter Volk, Professor of Immunology and Chair of the Institute of Medical Immunology and Berlin-Brandenburg Center for Regenerative Therapies (BCRT) at Charité Universitätsmedizin in Berlin, and Dr. Matthias von Herrath, Professor at the La Jolla Institute of Allergy and Immunology at University of San Diego, have agreed to join ISCO's scientific advisory board. Both have dedicated their careers to experimental and clinical immunology and are highly regarded immunogenetics experts internationally. They will be most valuable as ISCO attempts to demonstrate the unique immune-matching benefits of the hpSC technology experimentally and in clinical practice.

"We believe that providing human cells that can minimize rejection though immune-matching to the recipient is one of the most important tasks in developing effective regenerative medicine therapies," says Dr. Simon Craw, Vice President at ISCO. "We look forward to Drs. Volk and von Herrath helping us try to demonstrate how that need can be met with our parthenogenetic stem cells."

Embryonic stem cells (hESC) almost invariably have different forms of genes (called "alleles") at each genetic position of the paternal and maternal chromosomes, i.e. they are "heterozygous." This includes the human leukocyte antigen ("HLA") genes that are largely responsible for the distinction between "self" and "foreign," and thus acceptance or rejection of transplants. Since hESC are derived from fertilized embryos, they carry the genes of a unique individual, thus the therapeutic cells derived from hESC will carry HLA alleles that can be recognized as foreign and be rejected by most patients unless they receive immunosuppressive therapy. Such therapy is costly, has significant side effects, and often is disabling in the long term.

Like most individuals in the population, induced pluripotent stem cells ("iPS" cells) and adult stem cells are also predominantly heterozygous because they carry paternal and maternal chromosomes. They are a perfect immune match to the patient they came from and are therefore typically administered back to that same individual ("autologous therapy"). However, they would likely be rejected by most other recipients. Autologous therapy is time-consuming and expensive, which goes against the cost containment pressures globally. In addition, the quality of the therapy is directly related to the ability to secure clinically sufficient numbers of functional cells from the patient, which often poses a significant problem in clinical practice.

In contrast, the hpSCs developed by ISCO are derived from unfertilized eggs ("oocytes") that have been shown in peer-reviewed journals to exhibit unlimited proliferation potential and are pluripotent (can become cells from all three germ layers that form a human being). Most significantly, hpSC can be created in a "homozygous" state, where the alleles, including the HLA alleles, are the same at each genetic position. When these HLA alleles are also found with a high frequency in a population, these "HLA-homozygous" stem cells and their therapeutic derivatives have the potential to be immune matched to millions of people. For example, ISCO's first homozygous stem cell line with high-frequency HLA alleles has the potential to be immune matched to an estimated 75 million people worldwide.

Dr. Volk says: "Using my experience from transplantation immunology and medicine during the past three decades, I am very pleased to help ISCO in their efforts to make its hpSC technology a clinical reality where therapeutic cell derivatives will be immune matches for millions of people worldwide." Dr. von Herrath continues: "While stem cell technologies generally offer great regenerative potential, most clinical applications will be limited by immune rejection. I look much forward to joining ISCO in their quest for making stem cell-derived therapy a practical and attractive clinical option for many degenerative diseases."

Besides the immunogenetic developments, ISCO is advancing its hpSC technology into the differentiation of hpSC into therapeutic cells and tissues and into the establishment of processes and facilities to produce clinical-grade cells. The company is seeking to demonstrate the therapeutic potential of its hpSC technology as a safe, efficient, and superior alternative to other sources of stem cells for human therapy.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO's website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "should," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

To Read More: International Stem Cell Corporation Engages Leading Immunogeneticists to Advance its Industry-first, Immune-matched Stem Cells
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Law Headlines:Is it fair to patent genes? ACLU takes on biotech over issue – Legal Info Today

By Dr. Matthew Watson


TopNews United States
Law Headlines:Is it fair to patent genes? ACLU takes on biotech over issue
Legal Info Today
A successful ACLU lawsuit against the biotechnology company Myriad Genetics over the BRCA gene has some celebrating and others alarmed. ...
The profit strandThe Age
Making sense of patentsABC Online
Is it fair to patent genes? ACLU takes on biotech over issueUSA Today
Bizmology -Los Angeles Times -American Medical News
all 20 news articles »

To Read More: Law Headlines:Is it fair to patent genes? ACLU takes on biotech over issue – Legal Info Today
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Monoclonal Antibodies Promise New Chances For Ovarian Cancer Therapy: Research … – Pharmaceutical Business Review

By Dr. Matthew Watson


Live-PR.com (press release)
Monoclonal Antibodies Promise New Chances For Ovarian Cancer Therapy: Research ...
Pharmaceutical Business Review
According to a research conducted by a group of scientists in partnership with professor Michael Krainer, director of the molecular genetics working group, ...
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CSC news roundup 2010-04-11

By Dr. Matthew Watson

To Read More: CSC news roundup 2010-04-11
categoriaStem Cell Therapy commentoComments Off on CSC news roundup 2010-04-11 | dataApril 12th, 2010
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Sunlight May Help Protect Men From Kidney Cancer

By Dr. Matthew Watson

(HealthDay News) -- Men with jobs that expose them to high levels of sunlight are less likely to develop kidney cancer than those with little or no sunlight exposure at work, says a new study.

Previous research suggests that vitamin D, which is obtained from sun exposure and certain foods and supplements, may help prevent some cancers. Vitamin D is metabolized and most active within the kidneys.

This new study included 1,097 male and female kidney cancer patients and 1,476 healthy people in Europe who were interviewed about their work history and other demographic information.

Men with the highest levels of work-related exposure to sunlight were 24 percent to 38 percent less likely to have kidney cancer than other men. This association between job-related sunlight exposure and kidney cancer risk was not seen in women.

The study is published online March 8 in the journal Cancer. Read more...

Ayurtox for Body Detoxification

To Read More: Sunlight May Help Protect Men From Kidney Cancer
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ProShares Launches Two New Exchange Traded Funds Based on the NASDAQ … – CNNMoney.com (press release)

By Dr. Matthew Watson


ETF Database
ProShares Launches Two New Exchange Traded Funds Based on the NASDAQ ...
CNNMoney.com (press release)
2 ProShares Ultra Nasdaq Biotechnology (Nasdaq:BIB) aims to provide investment results that correspond to 200% of the daily performance of the NASDAQ ...
ProShares Launches First Leveraged and Inverse Biotechnology ETFsMarketWatch (press release)
Avoid New Biotech Leveraged ETFsTheStreet.com (subscription)
Double Your Biotech Returns! Really!Motley Fool
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all 52 news articles »

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Generex Biotechnology Firms About 4% on Funding Commitment – ONN.tv

By Dr. Matthew Watson


BNET
Generex Biotechnology Firms About 4% on Funding Commitment
ONN.tv
by MidnightTrader.com April 8, 2010 11:07 EDT Related Symbols: GNBT 11:07 AM Eastern Daylight Time, 04/08/2010 (MidnightTrader) — Generex Biotechnology ...
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all 23 news articles »

To Read More: Generex Biotechnology Firms About 4% on Funding Commitment – ONN.tv
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Trading looks for biotechs to decline – optionMONSTER Research (registration)

By Dr. Matthew Watson


ETF Trends (blog)
Trading looks for biotechs to decline
optionMONSTER Research (registration)
Unusual option action is showing that someone is positioning for a pullback in the Nasdaq Biotechnology Index Fund. The IBB exchange-traded fund is off 0.17 ...
ETFs and EarningsTheStreet.com (subscription)
Nine ETFs To Buy NowForbes
This Week in ETFs: April 9th EditionETF Database

all 52 news articles »

To Read More: Trading looks for biotechs to decline – optionMONSTER Research (registration)
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US Sen. Bob Casey presents Hanover Township biotechnology company ABEC with award – The Express Times – LehighValleyLive.com

By Dr. Matthew Watson


The Express Times - LehighValleyLive.com
US Sen. Bob Casey presents Hanover Township biotechnology company ABEC with award
The Express Times - LehighValleyLive.com
Local biotechnology company ABEC received a prestigious national award Friday for its success breaking into the international marketplace. US Sen. ...
Bob Casey presents award to Lehigh Valley businessThe Express Times - LehighValleyLive.com
Sen. Bob Casey to visit ABEC Inc. company in Hanover TownshipThe Express Times - LehighValleyLive.com

all 3 news articles »

To Read More: US Sen. Bob Casey presents Hanover Township biotechnology company ABEC with award – The Express Times – LehighValleyLive.com
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HIV invades through leaky cells: study – CBC.ca

By Dr. Matthew Watson


India Talkies
HIV invades through leaky cells: study
CBC.ca
The research was conducted in collaboration with researchers in the department of molecular genetics at the University of Toronto and the department of ...
New way HIV infects women discoveredOneindia

all 61 news articles »

To Read More: HIV invades through leaky cells: study – CBC.ca
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International Stem Cell Corporation Provides Strategic Update on its Skin Care Program

By Dr. Matthew Watson

OCEANSIDE, California - April 8, 2010 - International Stem Cell Corporation (ISCO.OB), http://www.internationalstemcell.com, announces today that it’s wholly owned subsidiary, Lifeline Skin Care Inc., has achieved positive results in human safety tests of its cosmetic products and is moving forward with arrangements with Cosmetic Enterprises Ltd. for the manufacture of three cosmetic products. These developments allow Lifeline Skin Care to plan a launch of its cosmetic product line in the late summer or fall of 2010.

Cosmetic face products developed by Lifeline Skin Care Inc., contain extracts from human parthenogenetic stem cells (hpSC) combined with a vitamin complex and other active ingredients. The products utilize a form of nanotechnology to deliver concentrated active ingredients to damaged skin. Laboratory tests show that an active “complex” of stem cell extract has the ability to rejuvenate skin. Also, early human trials show that these cosmetic products moisturize skin and strongly indicate the ability to decrease the depth of wrinkles and provide factors that lead to anti-aging effects.

Lifeline Skin Care is working with Cosmetic Enterprises, Ltd., located in California, to formulate and package its unique skin care product. Cosmetic Enterprises is a well-known OTC drug licensed manufacturer with over 30 years of experience. Lifeline Skin Care’s “parthenogenetic stem cell complex” the product’s active ingredient, is made in Lifeline Skin Care’s laboratory in Oceanside, California.


According to Gregory S. Keller, MD, FACS, “These positive safety studies in human testing are important, especially considering that preliminary human trial data show that products of the production of International Stem Cell’s parthenogenetic stem cells have significant beneficial effects on the skin and might also provide long term benefits in reducing wrinkles and other visible signs of aging. These results are a significant step forward in making this unique product available to the public.” Dr. Keller was named the 2007 “Specialist of the Year in Facial Cosmetic Surgery” in Strathmore’s “Who’s Who”.


The results of recent human safety tests show there were no identifiable signs or symptoms of sensitization (contact allergy). Safety testing is a series of tests to insure the product does not cause negative reactions such as irritation to the skin. This completed round of testing allows Lifeline Skin Care to move forward confidently with its commercial manufacturing plans.
International Stem Cell Corporation is a pioneer in development of a new class of stem cells called “human parthenogenetic stem cells” which avoid critical ethical issues by eliminating the need to use fertilized embryos and can be immune-matched to large segments of the population. As of today, ISCO has successfully derived 10 hpSC lines. One of these lines (hpSC-Hhom-4), carries the most common immune type found across racial groups within the US population and can be immune-matched to millions of people.


ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website,
http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link:
http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS
Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "should," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.


Key Words: Skin Care, Stem Cells, Biotechnology, Parthenogenesis


CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Lifeline Skin Care Inc.
Ruslan Semechkin, PhD, CEO
760-940-6383
ras@intlstemcell.com

To Read More: International Stem Cell Corporation Provides Strategic Update on its Skin Care Program
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Generex Launches $250000000 Lawsuit Against TheStreet.com and Feuerstein – MarketWatch (press release)

By Dr. Matthew Watson


TheStreet.com
Generex Launches $250000000 Lawsuit Against TheStreet.com and Feuerstein
MarketWatch (press release)
WORCESTER, Mass., Apr 6, 2010 (GlobeNewswire via COMTEX) -- Generex Biotechnology Corporation (NASDAQ:GNBT) (www.generex.com), the leader in drug delivery ...
Generex: What Happens in India, Stays in IndiaTheStreet.com
TheStreet stands up to Generex's bullyingEthiopian Review
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To Read More: Generex Launches $250000000 Lawsuit Against TheStreet.com and Feuerstein – MarketWatch (press release)
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Faulty Circuits (preview)

By Dr. Matthew Watson

In most areas of medicine, doctors have historically tried to glean something about the underlying cause of a patient’s illness before figuring out a treatment that addresses the source of the problem. When it came to mental or behavioral disorders in the past, however, no physical cause was detectable so the problem was long assumed by doctors to be solely “mental,” and psychological therapies followed suit.

Today scientific approaches based on modern biology, neuroscience and genomics are replacing nearly a century of purely psychological theories, yielding new approaches to the treatment of mental illnesses.

[More]

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To Read More: Faulty Circuits (preview)
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Biocon buys out Cuban firm in JV, hopes to break even in 5 yrs – Business Standard

By Dr. Matthew Watson


Hindu Business Line
Biocon buys out Cuban firm in JV, hopes to break even in 5 yrs
Business Standard
Biocon Ltd, the Bangalore-based biotechnology company, is taking full ownership of its subsidiary, Biocon Biopharmaceuticals Pvt Ltd (BBPL) by buying the ...
Biocon acquires 49% Cuban partner CIMAB's stake in JVEconomic Times
Biocon acquires stake of CIMAB in joint ventureTimes of India
Biocon gains after buying out JV partner in unitBloombergUTV
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To Read More: Biocon buys out Cuban firm in JV, hopes to break even in 5 yrs – Business Standard
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Genetic Engineering Raises Hope for Lyme Disease Vaccine – U.S. News & World Report

By Dr. Matthew Watson


USA Today
Genetic Engineering Raises Hope for Lyme Disease Vaccine
U.S. News & World Report
MONDAY, April 5 (HealthDay News) -- In an effort to combat Lyme disease, researchers have found that tick-borne transmission might be ...
One change in bacteria keeps ticks from passing along Lyme diseaseUSA Today

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To Read More: Genetic Engineering Raises Hope for Lyme Disease Vaccine – U.S. News & World Report
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Turmeric and Amla Health Remedies

By Dr. Matthew Watson

Be Your Own Doctor

There various vegetables , fruits and nuts readily available in our kitchens and our local markets. But we often forget the medicinal value and no soon we have a ailment we run to the doctors for help. It is very important to consult a doctor and take the medication, but the herbal medicenes that are available readily at our kitchen could help us if the ailment is very nominal. For eg. if someone has a gastric problem, or an acidity problem , then there are so many condiments, and other herbal cures which are at our reach, but that goes unnoticed or being ignored. I give you a few remedies on very normal and common ailments from the vegetables, condiments, fruits etc available at home.

1. Amla (indian gooseberry) Genera-Phylanthus Speices-emblica Read more...

Kama Raja Old Formula for Penis Enhancement!

To Read More: Turmeric and Amla Health Remedies
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