For most of my life, Ive credited my good skin to two products: a gentle cleanser and a powerful sunscreen. But something happened when I hit my 40s I noticed my skin no longer glowed like it used to and it always seemed to look and feel dry. When I noticed a few sunspots on the top of my right cheek, I realized it was time to elevate my morning and evening beauty routines.

Fine lines, dryness, sunspots and a loss of firmness are all things women begin to deal with in their 40s, says Dr. Mona Gohara, associate clinical professor of dermatology at Yale School of Medicine. Plummeting estrogen levels directly affect collagen production, skin thickness and hydration, so its important to develop an anti-aging skin care program, and stick with that program, during this decade.

With so many anti-aging products on the market boasting ingredients youd never thought youd put on your face (acids! oils!), it can be hard to figure out where to start.

So we reached out to top dermatologists across the country to help simplify the process. Everyone we spoke to listed sunscreen as the most important topical to keep forty-something skin looking great, followed by the appropriate cleanser, anti-ager, moisturizer and exfoliator.

Below, you'll find a quick guide to what youll need when it comes to choosing the right ingredients for your face, because as Gohara stressed, At this age, prevention not just correction should still be your goal.

When shopping for a sunscreen in your 40s, experts note you should be looking for the words zinc oxide, titanium dioxide and iron oxide on the label.

Zinc oxide and titanium dioxide protect against both UVA and UVB rays, while iron oxide guards against skin-damaging blue light from computer and cell phone screens, notes Gohara. Look for an SPF of 30 or higher and slather on half a teaspoon on your face daily, including your ears and neck, before applying makeup. If you drive, be sure to protect your hands, as UVA rays can penetrate glass, resulting in sunspots.

EltaMD UV Facial Broad-Spectrum SPF 30+, despite having zinc oxide, doesnt leave your skin with a whiteish tint. It's also formulated with hyaluronic acid, which can help keep your skin hydrated and firm.

Supergoop! Unseen Sunscreen SPF 40 is oil-free, goes on clear and works as a makeup primer to control shine. The vegan formula should be applied as the last step in your skin care regimen before you apply makeup, at least 15 minutes before you step out into the sun.

Gohara recommends keeping this brush-on SPF powder in your glove compartment. With SPF 50, the water-resistant formula provides both protection and sheer tinted coverage.

In your 40s, derms recommend using a cleanser containing ceramides, glycerin, and vitamin E.

Ceramides are lipids that help retain moisture, glycerin is a humectant that pulls water from the deepest layers of the skin, while vitamin E also adds moisture, says Dr. Martha Viera, volunteer faculty at the University of Miami Department of Dermatology. Before cleansing, wash your hands thoroughly to avoid dirt or bacteria from touching your skin, and splash your face with lukewarm water prior to application to activate the cleansing ingredients. Start and end your day by washing with a quarter-sized amount of cleanser, applying it in a circular motion over your face and neck.

Viera likes La Roche-Posay Toleriane Hydrating Gentle Cleanser because its designed to balance the skins pH levels, protecting the skins sensitive barrier. It is formulated to cleanse the skin without stripping it of moisture thanks to ingredients such as glycerin and niacinamide.

Bioderma Sensibio Foaming Gel has a soothing gel-cream texture that turns to foam when activated. The gentle formula works to remove makeup while also hydrating the skin.

Dove White Beauty Bar with Deep Moisture is great for sensitive skin as it combines cleansing ingredients with a dose of moisturizing cream. It is suitable for sensitive skin and gentle enough to use on both your face and body.

Youll need two anti-aging products in your 40s: a morning serum that contains moisture-drawing hyaluronic acid and antioxidants, and a night serum that includes peptides and retinol (retinol should be applied at night as it can make your skin sensitive to the sun).

Be sure to layer your anti-ager under your moisturizer and consider a serum which, thanks to their small molecular makeup, absorbs quickly and deeply, says Dr. Arisa Ortiz, director of laser and cosmetic dermatology at the University of California at San Diego. Antioxidants like vitamin C, E, B5, and resveratrol attach themselves to free radicals, preventing the free radicals from latching onto and damaging healthy skin cells, while retinoids and peptides exfoliate dead skin while stimulating collagen and softening lines.

Obagi Professional-C Serum contains ascorbic acid, a vitamin C derivative that softens the look of pigmentation and encourages collagen growth. It can be applied to the face, neck and chest in the mornings and followed with sunscreen.

Dr. Ortiz likes Rodan + Fields Intensive Renewing Serum because its lightweight, absorbs easily and has the highest levels of vitamin A for a nonprescription product. The serums are held in small capsules that you can open to smooth all over your skin.

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This dermatologist-approved pick is suitable for normal, sensitive and dry skin. The formula works to not only visibly brighten the skin but also reduce the appearance of fine lines and wrinkles.

To tackle dry skin in your 40s, Gohora recommends looking for ingredients that help boost and maintain moisture, including niacinamide, ceramides, glycerin and hyaluronic acid.

To be most effective, apply your moisturizer after your anti-aging serum. Dot your cheeks, forehead, chin and nose, and then rub in a circular upward motion both morning and night, notes Dr. Paul Jarrod Frank, clinical assistant professor of dermatology at The Icahn School of Medicine at Mount Sinai Hospital and author of "The Pro-Aging Playbook."

This moisturizer comes in a soothing light gel-cream formula and uses hyaluronic acid to fortify the lipid barrier to prevent dryness. It can be applied twice daily after a serum is applied to the skin.

Pause Collagen Boosting Moisturizer contains skin-conditioning fatty acids and B vitamins that work to promote healthy skin. The formula features the brand's "Pause Complex," which combines vitamins, antioxidants and peptides that help boost collagen production.

Dr. Frank likes Caudalie Vinoperfect Brightening Moisturizer, a lightweight gel that contains niacinamide and hyaluronic acid for a boost of hydration. It can be applied in the mornings to the face and neck in order to brighten and moisturize the skin.

Acids in exfoliators help remove layers of dead skin cells to promote cell turnover, clear pores and reduce pigmentation. Look for words such as glycolic, lactic, mandelic or salicylic acid on the label.

Apply a dime-sized amount of facial exfoliator two to three times a week at night, Jarrod told us. Just dont overdo it too much exfoliation can rob skin of the fatty acids that protect the skin barrier.

This treatment addresses skin care concerns by exfoliating, purifying and smoothing the skin. Depending on your skin type, it can be used up to three times a week to improve the appearance of your complexion.

Dr. Frank likes Drunk Elephant T.L.C. Sukari Babyfacial, which has an eye-popping 25% glycolic and lactic acid blend to smooth and brighten skin. Since the formula uses clean ingredients, it is fragrance-free and won't leave the skin feeling irritated.

A derivative of salicylic acid can be found in Lancme Renergie Lift Multi-Action Ultra Milk Peel, a leave-on exfoliator that you apply after cleansing and before your moisturizer. The milky consistency feels smooth on the skin and should be applied with a cotton round.

Dermalogica Daily Microfoliant contains salicylic acid and foams up into a paste when activated with water. The formula can be applied daily to the skin to slough off dead skin cells and even out your complexion.

Although it is a bit of a splurge, this daily serum uses rich ingredients such as mandelic and lactic acid to unclog pores, even skin texture, reduce the appearance of fine lines and more. It can be applied to the face and neck to reveal brighter skin over time.

Bonus products: Our experts noted theres no harm incorporating a neck or eye cream into your routine in your 40s.

Look for targeted ingredients in a neck cream, such as tetrapeptides to promote collagen formation, antioxidant algae extract to protect against free radicals, glucosamine to stimulate hyaluronic acid and improve hydration while decreasing wrinkles, and omega-3 fatty acids to add moisture.

Apply a dime-size amount in the morning and evening, working your way up the neck to the jawline until the product is evenly distributed and absorbed, notes Gohara. Neck creams tend to be thicker than traditional moisturizers, so allow more time for them to absorb and be sure to follow up with a sunscreen in the morning.

Viera likes Revision Nectifirm Advanced, which uses peptides to smooth dry skin. Other ingredients such as lingonberry extract work with the skin's natural microbiome to provide soothing results.

Prai Ageless Throat & Dcolletage Creme has shea butter and hyaluronic acid to plump lines and effectively smooth the skin. For best results, the brand recommends applying the moisturizer twice daily to target areas.

Suzanne Somers Organics Neck Firming Crme contains tetrapeptides to support collagen and elastin growth. The formula is packed with skin-boosting ingredients such as hyaluronic acid and Swiss apple stem cells that help to combat signs of aging.

This cream can be applied twice daily in upward motions to hydrate and revitalize the skin. The formula is quick-absorbing, so it won't leave the skin feeling oily or greasy.

Look for ingredients like caffeine to reduce puffiness and dark circles, niacinamide and hyaluronic acid to plump fine lines, and arginine, growth factors, and retinol to boost collagen production.

Apply a pea-sized amount twice daily by gently patting the cream on with your ring finger, Viera said. Be sure to use any eye products containing retinoids at night to avoid sun sensitivity.

Dr. Viera likes Neocutis Lumire Illuminating Eye Cream, a lightweight cream that contains antioxidants to protect against environmental damage. In addition to its protective qualities, it can also be used to reduce the appearance of puffiness and dark circles.

RoC Retinol Correxion Eye Cream uses a derivative of vitamin A to accelerate the removal of dead skin cells, leaving you with visibly brighter skin. It targets concerns such as crow's feet, under-eye wrinkles, deep wrinkles and fine lines.

Skinbetter Science Interfuse Eye Treatment Cream contains caffeine to reduce puffiness and vitamin C to brighten the under-eye area. It is packed with humectants to help lock in moisture and promote healthy skin.

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The best anti-aging skin care products to use in your 40s - TODAY

Skin Stem Cells Comments Off on The best anti-aging skin care products to use in your 40s – TODAY | August 10th, 2020

(Picture; Nuthing)

Lets face it, the past few months have been stressful enough were due a break. And frankly summer should be off-season for anything high-maintenance.

Whether you are WFH in August or actually managing a getaway, right now we are all looking for no-fuss makeup, hassle-free hair and stress-free style.

Heres what can help you look and feel your best, with as little effort as possible:

Lots has been written about the importance of Vitamin D in recent months and although were (hopefully) getting sunshine about now it important to keep levels high.

Myprotein makes a convenient spray in both Vitamin D3 and B12 that ensure everyone gets the essential micronutrients and vitamins that we might miss if were in front of a laptop.

Vitamin D3 Spray, 8.99, MyProtein

This award-winning collagen drink supplement is packed with the highest concentration of marine collagen on the market. Its also infused with vitamin C, which works with the collagen to enhance skin rejuvenation and tissue renewal.

A fuss-free and easy addition to your beauty regime, users say that their skin feels softer, more hydrated and firmer.

Comes in 14 ready-mixed 10ml sachets; can be added to hot or cold drinks.

Collagen Drink Supplement For Women, 32.99, Absolute Collagen

Too tired to make your own? These are insta-healthy meals. Purition is 100% whole food shakes, are made from crushed nuts, seeds, fruits and vegetables and come in ordinary or vegan recipe. All are gluten-free and low in sugar.

Flavours include superfood ingredients such as turmeric and beetroot.

Original Discovery Box, 13.50, Purition

Epsom salts have long been hailed by wellness experts for instantly de-bloating and helping with water retention.

These from Westlab do even more. Mixed with essential oils, the Alchemy range helps draw fluid and toxins from the body and can soothe tired, aching, overworked muscles and revive body and mind.

Plus they smell great.

Westlabs Recover Epsom Salts White Willow & Eucalyptus, 5.99, Amazon

A body hack that can help you lose around 5-7 lbs in 5 days and it is actually good for you.

Developed at the Longevity Institute of the University of Southern California (USC) and under the sponsorship of the National Institute for Aging and the National Institute of Health, this five day programme tricks your body into thinking its fasting, and while you get the health benefits, you can continue eating.

Each days complete nutrition arrives in 5 small boxes (one for each day) that include plant-based energy bars, soups, snacks, drinks, and supplements, all carefully designed to nourish your body and promote positive changes in metabolic markers, cellular rejuvenation, reduced inflammation, and healthy aging

ProLon Fasting Mimicking Diet, 200, ProLon

These brand new sauna blankets are built with layers of infrared heating and toxin-free fabrics that lets you feel like youre in a spa without ever leaving home.

You just roll it out on a heatproof surface like your bed and use a handheld controller to begin heating it up. The blanket uses far-infrared heat that makers promise can help detoxify the body, rejuvenate skin, reduce stress, burn calories and give you that relaxed, stress-busting feeling a sauna does.

Benefits also include better blood flow, sleep and of course, there is the calorie burn (who doesnt love a workout you can do lying down watching Netflix?). 30 mins to an 1 hour per session recommended.

Infrared Sauna Blanket, 374, MiHigh UK

Dr Galyna Selezneva, Londons top Body Doctor, gets asked every day about cellulite. If a visit to her or another expert practitioner is not on your summer agenda, she advises to drink more water and move more but the most important thing? Dry Brushing!

Calling it, one of the most underrated and effective ways to beat cellulite, Dr Galyna advises just a few minutes a day, is enough to see results. It improves lymphatic drainage, and fluid retention and lessens cellulite. Results are instant and lasting.

Dr Galyna Selezneva, Rita Rakus Clinic

A sustainable and organic brand created by Danish born US based, make-up artist Kirsten Kjaer Weis, these are the brands hero cream blushes together with a complementary highlighter shade which gives an instant glow.

Minimalist and sleek, the shades work together to create the ultimate bronze and flushed duo for light to medium skin tones and blush and highlight for deeper skin tones.

Kjaer Weis Flush and Glow Duo, 41, Content Beauty Wellbeing

Is lockdown face a real thing?

If youve picked up a bit of puff during all of this, this wonder cream can have you looking sleek and sharp on your zoom call in no time.

Tighter skin, instantly, minus the toxins of injectables. Beloved by cheekbone superior girls like Gwyneth Paltrow, Sienna Miller and Victoria Beckham, its packed with plant extracts and high actives and relies on neuropeptides (naturally derived from algae) to smooth skin. Regularly named as a best natural alternative to Botox by beauty editors.

V-Tox, 105, 99, Linda Meredith

Only sold online, this is a great way to cheat a tan.

Giving your face an instant, natural sun-kissed glow, its packed with ingredients that illuminate, hydrate and perfect the skin.

It comes with a Face Mist and handy Face Lifter Brush that makes it go on really evenly and without staining your hands.

The Bronze & Sculpt Duo, 55.00 Amanda Harrington

The golden glow you love with none of the fuss. Free of odours, orange tones and streaks it gives a great sun-kissed complexion but also sun protection.

Blended with organic sunscreens, it has SPF 50 UVA protection and combines natural gradual technology and instant tanning without clogging pores, allowing the skin to breathe.

Tancream All in One Self Tan, Bronzer and SPF50, Ideal World TV

Tired of scrubbing off old spray tan? Looking to get rid of bronze streaks, while you relax?

This new bath bomb from Lusso Tan is the worlds first tan-removing bath bomb, just relax in a bath filled with essential-oil infused water and watch your tan dissolve before your eyes!

Full of skin-loving ingredients, the Lusso Tan Bath Bomb removes tan in a matter of minutes, while repairing and protecting the skin at the same time. The longer you soak, the better the tan-removing results.

Summer Meadow Bath Bomb, 8.50, Lusso Tan

Specifically designed for the delicate eye area, these little beauties work to stop eyes from looking tired, no matter how little sleep youre getting.

Stick under the eye for around 15 minutes and notice immediate results.

Filled with antioxidant-rich flower extract serum that feels cool to the skin and aims to smooth the look of fine lines and wrinkles, the pack contains 5 x 2 eye pads.

Rose Blossom Glow Hydro-Gel Eye Pads 5 x 2 29.90, Eclat Skin London

Instantly glam up with these beauties.

With eyelash extensions having been on hold because of Covid, award-winning Dollbaby London has come up with a way to boost your lashes that is easy, effective and mess-free.

The UKs first 2-in-1 eyeliner and lash adhesive, the Dollbaby Duo Pen works with any strip (non magnetic) lashes. Simply line the eye with two coats like a regular eyeliner, apply your lashes immediately on top of the liner (no drying time required) and go!

Unlike other eyelash glues, theres drying time and its not sticky or messy. And the pens ultra-fine tip is easy to apply. Vegan and cruelty-free, it comes in black or clear for a more natural look.

To remove, simply peel lashes off and remove eyeliner with normal makeup remover. Will give you approx 30-40 applications

Duo Pen, 19.75, Doll Baby London

Why go to a salon when you can give yourself a 5-minute facial in your own bathroom?

A fantastic do-it-yourself facial peel, skin looks clear, clean and smooth instantly. Made with with dead-cell sloughing glycolic acids, powerful pomegranate enzymes, gentle bamboo scrub grains, purifying salicylic acid and anti-free-radical stem cells from raspberries.

Fruitizyme Five Minute Facial, Beauty Pie Members 10.26, Beauty Pie

Pretty summer dresses can also mean painful, sweaty and chafing thighs in the hot summer sunshine.

Smoovall is a skin contact spray that leaves an invisible protective layer that prevents the soreness and irritation caused by friction (chafing).

Its a non toxic spray and unlike the common roller balms and powders, is non-greasy and invisible.

Skin contact spray, 14.99, Smoovall

A super affordable summer essentials kit packed with everything you need beauty-wise.

New from GlossyBox, it includes everything from an ultra gentle facial peel, a jet lag recovery mask, a coco shimmer body mist, lip balm, nail polish, dry shampoo body cream, tangle teezer and lip balm.

Summer Essentials, (valued over 95, but 30 for subscribers and 35 for non-subscribers), Glossy Box

No time to social distance at a salon? Why not pedi at home?

This 7-day peel sock is the bomb. Just pull these on like socks, tape them around your ankles, wait an hour, wash, and 7 days and some very impressive exfoliation later, youll have feet so soft youll want to show them off.

Ingredients include glycolic and lactic acids, natural fruit extracts of grapefruit, orange and lemon, plus sweet almond and coconut extracts.

Dr Glycolic Soft Feet 7-Day Peel Socks, 3.92 Beauty Pie

This one is a game changer.

Remove & Chill is the first of its kind: an innovative, waterless, acetone-free removal cream that dissolves nail polish, nourishes nails and actually smells good. Its a nail polish remover cream, enriched with hydrating essential oils that removes nail polish in 3 minutes.

Its also travel friendly.

Remove & Chill Nail Polish Eraser Cream, 14.25, Beauty Mart

Want freedom from a hot blow dryer this summer? Who doesnt?

Celebrity stylist Edward James has created a signature treatment that offers smoothness without the hot air. Not to be confused with a Brazilian blow dry, which is made for thicker, stronger Brazilian hair, this one is gentler and suits finer hair.

An ammonia-free glossing oil adds shine and moisture followed by Edwards secret formula a smoothing keratin applied to the frizziest part of the hair with a paint brush.

Its 100, takes 15 minutes, contains no formaldehyde and is heaven in humidity. It lasts for up to 6 weeks, ensuring you will never resemble Monica from Friends even in the hottest days of summer.

British Blow Dry, 100, Edward James London

This is a great dry shampoo that cleans hair and lets you go longer between washes.

It uses Living Proofs triple cleaning technology to absorb and remove dirt, oil and sweat you just leave for 30 seconds and let the cleansing begin.

A time-release fragrances helps hair smell clean- a great way to wash less often protecting your fresh head of colour after your long-awaited salon appointment!

Living Proof Dry Shampoo, 19.99, Living Proof

These seamless clip-ins are amazing. Instantly change and update your look with no effort at all.

They are comfortable and lay flat on the scalp which means no irritating bits poking through your perfect coif.

Their silicone band technology fuses and bonds every single strand of hair at the top of each weft which means there is less shedding and tangling too.

14in Seamless Clip In Human Hair Extensions, 95, Foxy Locks

This 100% vegan friendly, cruelty-free brand makes waxing fun (well, as fun as it can be).

Enriched with things like apricot extract to soothe and moisturise the skin, plus Vitamin E for its antioxidants and anti-ageing effects, the body hair removal jelly is fuss-free and works fast in just 5-10 minutes.

For use on body hair of all lengths. Suitable for sensitive skin Available in 3 scents Strawberry & Watermelon, Pineapple & Coconut and Blueberry & Passionfruit.

Pink Shimmer Hair Removal Jelly, 9.99, Nuthing

Hair takes a beating in the summer and this new range of snazzy hair products are kind to both hair and the environment.

Promising no sulfates, parabens, silicones, or even gluten, the range is vegan and cruelty-free with 100% recyclable sugarcane bottles. They are also affordable and great on hair.

The rescue mask is a summer stand out ideal for colour treated hair, it seals cuticles and repairs split ends and it also has UV protection and a pollution barrier. Ingredients include coconut & yuzu scent, sugar beet extract, and vegetable derived conditioners.

Azure by PFB Rescue & Repair Mask, 10.99, Boots

If your eyebrows are an untamed as theyve ever been enter a summer must-have. This painless eyebrow trimmer looks like a stylish pen and trims eyebrows at the touch of a button.

A precision-engineered shaper, this nifty gadget has a tiny and super-accurate micro-precision trimming head, encased in 18 karat gold plate.

JML Finishing Touch Flawless Brows, 19.97, Amazon

Banish those unwanted hairs once and for all.

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40 Hot Weather Hacks: The lazy girls' hair and beauty product guide to summer - Metro.co.uk

Skin Stem Cells Comments Off on 40 Hot Weather Hacks: The lazy girls’ hair and beauty product guide to summer – Metro.co.uk | August 10th, 2020

The Covid-19 pandemic is one of the greatest challenges modern medicine has ever faced. Doctors and scientists are scrambling to find treatments and drugs that can save the lives of infected people and perhaps even prevent them from getting sick in the first place.

Below is an updated list of 20 of the most-talked-about treatments for the coronavirus. While some are accumulating evidence that theyre effective, most are still at early stages of research. We also included a warning about a few that are just bunk.

We are following 20 coronavirus treatments for effectiveness and safety:

Tentative or

mixed evidence

We are following 20 coronavirus treatments

for effectiveness and safety:

Tentative or

mixed evidence

We are following 20 coronavirus treatments

for effectiveness and safety:

There is no cure yet for Covid-19. And even the most promising treatments to date only help certain groups of patients and await validation from further trials. The F.D.A. has not fully licensed any treatment specifically for the coronavirus. Although it has granted emergency use authorization to some treatments, their effectiveness against Covid-19 has yet to be demonstrated in large-scale, randomized clinical trials.

This list provides a snapshot of the latest research on the coronavirus, but does not constitute medical endorsements. Always consult your doctor about treatments for Covid-19.

New additions and recent updates:

Added ivermectin, a drug typically used against parasitic worms that is being increasingly prescribed in Latin America. Aug. 10

Updated descriptions for several treatments. Aug. 10

We will update and expand the list as new evidence emerges. For details on evaluating treatments, see the N.I.H. Covid-19 Treatment Guidelines. For the current status of vaccine development, see our Coronavirus Vaccine Tracker.

WIDELY USED: These treatments have been used widely by doctors and nurses to treat patients hospitalized for diseases that affect the respiratory system, including Covid-19.

PROMISING EVIDENCE: Early evidence from studies on patients suggests effectiveness, but more research is needed. This category includes treatments that have shown improvements in morbidity, mortality and recovery in at least one randomized controlled trial, in which some people get a treatment and others get a placebo.

TENTATIVE OR MIXED EVIDENCE: Some treatments show promising results in cells or animals, which need to be confirmed in people. Others have yielded encouraging results in retrospective studies in humans, which look at existing datasets rather than starting a new trial. Some treatments have produced different results in different experiments, raising the need for larger, more rigorously designed studies to clear up the confusion.

NOT PROMISING: Early evidence suggests that these treatments do not work.

PSEUDOSCIENCE OR FRAUD: These are not treatments that researchers have ever considered using for Covid-19. Experts have warned against trying them, because they do not help against the disease and can instead be dangerous. Some people have even been arrested for their false promises of a Covid-19 cure.

EVIDENCE IN CELLS, ANIMALS or HUMANS: These labels indicate where the evidence for a treatment comes from. Researchers often start out with experiments on cells and then move onto animals. Many of those animal experiments often fail; if they dont, researchers may consider moving on to research on humans, such as retrospective studies or randomized clinical trials. In some cases, scientists are testing out treatments that were developed for other diseases, allowing them to move directly to human trials for Covid-19.

All treatmentsWidely usedPromisingTentative or mixedNot promisingPseudoscience

Antivirals can stop viruses such as H.I.V. and hepatitis C from hijacking our cells. Scientists are searching for antivirals that work against the new coronavirus.

PROMISING EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSEMERGENCY USE AUTHORIZATIONRemdesivirRemdesivir, made by Gilead Sciences, was the first drug to get emergency authorization from the F.D.A. for use on Covid-19. It stops viruses from replicating by inserting itself into new viral genes. Remdesivir was originally tested as an antiviral against Ebola and Hepatitis C, only to deliver lackluster results. But preliminary data from trials that began this spring suggested the drug can reduce the recovery time of people hospitalized with Covid-19 from 15 to 11 days. (The study defined recovery as either discharge from the hospital or hospitalization for infection-control purposes only.) These early results did not show any effect on mortality, though retrospective data released in July hints that the drug might reduce death rates among those who are very ill.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSFavipiravirOriginally designed to beat back influenza, favipiravir blocks a viruss ability to copy its genetic material. A small study in March indicated the drug might help purge the coronavirus from the airway, but results from larger, well-designed clinical trials are still pending.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSMK-4482Another antiviral originally designed to fight the flu, MK-4482 (previously known as EIDD-2801) has had promising results against the new coronavirus in studies in cells and on animals. Merck, which has been running clinical trials on the drug this summer, has announced it will launch a large Phase III trial in September.Updated Aug. 6

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS Recombinant ACE-2To enter cells, the coronavirus must first unlock them a feat it accomplishes by latching onto a human protein called ACE-2. Scientists have created artificial ACE-2 proteins which might be able to act as decoys, luring the coronavirus away from vulnerable cells. Recombinant ACE-2 proteins have shown promising results in experiments on cells, but not yet in animals or people.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS AND HUMANS IvermectinFor decades, ivermectin has served as a potent drug to treat parasitic worms. Doctors use it against river blindness and other diseases, while veterinarians give dogs a different formulation to cure heartworm. Studies on cells have suggested ivermectin might also kill viruses. But scientists have yet to find evidence in animal studies or human trials that it can treat viral diseases. As a result, Ivermectin is not approved to use as an antiviral.

In April, Australian researchers reported that the drug blocked coronaviruses in cell cultures, but they used a dosage that was so high it might have dangerous side effects in people. The FDA immediately issued a warning against taking pet medications to treat or prevent Covid-19. These animal drugs can cause serious harm in people, the agency warned.

Since then a number of clinical trials have been launched to see if a safe dose of ivermectin can fight Covid-19. In Singapore, for example, the National University Hospital is running a 5,000-person trial to see if it can prevent people from getting infected. As of now, theres no firm evidence that it works. Nevertheless ivermectin is being prescribed increasingly often in Latin America, much to the distress of disease experts.Updated Aug. 10

NOT PROMISING EVIDENCE IN CELLS AND HUMANS Lopinavir and ritonavirTwenty years ago, the F.D.A. approved this combination of drugs to treat H.I.V. Recently, researchers tried them out on the new coronavirus and found that they stopped the virus from replicating. But clinical trials in patients proved disappointing. In early July, the World Health Organization suspended trials on patients hospitalized for Covid-19. They didnt rule out studies to see if the drugs could help patients not sick enough to be hospitalized, or to prevent people exposed to the new coronavirus from falling ill. The drug could also still have a role to play in certain combination treatments.

NOT PROMISING EVIDENCE IN CELLS, ANIMALS AND HUMANSHydroxychloroquine and chloroquineGerman chemists synthesized chloroquine in the 1930s as a drug against malaria. A less toxic version, called hydroxychloroquine, was invented in 1946, and later was approved for other diseases such as lupus and rheumatoid arthritis. At the start of the Covid-19 pandemic, researchers discovered that both drugs could stop the coronavirus from replicating in cells.

Since then, theyve had a tumultuous ride. A few small studies on patients offered some hope that hydroxychloroquine could treat Covid-19. The World Health Organization launched a randomized clinical trial in March to see if it was indeed safe and effective for Covid-19, as did Novartis and a number of universities. Meanwhile, President Trump repeatedly promoted hydroxychloroquine at press conferences, touting it as a game changer, and even took it himself. The F.D.A. temporarily granted hydroxychloroquine emergency authorization for use in Covid-19 patients which a whistleblower later claimed was the result of political pressure. In the wake of the drugs newfound publicity, demand spiked, resulting in shortages for people who rely on hydroxychloroquine as a treatment for other diseases.

But more detailed studies proved disappointing. A study on monkeys found that hydroxychloroquine didnt prevent the animals from getting infected and didnt clear the virus once they got sick. Randomized clinical trials found that hydroxychloroquine didnt help people with Covid-19 get better or prevent healthy people from contracting the coronavirus. Another randomized clinical trial found that giving hydroxychloroquine to people right after being diagnosed with Covid-19 didnt reduce the severity of their disease. (One large-scale study that concluded the drug was harmful as well was later retracted.) The World Health Organization, the National Institutes of Health and Novartis have since halted trials investigating hydroxychloroquine as a treatment for Covid-19, and the F.D.A. revoked its emergency approval. The F.D.A. now warns that the drug can cause a host of serious side effects to the heart and other organs when used to treat Covid-19.

In July, researchers at Henry Ford hospital in Detroit published a study finding that hydroxychloroquine was associated with a reduction in mortality in Covid-19 patients. President Trump praised the study on Twitter, but experts raised doubts about it. The study was not a randomized controlled trial, in which some people got a placebo instead of hydroxychloroquine. The studys results might not be due to the drug killing the virus. Instead, doctors may have given the drug to people who were less sick, and thus more likely to recover anyway.

Despite negative results, a number of hydroxychloroquine trials have continued, although most are small, testing a few dozen or a few hundred patients. A recent analysis by STAT and Applied XL found more than 180 ongoing clinical trials testing hydroxychloroquine or chloroquine, for treating or preventing Covid-19. Although its clear the drugs are no panacea, its theoretically possible they could provide some benefit in combination with other treatments, or when given in early stages of the disease. Only well-designed trials can determine if thats the case.Updated Aug. 10

Most people who get Covid-19 successfully fight off the virus with a strong immune response. Drugs might help people who cant mount an adequate defense.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS AND HUMANS Convalescent plasmaA century ago, doctors filtered plasma from the blood of recovered flu patients. So-called convalescent plasma, rich with antibodies, helped people sick with flu fight their illness. Now researchers are trying out this strategy on Covid-19. In May, the F.D.A. designated convalescent plasma an investigational product. That means that despite not yet being shown as safe and effective, plasma can be used in clinical trials and given to some patients who are seriously ill with Covid-19. Tens of thousands of patients in the U.S. have received plasma through a program launched by the Mayo Clinic and the federal government.

The Trump administration has praised convalescent plasma, despite the lack of evidence yet that it works. The first wave of trials have been small and the results have been mixed. Large randomized clinical trials are underway, but theyve struggled to enroll enough participants, some of whom worry they will receive a placebo instead of the treatment itself.

Experts say that its vital to complete these trials to determine if convalescent plasma is safe and effective. If these trials are successful, it could serve as an important stopgap measure until more potent therapies become widely available.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSMonoclonal antibodiesConvalescent plasma from people who recover from Covid-19 contains a mix of different antibodies. Some of the molecules can attack the coronavirus, but many are directed at other pathogens. Researchers have sifted through this slurry to find the most potent antibodies against Covid-19. They have then manufactured synthetic copies of these molecules, known as monoclonal antibodies. Researchers have begun investigating them as a treatment for Covid-19, either individually or in cocktails.

Monoclonal antibodies were first developed as a therapy in the 1970s, and since then the F.D.A. has approved them for 79 diseases, ranging from cancer to AIDS. Since the start of the pandemic, researchers have found dozens of monoclonal antibodies that show promise against Covid-19 in preclinical studies on cells and animals. Companies like Eli Lilly and Regeneron recently began clinical trials studying monoclonal antibodies. Several other firms, as well as teams at universities, are slated to enter the race soon as well.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSInterferonsInterferons are molecules our cells naturally produce in response to viruses. They have profound effects on the immune system, rousing it to attack the invaders, while also reining it in to avoid damaging the bodys own tissues. Injecting synthetic interferons is now a standard treatment for a number of immune disorders. Rebif, for example, is prescribed for multiple sclerosis.

As part of its strategy to attack our bodies, the coronavirus appears to tamp down interferon. That finding has encouraged researchers to see whether a boost of interferon might help people weather Covid-19, particularly early in infection. Early studies, including experiments in cells and mice, have yielded encouraging results that have led to clinical trials.

An open-label study in China suggested that the molecules could help prevent healthy people from getting infected. On July 20, the British pharmaceutical company Synairgen announced that an inhaled form of interferon called SNG001 lowered the risk of severe Covid-19 in infected patients in a small clinical trial. The full data have not yet been released to the public, or published in a scientific journal. On August 6, the National Institute of Allergy and Infectious Diseases launched a Phase III trial on a combination of Rebif and the antiviral remdesivir, with results expected by fall 2020.Updated Aug. 10

The most severe symptoms of Covid-19 are the result of the immune systems overreaction to the virus. Scientists are testing drugs that can rein in its attack.

PROMISING EVIDENCE EVIDENCE IN HUMANS DexamethasoneThis cheap and widely available steroid blunts many types of immune responses. Doctors have long used it to treat allergies, asthma and inflammation. In June, it became the first drug shown to reduce Covid-19 deaths. That study of more than 6,000 people, which in July was published in the New England Journal of Medicine, found that dexamethasone reduced deaths by one-third in patients on ventilators, and by one-fifth in patients on oxygen. It may be less likely to help and may even harm patients who are at an earlier stage of Covid-19 infections, however. In its Covid-19 treatment guidelines, the National Institutes of Health recommends only using dexamethasone in patients with COVID-19 who are on a ventilator or are receiving supplemental oxygen.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS Cytokine InhibitorsThe body produces signaling molecules called cytokines to fight off diseases. But manufactured in excess, cytokines can trigger the immune system to wildly overreact to infections, in a process sometimes called a cytokine storm. Researchers have created a number of drugs to halt cytokine storms, and they have proven effective against arthritis and other inflammatory disorders. Some turn off the supply of molecules that launch the production of the cytokines themselves. Others block the receptors on immune cells to which cytokines would normally bind. A few block the cellular messages they send. Depending on how the drugs are formulated, they can block one cytokine at a time, or muffle signals from several at once.

Against the coronavirus, several of these drugs have offered modest help in some trials, but faltered in others. Drug companies Regeneron and Roche drug both recently announced that two drugs called sarilumab and tocilizumab, which both target the cytokine IL-6, did not appear to benefit patients in Phase 3 clinical trials. Many other trials remain underway, several of which combine cytokine inhibitors with other treatments.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS EMERGENCY USE AUTHORIZATIONBlood filtration systemsThe F.D.A. has granted emergency use authorization to several devices that filter cytokines from the blood in an attempt to cool cytokine storms. One machine, called Cytosorb, can reportedly purify a patients entire blood supply about 70 times in a 24-hour period. A small study in March suggested that Cytosorb had helped dozens of severely ill Covid-19 patients in Europe and China, but it was not a randomized clinical trial that could conclusively demonstrate it was effective. A number of studies on blood filtration systems are underway, but experts caution that these devices carry some risks. For example, such filters could remove beneficial components of blood as well, such as vitamins or medications.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS Stem cellsCertain kinds of stem cells can secrete anti-inflammatory molecules. Over the years, researchers have tried to use them as a treatment for cytokine storms, and now dozens of clinical trials are under way to see if they can help patients with Covid-19. But these stem cell treatments havent worked well in the past, and its not clear yet if theyll work against the coronavirus.

Doctors and nurses often administer other supportive treatments to help patients with Covid-19.

WIDELY USEDProne positioningThe simple act of flipping Covid-19 patients onto their bellies opens up the lungs. The maneuver has become commonplace in hospitals around the world since the start of the pandemic. It might help some individuals avoid the need for ventilators entirely. The treatments benefits continue to be tested in a range of clinical trials.

WIDELY USEDEMERGENCY USE AUTHORIZATIONVentilators and other respiratory support devicesDevices that help people breathe are an essential tool in the fight against deadly respiratory illnesses. Some patients do well if they get an extra supply of oxygen through the nose or via a mask connected to an oxygen machine. Patients in severe respiratory distress may need to have a ventilator breathe for them until their lungs heal. Doctors are divided about how long to treat patients with noninvasive oxygen before deciding whether or not they need a ventilator. Not all Covid-19 patients who go on ventilators survive, but the devices are thought to be lifesaving in many cases.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS AnticoagulantsThe coronavirus can invade cells in the lining of blood vessels, leading to tiny clots that can cause strokes and other serious harm. Anticoagulants are commonly used for other conditions, such as heart disease, to slow the formation of clots, and doctors sometimes use them on patients with Covid-19 who have clots. Many clinical trials teasing out this relationship are now underway. Some of these trials are looking at whether giving anticoagulants before any sign of clotting is beneficial.

False claims about Covid-19 cures abound. The F.D.A. maintains a list of more than 80 fraudulent Covid-19 products, and the W.H.O. debunks many myths about the disease.

WARNING: DO NOT DO THISDrinking or injecting bleach and disinfectantsIn April, President Trump suggested that disinfectants such as alcohol or bleach might be effective against the coronavirus if directly injected into the body. His comments were immediately refuted by health professionals and researchers around the world as well as the makers of Lysol and Clorox. Ingesting disinfectant would not only be ineffective against the virus, but also hazardous possibly even deadly. In July, Federal prosecutors charged four Florida men with marketing bleach as a cure for COVID-19.

WARNING: NO EVIDENCEUV lightPresident Trump also speculated about hitting the body with ultraviolet or just very powerful light. Researchers have used UV light to sterilize surfaces, including killing viruses, in carefully managed laboratories. But UV light would not be able to purge the virus from within a sick persons body. This kind of radiation can also damage the skin. Most skin cancers are a result of exposure to the UV rays naturally present in sunlight.

WARNING: NO EVIDENCESilverThe F.D.A. has threatened legal action against a host of people claiming silver-based products are safe and effective against Covid-19 including televangelist Jim Bakker and InfoWars host Alex Jones. Several metals do have natural antimicrobial properties. But products made from them have not been shown to prevent or treat the coronavirus.

Note: After additional discussions with experts we have adjusted several labels on the tracker. The Strong evidence label has been removed until further research identifies treatments that consistently benefit groups of patients infected by the coronavirus. In its place, Promising evidence will be used for drugs such as remdesivir and dexamethasone that have shown promise in at least one randomized controlled trial, and Widely used for treatments such as proning and ventilators that are often used with severely ill patients, including those with Covid-19. And we may reintroduce the Ineffective label when ongoing clinical trials repeatedly end with disappointing results.

Sources: National Library of Medicine; National Institutes of Health; William Amarquaye, University of South Florida; Paul Bieniasz, Rockefeller University; Jeremy Faust, Brigham & Womens Hospital; Matt Frieman, University of Maryland School of Medicine; Noah Haber, Stanford University; Swapnil Hiremath, University of Ottawa; Akiko Iwaskai, Yale University; Paul Knoepfler, University of California, Davis; Elena Massarotti, Brigham and Womens Hospital; John Moore and Douglas Nixon, Weill Cornell Medical College; Erica Ollman Saphire, La Jolla Institute for Immunology; Regina Rabinovich, Harvard T.H. Chan School of Public Health; Ilan Schwartz, University of Alberta; Phyllis Tien, University of California, San Francisco.

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Coronavirus Drug and Treatment Tracker - The New York Times

Skin Stem Cells Comments Off on Coronavirus Drug and Treatment Tracker – The New York Times | August 10th, 2020

Entrepreneur Dave Aspreys end-of-life plans are quite simple, really, even if some of his ambitions sound laughably optimistic to most of us.I want to die at a time and by a method of my own choosing, and keep doing awesome things until that day, he tells me. I dont think its outrageous to believe Ill make it to 180 years old. And if I run out of energy, itll just be because I did too much cool shit for my own good.

Asprey is strolling across his lush property in British Columbia, holding up his phone and pointing out the specimens in this years garden as we chat over Zoom in the midst of the global pandemic. Hes protecting his skin from the sun with a goofy Outdoor Research hat and wearing a long string of beads that he says are each over a hundred years old, from cultures around the world.

Asprey, 48, is the founder of the Bulletproof wellness empire and a vocal champion of the movement to extend human life expectancy beyond 100 years. Hes made millions by experimenting on his own body and packaging his home-brewed discoveries into books, a podcast, consulting services and consumer products (you may have even tried his butter-laced coffee). Asprey, who was a web-security executive before he became the Bulletproof Executive, is just one of a cadre of tech elite who have begun directing their attentionand truckloads of moneytoward the problem of life extension. Jeff Bezos, Peter Thiel, Sergey Brin, Larry Ellisonname a Silicon Valley A-lister and he or she is likely funding longevity research, experimenting with anti-aging interventions or both. These are the masters of the universe who see no reason they cant take the tech industrys optimization obsession and apply it to the ultimate challenge: conquering death itself.

And their efforts appear to be paying off: Thanks to a recent explosion of advances in longevity medicine, Aspreys vision of living healthfully into his second century might not be so crazy. In fact, for people in middle age right now, a handful of therapies in clinical trials have the potential, for the first time in human history, to radically transform what old age looks like. If the life extensionists are right, a person whos 40 today might reasonably expect to still be downhill skiing, running a 10K or playing singles tennis at 100.

Dave AspreyDave Asprey

If you do anti-aging right, Asprey insists, youll have a level of resilience and energy to fight what comes your way. If you get Covid-19, youre less likely to become very sick. The idea is that at a cellular level, youre making yourself very hard to kill.

The most extreme of the controversial interventions Asprey has undergone involved having stem cells extracted from his own bone marrow and fat and then injected into hundreds of locations on his body. Into every joint, between every vertebra and into my cerebrospinal fluid, face and sex organs, he tells me cheerfully. For what I spent on that, I could have bought a really nicely appointed Tesla.

He trots up a flight of stairs to his home office, which sits above a million-dollar lab filled with health gadgets, such as a cryochamber, a hypoxic trainer and an AI-enabled stationary bike. For a wealthy person, investing in your body should be a major part of your Im rich strategy, he explains. Personally, I think you should be spending at least 2 to 3 percent of your net worth on health and longevity. Get a personal chef who can cook you the right food. Its not that hard.

It might be an exaggeration to say BioViva CEO Liz Parrish believes death is optional, but for her, Aspreys goal of living to 180 shows a distinct lack of ambition. If you can reach homeostasis in the body, Parrish says, where its regenerating itself just a little bit faster than its degrading, then what do you die of? An accident or natural disaster, probably. Theres no expiration date at 90 or 100 years old.

Tall, blond and fit, Parrish cuts a strikingly youthful figure at 49one that might convince you to order whatever shes having. But, like Asprey, she has received criticism from the longevity research community for becoming patient zero in her own experimental drug trial, aimed at halting aging at the cellular level. In 2015, Parrish underwent telomerase and follistatin gene therapies in Bogota, Colombia. The procedures involved receiving around a hundred injections of a cocktail of genes and a virus modified to deliver those new genes into her bodys cells. The objective was to prevent age-related muscle loss and lengthen her telomeres: the caps at the end of our chromosomes. Scientists have identified their unraveling as not only a marker of aging but also a potential cause of age-related decline.

Liz ParrishLiz Parrish

Parrish told the media about her clandestine experiment and has published periodic updates on her condition in the five years since, and she reports that she has indeed increased her muscle mass and lengthened her telomeres. Parrishs punk-rock approach stems from her conviction that the medical-research communityboth the Food and Drug Administration (FDA) and researchers who arent business-mindedis moving too slowly, with too much red tape, when it comes to advancing aging therapeutics. But gene therapy is a relatively new area of medicine that brings with it a host of new risks, including cancer, severe immune reactions and infections caused by the viral vector used to deliver the drug.

Parrish downplays such worries. There may be risks, she tells Robb Report. But the known risk is that youre 100 percent likely to die. So you have to decide for yourself if the potential benefit outweighs that.

Humans have always aspired to find the fountain of youth, so people might be skeptical about the fact that anti-aging technologies are working now, says British investor and businessman Jim Mellon. But the fact is that this is finally happening, and we need to seize the moment. Mellon cofounded Juvenescence, a three-year-old pharmaceutical company thats investing in multiple technologies simultaneously to increase the odds of bringing winning products to market.

Mellon, 63, has made his fortune betting on well-timed investment opportunities, and he predicts that a new stock-market mania for life extension is just around the corner. This is like the internet dial-up phase of longevity biotech, he enthuses. If youd invested in the internet in the very early days, youd be one of the richest people on the planet. Were at that stage now, so the opportunity for investors is huge. According to a report by Bank of America Merrill Lynch, hes not wrong: The market for technologies to increase human life span is projected to grow sixfold to $610 billion in just the next five years.

When I talk to Mellon in the late spring, hes sequestered on the rugged coast of the Isle of Man, a tiny spit of land in the Irish Sea. Despite being what he describes as imprisoned there for 15 weeksand countingduring the Covid-19 shutdown, hes jovial and chatty and wants to make it clear that his interest in life extension is much more than financial. Working to extend life is an ethical cause, he says. If we can help people to live healthfully until the end of life, well transform the world completely. Well reduce a huge amount of pressure on failing health-care systems, and well have to reimagine pension and life insurance. This should be the number-one tick in anyones investment portfolio.

If youd like to get on board with this social-impact view of longevity, it helps to understand the trajectory of aging today. In Americas most affluent neighborhoods, the average life span is about 88 years. (Meanwhile, in this countrys poorest, it hovers around a meager 66 because of a raft of inequalities, such as diet, stress, smoking, pollution and health care.) For most people, health starts gradually diminishing in the last 15 years of life with the onset of chronic conditions, including arthritis, neurodegeneration and diabetes. If we could eliminate such diseases of aging, experts say, the US could save an estimated $7.1 trillion in health-care costs over the next 50 years. (Quite where all these sprightly centenarians might live on this already densely populated planet remains to be seen.)

Jim MellonEric Verdin

One of Mellons bets is on a class of drugs called senolytics, which destroy senescent cells: the so-called zombie cells that, for complex reasons, stop dividing as we age. Senescent cells harm the body by secreting compounds that cause inflammation in surrounding tissues. Many age-related conditionsarthritis, diabetes, Alzheimers, cancerhave an inflammatory component, and studies suggest that a buildup of senescent cells is a large part of the problem.

A number of biotech start-ups are devel- oping drugs that target cell senescence, but the furthest along is Unity Biotechnology, a company in South San Francisco that has three drugs in clinical trials to address aging conditions, starting with osteoar- thritis of the knee. Unity raised more than $200 million from such big names as Thiel and Bezos, who chipped in through their investment firms, before going public in 2018. Since then, Mellon has also bought a small stake.

The holy grail of senolytics will be the development of a preventive therapy to wipe out senescent cells in the body before they cause conditions of aging, theoretically extending life span. In June, a team from Sloan Kettering published new breakthrough research showing that CAR T cellstypically used for precision cancer therapycan also be used to target and kill senescent cells. Prescription senolytics for anti-aging therapy are still years away, but unsurprisingly, theres an audience of longevity enthusiasts who want to access such anti-aging miracles yesterdayand no shortage of FDA-unapproved ways to chase after them. For instance, after a few studies examined the senolytic effects of a chemotherapy drug called dasatinib, the website FightAging.org published a step-by-step guide to senolytic self-experimentation using chemotherapeutics.

It doesnt take a Ph.D. in biochemistry to guess that taking off-label chemo drugs might come with harmful side effects, but that hasnt stopped a zealous group of body-hackers from trying it themselves and chronicling their efforts online. The internet is littered with novice longevity adviceand sketchy anti-aging companies eager to separate the hopeful and desperate from their money, like the company that charges $8,000 for transfusions of plasma from the blood of teenagers and early-twentysomethings (yes, just like Gavin Belson on HBOs Silicon Valley). Many of these are at best ineffective and at worst deadly, since the same cellular systems that fuel growth in young people might cause cancer when tipped into overdrive. Imagine the tragic irony of paying tens of thousands for a therapy that promises to help you live longer but actually causes the cancer that kills you.

Adobe

Beyond the obvious red flags of repurposed chemo drugs and the bloodletting of teens, it can be difficult for a layperson to separate the world-changing longevity breakthroughs from the terrible ideas. Enter one of the worlds leading experts on longevity to help make sense of things.

Eric Verdin, 63, is president and CEO of the Buck Institute, a globally renowned center for aging research just outside San Francisco in Marin County. Verdin is bullish on the promise of living healthfully to at least 100. Today. But 180? Dont count on it. My prediction, based on everything we know today, is that getting to 120 is about the best we can do for the foreseeable future. Ill bet my house were not going to see anyone live to 180 for another 200 years, if ever, he says. But making everyone a healthy centenarian, this is something we can do today. And thats something to be excited about.

Verdins own lab at the Buck Institute studies the aging immune system and how its affected by lifestyle factors, such as nutrition and exercise. Informed by this research, Verdin follows a time-restricted diet in which he eats all of his meals in an eight-to-nine-hour window (similar to the Buchinger Wilhelmi process) and gets plenty of exercise mountain biking in Marins steep hills. The good news is that over 90 percent of what causes diseases of aging is environmental, and that means its within your control, he says.

But he emphasizes that responsible management of your health comes with limits, like avoiding experimental therapies. A group of people have decided to try some expensive and dangerous interventions, but there is zero evidence that any of these are going to help them live longer, he says. The problem, according to Verdin, is that the results of aging interventions in mouse trials can look very promising but rarely translate to success in humans. Theres a huge delta between the health of a stressed lab mouse and an optimally healthy mouse, Verdin says. So when you treat lab mice with longevity therapeutics, you see an outsized result that doesnt at all guarantee the same result in humans.

On the other hand, Verdin tells Robb Report, there are definitely new protocols worth getting excited about. Take, for instance, rapalogs, a class of drugs that interact with a protein called mTOR, which serves as a linchpin for multiple critical biological processes, including cell growth and metabolism. Rapalog drugs tamp down mTOR, possibly preventing age-related diseases such as diabetes, stroke and some cancers. The drug rapamycin, the most heavily studied formula, was approved in the US in 1999 to help prevent organ-transplant rejection. Last year the medical journal Aging published a rapturous opinion piece by oncologist Mikhail Blagosklonny in which he made the case that rapamycinin small or intermittent dosesis effective as a preventive treatment to ward off diseases of aging, and that, in the elderly, not taking rapamycin may be even more dangerous than smoking.

Eric VerdinJim Hughes Photography

Later this year, a biotech firm called resTORbio, which was spun out of the Swiss-based Big Pharma company Novartis in 2017, is expected to seek FDA approval for its rapalog RTB101, which clinical trials have shown to slow age-related decline of the immune system and improve immune response in elderly people by more than 20 percent, a key factor in protecting vulnerable aging populations from disease. (It is currently in trials on elderly patients with Covid-19.) This is the furthest-along program of anything in the aging field, Joan Mannick, cofounder and chief medical officer of resTORbio, told MIT Technology Review last year. If health authorities approve this drug well have a product for people to prevent age-related diseases. Not just in our lifetime, but in, you know, a few years.

One of the many effects of rapamycin is that it mimics the mechanisms of calorie restriction. As Verdins lab and others have shown, fasting provides a number of anti-aging benefits, including insulin regulation, reduced inflammation and, to put it colloquially, clearing out the gunky by-products of metabolismpart of the reason Twitter CEO Jack Dorsey and other tech titans eat just a few meals per week. For lesser mortals, fasting is extremely hard to commit to and not much fun, hence the huge interest in calorie-restriction mimetics like rapamycin, which provide all the benefits without the downer not-eating part.

Of all the calorie-restriction mimetics, the one sparking the most excitement among longevity researchers is already on the market: metformin, a decades-old diabetes drug. Metformin became a part of the Silicon Valley health regimen several years ago after an epidemiological study showed that Type 2 diabetics who took the drug lived longer than non-diabetics who didnt. Just about everyone in the longevity industry takes metformin, Verdin tells me. He takes it himself, and nearly everybody I interviewed is taking or has taken it, too.

In April, Nir Barzilai, the renowned endocrinologist who spearheaded research on the anti-aging properties of metformin, announced in an opinion piece he co-authored in the journal Cell Metabolism that his lab is launching a large clinical trial to investigate the anti-aging effects of the drug on non-diabetic populations. Barzilais goal is to prove to the FDA that aging itselfrather than conditions associated with it, like Alzheimers and arthritiscan be targeted as a disease. If Barzilai is successful and the FDA approves aging as a treatment indication, the process of bringing longevity therapies to market would accelerate rapidly.

Just as the FDA was able to move faster to bring Covid-19 therapies to market this year, we will reach a tipping point when public opinion pushes the FDA to approve aging as an indication, and the longevity-research field will make leaps as a result, Mellon says. He has contributed funding to Barzilais metformin research, which he believes will be instrumental in proving that there are compounds that can extend human life across the board.

The fact of the matter is that the US has the best regulatory system for new drug development in the world, Mellon says. Were in the first era ever when humans can be bioengineered to live longer. And in 10 years, well have solutions that are even better than today. Just wait, its coming.

Liz Parrish

Jim Mellon

Diet:Vegetarian.Mindfulness practice:Nightly meditation.

Exercise regimen:30 minutes of cardio and 10 minutes of weights,five days a week.

Anti-aging Rx:Regenerative gene therapies. Im certain most peoplewill take them in the next couple decades.

180th-birthday wish:Solving another critical issue.

Sleep routine:7.5 hours plus a 30-minute nap; in bed by 9 p.m.

Vitamins/supplements/ prescription meds:Vitamins D and B12, metformin.

Exercise regimen:Walk or run minimum 10,000 steps a day;weights three times week.

Anti-aging Rx:Green tea.

100th-birthday wish:Another 25 years.

Dave Asprey

Jim Hughes Photography

180th-birthday wish:Either a cruise to Mars or a 1970 Mustang Fastback,which by then will be 210 years old!

Sleep Routine:Avoid: coffee after 2 p.m., heavy workouts after 6 p.m.,alcohol during the week and heavy eating in the evening.

Vitamins/supplements:Vitamin D, omega fatty acids, NMN, citrus bioflavonoidcomplex, fiber supplement, prebiotic supplement.

Diet:Fasting-mimicking diet once every four to six months;roughly 16:8 intermittent fasting at other times.

Mindfulness practice:Daily meditation.

Anti-aging Rx:I love cooking and eating, so I do not restrict foodon the weekend. Happiness with friends and family is thesurest path to longevity.

100th-birthday wish:A bike tour across the US, from coast to coast.

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Why Silicon Valley Execs Are Investing Billions to Stay Young - Robb Report

Skin Stem Cells Comments Off on Why Silicon Valley Execs Are Investing Billions to Stay Young – Robb Report | August 10th, 2020

As Cosmetic Skin Care market document has precise and accurate analysis of market trends, future developments, market segments and competitive analysis which suits the needs of all sizes of businesses in the Cosmetic Skin Care industry. This market research report involves a key data and information about the market, emerging trends, product usage, motivating factors for customers and competitors, restraints, brand positioning, and customer behaviour, which is of utmost importance when it comes to achieving a success in the competitive marketplace. A winning Cosmetic Skin Care market report encompasses many vital parameters about market analysis which can be used for the business.

A detailed market study and analysis of trends in consumer and supply chain dynamics cited in this Cosmetic Skin Care market analysis report helps businesses draw the strategies about sales, marketing, and promotion. Company profiles of the key market competitors are analysed with respect to company snapshot, geographical presence, product portfolio, and recent developments. The report also helps to know about the types of consumers, their response and views about particular products, and their thoughts for the step up of a product. Company profiles covered in this Cosmetic Skin Care report can be quite useful for making At present, the market is developing its presence and some of the Global Cosmetic Skin Care Market key players Involved in the study are LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics.

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026.

Complete study compiled with over 100+ pages, list of tables & figures, profiling 10+ companies. Ask for Sample @ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-cosmetic-skin-care-market&SR

Global Cosmetic Skin Care Market Dynamics:

Market Drivers:

Increasing spending on personal care acts as a market driver

Rising prevalence for natural active ingredients based cosmetic among population will also drive the market growth

Growing demand for sun protection products will propel the growth of this market

Market Restraints:

High cost of the skin care products will restrain the market growth

Strict government rules associated with the less usage of antioxidants will also hamper the market growth

Emerging competition in the cosmetic skin care products is another factor impeding the market growth

Important Features of the Global Cosmetic Skin Care Market Report:

1) What all companies are currently profiled in the report?

List of players that are currently profiled in the report- LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics.

** List of companies mentioned may vary in the final report subject to Name Change / Merger etc.

2) What all regional segmentation covered? Can specific country of interest be added?

Currently, research report gives special attention and focus on following regions:

North America, Europe, Asia-Pacific etc.

** One country of specific interest can be included at no added cost. For inclusion of more regional segment quote may vary.

3) Can inclusion of additional Segmentation / Market breakdown is possible?

Yes, inclusion of additional segmentation / Market breakdown is possible subject to data availability and difficulty of survey. However a detailed requirement needs to be shared with our research before giving final confirmation to client.

** Depending upon the requirement the deliverable time and quote will vary.

Global Cosmetic Skin Care Market Segmentation:

By Product: Anti-Aging Cosmetic Products, Skin Whitening Cosmetic Products, Sensitive Skin Care Products, Anti-Acne Products, Dry Skin Care Products, Warts Removal Products, Infant Skin Care Products, Anti-Scars Solution Products, Mole Removal Products, Multi Utility Products

By Application: Flakiness Reduction, Stem Cells Protection against UV, Rehydrate the skins surface, Minimize wrinkles, Increase the viscosity of Aqueous, Others

By Gender: Men, Women

Check Complete Report Details of Cosmetic Skin Care Market @ https://www.databridgemarketresearch.com/toc/?dbmr=global-cosmetic-skin-care-market&SR

The Cosmetic Skin Care Market report provides insights on the following pointers:

Major Key Contents Covered in Cosmetic Skin Care Market:

This Cosmetic Skin Care Market Research/analysis Report Contains Answers to your following Questions

Note TheCOVID-19 (coronavirus) pandemic is impacting society and the overall economy across the world. The impact of this pandemic is growing day by day as well as affecting the supply chain. The COVID-19 crisis is creating uncertainty in the stock market, massive slowing of supply chain, falling business confidence, and increasing panic among the customer segments. The overall effect of the pandemic is impacting the production process of several industries. This report onMarket provides the analysis on impact on COVID-19 on various business segments and country markets. The reports also showcase market trends and forecast, factoring theimpact of COVID-19 Situation.

Thanks for reading this article; you can also get individual chapter wise section or region wise report versions like North America, Europe, or Asia Etc.

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Cosmetic Skin Care Market -Product Overview and Scope, Opportunities, Market Volume, Competitive Landscape, Possible Challenges and Forecast to 2026 -...

Skin Stem Cells Comments Off on Cosmetic Skin Care Market -Product Overview and Scope, Opportunities, Market Volume, Competitive Landscape, Possible Challenges and Forecast to 2026 -… | August 10th, 2020

Since sunscreen should be applied every dayyes, every daywhy not consolidate steps by using a sunscreen/moisturizer hybrid? The hydrating formulas give you the benefits of sun protection without the white, streaky aftermath. Plus, it makes it that much easier to apply (aka no more excuses about forgetting to put on sunscreen). Look for moisturizing ingredients like hyaluronic acid, ceramides, or niacinamide that give your skin a drink without leaving it greasy.

And if you're still in the camp of "my skin doesn't get burned," that's not an excuse to skip daily SPF. According to The Skin Cancer Foundation, "no matter your skin type, UV radiation from the sun and other sources can cause dangerous, lasting damage to your skin." Sunscreen isn't just about protecting your skin from a sunburn; it also reduces your risk of developing squamous cell carcinoma (the second most common type of skin cancer) by about 40 percent (again, according to The Skin Cancer Foundation) and lowers your melanoma risk by 50 percent. And if it's aging you're worried about, it has your skin covered there too as it prevents wrinkles, sagging, and age spots as well.

Ghostly white cast turning you off? Say hello to tinted sunscreen! (Keep reading for some favorites.)

To get all these benefits of SPF, you have to make sure you're wearing it correctly: Just remember, you need at least a nickel-size drop of sunscreen or SPF moisturizer to cover your face every morning," says Mona Gohara, MD, dermatologist and Women's Health advisory board member.

Here are the 15 best moisturizers with SPF that you won't mind applying every. Single. Day.

You would never know this natural sunscreen houses a whopping 20% zinc oxide thanks to the blendable tint. (Read: You will not mind applying this every day.) You'll also get antioxidant protection thanks to algae and sunflower sprout extract.

This oil-free, lightweight moisturizer blends right in so fast you'll forget if you even applied it. And if you don't want to listen to WH about wearing sunscreen, maybe you'll take a page out of Rihanna's book: You gotta protect your skin from the sun no matter what your skin color is" she says on the Fenty site. "If you have discoloration, guess what, you can get that from the sun. I think a lot of people with darker skin tones think because theyre not burning that they dont need SPF but we can still get sun damage."

Fenty Skin HYDRA VIZOR INVISIBLE MOISTURIZER SPF 30

Whether you have oily skin or you just prefer a lighter consistency, this lotion will be your new fave. It soaks into skin quickly and is basically weightless after it's been appliedyou might even forget you have it onmaking it ideal for layering. Plus, it's non-comedogenic so acne-prone folks won't have to worry.

Simple Skincare, Protecting Light Moisturizer, SPF 15

Made by Black women for Black women, you can trust that this sunscreen/moisturizer hybrid isn't going to leave any white streaks behind. Avocado, jojoba, and sunflower oil all contribute to the rich, hydrating texture that sinks in without clogging pores or leading to breakouts.

Black Girl Sunscreen SPF 30

$18.99

If you're prone to an oily T-zone, this hydrating sunscreen is for you. Ceramides and niacinamide nourish your skin without making it feel greasy, and the mineral SPF ingredients (it contains both titanium dioxide and zinc oxide) keep you sun safe.

CeraVe Hydrating Sunscreen SPF 50 Face

Moisturizing gold standard hyaluronic acid is paired alongside coconut oil and aloe vera for a refreshing and hydrating formula. And thanks to the tint (there's four shades to choose from), it'll even out your complexion too.

Suntegrity 5-in-1 Tinted Moisturizing Face Sunscreen

Most derms recommend a combination of sunscreen and an antioxidant product (to fight aging free radical damage from UV exposure) for the best daily protection. This lightweight lotion has it all in one. It hydrates, has SPF 30, and contains a combination of blackberry extract and vitamins C and E for an antioxidant boost.

Aveeno Absolutely Ageless Daily Moisturizer SPF 30

Hate the feeling of thick, greasy sunscreen? Meet the complete opposite. This gel sunscreen hydrates (thanks to hyaluronic acid, glycerin, and vitamin E) and protects (thanks to a combo of proven chemical sunscreen ingredients) all while feeling like nothing on your skin.

Neutrogena Hydro Boost Water Gel Lotion SPF 50

This triple threat corrects redness, moisturizes, and protects your skin from UV damage. Centella asiatica (an herb native to Asia) is the hero ingredient that works to protect the skin from environmental stress that can lead to irritated, inflamed skin. While the cream goes on green, it quickly turns into a neutral shade to blend into your skin tone for a more even complexion.

Cicapair Tiger Grass Color Correcting Treatment SPF 30

$18.00

Yes, this is a moisturizer with sunscreen, but if you couldn't tell from the name, it's also packed with plant stem cells (they actually make up 15.5 percent of the formula) that fight free radicals to prevent collagen breakdown, promote firmer looking skin, and help smooth fine lines.

Plant Stem Cell Day Cream SPF 30

$75.00

Ever feel like your sunscreen is leaving your skin looking like an oil slick? Meet your new SPF BFF. Not only does it protect your skin from UVA (what causes aging) and UVB (what causes your skin to burn) rays, it also claims to minimize pores by 54 percent and keeps your skin matte for up to 10 hours.

Oil and Pore Control Mattifier Broad Spectrum SPF 45 PA++++

The combo of chemical sun protection ingredients (avobenzone, homosalate, and octisalate) in this nourishing cream provide your skin safety from UVA and UVB rays. It also contains cerium, a mineral that protects from the blue of your computer screen, television, and phone. So, you're double protected.

Supergoop! Superscreen Daily Moisturizer Broad Spectrum SPF 40 PA+++

Think of this moisturizer with sunscreen like a cup of coffee for your skin. While it protects and nourishes, it also boosts your skin's energy from actual coffee beans (the caffeine is also an anti-irritant). Because who couldn't use a extra jolt in the morning?

Origins Ginzing SPF 40 Energy-Boosting Tinted Moisturizer

Extra oily skin types, meet the moisturizer-SPF face cream that will not leave you looking like a greaseball. It has a whipped texture that absorbs in seconds and leaves a velvety smooth finish that looks great under makeup.

Olay Total Effects Whip Face Moisturizer SPF 25

If you're starting to see hyperpigmentation, then you need to up your SPF game. Stat with a brightening product like L'Oral's. This sunscreen lotion contains SPF 30 to stop new dark spots from forming and a combination of glycolic acid, vitamin C, and retinol to treat any existing discoloration.

L'Oral Paris RevitaLift Bright Reveal Brightening Day Moisturizer SPF 30

$19.98

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15 Best Face Moisturizers With SPF 2020 - Moisturizer With Sunscreen - Women's Health

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Embryonic stem cells. The ethical issues associated with stem cell research could be resolved through the use of induced pluripotent stem cells, which are derived from fully committed and differentiated cells of the adult body

The almost miraculous benefits that stem cells may one day deliver have long been speculated on. Capable of becoming different types of cells, they offer huge promise in terms of transplant and regenerative medicine. It is, however, also a medical field that urges caution one that must constantly battle exaggeration. If stem cells do in fact hold the potential to reverse the ageing process, for example, then such breakthroughs remain many years away.

Recently, though, the field has had cause for excitement. In 2006, Japanese researcher Shinya Yamanaka discovered that mature cells could be reprogrammed to become pluripotent, meaning they can give rise to any cell type of the body. In 2012, the discovery of these induced pluripotent stem cells (iPSCs) saw Yamanaka and British biologist John Gurdon awarded the Nobel Prize in Physiology or Medicine. Since then, there has been much talk regarding the potential iPSCs possess, not only for the world of medicine, but for society more generally, too.

A big stepHistorically, one of the major hurdles preventing further research into stem cells has been an ethical one. Until the discovery of iPSCs, embryonic stem cells (ESCs) represented the predominant area of research, with cells being taken from preimplantation human embryos. This process, however, involves the destruction of the embryo and, therefore, prevents the development of human life. Due to differences in opinion over when life is said to begin during embryonic development, stem cell researchers face an ethical quandary.

The promise of significant health benefits and new revenue streams has led some clinics to offer unproven stem cell treatments to individuals

With iPSCs, though, no such dilemmas exist. IPSCs are almost identical to ESCs but are derived from fully committed and differentiated cells of the adult body, such as a skin cell. Like ESCs, iPSCs are pluripotent and, as they are stem cells, can self-renew and differentiate, remaining indefinitely propagated and retaining the ability to give rise to any human cell type over time.

One important distinction to make is that both ESCs and iPSCs do not exist in nature, Vittorio Sebastiano, Assistant Professor (Research) of Obstetrics and Gynaecology (Reproductive and Stem Cell Biology) at Stanford Universitys Institute for Stem Cell Biology and Regenerative Medicine, told The New Economy. They are both beautiful laboratory artefacts. This means that at any stage of development, you cannot find ESCs or iPSCs in the developing embryo, foetus or even in the postnatal or adult body. Both ESCs and iPSCs can only be established and propagated in the test tube.

The reason neither ESCs nor iPSCs can be found in the body is that they harbour the potential to be very dangerous. As Sebastiano explained, these cells could spontaneously differentiate into tumorigenic masses because of their intrinsic ability to give rise to any cell type of the body. Over many years of research, scientists have learned how to isolate parts of the embryo (in the case of ESCs) and apply certain culture conditions that can lock cells in their proliferative and stem conditions. The same is true for iPSCs.

To create iPSCs, scientists take adult cells and exogenously provide a cocktail of embryonic factors, known as Yamanaka factors, for a period of two to three weeks. If the expression of such factors is sustained for long enough, they can reset the programme of the adult cells and establish an embryonic-like programme.

Turning back the clockThere is already a significant body of research dedicated to how stem cells can be used to treat disease. For example, mesenchymal stem cells (usually taken from adult bone marrow) have been deployed to treat bone fractures or as treatments for autoimmune diseases. It is hoped that iPSCs could hold the key for many more treatments.

Global stem cell market:25.5%Expected compound annual growth rate (2018-24)$467bnExpected market value (2024)

IPSCs are currently utilised to model diseases in vitro for drug screening and to develop therapies that one day will be implemented in people, Sebastiano explained. Given their ability to differentiate into any cell type, iPSCs can be used to differentiate into, for example, neurons or cardiac cells, and study specific diseases. In addition, once differentiated they can be used to test drugs on the relevant cell type. Some groups and companies are developing platforms for cell therapy, and I am personally involved in two projects that will soon reach the clinical stage.

Perhaps the most exciting prospects draw on iPSCs regenerative properties. Over time, cells age for a variety of reasons namely, increased oxidative stress, inflammation and exposure to pollutants or sunlight, among others. All these inputs lead to an accumulation of epigenetic mistakes those that relate to gene expression rather than an alteration of the genetic code itself in the cells, which, over time, results in the aberrant expression of genes, dysfunctionality at different levels, reduced mitochondrial activity, senescence and more besides. Although the epigenetic changes that occur with time may not be the primary cause of ageing, the epigenetic landscape ultimately affects and controls cell functionality.

What we have shown is that, if instead of being expressed for two weeks we express the reprogramming factors for a very short time, then we see that the cells rejuvenate without changing their identity, Sebastiano said. In other words, if you take a skin cell and express the reprogramming genes for two to four days, what you get is a younger skin cell.

By reprogramming a cell into an iPSC, you end up with an embryonic-like cell the reprogramming erases any epigenetic errors. If expressed long enough, it erases the epigenetic information of cell identity, leaving embryonic-like cells that are also young.

Slow and steadyAs with any scientific advancement, financial matters are key. According to Market Research Engine, the global stem cell market is expected to grow at a compound annual growth rate of 25.5 percent between 2018 and 2024, eventually reaching a market value of $467bn. The emergence of iPSCs has played a significant role in shaping these predictions, with major bioscience players, such as Australias Mesoblast and the US Celgene, working on treatments involving this particular type of stem cell.

The business potential around stem cell research is huge, Sebastiano told The New Economy. [Particularly] when it comes to developing cell banks for which we have detailed genetic information and, for example, studying how different drugs are toxic or not on certain genetic backgrounds, or when specific susceptibility mutations are present.

Unfortunately, even as the business cases for iPSC treatments increase, a certain degree of caution must be maintained. The promise of significant health benefits and new revenue streams has led some clinics to offer unproven stem cell treatments to individuals. There have been numerous reports of complications emerging, including the formation of a tumour following experimental stem cell treatment in one particular patient, as recorded in the Canadian Medical Association Journal last year. Such failures risk setting the field back years.

The challenge for researchers now will be one of balance. The potential of iPSCs is huge both in terms of medical progress and business development but can easily be undermined by misuse. Medical advancements, particularly ones as profound as those associated with iPSCs, simply cannot be rushed.

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Could induced pluripotent stem cells be the breakthrough genetics has been waiting for? - The New Economy

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New HCPCS Code Enables Facility Reimbursement to Physician Offices Performing Skin Graft Substitute Procedures, Benefiting Wound Patients

RESEARCH TRIANGLE PARK, N.C.--(BUSINESS WIRE)-- Merakris Therapeutics, LLC., a leader in innovative approaches for cutaneous wound healing, announces that the Centers for Medicare & Medicaid Services (CMS) has assigned a Healthcare Common Procedure Coding System (HCPCS) product code Q4248 for its topical skin graft substitute, Dermacyte Matrix. The new HCPCS code, effective July 1, 2020, enables physician office reimbursement under Medicare Part B. Dermacyte Matrix is a crosslinked amniotic membrane allograft designed for cutaneous wound applications, commonly used by outpatient surgical, podiatry and dermatology clinics. Dermacyte is available in dehydrated and hydrated configurations with 5 years of shelf stability at room temperature.

This is another milestone for Merakris Therapeutics that the largest healthcare payer, CMS, has recognized Dermacyte Matrix with a unique reimbursement code. This strengthens our position with broader payer coverage for Dermacyte Matrix, says Chris Broderick, CEO of Merakris. We are dedicated to continued leadership in cell-free biologics and have aligned with academic institutions to support its product development and commercial operations while retaining full rights to our intellectual property.

Merakris has developed a novel purification system yielding two separate amniotic biomolecule fractions, one capable of promoting early-stage cutaneous wound healing, and the second fraction promoting late stage wound healing, including epithelialization and re-keratinization. Dr. W. Sam Fagg, MSc., PhD says this technology distinguishes our value proposition to physicians and payers. Merakris has successfully combined these with Dermacyte Matrix to demonstrate improved healing outcomes in cutaneous ulcers. Pursuant to recent FDA guidance, Merakris has completed a pre-IND meeting with the FDA and is preparing an IND to further develop the use of this technology in combination with Dermacyte Matrix.

About Merakris Therapeutics, LLC

Merakris Therapeutics, based in Research Triangle Park, North Carolina, is focused on researching, developing, and actively marketing regenerative healthcare products for wound care, ophthalmology, pain management, and skin rejuvenation. Our vision is to improve global patient care by pioneering commercially scalable biotherapeutic technologies primarily derived from perinatal cells and tissues. The company has filed patents to protect its amniotic fractionation technology, and a novel stem cell co-culture technology that produces an amniotic fluid-like solution targeted for scalable manufacturing for various therapies.

For more information contact Matt Murray at mmurray@merakris.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200709005591/en/

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Merakris Therapeutics, LLC Announces the Commercial Launch of Dermacyte Matrix and CMS Assignment of an HCPCS Code for Use as a Skin Graft Substitute...

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Plasma transfers exercise benefit in mice

Exercise has a broad range of beneficial healthful effects. Horowitz et al. tested whether the beneficial effects of exercise on neurogenesis in the brain and improved cognition in aged mice could be transferred in plasma (blood without its cellular components) from one mouse to another (see the Perspective by Ansere and Freeman). Indeed, aged mice that received plasma from young or old mice that had exercised showed beneficial effects in their brains without hitting the treadmill. The authors identified glycosylphosphatidylinositol-specific phospholipase D1 as a factor in plasma that might, in part, mediate this favorable effect.

Science, this issue p. 167; see also p. 144

Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age.

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Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain - Science Magazine

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Remember Owen Buell of Joliet, the toddler who was diagnosed with a neuroblastoma right before the COVID-19 pandemic began?

His abdomen had doubled in size and his eye looked bruised and was drooping, the story also said.

Since his diagnosis, Owen's had chemotherapy and abdominal surgery to remove a large tumor that had wrapped itself around major blood vessels.

And Tuesday night, Owen, who wont even turn 2 until Aug. 10, had the first of two stem cell treatments.

His health care team is hoping will help to address the hot spots in some of his bones his shoulders and one of his shins places chemo struggles to reach, according to his great-grandmother Jackie Moore of Florida.

The big thing yesterday is that he had very high blood pressure, Moore said. But sometimes thats from too much hydrationonce they put that IV in, he had tons of fluid.

But the family, which includes his parents Brian Buell and Valerie Mitchell, along with his brothers Elliott, age 8, and Bentley, age 5, still needs financial help.

Although the GoFundMe account has raised $20,000 of its $30,000 goal, donations have stalled, Moore said, but the familys needs are still so high.

Brian and Val are exhausted," Moore wrote on the Help for Baby Owen Buell Facebook page. "Val has the weight of the world on her shoulders and it shows on her face. Brian has done so much.

"Now after almost 5 months he is able to give Val a day off from the hospital. Otherwise, they have been there 24/7 with Owen. There are no volunteers right now because of the Covid virus."

No one is working right now and the familys van has taken a toll with the continual trips to Ann & Robert H. Lurie Children's Hospital of Chicago.

The medical bills for all this care has gone over a million dollars, Moore wrote on the Help for Baby Owen Buell Facebook page. Just one of Owen's shots is $6,000.

On top of the financial worries, Owens chemotherapy treatments have been very rough, Jackie said. When his platelet count would plummet, he went to the hospital for transfusions, she added.

Owen requires frequent diaper changes because the chemotherapy is so acid it can burn his skin, Moore said, so his parents have a special cream to use, too.

Doctors could not remove the part of Owens tumor that had wrapped itself around his major blood vessels, Moore said.

They literally would have scraped them off the blood vessels. It was too risky, Moore said. They could have nicked one of those blood vessels and he could have had a major bleed.

Owen required a special chemotherapy before the stem cell transplant. And then he had to be submerged in water every six hours to reduce the likelihood of welts, a reaction from this type of chemo, Moore said.

Sometimes he complains his leg is hurting, Moore said. But he never says his head hurts from the chemotherapy or that he is going to throw up because he doesnt have enough vocabulary for it yet, she added.

He simply throws up.

A nasogastric tube makes it difficult for Owen to eat.

And still he smiles, Moore said. Sometimes not the biggest of smiles.

But about 2 million stem cells were harvested from Owens body. He will stay in the hospital for a month and a parent can remain with him. Then Owen will go to a Ronald McDonald House for two weeks because he will need to stay close to the hospital, Moore said.

And then Owen will repeat the process: two rounds of potent chemo, a second stem cell transplant, a month-long stay in the hospital and two weeks at Ronald McDonald House, Moore said.

Hes at the point where he knows something is wrong, Jackie said. But you cant sit him down like you could to even an 8-year-old and say, Youve got this thing that wants to hurt your body.

People can donate to the GoFundMe page at bit.ly/2S7sPN7 or visit the Help for Baby Owen Buell and His Family Facebook page for updates and detailed instructions on other ways to help the family.

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Whatever happened to baby Owen? - The Herald-News

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Written by Jayashree Narayanan | Pune | Updated: July 9, 2020 6:38:55 pm Lifestyle coach Luke Coutinho on dry fasting and why it matters for your body. (Source: PR Handout)

Dry fasting for good health has raised eyebrows for its complete abstinence from food and water for an extended period, but the trend has been presented as a superior form of fasting and cleansing by Luke Coutinho in his book The Dry Fasting Miracle: From Deprive to Thrive, published by Penguin Random House India.

Coutinho, a holistic lifestyle coach-integrative medicine, who has co-authored the book with Sheikh Abdul Aziz Nuaimi aka Green Sheikh, from UAEs Ajman royal family, advocates dry fasting and intermittent fasting for healthy living. He talks to indianexpress.com on the book, why fasting is for everyone, and how it could be a way to build immunity given the pandemic concerns.

Excerpts:

Why do you think fasting is important?

Fasting in earlier times was built into ones lifestyle; people ate early because there was hardly any light after sunset and their next meal would only be after sunrise. This practice spread to all religions as a discipline due to its health and spiritual benefits. Sickness too was followed by fasting, because it allowed the body to redirect its energy towards healing and repairing. So, fasting is very natural to us, however, we have moved too far away from this concept because of the habit of constant nibbling, an abundance of food and storage options, etc. Our bodies were never designed to eat the amount of food we actually eat today. Overeating turns out to be one of the most common causes of sickness, more so when the quality of food is bad and inappropriate.

Today, science is proving how necessary fasting is for the immune system, digestive system, energy, spirituality, cardiovascular health, obesity, mental health and so much more.

Fasting draws up an image of no food, no water, and basically starving. How is dry fasting different?

Fasting is not starvation. Fasting is not deprivation. Fasting is a discipline where one willingly gives their body and digestive system a break, redirecting the energy towards rejuvenation and detoxification. Fasting is way more disciplined and planned. Skipping meals is not fasting.

Fasting must be practiced around the same time, so our body builds a memory around when it can expect food. Starvation can lead to nutritional deficiencies and acidity, whereas a well-planned fasting schedule eradicates acidity.

Isnt it dangerous for the body to go without food and, more importantly, water for more than 12 hours?

Dry fasting is a cleansing practice that involves complete abstinence from food and water (in any form) for a brief period of time, which could range from 10 hours to 16, 18, 20 hours, depending upon an individuals comfort level.

Our digestive system utilises almost 80 per cent of the energy into digestion, absorption and assimilation with 20 per cent of the energy towards healing, repair, recovery, growth, rejuvenation, detoxification and building the immune system. Too much eating, eating at the wrong timings, overeating can all drain energy, leaving little or no energy for repair and recovery. Fasting gives the digestive system a temporary shutdown, boosting the immune system, stem cell regeneration, hormonal balance, etc.

Dry fasting also sends our body into the autophagy mode (prolonged fasting) wherein its intelligence sacrifices the sickest cells and activates stem cell regeneration. All of this and more can be achieved through fasting, provided its done the right way.

Of course, if someone has a medical condition and cannot fast, they must refrain or modify it according to what their health experts recommend. For example, dry fasting may not suit someone with recurrent UTI infection, so he/she may adopt intermittent fasting. Or someone on water restriction may not be able to do intermittent fasting and can take short fasts under expert guidance only.

Interestingly, the book also mentions hard dry fasting, which means absolutely no contact with water, not just consumption of it but also bathing, washing or cleaning. Is it possible?

Yes, for a brief period of time. Also, hard dry fasting is intense, so its a personal choice whether one is comfortable with fasting by not washing hands, bathing, brushing, or handling water. Not many people are because they go to offices and travel or work and that is absolutely fine. Soft dry fasting (which includes brushing, bathing, etc) if done the right way is powerful in itself.

Fasting is viewed from a religious angle. But in the book, you mention, it is more than that. Can you elaborate?

Fasting does have religious and spiritual significance but its benefits extend beyond that. In fact, it improves the health of an individual from all dimensions physical, mental, emotional, intellectual as well as spiritual.

Fasting is also turning into another fad simply because it is used as a quick fix to achieve health goals, especially losing weight and belly fat.

Fasting is not a solution for weight gain. Use it to instill discipline with reference to eating and constant nibbling, start listening to your body.

Secondly, individuals try to complete with each other on fasting and the number of hours fasted. If someone is doing a 16-hour fast, everyone wants to do a 16 hour fast. Fasting is not a competition. Its what suits you. There is no magic number of hours one should fast.

Lastly, some people claim to be fasting but still have tea/coffee/juices, etc. Such an approach can be detrimental to ones health. Fasting is not a fad.

You mention that the human body is designed for fasting and the simplest way to begin is to have an early dinner. But, people rarely follow that and tend to even eat at odd hours. Is it healthy?

Times may have changed, but not the way the human body functions.While the wisdom of early dinner comes through our grandparents, today, science is proving how late-night meals mess up our digestion, immunity, blood sugar levels, weight, etc. The very fact that the pancreatic cells have melatonin receptors on them proves that our pancreas is meant to shut down when our body starts to secrete melatonin which is when the sun sets. A person who has had a late-night dinner would be able to answer how heavy and uncomfortable it could make one feel the next day and even during the course of the night. Even worse, if the dinner is heavy, because our body is just not designed to digest it at night.

By far, eating an early dinner which is as close to sunset is a powerful lifestyle change. It can result in better immunity, digestion, energy levels, better skin and hair, etc.

Considering each and everyones body systems are different, do you think dry fasting is everyone?

Absolutely. What do you lose by trying? Most people do not fear fasting, they resist moving out of their comfort zones. There are so many people who report literally magical benefits from fasting. If someone is in a dilemma, read about these inspiring stories.At the same time, fasting doesnt have to suit all. Also, if one form of fasting doesnt suit a person, for e.g. dry fasting, in case of a health condition like recurrent UTI, they can adopt intermittent fasting. In the end, its about what suits a person.

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Fasting is not starvation or a fad, it is a discipline: Luke Coutinho - The Indian Express

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The Skin Care Cosmetic market revenue was xx.xx Million USD in 2014, grew to xx.xx Million USD in 2018, and will reach xx.xx Million USD in 2024, with a CAGR of x.x% during 2019-2024. Based on the Skin Care Cosmetic industrial chain, this report mainly elaborates the definition, types, applications and major players of Skin Care Cosmetic market in details. Deep analysis about market status (2014-2019), enterprise competition pattern, advantages and disadvantages of enterprise products, industry development trends (2019-2024), regional industrial layout characteristics and macroeconomic policies, industrial policy has also be included. From raw materials to downstream buyers of this industry will be analyzed scientifically, the feature of product circulation and sales channel will be presented as well. In a word, this report will help you to establish a panorama of industrial development and characteristics of the Skin Care Cosmetic market., The Skin Care Cosmetic market can be split based on product types, major applications, and important regions.

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Major Players in Skin Care Cosmetic market are:, Avon Products Inc, Kao Corporation, Procter & Gamble, The Estee Lauder Companies Inc, Beiersdorf AG, Unilever PLC, The Body Shop International PLC, Johnson & Johnson, LOreal S.A.

Major Regions that plays a vital role in Skin Care Cosmetic market are:, North America, Europe, China, Japan, Middle East & Africa, India, South America, Others

Brief about Skin Care Cosmetic Market Report with [emailprotected] https://arcognizance.com/report/global-skin-care-cosmetic-industry-market-research-report

Most important types of Skin Care Cosmetic products covered in this report are:, Sensitive Skin Care, Dry Skin Care, Infants Skin Care, Others

Most widely used downstream fields of Skin Care Cosmetic market covered in this report are:, Stem Cells Protection Against UV, Flakiness Reduction, Rehydrate the Skin Surface, Minimize wrinkles, Increase the viscosity of Aqueous

There are 13 Chapters to thoroughly display the Skin Care Cosmetic market. This report included the analysis of market overview, market characteristics, industry chain, competition landscape, historical and future data by types, applications and regions.

Chapter 1: Skin Care Cosmetic Market Overview, Product Overview, Market Segmentation, Market Overview of Regions, Market Dynamics, Limitations, Opportunities and Industry News and Policies.

Chapter 2: Skin Care Cosmetic Industry Chain Analysis, Upstream Raw Material Suppliers, Major Players, Production Process Analysis, Cost Analysis, Market Channels and Major Downstream Buyers.

Chapter 3: Value Analysis, Production, Growth Rate and Price Analysis by Type of Skin Care Cosmetic.

Chapter 4: Downstream Characteristics, Consumption and Market Share by Application of Skin Care Cosmetic.

Chapter 5: Production Volume, Price, Gross Margin, and Revenue ($) of Skin Care Cosmetic by Regions (2014-2019).

Chapter 6: Skin Care Cosmetic Production, Consumption, Export and Import by Regions (2014-2019).

Chapter 7: Skin Care Cosmetic Market Status and SWOT Analysis by Regions.

Chapter 8: Competitive Landscape, Product Introduction, Company Profiles, Market Distribution Status by Players of Skin Care Cosmetic.

Chapter 9: Skin Care Cosmetic Market Analysis and Forecast by Type and Application (2019-2024).

Chapter 10: Market Analysis and Forecast by Regions (2019-2024).

Chapter 11: Industry Characteristics, Key Factors, New Entrants SWOT Analysis, Investment Feasibility Analysis.

Chapter 12: Market Conclusion of the Whole Report.

Chapter 13: Appendix Such as Methodology and Data Resources of This Research.

Some Point of Table of Content:

Chapter One: Skin Care Cosmetic Introduction and Market Overview

Chapter Two: Industry Chain Analysis

Chapter Three: Global Skin Care Cosmetic Market, by Type

Chapter Four: Skin Care Cosmetic Market, by Application

Chapter Five: Global Skin Care Cosmetic Production, Value ($) by Region (2014-2019)

Chapter Six: Global Skin Care Cosmetic Production, Consumption, Export, Import by Regions (2014-2019)

Chapter Seven: Global Skin Care Cosmetic Market Status and SWOT Analysis by Regions

Chapter Eight: Competitive Landscape

Chapter Nine: Global Skin Care Cosmetic Market Analysis and Forecast by Type and Application

Chapter Ten: Skin Care Cosmetic Market Analysis and Forecast by Region

Chapter Eleven: New Project Feasibility Analysis

Chapter Twelve: Research Finding and Conclusion

Chapter Thirteen: Appendix continued

List of tablesList of Tables and FiguresFigure Product Picture of Skin Care CosmeticTable Product Specification of Skin Care CosmeticFigure Market Concentration Ratio and Market Maturity Analysis of Skin Care CosmeticFigure Global Skin Care Cosmetic Value ($) and Growth Rate from 2014-2024Table Different Types of Skin Care CosmeticFigure Global Skin Care Cosmetic Value ($) Segment by Type from 2014-2019Figure Sensitive Skin Care PictureFigure Dry Skin Care PictureFigure Infants Skin Care PictureFigure Others PictureTable Different Applications of Skin Care CosmeticFigure Global Skin Care Cosmetic Value ($) Segment by Applications from 2014-2019Figure Stem Cells Protection Against UV PictureFigure Flakiness Reduction PictureFigure Rehydrate the Skin Surface PictureFigure Minimize wrinkles PictureFigure Increase the viscosity of Aqueous PictureTable Research Regions of Skin Care CosmeticFigure North America Skin Care Cosmetic Production Value ($) and Growth Rate (2014-2019)Figure Europe Skin Care Cosmetic Production Value ($) and Growth Rate (2014-2019)Table China Skin Care Cosmetic Production Value ($) and Growth Rate (2014-2019)Table Japan Skin Care Cosmetic Production Value ($) and Growth Rate (2014-2019)continued

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NOTE: Our report does take into account the impact of coronavirus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

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Impact Of COVID-19 On Skin Care Cosmetic Market 2020 Industry Challenges, Business Overview And Forecast Research Study 2024 - Owned

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The studies show that JAK inhibitors and other small molecules are capable of reawakening dormant hair follicles and stem cell therapies that can develop new follicles.

The first study was led by Angela Christiano, whos a professor of Dermatology at Columbia University Vagelos College of Physicians and Surgeons. The researchers discovered some previously unknown cells that ensure that mouse hair follicles dont leave a resting state. If the activities of these cells are inhibited, dormant follicles can be reawakened.

In the second research, the team of Christiano found a method for growing human hair in a dish. This method could make more men and women start exploring the idea of hair restoration surgery. It could also enhance the method that pharmaceutical companies consider when looking for new hair-growth medications.

In pattern baldness, lots of hair follicles are still in existence. However, they are dormant. The focus of researchers on getting drugs that function effectively in the same pathways as minoxidil and finasteride has affected their quest to find new drugs that can reawaken follicles and inhibit hair growth. Notably, minoxidil and finasteride are the only two medications that can be used by men suffering from male pattern baldness.

The researchers had previously found a new pathway, known as JAK-STAT, which is active in the stem cells of resting hair follicles and makes them remain in a state of dormancy. Christiano and other researchers in his team showed that JAK inhibitors used on mouse skin are good for reawakening resting follicles in mice.

Their second study was targeted at knowing more about the natural processes of making sure that the follicles remain dormant. Therefore, the researchers searched for factors that managed the activity of the JAK pathway in the hair follicle.

During the search, the Colombian researchers found a formerly unknown immune-related cell type that is capable of creating a substance called Oncostatin M. This substance makes sure that the follicle doesnt leave a dormant state. One of the authors of the study, Etienne Wang, Ph.D., notes Rare subsets of immune cells were previously difficult to identify in a whole skin, but this work was facilitated by our ability to sequence individual cells and pinpoint the ones making Oncostatin M.

There are some resemblances between these cells and macrophages, which are regarded as the immune systems scavenger cells. The researchers discovered that these cells are close to resting hair follicles.

These cells have been named trichophages. It should be noted that this name is taken from tricho, which is a Greek word for hair.

Besides, the hair cycle could be turned on when the trichophages are being targeted. By utilizing antibodies and small molecular inhibitors for inhibiting Csf1R, which is a receptor that is found on the trichophages, the flow of Oncostatin M could be blocked so that the hair cycle can start once again.

The second study involved the creation of a means of growing human hair in a dish. This method could lead to hair restoration surgery for an increased number of individuals including women. This new development could also enhance the method through which pharmaceutical companies find new hair growth medications.

It is worthwhile to note that this study brings a novel idea of growing human hair follicles in a dish without using any implantation in the skin.

Notably, researchers have been generating new rat or mouse hairs by culturing cells that were extracted from the end of existing follicles.

To find a way around human hair cells resistance, the Colombian researchers have been looking for ways to build conditions that look like the 3D environment that is the habitat of human hair cells. Although they failed at the beginning, they are making progress now as they have found a way to grow new human hair follicles in a dish in a lab.

In a nutshell, these new approaches can bring a significant change to the process of dealing with hair loss in both men and women. While studies are still going on, you can cope with your hair loss by picking the right products at Lilyhair.co.uk to improve your overall look.

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As reported in an eye-opening new research paper, scientists have created tiny human livers out of human skin cells before successfully transplanting them into rats.

What we are planning to do is to start making mini human organs that are universal, explained the papers co-author, Alejandro Soto-Gutirrez, from the University of Pittsburgh.That would change the paradigm of transplants.

The science-fiction-like procedure was done by taking adult skin cells and genetically altering certain genes and transcription factors to create what are known as pluripotent stem cells.

It starts with human skin cells called fibroblasts, in 2006 the pioneering field of genetic-editing led scientists to discover that they can simply take any cell from a living adult and turn it into a pluripotent stem cell.

Pluri, meaning plurality, indicates its ability to carry the genetic code of all organ types, which is how they can become liver cells.

RELATED: For the First Time in the US, Surgeons Pump New Life into Dead Donor Heart for Life-Saving Transplant

According to the Mayo Clinic, the number of people on current waiting lists for liver transplants far exceeds the number of available liver donors. The cost is just as high: the medical journal Inverse reports the average cost of a transplant, accounting for the entire procedure, is about $812,000.

New technologies always reduce the cost of existing products (remember how expensive flat screen televisions were?) and a new paradigm of made-to-order fabrication of organs would likely fulfill all the demand for transplants while lowering the cost at the same time.

As fascinating as it is a little unsettling, the science took a decade to perfect, but is far still from human trials. The tiny organs from human cells continued working normally after they were transplanted into rats bred to have suppressed immune systems otherwise the body would reject the foreign organ.

RELATED: Game-Changing Approval of Liver Transplant Procedure Expected to Halve the Waiting List

The method and associated technology could produce part-time liver grafts, that could prolong the lives of people waiting on the transplant list.

The long-term goal is to create organs that can replace organ donation, but in the near future, I see this as a bridge to transplant, Soto-Gutirrez told Inverse. For instance, in acute liver failure, you might just need a hepatic boost for a while, instead of a whole new liver.

(File photo by OPCW Laboratory in Rijswijk, CC license)

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Dream of Plentiful Organ Transplants Moves Closer to Reality as Scientists Grow Tiny Working Livers from Skin Cells - Good News Network

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Oncology is a branch of study and treatment of cancer. Cancer is disease in which abnormal cells grow and divide without control. Oncology drugs help in diagnosis cancer. Some of the causes of cancer are tobacco and smoking, viral infections, genetic causes, carcinogens, bacterial infections, physical activities, eating habits and age. Various types of cancer that can be treated by oncology drugs are blood cancer, endocrine cancer, lung cancer, bone cancer, skin cancer, genitourinary cancer, gastrointestinal cancer, breast cancer, eye cancer, head and neck cancers and gynaecologic cancer. On the basis of treatment, oncology drugs market can be segmented into chemotherapy, immunotherapy, surgery, radiation therapy, stem cell transplant, hormone therapy and others.

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North America, followed by Europe, has the largest market for oncology drugs due to new drug development, government initiatives and developed healthcare infrastructure in this region. Asia is expected to show high growth rate in the oncology drugs market in next few years due to increasing incidence of cancer cases, rise in the use of tobacco products and growth in aging population in the region.

Technological advancement, increasing incidence of various type of cancers, rise in need for R&D activities in cancer and growing concerns over high death rates due to cancer are driving the market for oncology drugs. In addition, introduction of new drugs and therapies for cancer and government support to improve healthcare condition are expected to drive the market for oncology drugs. However, high cost of cancer treatments, strict government regulations, huge investment involvement in the development and clinical trials of the therapies and side effects of cancer treatments are some of the major factors restraining the growth for global oncology drugs market.

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Growing demographics and economies in the developing countries such as China and India are expected to offer good opportunities in oncology drugs market in Asia. In addition, new innovations in cancer drugs and therapies and rise in awareness about the new drugs and therapies available in the market are expected to offer new opportunities for global oncology drugs market. Personalized medicines, increasing number of mergers and acquisitions, new product launches and rise in number of collaborations and partnerships are some of the trends that have been observed in global oncology drugs market.

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Some of the major companies operating in the global oncology drugs market are

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A man undergoes a rapid HIV test. (CLAUDIO REYES/AFP via Getty)

In a major leap forward in the search for a HIV/AIDS cure, a person has been cured of HIV using a cocktail of medicines in what activists have dubbed a breakthrough as exciting as it was unexpected.

HIV, known as human immunodeficiency virus, hobbles peoples immune systems leaving them more vulnerable to once everyday diseases.

In a new study, presented Tuesday (July 7) at the International AIDS conference 2020, a patient on a relatively simple antiretroviral drugregimen was given a medicine commonly used to treat skin cancer.

Previous milestones of individuals HIV appearing to go into long-term remission resulted from bone-marrow transplants given to infected patients. Similarly, the transplants were intended to treat cancer in the patients, not HIV.

But bone-marrow transplants on top of being costly are unlikely to be realistic or reliable treatment options and are, at times, riddled with risk. Yet, this case involved no invasive medical procedures.

As a result, experts told PinkNews, while they are wearily calling it a cure for the virus, it is difficult how to define the word when instances of the virus demise are so few.

Moreover, they said, caution must be exercised in pivoting the case as a success, as scientists must assess whether the outcome can be replicated.

And while the HIV epidemic continues, advocates have warned that the emergence of the coronavirus pandemic its continually sweeping infection rates and how it is vacuuming the attention of scientists and healthcare officials will no doubt knock back success made in recent years.

Dr Andrea Savarino, of the Instituto Superiore di Sanit in Rome, Italy, explained to HIV advocacy group aidsmap during a video call seen by PinkNews that the patient, one of five, was given an experimental drug commonly used as a skin cancer preventative called Nicotinamide as part of the study.

The medicine boosts the immune system, and some academics have demonstrated how Nicotinamide inhibits advanced stages of HIVinfection in cell culture and works on multiple mechanisms to reel back HIV, Savarino said.

By the end of the study, Savarino said, a common indicator of the virus presence viral DNA was undetectable in the patient. Savarino admitted this was not an optimal marker, but it may give an indication of the size of the viral reservoir.

Researchers have long struggled to find a way to destroy HIV reservoirs clusters of infected immune cells that are not producing new HIV but this strategy, Savarino explained, may provide a possible blueprint.

Even after the patient was taken off of his antiretrovirals treatments, the virus did not rebound, the viral DNA was maintained negative, he said. The antibody response decreased over time, if the antibody decreases, it is possible that the virus has stopped its repetition.

The other four patients did rebound, the researcher said.

He stressed that the antibodies made to fight HIV have not disappeared altogether, but did decrease hes still being monitored in order to understand whether the antibodies might disappear as in the case of Mr Timothy Brown,Savarino added.

Brown, often referred to as the Berlin patient, beat HIV with a combination of stem cell transplants and radiotherapy following a diagnosis of leukaemia.

During the trial, only mild side-effects were observed from the cocktail of medicines: No real side-effects were observed from Nicotinamide, which was in-line with previous trials of the medicines impact on cancer.

However, the HIV expert stressed that those living with HIV should not take Nicotinamide in a non-medical setting, being that it is a potent and still experimental medicine.

I really hope that [the study] boosts further research into a HIV cure because it is the first time such a condition is seen, to my knowledge, in a patient under chronic HIV infection, and without having been subjected to a life-threatening medical procedure such as bone marrow transplant, he said.

However, this is our very first experiment, and I wouldnt foresee beyond that.

This was an unexpected result its proof of a concept that we werent really looking out for, Matthew Hodson, executive director of aidsmap, told PinkNews.

We have had effective treatment for HIV for 34 years but 690,000 people died of AIDS last year.

We anticipate that due to COVIDs disruption of health services there will be an even greater number of AIDS-related deaths this year. People around the world are desperately in need of a cure and this case does give us renewed hope.

Although the news is exciting, at this point we have to proceed with caution. We know that a very small number of people can achieve what appears to be remission with antiretroviral drugs alone and it remains possible that this is the case here.

We need to know whether this finding will be replicated in other people, especially as it was not replicated in four other people on the trial.

This particular treatment is relatively inexpensive and, unlike the bone marrow transplant that resulted in previous cure cases, is not especially dangerous to the patient.

This gives me hope that it could be rolled out widely if we found it to work in other people.

Only one person in the small group given this treatment seems to be cured.

Further trials are necessary to find out whether it works for others and which part of the treatment made the difference. This means that it will be some years yet before this treatment will be accessible.

The global fight against AIDS was staggering even before the COVID-19 pandemic, activists admitted, as the United Nations said Sunday that global HIV targets will not be reached.

The organisations AIDS agency said in a report that COVID-19 may hurl progress against the virus back by a decade or even more.

Data from 2019 shows that more than 38 million people worldwide have acquired HIV a million more than in 2018.

UN officials noted that while some 25.7 million people living with HIV were on antiretroviral treatment in 2019 a feat unimaginable a decade prior it still leaves12.6 million not on the life-saving medications.

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Cosmetic Skin CareMarketBusiness Insights and Updates:

The latest Marketreport by a Data Bridge Market Researchwith the title[Global Cosmetic Skin CareMarket Industry Trends and Forecast to 2026].The new report on the worldwide Cosmetic Skin CareMarketis committed to fulfilling the necessities of the clients by giving them thorough insights into the Market. The various providers involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers.The reports provide Insightful information to the clients enhancing their basic leadership capacity identified.Exclusive information offered in this report is collected by analysis and trade consultants.

Global cosmetic skin care market is set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026.

Cosmetic skin care is a variety of products which are used to improve the skins appearance and alleviate skin conditions. It consists different products such as anti- aging cosmetic products, sensitive skin care products, anti- scar solution products, warts removal products, infant skin care products and other. They contain various ingredients which are beneficial for the skin such as phytochemicals, vitamins, essential oils, and other. Their main function is to make the skin healthy and repair the skin damages.Get PDF Samplecopy(including TOC, Tables, and Figures) @https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-cosmetic-skin-care-market

Thestudy considers the Cosmetic Skin CareMarketvalue and volume generated from the sales of the following segments:Major Marketmanufacturerscovered in the Cosmetic Skin CareMarketare:LOral, Unilever, New Avon Company, Este Lauder Companies, Espa, Kao Corporation, Johnson & Johnson Services, Inc., Procter & Gamble, Beiersdorf, THE BODY SHOP INTERNATIONAL LIMITED, Shiseido Co.,Ltd., Coty Inc., Bo International, A One Cosmetics Products, Lancme, Clinique Laboratories, llc., Galderma Laboratories, L.P., AVON Beauty Products India Pvt Ltd, Nutriglow Cosmetics Pvt. Ltd, Shree Cosmetics Ltd

By Product

By Application

By Gender

By Distribution Channel

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Based on regions, the Cosmetic Skin CareMarketis classified into North America, Europe, Asia- Pacific, Middle East & Africa, and Latin AmericaMiddle East and Africa (GCC Countries and Egypt)North America (United States, Mexico, and Canada)South America(Brazil, Argentina etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Market Drivers:

Market Restraints:

Key Developments in the Market:

Key Benefits for Cosmetic Skin CareMarket:

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About Us:Data Bridge Marketresearch endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process Data Bridge set forth itself as an unconventional and neoteric Marketresearch and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best Marketopportunities and foster efficient information for your business to thrive in the Market.We ponder into the heterogeneous Markets in accord with our clients needs and scoop out the best possible solutions and detailed information about the Markettrends. Data Bridge delves into the Markets across Asia, North America, South America, Africa to name few.

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Global Cosmetic Skin Care Market Updates, Future Growth, Business Prospects, Forthcoming Developments by Forecast to 2026 - 3rd Watch News

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From Netdoctor

Lymphoma, a type of blood cancer, is the fifth most common cancer in the UK. Lymphomas can be hard to diagnose and with sixty different types, the treatments vary hugely from a watch and wait option to intensive chemotherapy, radiotherapy and even stem cell transplants. People can live for many years with lymphomas so lets look at how they present and what the treatment options are.

Lymphoma is a cancer of lymphocyte cells. Lymphocytes are one of our white blood cells and they play an important role in helping our body to fight off infection. They are present in lymph fluid which circulates around the body via a network of lymph nodes and lymph vessels which form the lymphatic system.

It is common for lymph nodes (also called lymph glands) to swell up when you have an infection. For example, you may notice swollen glands in your neck when you have a sore throat. The glands shrink back down again as the infection clears.

In lymphoma, something happens to the DNA of the lymphocytes which results in the lymphocytes behaving abnormally, they reproduce and multiply in an uncontrolled way. Large numbers of lymphocytes mean that the lymph nodes become congested and swollen without the presence of infection.

There are different type of lymphocyte cells and around sixty different types of lymphoma but they can be divided into two groups:

Non-Hodgkin can be further divided into:

People of any age can get lymphoma, including children. Hodgkin lymphoma occurs most commonly in people in their early twenties and in the over seventies. It affects around 2,000 people each year in the UK. Non-Hodgkin lymphoma is more common affecting around 14,000 people each year, a third of whom are over the age of 75.

The causes of lymphoma are largely unknown. There may be an inherited genetic mutation which causes the DNA to wrongly instruct the lymphocytes to multiply but its not known for certain if lymphoma runs in families.

Whilst it doesnt point to the cause, certain people are at higher risk of developing lymphoma. These include people who have a suppressed immune system. The suppression may come from the presence of a medical condition which directly affects the immune system such as HIV or from taking an immune suppressing medication. People who have previously been infected by the Epstein Barr virus (responsible for glandular fever) also seem to be at higher risk of lymphoma.

Because some of the symptoms of lymphoma such as swollen nodes and fatigue are common, it can be hard to diagnose lymphoma. Superficial lymph nodes in the neck and armpits are easy to feel but many nodes lie deep within the chest or abdomen and cant be seen or felt.

The most common symptoms of lymphoma are:

These are most commonly in the neck, armpits and groin area. Smooth, rubbery lumps can be felt. They arent usually painful and gradually enlarge although they may go up and down in a low grade, non-Hodgkin lymphoma.

If you have swollen glands that have persisted for over two to three weeks or are getting progressively bigger, then see your doctor.

Photo credit: Christopher Futcher - Getty Images

The following generalised symptoms, also called systemic symptoms may be present:

Story continues

When lymph nodes become enlarged they can press on the body tissues surrounding them resulting in a variety of symptoms depending on the location of the nodes. These include:

Some people may have only one symptom, whereas others will have multiple. Similarly, some people may become rapidly very unwell whilst others have a slower, milder form of lymphoma. The variety is huge due to the many different types and locations of lymphoma.

When you feel unwell or notice swollen glands, your first contact is usually with your GP. He or she will not be able to make a diagnosis of lymphoma but may have suspicions based on listening to your explanation of your symptoms and after examining you.

Blood tests will usually be ordered. These include a Full Blood Count (FBC) which gives details of the number of white blood cells, including lymphocytes in your blood. It cannot however give a diagnosis of lymphoma. To reach this you will be referred to a specialist who will arrange specific tests to not only confirm lymphoma but also to work out how advanced the lymphoma is. These include a biopsy where a sample of the tissue from a gland (or commonly a whole gland) is removed and examined under the microscope. Scans such as CT scans, ultrasound scans and X-rays all help to diagnose lymphoma and determine the best treatment plan.

Once the diagnosis has been made, the doctor will find out what stage the lymphoma is at. This means working out which parts of the body are affected and how advanced the disease is. Staging helps to plan the right treatment.

The following staging is for adults with Hodgkin and non-Hodgkin lymphoma. The staging is different in children

Stage 1 only one group of lymph nodes is affected

Stage 2 two groups of lymph nodes are affected but they are both on the same side of the diaphragm e.g. in the neck and armpit

Stage 3 Lymph nodes on both sides of the diaphragm are affected e.g. neck, armpit and groin

Stage 4 Lymphoma has spread to organs outside of the lymphatic system e.g. lungs, liver

Photo credit: Peathegee Inc - Getty Images

The treatment plan for lymphoma varies according to the type and stage of lymphoma however factors such as age, other medical conditions and general health can influence how effective and well tolerated treatment is.

Treatment plans are usually drawn up after a Multi-Disciplinary Team meeting. This is a discussion between a collection of specialists who all use their expertise and previous experience to determine the best course of action for each individual patient.

The aim of treatment is to push the lymphoma into complete remission where there is no evidence that it is still present in the body and to prevent relapses. Sometimes where the lymphoma is a low grade, non-Hodgkin type, the aim is for a partial remission, quietening the disease. In this situation, sometimes treatment isnt offered immediately and a watch and wait approach is taken.

Treatment options include:

The charity Lymphoma action states, In the UK, no alternative therapies are registered for the treatment of lymphoma. There is no evidence that they are effective and they are not recommended by the NHS. Although not recommended as a treatment, many patients gain benefit from complementary therapies alongside their medical treatment. Therapies such as massage, aromatherapy, meditation and mindfulness, can all help to lower stress and anxiety and improve wellbeing and quality of life.

Most cases of lymphoma are treatable.

In England, approximately 75 per cent of people with Hodgkin lymphoma will survive for ten years or more. Younger people and those who are diagnosed earliest have the best survival rates.

The survival rate for non-Hodgkin lymphoma has tripled in the last 40 years in the UK and almost two thirds of people will survive beyond ten years. The survival rates are highest in young people and 9 in 10 people diagnosed with non-Hodgkin lymphoma between the ages of 15 and 39 will survive for more than five years.

*stats from Cancer Research UK https://www.cancerresearchuk.org

Lymphoma action

Blood Cancer UK

Last medically reviewed: 08-07-2020

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What is lymphoma? Symptoms, causes and diagnosis - Yahoo Lifestyle UK

Skin Stem Cells Comments Off on What is lymphoma? Symptoms, causes and diagnosis – Yahoo Lifestyle UK | July 7th, 2020

Medical skin care products are used for beautifying or to address some other skin care problems. The cosmetic industry is booming and skin care forms a very huge part of this industry. The aesthetic appearance is so important that people spend a lot on skin care products and treatment. People being more technologically aware of the various new skin care products trending in the market. In addition to the aesthetic application, the medical skin care products are also used to address issues such as acne, pimples or scars.

Medical Skin Care Products Market: Drivers and Restraints

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

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Medical Skin Care Products Market: Segmentation

On the basis of product type the medical skin care products market can be segmented as:

On the basis of application, the medical skin care products market can be segment as:

On the basis of distribution channel, the medical skin care products market can be segment as:

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Medical Skin Care Products Market: Overview

Medical skin care products are used to address basic skin problems ranging from acne to scars. There are various advancements in the ingredients used to offer skin care products to the consumers. For instance, the use of hyaluronic acid and retinoids is the latest development in the industry. The anti-aging creams are at the forefront as the help treating issues such as wrinkles, scars, acne, and sun damage. Another, product in demand is the probiotic skincare which include lactobacillus and bifidobacterium.

Medical Skin Care Products Market: Region-wise Outlook

In terms of geography, medical skin care products market has been divided into five regions including North- America, Asia- Pacific, Middle-East & Africa, Latin America and Europe. North America dominated the global medical skin care products market as international players are acquiring domestic companies to make their hold strong in the U.S. LOral is accelerating its U.S. market by signing a definitive agreement with Valeant Pharmaceuticals International Inc. to acquire CeraVe, AcneFree and Ambi skin-care brands for US$ 1.3 billion. The acquisition is expected LOreal to get hold of the brands in the price-accessible segment. Asia Pacific is expected to be the fastest growing region owing to the increasing disposable income and rising awareness towards the skin care products.

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Medical Skin Care Products Market: Key Market Participants

Some of the medical skin care products market participants are

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Increasing Demand for Medical Skin Care Products Market to Fuel Revenue Growth Through 2025 - Lake Shore Gazette

Skin Stem Cells Comments Off on Increasing Demand for Medical Skin Care Products Market to Fuel Revenue Growth Through 2025 – Lake Shore Gazette | July 6th, 2020

New York, July 1 (IANS) A team of US scientists, led by an Indian-origin researcher revealed that SARS-CoV-2 (coronavirus), the virus behind Covid-19, can infect heart cells in a lab dish.

This suggests it may be possible for heart cells in Covid-19 patients to be directly infected by the virus.

The discovery, published today in the journal Cell Reports Medicine, was made using heart muscle cells that were produced by stem cell technology.

"We not only uncovered that these stem cell-derived heart cells are susceptible to infection by a novel coronavirus, but that the virus can also quickly divide within the heart muscle cells," said study researcher Arun Sharma from the Cedars-Sinai Board of Governors Regenerative Medicine Institute in the US.

"Even more significant, the infected heart cells showed changes in their ability to beat after 72 hours of infection," Sharma added.Although many COVID-19 patients experience heart problems, the reasons remain unclear. Pre-existing cardiac conditions or inflammation and oxygen deprivation resulting from the infection have all been implicated.

But there has until now been only limited evidence the SARS-CoV-2 virus directly infects the individual muscle cells of the heart.The study also demonstrated human stem cell-derived heart cells infected by SARS-CoV-2 change their gene expression profile.This offers further confirmation the cells can be actively infected by the virus and activate innate cellular 'defence mechanisms' in an effort to help clear-out the virus.

"This viral pandemic is predominately defined by respiratory symptoms, but there are also cardiac complications, including arrhythmia, heart failure and viral myocarditis," said study co-author Clive Svendsen.

"While this could be the result of massive inflammation in response to the virus, our data suggest that the heart could also be directly affected by the virus in Covid-19," Svendsen added.

Researchers also found that treatment with an ACE2 antibody was able to blunt viral replication on stem cell-derived heart cells, suggesting that the ACE2 receptor could be used by SARS-CoV-2 to enter human heart muscle cells.

"By blocking the ACE2 protein with an antibody, the virus is not as easily able to bind to the ACE2 protein, and thus cannot easily enter the cell," said Sharma. "This not only helps us understand the mechanisms of how this virus functions, but also suggests therapeutic approaches that could be used as a potential treatment for SARS-CoV-2 infection," he explained.

The study used human induced pluripotent stem cells (iPSCs), a type of stem cell that is created in the lab from a person's blood or skin cells. IPSCs can make any cell type found in the body, each one carrying the DNA of the individual. "This work illustrates the power of being able to study human tissue in a dish," the authors wrote.

--IANS

bu/pgh

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Coronavirus may infect heart cells of Covid-19 patients: Study - Sify News

Skin Stem Cells Comments Off on Coronavirus may infect heart cells of Covid-19 patients: Study – Sify News | July 6th, 2020