WASHINGTON, Dec. 4, 2020 /PRNewswire/ --Four studies being presented during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition present opportunities to improve care for patients with a variety of blood disorders. Together, the studies provide support for new clinical approaches such as alternate treatment delivery methods, updated uses for existing therapies, and earlier referrals to specialty care.

"These are very practical trials with real-world implications," said press briefing moderator Lisa Hicks, MD, of St. Michael's Hospital and the University of Toronto. "They address important questions relevant to everyday practice in the clinic."

The first study supports administering the monoclonal antibody daratumumab for multiple myeloma via a quick injection instead of an intravenous infusion, an approach that could save significant time for patients and clinics.

The second study found that, despite being routinely used in practice, the clot stabilizer tranexamic acid does not prevent bleeding when used prophylactically for patients undergoing treatment for blood cancers, although it leaves open the possibility that the drug may be an effective treatment for these patients when bleeding occurs.

The third study reports the drug ruxolitinib can offer relief for patients with chronic graft-versus-host disease (GVHD) after a stem cell transplant, suggesting ruxolitinib is a viable second-line treatment for patients whose symptoms are not fully resolved with corticosteroids.

Finally, the fourth study supports referring older patients with myelodysplastic syndromes to transplant centers for allogeneic hematopoietic cell transplantation, an important shift from current practice that could offer many more patients the potential for a cure.

This press briefing will take place on Friday, December 4, at 9:30 a.m. Pacific time on the ASH annual meeting virtual platform.

Study Bolsters Case for Delivering Daratumumab Subcutaneously for Multiple Myeloma412: Apollo: Phase 3 Randomized Study of Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) Versus Pomalidomide and Dexamethasone (Pd) Alone in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)

A new study suggests the monoclonal antibody daratumumab has similar benefits when delivered via subcutaneous injection as it does when delivered intravenously to individuals with multiple myeloma which persists or recurs after first-line treatments. Patients given subcutaneous daratumumab along with the immunomodulator pomalidomide and the anti-inflammatory steroid dexamethasone were 37% less likely to die or have their disease worsen compared to patients who received pomalidomide and dexamethasone alone in the phase III trial.

"This is an effective combination with a predictable safety profile that allows for the use of subcutaneous daratumumab along with oral pomalidomide and dexamethasone for patients who have received at least one prior line of therapy that included lenalidomide and a proteasome inhibitor," said senior study authorMeletios A. Dimopoulos, MD,of National and Kapodistrian University of Athens in Athens, Greece. "Subcutaneous daratumumab is much easier for the patient and reduces the time they need to spend at the outpatient chemotherapy unit."

The combination of intravenous daratumumab and pomalidomide with dexamethasone has been widely adopted in the U.S. as a second-line therapy for patients whose multiple myeloma does not respond durably to lenalidomide and proteasome inhibitors. However, delivering daratumumab intravenously typically requires patients to spend a full day at the clinic for each infusion. Administering the therapy via a five-minute subcutaneous injection can substantially reduce the burden for patients and clinics, Dr. Dimopoulos said.

The researchers enrolled 304 patients in 12 European countries. Half were randomly assigned to receive daratumumab plus pomalidomide with dexamethasone and half only received pomalidomide with dexamethasone. Patients underwent 28-day treatment cycles until their disease worsened or they experienced unacceptable side effects.

About one-third of patients died during the trial's median follow-up period of about 17 months. The study met its primary endpoint, showing a significantly higher rate of progression-free survival at 12 months among patients receiving the combination therapy. Participants receiving the daratumumab-pomalidomide combination were treated for a median of nearly 12 months, substantially longer than the median treatment duration of less than seven months among those receiving pomalidomide alone.

Patients receiving daratumumab experienced adverse events at a rate consistent with previous studies, raising no new safety concerns. Dr. Dimopoulos said the findings suggest the combination therapy can be a good option for patients who have not experienced lasting benefits from lenalidomide and proteasome inhibitors, particularly those whose cancer is resistant to lenalidomide. He noted that the study suggested a slight trend toward increased survival in the daratumumab arm, but additional follow-up is necessary to assess any survival benefit.

Meletios A. Dimopoulos, MD,National and Kapodistrian University of Athens, will present this study in an oral presentation on Sunday, December 6, at 12:00 noon Pacific time on the ASH annual meeting virtual platform.

Tranexamic Acid Not Found to Prevent Bleeding in Patients with Blood Cancers 2: Effects of Tranexamic Acid Prophylaxis on Bleeding Outcomes in Hematologic Malignancy: The A-TREAT Trial

The clot stabilizer tranexamic acid performed no better than placebo when administered prophylactically to prevent bleeding in patients with blood cancers who also received routine prophylactic platelet transfusions. Researchers cautioned that the study's focus is different from other situations in which tranexamic acid has been found effective, such as its use in treating bleeding related to childbirth, surgery, or inherited blood disorders.

"Clearly patients with low platelet counts and blood cancers have a different kind of bleeding than the bleeding experienced by patients who have suffered some kind of trauma or surgery," said senior study author Terry B. Gernsheimer, MD, of the University of Washington School of Medicine. "Their bleeding likely is due to endothelial damage damage to the lining of blood vessels that tranexamic acid would not treat. To prevent bleeding in these patients, we may need to look at ways to speed the healing of the endothelium that occurs with chemotherapy, radiation, and graft-versus-host disease in patients receiving a transplant."

Between 48% and 70% of patients undergoing treatment for blood cancers experience bleeding complications of World Health Organization grade 2 or higher. Though not life-threatening, grade 2 bleeding for example, a nosebleed lasting more than 30 minutes can be concerning. Bleeding of grade 3 or 4 can be life-threatening and warrant blood transfusions. Most patients undergoing treatment for blood cancers are routinely given platelet transfusions to prevent bleeding, but many continue to experience bleeding episodes, nevertheless.

Tranexamic acid works by slowing the process by which blood clots naturally break down. To determine whether tranexamic acid could help to further reduce bleeding in these patients, the researchers enrolled 327 patients undergoing treatment for blood cancers at three U.S. medical centers. Half were randomly assigned to receive tranexamic acid and half received a placebo, administered either orally or intravenously three times a day until they recovered their platelet count, or for up to 30 days. Researchers regularly followed up with participants to assess bleeding events both in and outside of the hospital.

The results revealed no significant differences among the study groups in terms of the number of bleeding events, the number of red blood cell transfusions, or the number of platelet transfusions patients required during the treatment period and for up to 14 days afterward. Patients receiving tranexamic acid had a significantly higher rate of occlusions in their central venous line (a catheter placed in a large vein commonly used for delivering cancer drugs) which required clearing with a clot-dissolving drug, but there was no difference in the occurrence of clots in patients' veins or arteries.

Dr. Gernsheimer noted that other studies could help elucidate whether the drug may be helpful for specific subgroups of patients with blood cancers or as a treatment for bleeding, rather than as a preventive measure in these patients. It may also be useful to prevent or treat bleeding in patients with other causes of low platelet counts.

Terry B. Gernsheimer, MD, University of Washington School of Medicine, will present this study in a plenary presentation on Sunday, December 6, 2020 at 7:00 a.m. Pacific time on the ASH annual meeting virtual platform.

Researchers Report First Successful Second-Line Treatment for Chronic Graft-Versus-Host Disease77: Ruxolitinib (RUX) Vs Best Available Therapy (BAT) in Patients with Steroid- Refractory/Steroid-Dependent Chronic Graft-Vs-Host Disease (cGVHD): Primary Findings from the Phase 3, Randomized REACH3 Study

The drug ruxolitinib brought relief from the debilitating effects of chronic graft-versus-host disease (GVHD) at twice the rate of the best available therapy in a phase III trial. The findings represent a major step forward for patients with chronic GVHD that is not resolved by taking corticosteroids, said researchers. There is currently no approved second-line therapy for chronic forms of the disease.

"This is the first multicenter randomized controlled trial for chronic, steroid-refractory or steroid-dependent GVHD that is positive," said senior study authorRobert Zeiser, PhD,of University Medical Center, Freiburg Im Breisgau, Germany. "It shows a significant advantage for ruxolitinib. It is likely that this trial will lead to approval for this indication and change the guidelines for the treatment of this disease."

GVHD is a complication of allogeneic hematopoietic (stem) cell transplantation, a therapy used to treat blood cancers. It occurs when T cells (the graft) received from a donor through the transplant see the patient's healthy cells and tissue (the host) as foreign and start to attack them. Roughly half of patients undergoing a stem cell transplant develop GVHD. About half of these patients are able to resolve their symptoms with a temporary course of corticosteroids, a class of drugs that lower inflammation in the body. The remaining patients either do not respond to steroids, cannot take them, or must take them continuously to stave off symptoms.

Ruxolitinib is designed to block a molecular signal involved in triggering inflammation. A previous trial, REACH2, found that ruxolitinib offered benefits for patients with acute GVHD, a severe form of GVHD with a mortality rate of 80%. The new trial, REACH3, aimed to determine whether the drug could bring similar benefits for the much larger number of patients affected by chronic GVHD. While chronic GVHD is not nearly as deadly as acute GVHD, its symptoms, which include weight loss, skin stiffness, and multiple disabilities, can severely and permanently affect patients' quality of life.

Researchers enrolled 329 patients with moderate-to-severe chronic GVHD. Half were randomly assigned to receive ruxolitinib for six 28-day cycles. The other half received one of nine alternative treatments, representing the best available therapy, at the discretion of their physician. At the end of the six treatment cycles, researchers assessed symptoms of 125 patients who had completed the full course of treatment to which they were assigned.

The trial met its primary endpoint, showing a clear and substantial improvement in the overall response to treatment among patients taking ruxolitinib. Of the 125 patients assessed, 50% of those receiving ruxolitinib had at least some reduction in symptoms, compared to only 25% among those receiving best available therapy. Seven percent of those taking ruxolitinib saw their symptoms resolve completely, compared to only 3% among those receiving best available therapy.

Participants in both arms of the study experienced similar rates of adverse events, which aligned with the health challenges commonly faced by patients with chronic GVHD, suggesting ruxolitinib has an acceptable safety profile in these patients, according to Dr. Zeiser.

Robert Zeiser, PhD, University Medical Center, Freiburg Im Breisgau, Germany, will present this study in an oral presentation on Saturday, December 5, at 8:00 a.m. Pacific time on the ASH annual meeting virtual platform.

Curative Transplant Improves Survival for Older Adults with Myelodysplastic Syndrome75: A Multi-Center Biologic Assignment Trial Comparing Reduced Intensity Allogeneic Hematopoietic Cell Transplantation to Hypomethylating Therapy or Best Supportive Care in Patients Aged 50-75 with Advanced Myelodysplastic Syndrome: Blood and Marrow Transplant Clinical Trials Network Study 1102

Allogeneic hematopoietic cell transplantation nearly doubled the rate of survival among patients 50 to 75 years old with myelodysplastic syndrome (MDS) in a trial conducted by the Blood and Marrow Transplant Clinical Trials Network. Despite being the only known cure for MDS, this therapy is typically only offered to younger patients because its benefits for older adults have not previously been proven. Researchers say the study offers the most definitive evidence to date that this type of stem cell transplantation significantly improves the outlook for older adults who would otherwise face a high likelihood of dying.

"Transplantation has been underutilized, historically, in this patient group," said senior study author Corey Cutler, MD, MPH,of Dana-Farber Cancer Institute. "Based on our findings, all patients should at least be referred to a transplant center so that those who are eligible and who have a suitable donor can undergo transplant and have better survival. It is important to refer these patients early so that the transplant center can work on finding an optimal donor right from the get-go."

Allogeneic hematopoietic (stem) cell transplantation is a process to replace a recipient's stem cells and immune system with cells from a healthy donor. It is the only known method to cure patients with MDS. The Centers for Medicare and Medicaid Services (CMS) covers transplantation for MDS as part of a Coverage with Evidence Development program. CMS approved the design of the trial and is expected to consider the findings when determining future payment policies.

Researchers from the Blood and Marrow Transplant Clinical Trials Network enrolled 384 patients treated for MDS at 34 U.S. medical centers. Patients were referred to transplant centers, which searched for suitable stem cell donors. The 260 patients who were matched with a donor within 90 days were assigned to receive a stem cell transplant; the other 124 patients with no suitable donor received standard supportive care. Participants were followed for roughly three years from their date of enrollment.

Overall survival was much higher in patients assigned to receive a stem cell transplant (47.9%) compared to those who were not (26.6%) at three years from treatment assignment. Leukemia-free survival was also higher in those assigned to receive a transplant (35.8%) than those who were not (20.6%). The researchers observed no significant differences among subgroups and no differences in quality of life between the two study arms.

Dr. Cutler noted that starting the transplantation process as early as possible can increase a patient's chance of finding a suitable donor and successfully proceeding with a transplant.

This study was co-funded by the National, Heart, Lung and Blood Institute (NHLBI) and the National Cancer Institute (NCI), both part of the National Institutes of Health.

Corey Cutler, MD, MPH, Dana-Farber Cancer Institute, will present this study in an oral presentation on Saturday, December 5, at 7:30 a.m. Pacific time on the ASH annual meeting virtual platform.

Additional press briefings will take place throughout the meeting on health disparities, genome editing and cellular therapy, COVID-19, and late-breaking abstracts. For the complete annual meeting program and abstracts, visit http://www.hematology.org/annual-meeting. Follow ASH and #ASH20 on Twitter, Instagram, LinkedIn, and Facebook for the most up-to-date information about the 2020 ASH Annual Meeting.

The American Society of Hematology (ASH) (www.hematology.org) is the world's largest professional society of hematologists dedicated to furthering the understanding, diagnosis, treatment, and prevention of disorders affecting the blood. For more than 60 years, the Society has led the development of hematology as a discipline by promoting research, patient care, education, training, and advocacy in hematology. ASH publishes Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field, and Blood Advances (www.bloodadvances.org), an online, peer-reviewed open-access journal.

SOURCE American Society of Hematology

http://www.hematology.org

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Clinical Trials Offer Opportunities to Change Practice to Improve Prevention and Treatment of Blood Disorders - PRNewswire

Skin Stem Cells Comments Off on Clinical Trials Offer Opportunities to Change Practice to Improve Prevention and Treatment of Blood Disorders – PRNewswire | December 5th, 2020

Stem cells are biological cells which have the ability to distinguish into specialized cells, which are capable of cell division through mitosis. Amniotic fluid stem cells are a collective mixture of stem cells obtained from amniotic tissues and fluid. Amniotic fluid is clear, slightly yellowish liquid which surrounds the fetus during pregnancy and is discarded as medical waste during caesarean section deliveries. Amniotic fluid is a source of valuable biological material which includes stem cells which can be potentially used in cell therapy and regenerative therapies. Amniotic fluid stem cells can be developed into a different type of tissues such as cartilage, skin, cardiac nerves, bone, and muscles. Amniotic fluid stem cells are able to find the damaged joint caused by rheumatoid arthritis and differentiate tissues which are damaged. Medical conditions where no drug is able to lessen the symptoms and begin the healing process are the major target for amniotic fluid stem cell therapy. Amniotic fluid stem cells therapy is a solution to those patients who do not want to undergo surgery. Amniotic fluid has a high concentration of stem cells, cytokines, proteins and other important components. Amniotic fluid stem cell therapy is safe and effective treatment which contain growth factor helps to stimulate tissue growth, naturally reduce inflammation. Amniotic fluid also contains hyaluronic acid which acts as a lubricant and promotes cartilage growth.

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With increasing technological advancement in the healthcare, amniotic fluid stem cell therapy has more advantage over the other therapy. Amniotic fluid stem cell therapy eliminates the chances of surgery and organs are regenerated, without causing any damage. These are some of the factors driving the growth of amniotic fluid stem cell therapy market over the forecast period. Increasing prevalence of chronic diseases which can be treated with the amniotic fluid stem cell therapy propel the market growth for amniotic fluid stem cell therapy, globally. Increasing funding by the government in research and development of stem cell therapy may drive the amniotic fluid stem cell therapy market growth. But, high procedure cost, difficulties in collecting the amniotic fluid and lack of reimbursement policies hinder the growth of amniotic fluid stem cell therapy market.

The global amniotic fluid stem cell therapy market is segmented on basis of treatment, application, end user and geography:

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Rapid technological advancement in healthcare, and favorable results of the amniotic fluid stem cells therapy will increase the market for amniotic fluid stem cell therapy over the forecast period. Increasing public-private investment for stem cells in managing disease and improving healthcare infrastructure are expected to propel the growth of the amniotic fluid stem cell therapy market.

However, on the basis of geography, global Amniotic Fluid Stem Cell Therapy Market is segmented into six key regionsviz. North America, Latin America, Europe, Asia Pacific Excluding China, China and Middle East & Africa. North America captured the largest shares in global Amniotic Fluid Stem Cell Therapy Market and is projected to continue over the forecast period owing to technological advancement in the healthcare and growing awareness among the population towards the new research and development in the stem cell therapy. Europe is expected to account for the second largest revenue share in the amniotic fluid stem cell therapy market. The Asia Pacific is anticipated to have rapid growth in near future owing to increasing healthcare set up and improving healthcare expenditure. Latin America and the Middle East and Africa account for slow growth in the market of amniotic fluid stem cell therapy due to lack of medical facilities and technical knowledge.

Some of the key players operating in global amniotic fluid stem cell therapy market are Stem Shot, Provia Laboratories LLC, Thermo Fisher Scientific Inc. Mesoblast Ltd., Roslin Cells, Regeneus Ltd. etc. among others.

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The Amniotic Fluid Stem Cell Therapy Market to Cascade the Success Trove - The Haitian-Caribbean News Network

Skin Stem Cells Comments Off on The Amniotic Fluid Stem Cell Therapy Market to Cascade the Success Trove – The Haitian-Caribbean News Network | December 2nd, 2020

The globalAnti-Ageing Drugs marketreport offers a deep analysis of the global Anti-Ageing Drugs market. It demonstrates a brief summary of industry data and key nomenclature of the market. The report has highlights well-known performers from the global market together with their contribution to the market to determine their progress within the estimated time.

The most preeminent Anti-Ageing Drugs market players are Nu Skin, BIOTIME, INC., DermaFix, Unity Biotechnology, LORAL, Frequency Therapeutics, Elysium Health Inc., Nuritas, Calico, Revision Optics, Elysium, La Roche-Posay. The global Anti-Ageing Drugs research report covers recent improvements while predicting the growth of the main players along with their market shares.

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The report estimates the global Anti-Ageing Drugs market volume in the earlier years. It assesses the global Anti-Ageing Drugs market on the basis of returns [USD Million] and quantity [k MT]. The study emphasizes the main constraints and devices determining the market growth. It also determines the valuation of the global Anti-Ageing Drugs market for the predicted time. The report covers the growing movements along with the key opportunities for the development of the global Anti-Ageing Drugs market.

The global Anti-Ageing Drugs market research report covers the key product category and sections Serums and supplements, Antioxidants and enzymes, Stem cells and drugs as well as the sub-sections Skin and hair, Skeletal and muscles, Age-related disorders, Others of the global Anti-Ageing Drugs market. The complete classification of the Anti-Ageing Drugs market is available in the global report related to the analytics of the restraining and supporting factors of the market.

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The global Anti-Ageing Drugs market report evaluates the market development across foremost zonal sections. It is divided on the basis of topography as Europe, North America, Latin America, Asia Pacific, and Middle East & Africa. The report embraces the spirited circumstances obtainable in the global Anti-Ageing Drugs market.

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Global Anti-Ageing Drugs Industry Market Growth Graph To Demonstrate Inclination Towards Positive Axis By 2026 - The Courier

Skin Stem Cells Comments Off on Global Anti-Ageing Drugs Industry Market Growth Graph To Demonstrate Inclination Towards Positive Axis By 2026 – The Courier | December 2nd, 2020

Graft Versus Host Disease (GVHD) Epidemiology

According to the National Cancer Institute (NCI), Graft versus host disease (GVHD) is a disease caused when cells from a donated stem cell graft attack the normal tissues of the transplant patient. Symptoms include jaundice, skin rash or blisters, a dry mouth, or dry eyes. GVHD occurs when particular types of white blood cells (T cells) in the donated bone marrow or stem cells attack the host body cells because the donated cells (the graft) see the host cells as foreign and attack them.

GVHDhas two types Acute GVHDand Chronic GvHD. Acute GvHD is also known as fulminant GVHD and occurs usually in the initial 2-3 months after transplantation. Chronic GVHD occurs around 3-4 months after the transplantation has happened, and has more diverse complications. This type affects the liver, stomach, vagina, joints, lungs, gut, mouth and glands secreting mucus or saliva.

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DelveInsights Graft Versus Host Disease (GVHD) Epidemiology Forecast to 2030 report delivers an in-depth understanding of the disease, historical and forecasted Graft Versus Host Disease (GVHD) epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.The DelveInsight Graft Versus Host Disease (GVHD) epidemiology report gives a thorough understanding of the Graft Versus Host Disease (GVHD) disease symptoms and causes, along with the risk factors, diagnosis, pathophysiology associated with the disease, and. It also provides treatment algorithms and treatment guidelines for Graft Versus Host Disease (GVHD) in the US, Europe, and Japan. The report covers the detailed information of the Graft Versus Host Disease (GVHD) epidemiology scenario in seven major countries (US, EU5, and Japan).

Key Highlights Of The Report

As per a study by Elgaz S. et al., (2019), GVHDoccurs in 3050% of recipients and 14% of all patients suffer severe GVHDgrades 34. Chronic GVHDaffects 3070% of patients receiving allo-SCT.

As per a study by Jacobsohn and Vogelsang (n.d.) titled Acute graft versus host disease, in the United States, approximately 5,500 patients/year can develop acute GVHD and in 2003, the incidence of grade II-IV acute GVHD was roughly 3550%.

As per Orphanet, about 35%-50% of hematopoietic stem cell transplant (HSCT) recipients will develop acute Graft versus host disease (GVHD). And about 50% of patients with acute GVHD will eventually have manifestations of chronic GVHD.

Graft Versus Host Disease (GVHD) Epidemiology

Scope of the Report

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Table of Contents

*The table of contents is not exhaustive; will be provided in the final report

Related ReportsGraft versus host disease (GVHD)- Market Insight, Epidemiology and Market Forecast -2030DelveInsight s Graft versus host disease (GVHD) Market Insights, Epidemiology and Market Forecast 2030 report provides a detailed overview of the disease and in depth understanding of historical and forecasted epidemiology.

Graft versus host disease (GVHD) Pipeline Insights, 2020Graft versus host disease (GVHD) Pipeline Insight, 2020 report by DelveInsight outlays comprehensive insights of present clinical development scenario and growth prospects across the Graft versus host disease (GVHD) market.

About DelveInsightDelveInsight is a leading Business Consultant, and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing end to end comprehensive solutions to improve their performance.

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Graft Versus Host Disease (GVHD) Patient Population, Treatment Algorithm, Medical Practices And Epidemiology Forecast To 2030 - The Market Feed

Skin Stem Cells Comments Off on Graft Versus Host Disease (GVHD) Patient Population, Treatment Algorithm, Medical Practices And Epidemiology Forecast To 2030 – The Market Feed | December 2nd, 2020

Medical skin care products are used for beautifying or to address some other skin care problems. The cosmetic industry is booming and skin care forms a very huge part of this industry. The aesthetic appearance is so important that people spend a lot on skin care products and treatment. People being more technologically aware of the various new skin care products trending in the market. In addition to the aesthetic application, the medical skin care products are also used to address issues such as acne, pimples or scars.

Medical Skin Care Products Market: Drivers and Restraints

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

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Medical Skin Care Products Market: Segmentation

On the basis of product type the medical skin care products market can be segmented as:

On the basis of application, the medical skin care products market can be segment as:

On the basis of distribution channel, the medical skin care products market can be segment as:

Medical Skin Care Products Market: Overview

Medical skin care products are used to address basic skin problems ranging from acne to scars. There are various advancements in the ingredients used to offer skin care products to the consumers. For instance, the use of hyaluronic acid and retinoids is the latest development in the industry. The anti-aging creams are at the forefront as the help treating issues such as wrinkles, scars, acne, and sun damage. Another, product in demand is the probiotic skincare which include lactobacillus and bifidobacterium.

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Medical Skin Care Products Market: Region-wise Outlook

In terms of geography, medical skin care products market has been divided into five regions including North- America, Asia- Pacific, Middle-East & Africa, Latin America and Europe. North America dominated the global medical skin care products market as international players are acquiring domestic companies to make their hold strong in the U.S. LOral is accelerating its U.S. market by signing a definitive agreement with Valeant Pharmaceuticals International Inc. to acquire CeraVe, AcneFree and Ambi skin-care brands for US$ 1.3 billion. The acquisition is expected LOreal to get hold of the brands in the price-accessible segment. Asia Pacific is expected to be the fastest growing region owing to the increasing disposable income and rising awareness towards the skin care products.

Medical Skin Care Products Market: Key Market Participants

Some of the medical skin care products market participants are Avon Products Inc., Beiersdorf AG, Colgate-Palmolive Company, Kao Corporation, LOral S.A., Procter & Gamble, Shiseido Company, The Estee Lauder Companies Inc., Unilever PLC, Revlon, Clinique Laboratories, llc., Murad, LLC., SkinCeuticals, RMS Beauty, J.R. Watkins and 100% PURE.

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The end-use Industries to Help the Medical Skin Care Products Market stand in a good stead between 2017 and 2025 - Cheshire Media

Skin Stem Cells Comments Off on The end-use Industries to Help the Medical Skin Care Products Market stand in a good stead between 2017 and 2025 – Cheshire Media | November 30th, 2020

By Mark Philips.

New York - November 30th, 2020 - To put it simply, it concerns nanotechnological research, its adaptation and then application in cosmetology. Nanoasia, under the management of Kira Sorokina, was one of the first international companies to work in this field when it started more than five years ago. Nanoasia is a brand of exclusive cosmetics for use in salons and at home, which was the first to test and bring airbrush non-injection anti-ageing products to the market.

The secret lies in tiny nano particles, each around 4 nanometers in length (and so therefore smaller than the diameter of even the driest skin pores). This means that the active components can penetrate deeper into the skin without needing to use an injection, mentioned Kira Sorokina. The product contains peptides, biosynthesized from plants, amino acids (proteins) and plant extracts of the highest quality. It is important to note that Nanoasias ingredients are all able to serve their complex individual function due to the balanced recipe, which ensures that every ingredient compliments and enhances the others. This is why just a handful of components can come together to provide an integrated product that solves all of the most common issues, she added. Despite Nanoasia being produced in South Korea, using their technologies, all of the formulas are adapted to the needs of European skin types. The device and cosmetic products, developed and produced by Nanoasia, are designed to work with the skin, skin cells and facial muscles.

Now lets take a closer look at Nanoasias innovative components and how they work!

Nanoasias serums (which are currently produced in three distinct varieties) represent the new generation of non-injection bio-revitalizers. These unique plant-based nanocomplexes contain a high concentration of nano-peptides, amino acids and plant extracts. They target all of a skins age-related changes, penetrating directly into the dermis and working instantly from the first application! They can correct the faces oval shape, tightening the cheeks and restoring their elasticity. They iron out any smile lines and baggy skin under the eyes, whilst also helping lose any facial fat (by improving blood circulation and lymphatic drainage). They nourish and rejuvenate the skin at a cellular level. They help to lighten up any pigment stains and bleaching. They help to prevent muscular spasms, preserving your natural facial expressions, reducing puffiness and dark circles under the eyes. They restore the cellular structure of collagen fibers, preventing the sebaceous glands from becoming overactive. They enhance cell regeneration, removing any pigment stains and rebuilding the structure of the dermis.

Nanoasia has developed a unique device to allow these special serums to penetrate deep into the skin. Simply put, it is a portable compressor, suitable for use at a salon or, indeed, at home. Thanks to the products low-molecular composition and the tiny dimensions of the particles, non-injection mesotherapy using Nanoasias serums easily gets into the deeper layers of the skin, helped by the compressed air brush. The procedure of applying the product to the skin with a strong jet of air is as painless as can be.

Besides the serums, Nanoasia also produces many incredible products which work on both the dermis and the facial muscles. Our mousse, enzyme exfoliating roll and the serum effectively clean and maintain the skin thanks to their Air Bubbles technology. This is the ideal base care for everyone - deep and delicate cleansing, intense moisturization, nourishment and stimulation to help the skin become rejuvenated and regenerated. This all comes from the high concentration of peptides, amino acids and plant extracts.

The product containing nanoneedles (cream + serum) has a comprehensive effect: it lifts and rejuvenates the skin, eliminating wrinkles and pigmentation, improving skin tone and elasticity. It provides nutrition and protection to the skin, thanks to the inclusion of plant extracts, amino acids and the self-soluble nanoneedles (compounds derived from seaweed which ensure that the nutritional components can penetrate as far as possible into the skin).

Nanoasias creams have a unique formula. The My Che duet (cream for the skin around your eyes and face), our EVA body cream and VS - our air-cushioning cream - are all the first of their kind in the world. They contain a high concentration of amino acids (the building blocks of our very organisms), peptides and plant stem cell extracts from a 100 year old ginseng plant and a 1000 year old yew tree. The formulas of these products guarantee rejuvenation, recovery and care from within, at a cellular level, giving you a powerful lifting effect, nourishment, protection and ironing out any wrinkles, pigments and much more. Air Cushion is also SPF 50+ and contains UV protection thanks to its intelligent fluid formula and nano-particle technologies. This ensures the ideal coverage for every day, without clogging or overwhelming the pores. It is a light foundation with an almost weightless texture and is compatible with any skin color when heated.

Their products pay special attention to your facial muscles. Their mask contains 45 active components including peptides, extracts from gem stones and plants. The mask stimulates isometric pressures within the skin. The muscles pulsate against this pressure with the uniform pressure acting like yoga for the face. The muscles then become toned and stronger. Facial and dermal muscles are smoothed out, skin elasticity is restored, the youthful oval shape of one's face returns and double chins are removed. Our Nanolifting system for Youthful Skin is a revolutionary lifting mask forone's facial muscles and dermis, containing powerful antioxidant and antiseptic components. The mask contains the highly-prized components of Astragalus root extract, Trehalose, 9 different peptides and 12 plant extracts which combine to achieve the following: they slow down the ageing process of cells; kickstart the extracellular matrix; regulate the tension of the vascular wall (Rosacea) and stimulate the restoration of the structural elements of the dermis - collagen, elastin, fibronectin and glycosaminoglycans.

Besides its exterior care potential, Nanoasia also looks after the skin from within. To achieve this they have developed unique products, including a bio-active additive (Nanodessert Nutritional) and a youthful elixir (Nanocell Youth Elixir).

Nanoasia holds three patents for cutting-edge research in cosmetology, as well as having a few further patents pending approval. The company has not only won praise in Russia, CIS countries and Europe, but also made it to Canada and Panama, and it is expected to open a branch in the United States soon expressed Kira; today, Nanoasia has 60 representatives in 28 cities and 8 countries. Our brands mission is to give every woman the opportunity to hold onto her natural beauty for as long as possible.

Media ContactCompany Name: Prysma MediaContact Person: Mark PhilippsEmail: Send EmailCountry: United StatesWebsite: https://nanoasia.ru/

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What exactly is the revolutionary Smart Beauty Technology, and how Kira Sorokina, the Founder of NanoAsia leads it - Press Release - Digital Journal

Skin Stem Cells Comments Off on What exactly is the revolutionary Smart Beauty Technology, and how Kira Sorokina, the Founder of NanoAsia leads it – Press Release – Digital Journal | November 30th, 2020

Chronic inflammation in the body is linked to cancer, heart disease, diabetes and more, and recently, scientists have discovered that inflammation is also one of the main culprits of skin aging.But what causes it and how do we stop it from getting worse? Weve got the answers below.

Why Inflammation OccursAccording to San Diego, CA dermatologist Zenovia Gabriel, MD, in the body, inflammation stems from an increase in oxygen free radicals that subsequently lead to a cascade of downstream cellular effects. The toxic oxygen radicals trigger inflammatory signals that lead to a host of negative cellular responses, she explains. Skin inflammation is a result of the immune systems response to stimuli or triggers, serving as a defense mechanism to protect your body against injury, infection or cancer.

There are two types of skin inflammation: acute and chronic. Acute inflammation is your bodys immediate response to a physiological insult such as an infection, trauma, stressanything that disrupts your immune system, says Dr. Zenovia. The body expresses inflammation by tissue swelling, warmth, pain or redness, as well as systemic symptoms like fever, aches and fatigue.

Acute inflammatory symptoms generally minimize after several days and eventually normalize, but chronic inflammation implies a longstanding issue that Dr. Zenovia says is often caused by underlying conditions such as autoimmune disorders or chronic infections. Chronic inflammation can be worsened by environmental stressors or unhealthy lifestyle habits, she adds. As we age, our bodies become less efficient at managing the inflammatory response. In addition, chronic low-grade inflammation is common as we age because our bodies and cells are less efficient at regulating this process.

Our diets play a role, too: High blood sugar and poor diet can result in a process called glycation. This leads to protein malfunction in the cells, causing a disruption to normal function, says Dr. Zenovia. In effect, if your body is inflamed and cant handle the level of inflammation, then there are consequences at the cellular and then tissue levelsthis is what we see and feel. We see the cellular disruption manifested on our skin. And these symptoms, such as sagging, wrinkles and brown spots, are all manifestation of cellular disruption and inflammation.

How It Impacts Our SkinThe process is coined inflamm-aging because inflammation ages us, says Dr. Zenovia. Acute inflammation can manifest on the skin as a rashsmooth or scalyredness or warmth in the affected area. Mild low-grade chronic inflammation, such as rosacea or undetectable sun damage often causes skin dryness, dullness, uneven tone, texture, loss of elasticity, or fine lines and wrinkles.Therefore, antioxidants and other actives that specifically target inflammation in the skin are a new frontier for anti-aging. Its not just moisturizers, retinols and hydroxy acidswe need anti-inflammatory support for our skin too.

That undetectable sun damage plays a significant role in the inflammation process. Inflammation is thought to be one of the main causes of skin aging, and the constant exposure to UV radiation from the sun can cause inflammation and DNA damage in the skin, leading to fine lines, wrinkles and spots, says Fort Lauderdale, FL dermatologist Dr. Matthew J. Elias.The single most important product we recommend for skin aging is sunscreen, and while any sunscreen will help protect skin from the untoward effects of chronic UV exposure, the only sunscreen that can actually repair the DNA damage done by the sun is ISDIN Eryfotona Actinica, which actually contains DNA repairsomes that can repair the damage caused by the sun and lessen inflammation.

Dr. Zenovia says an inflammatory cascade can also cause the body to produce more hyaluronidase, the enzyme responsible for breaking down hyaluronic acid (HA), which is critical to skin thickness and health. Fibroblastscollagen-producing cellsare also affected by inflammation, and can become damaged and produce less collagen, she explains. This causes skin to lose its firmness and elasticity.

How to Minimize the EffectsThe first brand to put inflamm-aging skin care on the map, Heraux created a patented molecule called HX-1 that gently exfoliates the skin while helping to prevent inflammation, which is the key ingredient in its Molecular Anti-Inflammaging Serum. HX-1 works directly on skin stem cells to support their peak performance and shield them from stressors that can promote irritation, says Ben Van Handel, PhD, cofounder of Heraux and stem cell biologist at the University of Southern California. Clinical studies of HX-1 have shown significant improvements occurringin the first four weeks without any skin irritation. Daily use of the serum will enable youthful function of skin stem cells longer, increasing the health span of the skin.

Dr. Amir Nobakht, cofounder of Heraux, says its an alternative to retinol without the potential side effects. Retinols historically have had good results but also cause irritation, redness and sun sensitivity, making them unusable for many people. HX-1 on the other hand can accomplish the same goals of a retinol without the harsh side effects. Even those with sensitive skin or who are prone to sunburns can get results without worrying.

One of Dr. Zenovias bestsellers in her Essentials line, Inflam-Aging Night Repair Treatment specifically targets inflammation and is clinically formulated to combat key signs of aging. Everyone could benefit from this product: acne, aging, young and old, she says. This powerhouse night repair treatment features a highly potent triple antioxidant blend of green tea polyphenols, medical-grade resveratrol and caffeine to help reduce inflammation while reducing the appearance of fine lines and wrinkles, and enhancing the look of firm, plump, even-toned skin. Sleep is also really important. Its one of the most restorative things we can do for our bodies and our skin. It decreases stress, lowers inflammation and regenerates our cells.

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Detroit Lions senior VP of business development Kelly Kozole works with her daughter, Morgan, who has a rare neurological disorder called beta-propeller protein-associated neurodegeneration, or BPAN.Michael Rothstein

TROY, Mich. -- Wearing a white T-shirt with a massive star in sparkling shades of pink, yellow and seafoam green on the front, Morgan Kozole sits in front of a fold-up chalkboard in the living room of her family's Detroit-area home and starts to draw.

Using pink and yellow chalk, she sketches Mickey and Minnie Mouse. The Disney characters are dominant fixtures in the 5-year-old's life and therefore become a soundtrack for the Kozole family: Morgan constantly saying "Mickey," with her long, blond ponytail bouncing to whatever song happens to be playing on the Mickey Mouse Club.

"These are the two Mickeys," Morgan says, pointing to the chalkboard. Her mother, Detroit Lions senior vice president of business development Kelly Kozole, explains that this is her way of communicating that she would like a visitor to draw Mickey too. If it's close, Morgan accepts it. Another Mickey to fawn over.

For Morgan's birthday earlier this year, the family went to Disney World. On this trip, the Kozoles saw what they had longed for: the potential of progress.

"She knew where we were. She knew Mickey Mouse," Kelly said. "Before, she wouldn't go to the characters, and now she's jumping up and down, hugging. She really, along those lines, is also really into birthdays.

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"The 'Happy Birthday' song. Before that, she was just kind of looking. Sometimes it was too much for her with everyone singing -- sometimes loud noises are too much. This year, we had to sing 'Happy Birthday' to her three times."

Birthdays, for children, are happy occasions -- reasons for grand celebrations of progress toward adulthood. For the rest of Morgan's family it is more complicated.

Morgan has a rare neurological disease called beta-propeller protein-associated neurodegeneration, known as BPAN. It's a disorder, more prevalent in girls than boys, that causes delayed development and seizures, communication issues and, sometimes, motor dysfunction. It's unclear exactly how many people are living with BPAN worldwide due to its rarity, although Dr. Sami Barmada, a scientist at the University of Michigan studying BPAN, estimates roughly 500 to 600 people.

It's rare enough that Dr. Henry Paulson, the director of the Michigan Alzheimer's Disease Center, said there are experts in neurodegeneration who are unfamiliar with BPAN. While Kelly is trying to advocate for her daughter and others with BPAN through fundraising for research, science moves only so fast.

The Kozoles understand that. So birthdays for the family aren't always happy. They are a reminder of what could come.

"That ticking time clock," Kelly said. "Every birthday isn't exciting for me for her. Because it's one year closer to when this bomb is going to go off."

BPAN's rarity makes the reality heartbreakingly simple: There are very few effective treatments, little research and no cure. As Morgan learns how to organize her Peppa Pig characters and learns new words on her iPad -- her future looms.

At some unpredictable point in Morgan's teen and adult years -- the average is around age 25, according to Barmada -- development will just stop. Progress will decline and, in some cases, disappear. Those afflicted with BPAN begin suffering from progressive dystonia parkinsonism -- making it difficult to walk, talk or stand.

"Any day," Kelly said, "it could be like, 'Oh, your daughter's gone.'"

WHEN MORGAN WAS born on Jan. 12, 2015, she was, largely, a healthy baby. She was a little jaundiced but nothing worrisome.

When she would go to the doctor's office for shots, Morgan didn't cry. It was a little abnormal, but when you're a parent of a young child, no crying is viewed as a minor miracle. Kelly and her husband, Kevin, took this as a sign of a tough kid. Nurses even said how great it was.

Looking back, it was a warning sign that something was wrong. BPAN causes a high pain tolerance. Before long, more concerns popped up. Morgan wasn't crawling at nine months, wasn't walking at a year. Expected milestones passed without Morgan reaching them. Kevin and Kelly put her in therapy in late 2016 to work up to these childhood progressive traits and began researching potential causes. They wouldn't find an answer for more than two years.

"She was diagnosed with cerebral palsy at first. One doctor diagnosed her with that, and then another, our neurologist, said she doesn't have that," Kelly said. "Then there was speculation but not a full diagnosis she had autism, so we did all the tests for that.

"So through this kind of journey of trying to find out what was wrong, it was exciting that she didn't have something that you were going to this test for, but you still had so many more questions as you were eliminating all these potential diseases that she could have."

Befuddled, they began genetic testing and in November 2018 received a letter about a mutation on Morgan's WDR45 gene. Kelly Googled it, stumbled upon BPAN and freaked out, calling their neurologist. The neurologist told Kelly not to worry -- BPAN was very rare, and Morgan didn't have it.

Doctors diagnosed her with epilepsy because of seizures. Morgan took Keppra, which helped accelerate her vocabulary to about 50 words, typical for a 1-year-old, when she was 3. Then doctors said no, it wasn't epilepsy either.

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Another meeting with another neurologist led to a different diagnosis. Three days after she and Kevin returned to Michigan from Super Bowl LIII in February 2019, they received a call. Doctors figured out what was wrong.

It was BPAN.

"In my mind, it's worse than cancer," Kelly said. "How is this even possible? That this can even be so painful for kids later on in life. You try so hard to gain all these abilities, and then early adolescence or early adulthood, it's just [gone] one day, and I've seen a lot of these stories.

"There's a BPAN Facebook website, and that's where the doctors sent us. There's no cure. There's no therapy. 'Go to this website.' That's what I was told."

FOR MONTHS KELLY cried, angry and heartbroken. The Kozoles initially told their families and no one else.

In May 2019, Kelly went to her first Neurodegeneration with Brain Iron Accumulation (NBIA) conference. She met other parents, heard their stories and began the new normal.

She used her skills -- organization, fundraising and business -- to brainstorm ways to help. Hardly anyone had researched BPAN. Without it, there would be no chance for a cure -- not in Morgan's lifetime, which could reach her 40s, and not in the lifetime of those who might come after.

She shared what was happening with her boss, Detroit Lions president Rod Wood, and his wife, Susan, using a website link to explain BPAN. Wood knew something was wrong because of texts and emails saying they had to take Morgan to this specialist or that appointment.

"As that was confirmed and became her reality, she is now able to talk about it, in a way," Wood said. "Because she's full bore on trying to help generate awareness and financial resources to find a cure for it.

"She went from the unknown to the very tragic known to, 'OK, what are we going to do about it?'"

Kelly consulted her aunts, both of whom worked in medicine. Linda Narhi worked in biotechnology for Amgen for more than 30 years; Dr. Diane Narhi was the first female chief of staff at Simi Valley (California) Hospital. From talking with another group of fundraising BPAN parents -- BPAN Warriors -- Kelly found a guide.

If her aunts had not been resources, she might have joined BPAN Warriors. But Kelly admittedly needs to be in control, and this was her daughter. She needed to manage this herself. She created a nonprofit called Don't Forget Morgan.

Kelly's aunts provided guidance, and Wood offered contacts he had in the finance industry and Silicon Valley. Wood and Lions general counsel Jay Colvin sit on the board. Other Lions coworkers -- with Wood's blessing -- built the website, designed the logo and created social media plans and the first pitch video for Don't Forget Morgan's rollout in 2020.

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Progress started with a $15,000 grant to help with a mouse model study at Sanford Research in South Dakota, with another, larger, potential grant to come. In recent months, Kelly has focused largely on fundraising, and another parent of a child with BPAN, Christina Mascarenhas Ftikas, has focused on the medical side of the nonprofit.

"This is why I'm here," Kelly said. "I'm supposed to be a vehicle to get all of this awareness and hopefully a cure for BPAN so the child one, two, three, five years from now, there is hope.

"There is no, 'Go to Facebook.' There is something where you can actually give a parent, 'Here's the symptoms to look for.'"

ABOUT AN HOUR away in Ann Arbor, Michigan, Kaci Kegler and her husband, Brian, had been in the same Facebook community. Kelly, new to the group and looking for a nearby connection, wrote Kaci a message.

"Hey, my daughter was just diagnosed, could we connect?"

Kaci understood. She did the same thing, reaching out without success in 2016 after her daughter, Elle, was diagnosed. Kaci wanted to be a resource.

They talked for an hour. There wasn't much Kaci could say to soothe her. Kelly pinged a year later with another message: I'm starting a nonprofit. Kaci offered to help.Despite suffering from BPAN, Morgan is like any other 5-year-old who enjoys playing with her brother, Connor.Michael Rothstein

Days later, on Feb. 28, Kaci and her husband, Brian, an assistant athletic director for development at the University of Michigan, had their yearly fundraiser for BPAN research on Rare Disease Day at Pizza House in Ann Arbor. They met a doctor who had a connection to researchers at Michigan.

"I literally came home and texted [Kelly] and was like, 'Oh my gosh, we may have inroads,'" Kaci said. "We just started texting. I have never met Kelly face-to-face. We still haven't. But we've texted a lot and we've emailed quite a bit.

"It just kind of started."

By summer, they went from nothing to putting pieces in place for a full-fledged research project with a two-year, $140,000 grant for Barmada and Dr. Jason Chua to help start to solve BPAN.

Chua was working on the regulation of autophagy, which is the cleaning out of damaged cells, and studying BPAN became a natural extension of the work he had already been putting in. BPAN alters that in neurons. Barmada said Chua's research provided a "rare win-win situation" to potentially help with BPAN and other diseases too.

"There are a set of questions in BPAN that nobody has the answer to," Barmada said. "And Jason and myself, we just seem to be in the right position, the right place to be able to help out."

The goal is to understand what is happening within BPAN itself and how people end up with it, while also trying to find therapies for existing patients. Within a year, they are hoping to grow stem cells from people with BPAN in their lab, allowing for the creation of their own stem cells missing the WDR45 gene. Then they will try to either replace the gene or "stimulate autophagy through genetic or pharmacologic means," Barmada said. The hope is this can prevent neurodegeneration.

So far, they've hired a research assistant to work with Chua, developed tools to manipulate the gene using the genome-editing tool CRISPR and applied for approval from Michigan and the institutional review board to get skin biopsies to obtain stem cells from BPAN patients.

It's a process, but it's also a start.

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After partnering with Michigan and Sanford, Don't Forget Morgan also began working with Dr. Kathrin Meyer, a researcher at the Center for Gene Therapy at Nationwide Children's Hospital at Ohio State.

"Solving this disease is going to require more than Jason and Sami," Paulson said. "It's going to be a first shot across the bow, but it's going to require more than that. I'll say this, being in the field for a long time. Scientists who are coming up the pike say they want to look at Alzheimer's, want to look at epilepsy. They don't say, 'I want to look at a rare disease.'

"The only way to solve a rare disease is to get someone hooked. Sometimes when you hook a really good one, as I think we have with Jason here, you hook them for life and they make a difference."

MORGAN IS BOUNCING around the Kozoles' suburban Detroit home on this late August day. They just returned from northern Michigan, and having two kids, especially one with special needs, makes tidiness unrealistic.

COVID-19 changed things. Morgan hadn't been to many of her therapies for months. Online school barely kept her attention. There was concern she would have regression in her learning. Instead, her speech advanced by being around Kelly, Kevin and her older brother, Connor, all day. She has sung more songs recently to help increase her vocabulary. Sometimes, she'll listen 20 times in a row.

"Even more than that," Connor said. They aren't sure how much she's truly learning versus memorization. But it is something.Morgan Kozole has inspired her mother, Detroit Lions VP Kelly Kozole, to marshal researchers and other advocates to develop a cure for BPAN, and perhaps help future generations of children who live with the disorder.Michael Rothstein

The family gathers inside Morgan's bedroom -- complete with a special Haven Bed with a zipper to keep her safe from wandering around at night, when she could accidentally turn on the stove and hurt herself or others -- sleep disorders are another BPAN issue. She sits on the floor and starts playing with her small, yellow dollhouse and a fake ice-cream maker. Kelly asks for an ice cream. Morgan makes one for herself instead and pretends to eat it.

Later, outside, Morgan kicks a soccer ball and plays a modified game of catch with a squishy football. Football, no surprise, is big. She says "hike" a lot. "She knows that term," Kevin says, laughing.

In these moments, Morgan seems like any other young child. She attends St. Hugo of the Hills Parish School in Bloomfield Hills, Michigan, but has a one-on-one para nanny to help. She interacts with people, often overly affectionate.

Sitting at the kitchen table after playtime outside, she plays with Starfall, a children's learning app, on her iPad. They hope it accelerates her word recognition. Morgan is entranced watching "Farmer in the Dell" and using her hands to eat orange slices and Cheerios. She needs a mirror in front of her to provide her a target for her mouth. She listens to books, another way to try absorbing information.

Morgan can now count to 20 and say three sentences in a row. Kelly and Kevin have tried to give Morgan a normal life in an abnormal situation, but they worry about the future -- what she won't have and won't be able to experience.

But Morgan has changed some of that outlook too.

"Focus on how she is so loving and has so much pure joy. A lot of parents of special needs [kids] say you can learn so much from these kids, and you really can," Kelly said. "She is, every morning, just so happy, and 'Mama!' Hugs and kisses to strangers. She has none of those behaviors you learn as an adult where you're not kind to people or you don't want to talk to someone.

"She is just open arms, will give you a hug and is so loving, and it's like, 'Wow, this is really what life is about.'"

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'This is why I'm here': A Detroit Lions VP tries to save her daughter from rare disease - ESPN

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Want to go back in time and look younger? Thats possible now. Yes, you read that right. In a path-breaking discovering, Israeli scientists have made reverse ageing possible. They have found a way to make you look up to 25 years younger. Also Read - Weight Lifting, Sleeping Face-Down And More: Here're 5 Lifestyle Habits That May be Ageing Your Skin

Researchers at Tel Aviv University and the Shamir Medical Centre have collaboratively conducted a study for which they enrolled 35 adults over 64. The subjects were given hyperbaric oxygen treatments (HBOT) 5 times a week for 90 minutes. This continued for three months. Later, the study results published in the journal Ageing showed that the use of this oxygen treatment shortened the ends of the chromosome (telomers) and reversed the accumulation of old body cells. Also Read - 3 Anti-Ageing Essential Oils That Can Offer You Youthful Skin

Notably, ageing depends upon sequences of DNA called telomeres. They are located at the ends of chromosomes and their function is to protect the genetic material contained within. These telomeres shorten and degrade every time a cell divides. This process keeps happening until they become so worn down that they can no longer function. This further results in an unstable or dead chromosome. Also Read - 5 Anti-Ageing Food Items You Must Include in Your Diet to Look Young

One of the study researchers named Professor Shai Efrati said, Today telomere shortening is considered the Holy Grail of the biology of ageing. Researchers around the world are trying to develop pharmacological and environmental interventions that enable telomere elongation. Our HBOT protocol was able to achieve this, proving that the ageing process can, in fact, be reversed at the basic cellular-molecular level.

Hyperbaric Oxygen Treatment (HBOT) is a type of therapy during which a patient is kept in a pressurized chamber where the level of oxygen is increased 3 to 4 times more than what you can breathe at normal air pressure. This aims at treating patients suffering from decompression sickness, brain abscess, severe anemia, who have developed air bubbles in their blood vessels, non-healing wounds, radiation injury, vision loss etc.

When your body gets extra oxygen, it releases growth factors and stem cells that are known to promote healing. In a normal scenario, the oxygen you get through the air is adequate for your body to perform different functions. However, when tissue in your body gets damaged or injured, it needs extra oxygen to survive. Through hyperbaric oxygen treatment, doctors temporarily increase the amount of blood your body is carrying and thus helps maintain the oxygen level in tissue to ensure its survival.

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Israeli Scientists Discover Oxygen Beauty Treatment That Can Make You Look 25 Years Younger - All You Need to - India.com

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It dawned on Eian Kantor on a Saturday in early April as he brewed a cup of tea from fresh mint leaves: he had lost his sense of smell. The tea suspiciously smelled of nothing at all. Kantor proceeded to rifle through the fridge, sniffing jars of pickles, chili sauce and garlicnothing.

Ever since New York State went into lockdownin late March,Kantor, age 30, and his girlfriend had stayed isolated in their Queens, N.Y., apartment. So he did not suspect he had COVID-19 despite running a slight fever that he chalked up to seasonal allergies. When he was finally able to get tested weeks into his loss of smell, or anosmia, he tested negative. But months later, he says, several tests showed that his antibodies to the novel coronavirus were off the charts high, which affirmed that I had had it.

An estimated 80 percent of people with COVID-19 have smell disturbances, and many also have dysgeusia or ageusia (a disruption or loss of taste, respectively) or changes in chemesthesis (the ability to sense chemical irritants such as hot chilies). Smell loss is so common in people with the disease that some researchers have recommended its use as adiagnostic testbecause it may be a more reliable marker than fever or other symptoms.

One lingering mystery is how the novel coronavirus robs its victims of these senses. Early in the pandemic, physicians and researchers worried that COVID-related anosmia might signal that the virus makes its way into the brain through the nose, where it could do severe and lasting damage. A suspected route would be via the olfactory neurons that sense odors in the air and transmit these signals to the brain. But studies have shown that this isprobably not the case, says Sandeep Robert Datta, a neuroscientist at Harvard Medical School. My gestalt read of the data to date suggests that the primary source of insult is actually in the nose, in the nasal epithelium, the skinlike layer of cells responsible for registering odors. It looks like the virus attacks, predominantly, support cells and stem cells and not neurons directly, Datta says. But that fact does not mean that neurons cannot be affected, he emphasizes.

Olfactory neurons do not have angiotensin-converting enzyme 2 (ACE2) receptors, which allow the virus entry to cells, on their surface. But sustentacular cells, which support olfactory neurons in important ways, are studded with the receptors. These cells maintain the delicate balance of salt ions in the mucus that neurons depend on to send signals to the brain. If that balance is disrupted, it could lead to a shutdown of neuronal signalingand therefore of smell.

The sustentacular cells also provide the metabolic and physical support needed to sustain the fingerlike cilia on the olfactory neurons where receptors that detect odors are concentrated. If you physically disrupt those cilia, you lose the ability to smell, Datta says.

In astudyinBrain, Behavior and Immunity, Nicolas Meunier, a neuroscientist at the Paris-Saclay University in France, infected the noses of golden Syrian hamsters with SARS-CoV-2. Just two days later, about half of the hamsters sustentacular cells were infected. But olfactory neurons were not infected even after two weeks. And strikingly, the olfactory epithelia were completely detached, which, Meunier says, resembled skin peeling after a sunburn. Although olfactory neurons were not infected, their cilia were entirely gone. If you remove the cilia, you remove the olfactory receptors and the ability to detect odorants, he says.

Disruption of the olfactory epithelium could explain the loss of smell. Yet it remains unclear whether the damage is done by the virus itself or invading immune cells, which Meunier observed after infection. Widespread reports of anosmia with COVID are not typical of other diseases caused by viruses. We think its very specific to SARS-CoV-2, Meunier says. In aprevious studywith other respiratory viruses at his lab, he foundsustentacular cells infected only rarely, whereas with SARS-CoV-2, about half of cells contained the pathogen. With other viruses, smell is usually compromised by a stuffed-up nose, but COVID doesnt usually cause nasal congestion. This is very different, Meunier says.

Researchers have found a few clues about the loss of smell, but they are less certain about how the virus causes a loss of taste. Taste receptor cells, which detect chemicals in the saliva and send signals to the brain,do not contain ACE2, so they probably do not get infected by SARS-CoV-2. But other support cells in the tongue carry the receptor, perhaps providing some indication of why taste goes away. (Although taste can seem to disappear with anosmia because odors are such a key component of flavor, many people with COVID truly develop ageusia and cannot detect even sweet or salty taste.)

The loss of chemical sensingthe burn of hot chilies or the refreshing sensation of mintalso remains unexplained and largely unexplored. These sensations are not tastes. Instead their detection is conveyed by pain-sensing nervessome of whichcontain ACE2throughout the body, including the mouth.

More clues to how the virus obliterates smell come from people recovering from anosmia. The majority of patients lose smell like a light switch going off and recover it rapidly, Datta says. Theres a fraction of patients that have much more persistent anosmia and recover on longer time scales. The olfactory epithelium regularly regenerates. Thats the bodys way of protecting against the constant onslaught of toxins in the environment, Meunier says.

Still, more than seven months after he first experienced anosmia, Kantor falls in the second group of patients: he has yet to detect any odors at all. Its hard because you dont realize how much you relate to smell until you lose it, he says. If the house were on fire, I wouldnt know it. Its very concerning. And then there is what anosmia does to the joy of eating. Foods that used to be good now taste meh, Kantor says.

Carol Yan, a rhinologist at the University of California, San Diego, says that anosmia poses a real health risk. It actually increases mortality. If you cant smell and taste food, it can predispose you to harm, like rotten food or a gas leak, she says. It can also cause social withdrawal or nutritional deficits.

The variation on sensory themes extends to another symptom called parosmia, a possible sign of recovery in people with long-lasting anosmia. Freya Sawbridge, a 27-year-old New Zealand woman, is such an individual. She got COVID-19 in March. After several weeks of anosmia and ageusia, when everything tasted of ice cubes and cardboard, she says, Sawbridge began to regain the most basic tastessweet, salty, sourbut no nuance of flavor, which comes from foods aromas. Chocolate tastes like sweet rubber, she says.

Then, after about five months, some odors returned but not as expected. For a while, all foods smelled of artificial strawberry flavor. But now everything smells hideous and distorted, Sawbridge says. Nothing is accurate, and the odors are all unpleasant. The smell of onions, she says, is unbearable, and a strange chemical flavor permeates everything. All my food tastes like it was sprayed with window cleaner, Sawbridge adds.

Parosmia may occur when newly grown stem cells that develop into neurons in the nose attempt to extend their long fibers, called axons, through tiny holes in the base of the skull and connect with a structure in the brain called the olfactory bulb. Sometimes axons connect to the wrong place, causing erratic smell, but the miswiring can potentially correct itself, given enough time.

That news is welcome for people such as Sawbridge. But the question she wants answered is: How long will her anosmia last? We dont know the final time course of recovery for those with anosmia, Yan says, but it is usually from six months to a year. With long-term postviral smell loss from the flu, after six months, there is a 30 to 50 percent chance of spontaneous recovery without any treatment, she adds. There have been case reports of recovery after two years. But after that, we think the regenerative capability may be hindered. And the chances of recovery are quite slim, unfortunately.

Kantor has tried every avenue imaginable to regain his sense of smell: a course of high-dose steroids to reduce inflammation; a smell-training program with essential oils; beta-carotene supplements for nerve regeneration; acupuncture. Nothing has made a difference. Yan recommends irrigation of the sinuses with budesonide, a topical steroid shown to improve outcomesin a Stanford Universitystudy of people with postflu smell loss for more than six months. Another promising treatment Yan and others areinvestigating is platelet-rich plasma, an anti-inflammatory concoction isolated from blood that has been used to treat some types of nerve damage. But with any treatment, Yan says, the results are not amazing. Its not like youll wake up and say, Wow, I can smell again. But if you can smell soap again or enjoy the taste of some foods, thats a big gain.

There is one final worrying note about anosmia: it has beenidentified as a risk factorfor some neurodegenerative diseases. After the flu pandemic of 1919, we saw an increase in the prevalence of Parkinsons disease, Meunier says. It would be really concerning if something similar were happening here.

But Yan thinks that fear is overblown. There is certainly a link between anosmia and diseases, but we think that viral-induced anosmia is [working by] a totally different mechanism, she says. Having postviral anosmia doesnt put you at higher risk for disease. These are two completely separate phenomena. That should reassure Sawbridge and Kantorand the millions of others worldwide affected with COVID-related smell loss.

Read more about the coronavirus outbreak fromScientific Americanhere. And read coverage from our international network of magazineshere.

This article was first published atScientificAmerican.com. ScientificAmerican.com. All rights reserved. Follow Scientific American on Twitter @SciAm and @SciamBlogs. VisitScientificAmerican.comfor the latest in science, health and technology news.

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Mysteries of COVID smell loss finally yield some answers - Livescience.com

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The new year is always a good time to 'reset' your life and implement new and improved health and fitness habits.

Maintaining new routines isnt easy, but here are four wellness retreats around the world that will help put the architecture in place that you need to live better.

Following the opening of Revivo in Bali in 2018, the brand will be launching a new wellness retreat in the Tarn region of France, in summer 2021.

Revivo Chteau de Fiac will take over a renovated castle on a three-hectare estate, and will feature 16 bedrooms, as well as a salt cave, a spa offering massages and hydrotherapy, bootcamp circuits, and the chance to eat freshly grown vegetables from the on-site garden.

Revivo is a proponent of teaching mind-body connectivity so always incorporates physical activity such as yoga with art classes and meditation, for example.

Also opening in spring/summer 2021, Qatars Zulal Wellness Resort will be the Middle Easts inaugural full-immersion wellness destination and the worlds first centre for traditional Arabic Islamic medicine.

Operated by wellness pioneer Chiva-Som, Zulal will have 120 rooms in a Family Wellness enclave, and 60 suites and villas in a separate zone for adults-only.

Just one hours drive away from Doha International airport, the extravagant hideaway will prescribe healing methods based on centuries of knowledge provided by Islamic medicinal historians and herbalists.

Situated in northern Goa, India, Kings Mansion will join Revivo and Zulal in making its debut in 2021.

Bringing together science and genomics with Ayurvedic medicine, the cutting-edge retreat will offer six wellbeing programmes, including areas such as:

Stays are a minimum of one week and both the Shodhana and Kshipra Shodhana detox programmes require a DNA test before arrival. These tests are to determine genetic pre-dispositions for certain health conditions, thereby allowing for highly personalised treatments.

Located on Lake Constance in southern Germany, Buchinger Wilhelmi is a hotel-clinic specialising in therapeutic fasting and integrative medicine.

In September it launched a new Immunity+ programme that is designed to boost wellbeing (with the specific aim of reducing the risk of getting Covid-19), and is bookable as a 110 add-on to its fasting packages.

After guests have been given a quick blood test on arrival to make sure they dont have Covid, they then get to relax in luxurious surroundings while embarking on a calorie-restricted regime (ten days costs 2,340 per person), which includes nurse checks, consultations with a doctor, daily activities, and a menu of freshly-made vegetable bouillon and pressed fruit juices.

Dr Francoise Wilhelmi de Toledo, scientific director at Buchinger Wilhelmi, explains, When you fast, all your digestive processes are in rest. Without needing the energy to digest, all stresses are diminished and you actually need less immunity.

"During this time, you change your microbiome. You stimulate the lungs, skin, kidneys, liver and the system itself triggers autophagy an extraordinary capacity of the body to eliminate damaged cellular structures. When you fast, you activate stem cells to rejuvenate immune cells.

Jenny Southan is editor and founder of travel trend forecasting agency Globetrender.

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Avrobio has shared data on the first Gaucher disease patient to receive its gene therapy AVR-RD-02. The patient, who was stable on enzyme replacement therapy at baseline, experienced a 22% drop in a toxic metabolite after receiving AVR-RD-02 and stopping taking the standard of care.

Gaucher, like the Fabry disease targeted by Avrobios lead prospect, is currently treated using enzyme replacement therapies sold by Sanofi and Takeda, which entered the market through its takeover of Shire. However, a significant minority of patients experience physical limitations despite treatment. Negative outcomes include bone pain and spleen enlargement. Johnson & Johnsons Zavesca offers an oral alternative, but there remain unmet medical needs.

Avrobio is developing AVR-RD-02 to address those needs. The data shared as part of Avrobios R&D day mark the start of the effort to show AVR-RD-02 performs as hoped in the clinic.

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The first patient to receive AVR-RD-02 discontinued enzyme replacement therapy one month before taking the gene therapy. Three months after receiving the gene therapy, levels of Gaucher biomarker lyso-Gb1 had fallen 22%. The patients level of plasma chitotriosidase, a biomarker of cells associated with severe organ damage, was down 17%. Hemoglobin and platelets were in the normal range.

AVR-RD-02 triggered those changes without causing serious adverse events. The data drop offers an early indication that Avrobio may be able to improve outcomes by harvesting hematopoietic stem cells, adding a gene that encodes for glucocerebrosidase and reinfusing the cells back into the same patient. With enzyme replacement therapies costing healthcare systems up to $400,000 a year per patient, there is scope for AVR-RD-02 to cut the cost of treating Gaucher disease.

Avrobio shared the early look at clinical data on AVR-RD-02 alongside updates about other assets. There is now more than three years of data on some Fabry patients treated with Avrobios lead asset, putting the company in a position to plot a path to accelerated approval. Avrobio plans to submit its briefing book to the FDA by the end of the year to align on an accelerated approval strategy.

The update also covered cystinosis candidate AVR-RD-04. The first patient to receive the candidate is off oral and eye drop cysteamine 12 months after receiving the gene therapy. The number of crystals in the patients skin are down 56%, leading Avrobio to posit they may have gained the ability to make their own functional cystinosin protein.

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Voters in California have approved Proposition 14, which will pump billions of dollars into the state's stem cell research program. The Associated Press called the vote on Thursday, with 51 percent of ballots for and 49 percent against.

The result will allow the state to borrow $5.5 billion from investors for its stem cell agency, the California Institute for Regenerative Medicine (CIRM). The moneywhich taxpayers will repay with interest over the next 30 yearswill enable the institute to stay open, expand its research programs, and build new facilities.

Some $1.5 billion of the money will be spent researching conditions affecting the brain and central nervous system, such as Alzheimer's, Parkinson's, epilepsy, and stroke.

Unlike specialized cellssuch as blood cells or bone cellsstem cells do not have a specific job. Think of them as the raw materials of our bodies. When they divide, they can either renew and make new stem cells, or turn into specialized cells.

Despite making headlines for years, stem cell research is still in its early stages, with some treatments that have appeared to have worked in animals now going into clinical trials. These include treatments for macular degeneration, a common cause of blindness, as well as stroke, Lou Gehrig's disease, and spinal cord injuries.

It is hoped growing stem cells into specialized cells could also one day be used to replace damaged tissue and organs, for instance by helping the pancreas produce insulin in people with diabetes.

Currently, stem bone marrow transplantation is the most common form of stem cell therapy, used to treat blood cancer patients. Stem cell therapy has also been used for grafts of corneal stem cells, as well as skin grafts for burns victims.

As well as creating treatments, stem cell research can also help scientists understand diseases. Observing the cells in a lab as they turn into specialized cells, for instance, can provide clues on how we develop certain conditions.

There are a number of stem cells: embryonic stem cells, adult stem cells, adult stem cells tweaked to behave like embryonic stem cells, and stem cells found in the amniotic fluid and the umbilical cord of babies.

The controversy around stem cell research largely lies in the use of embryonic stem cells. These are taken from human embryos in their early stages of development. Opponents have likened this to abortion, although others disagree with this stance.

Embryonic stem cells used in research come from donations from IVF clinics, where an egg is fertilized with a sperm but not implanted into a patient because it is not needed. Embryonic stem cells are preferred over adult stem cells, as it may not be possible to specialize the latter and they are more likely to have abnormalities. But research suggests that it may be possible to turn adult stem cells into a wider range of specialized cells than previously thought, which may make them more useful.

In 2001, the Bush administration banned federal funding for stem cell research. This lead real estate developer Robert N. Klein II to initiate and help fund Proposition 71 in California. The aim was to enshrine the right to carry out stem cell research in the state's constitution, and establish CIRM. Klein was motivated by his son's experience with Type 1 diabetes, and his mother's Alzheimer's diagnosis. In 2004, Californians voted in favor of the proposition.

The institute has performed 64 clinical trials, and published over 3,000 scientific articles on the subject. But 16 years after Proposition 71 passed, CIRM started to run out of funds, and stopped accepting applications for new projects last year. This prompted the Californians for Stem Cell Research, Treatments and Cures political action committee (PAC) to lead the campaign for Proposition 14. Klein was among its supporters, as well as California governor Gavin Newsom, LA mayor Eric Garcetti, and the Michael J. Fox Foundation established by the Back to the Future actor and Parkison's disease patient who is its namesake.

On November 1, the foundation urged people via Twitter to vote in favor of Prop 14 to fund research on neurological disease. "Without this proposition vital research may come to a halt, delaying new treatments for people with," it said.

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As California Passes Prop 14, What Is Stem Cell Research and Why Is It Controversial? - Newsweek

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The company's active ingredient product lines meet consumer expectations of quality, performance, and sustainability

LONDON, Nov. 18, 2020 /PRNewswire/ --Based on its recent analysis of the global personal care active ingredientsmarket, Frost & Sullivan recognizes Mibelle AG Biochemistry with the 2020 Global Company of the Year Award. It has successfully introduced several breakthrough sustainable active ingredients, whose efficacy is shttps://mma.prnewswire.com/media/1337466/Mibelle_Award.jpg upported by in-vivo and in-vitro study results. Mibelle is a pioneer with regards to using senolytics to delay skin aging in cosmetic applications, which has helped the company achieve a leading positioning in the market.

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Click here to view the full multimedia release: https://best-practices.frost.com/mibelle-biochemistry/

"Demonstrating its expertise in recognizing the dynamic needs of the cosmetics industry, Mibelle launched the Alpine Rose Active line of products to fight skin aging,"said Prateeksha Kaul Research Analyst. "This line of products uses a natural senolytic agent extracted from the Alpine rose leaves in the Swiss Alps to eliminate senescent cells, which are the cells responsible for aging, without affecting the neighboring cells. This halts the skin's aging process while rejuvenating it and increasing its elasticity. This product also meets the rising demand for natural and sustainable products over harsh chemicals that are harmful to both the environment and the skin."

Similarly, in response to the growing interest in phytocannabinods, Mibelle introduced an encapsulated cannabidiol (CBD) product, the Lipobelle Pino C. Other players in the market have had limited success with CBD in spite of its potential benefits for the skin because it is not soluble in water. Mibelle addressed this limitation with the Lipobelle Pino C. By encapsulating the CBD into a nanoemulsion using hemp oil, Mibelle made it water-soluble and stable in cosmetic formulations. Its combination with an extract from Swiss stone pines also helps the product fight inflammation. Lipobelle Pino C exploits the anti-inflammatory and regenerating effects of CBD for cosmetic benefits such as easing facial tension, reducing inflammation, and regenerating tissue.

Mibelle has been a pioneer in utilizing interesting biochemical concepts for its active ingredients. In 2008, it gained a first-mover advantage with the launch of its active ingredient PhytoCellTec Malus Domestica, which involved the application of stem cells in cosmetics for the very first time. In 2019, Mibelle utilized its PhytoCellTec technology to launch the PhytoCellTec Goji, which stimulates the mesenchymal stem cell (MSC) culture with goji stem cells for enhancing face shape by preventing the skin from sagging. The success of this technology and other recent innovations has allowed the company to achieve a 15 percent growth rate annually.

"Mibelle works closely with certification bodies to analyze the ingredients, raw materials, and processes to obtain the required certifications for its products. It also collaborates with personal care product manufacturers to offer premium high-quality products that benefit the end user," noted Kaul. "With its ability to introduce breakthrough active ingredients, Mibelle AG Biochemistry has carved a niche for itself in the personal care industry. It has consistently adopted a holistic innovation approach that has enabled it to consistently develop novel concepts and ingredients."

Each year, Frost & Sullivan presents a Company of the Year award to the organization that demonstrates excellence in terms of growth strategy and implementation in its field. The award recognizes a high degree of innovation with products and technologies, and the resulting leadership in terms of customer value and market penetration.

Frost & Sullivan Best Practices awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analysis, and extensive secondary research to identify best practices in the industry.

About Frost & Sullivan

For over five decades, Frost & Sullivan has become world-renowned for its role in helping investors, corporate leaders, and governments navigate economic changes and identify disruptive technologies, Mega Trends, new business models, and companies to action, resulting in a continuous flow of growth opportunities to drive future success. Contact us: Start the discussion.

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Harley GadomskiP: 12104778469E: [emailprotected]

About Mibelle AG Biochemistry

Mibelle Biochemistry designs and develops innovative, high-quality actives based on naturally derived compounds and profound scientific know-how. Inspired by nature - Realized by Science.

For more information on Mibelle Biochemistry, please visit http://www.mibellebiochemistry.com

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Esther Belser Mibelle Biochemistry, SwitzerlandHead of MarketingPhone: +41 62 836 13 47Email: [emailprotected]

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Mibelle Biochemistry's Ability to Introduce Breakthrough Active Ingredients for the Personal Care Market Lauded by Frost & Sullivan - PR Newswire...

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18-Nov-2020

Ingredients | Marketing

The company's active ingredient product lines meet consumer expectations of quality, performance andsustainability

Based on its recent analysis of the global personal care active ingredients market, Frost & Sullivan recognises Mibelle AG Biochemistry with the 2020 Global Company of the Year Award.

It has successfully introduced several breakthrough sustainable active ingredients, whose efficacy is supported by in-vivo and in-vitro study results. Mibelle Biochemistry is a pioneer with regards to using senolytics to delay skin aging in cosmetic applications, which has helped the company achieve a leading positioning in the market.

"Demonstrating its expertise in recognising the dynamic needs of the cosmetics industry, Mibelle Biochemistry launched the Alpine Rose Active ingredient to fight skin aging," said Prateeksha Kaul Research Analyst.

"This ingredient contains a natural senolytic agent extracted from the Alpine rose leaves in the Swiss Alps to eliminate senescent cells, which are the cells responsible for ageing, without affecting the neighboring cells.

"This halts the skins aging process while rejuvenating it and increasing its elasticity. This active also meets the rising demand fornatural and sustainable products over harsh chemicals that are harmful to both the environment and the skin."

Similarly, in response to the growing interest in phytocannabinods, Mibelle Biochemistry introduced an encapsulated cannabidiol (CBD) ingredient, the Lipobelle Pino C. Other players in the market have had limited success with CBD in spite of its potential benefits for the skin because it is not soluble in water.

Mibelle addressed this limitation with the Lipobelle Pino C. By encapsulating the CBD into a nanoemulsion using hemp oil, Mibelle made it water-soluble and stable in cosmetic formulations.

Its combination with an extract from Swiss stone pines also helps the product fight inflammation. Lipobelle Pino C exploits the anti-inflammatory and regenerating effects of CBD for cosmetic benefits such as easing facial tension, reducing inflammation, and regenerating tissue.

Mibelle Biochemistry has been a pioneer in utilising interesting biochemical concepts for its active ingredients. In 2008, it gained a first-mover advantage with the launch of its active ingredient PhytoCellTec Malus Domestica, which involved the application of stem cells in cosmetics for the very first time.

In 2019, Mibelle utilised its PhytoCellTec technology to launch the PhytoCellTec Goji, which stimulates the mesenchymal stem cell (MSC) culture with goji stem cells for enhancing face shape by preventing the skin from sagging. The success of this technology and other recent innovations has allowed the company to achieve a 15 percent growth rate annually.

Each year, Frost & Sullivan presents a Company of the Year award to the organisation that demonstrates excellence in terms of growth strategy and implementation in its field.

The award recognises a high degree of innovation with products and technologies, and the resulting leadership in terms of customer value and marketpenetration.

Frost & Sullivan Best Practices awards recognize companies in a variety of regional and global markets for demonstrating outstanding achievement and superior performance in areas such as leadership, technological innovation, customer service, and strategic product development.

Industry analysts compare market participants and measure performance through in-depth interviews, analysis, and extensive secondary research to identify best practices in the industry.

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Mibelle Biochemistry announces: Mibelle Biochemistrys Ability to Introduce Breakthrough Active Ingredients for the Personal Care Market by Frost and...

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A doll-obsessed couple describe themselves as human Barbie and Ken.

The Los Angeles-based pair have had futuristic stem-cell injections to achieve their looks.

Marcela Iglesias and her husband Steven Berman get the treatment in the hope of rejuvenating their bodies, skin and hair.

The former said: "Weve both had stem cell therapy through IV.

Thirty million mysenthanial cells each a total of 60 million stem cells through the drip.

The 43-year-old has also turned back the clock by getting 60,000 worth of cosmetic procedures.

As well as this, Marcela hones her sculpted figure by following a gruelling fitness regime.

She said: "I never had plastic surgery but I am not against it just a couple of cosmetic procedures like Botox and a little filler to maintain face volume, but have never completely changed or modified my appearance.

"The Barbie doll is an inspiration for becoming whoever you want to be and achieving all your life goals.

Obviously, the aesthetic of the doll is impeccable but at the same time, my approach is a more natural look and I achieve it by working out all the time on my Edgecross-X training system.

"Surgery-wise, I have been contemplating a mini facelift but with the new Morpheus 8, a non-surgical advanced needling treatment that uses radio frequency to tighten and smooth wrinkles on the face and body.

Marcela added: I am also considering a boob and booty boost, basically to make them perky and firm again.

"I admire what the doll represents more than how she looks; I am very respectful of the image of the Barbie doll as I want to encourage all men and women around the world to pursue their dreams and to achieve the look they want.

While the Barbie fan hasnt had any invasive plastic ops done, her Ken doll-loving husband has.

Steven 53, has had a chin implant, two hair transplantations and neck surgery.

The couples extreme appearance helps them to stand out on the street.

Marcela said: "When we go out together, people tell us that we look like Barbie and Ken because we are both blonde and have the doll-like aesthetic.

"I always wear vibrant colours. We break the mould I guess.

The couple, who have been together since meeting on Myspace in 2009, seem to enjoy the attention their looks bring.

Their fame has allowed them to buy McLaren 570s sports cars that cost 200,000.

The motor features an oil-slick rainbow paint job, courtesy of hit TV show Pimp My Ride's West Coast Customs in Los Angeles.

Marcela, who sometimes goes by the nickname 'Queen of Hollywood' and shares glossy lifestyle shots with 310,000 followers on Instagram page @marcelaiglesiashollywood, added: "This type of car is more like a fulfilling a fantasy and achieving one of my dreams.

"I always wanted a car where the doors open like angel wings, so this year with everything that's been going on, I decided to treat myself and my husband.

"I must admit that I had to compromise on the colour because I originally wanted something more pinky toned, but my husband has to drive the car as well and I didn't want him to feel embarrassed!

I believe this car is an extension of my personality - a reflection of myself... I dress the car like I would like to dress!

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Real life 'Barbie and Ken' achieve doll-like looks with futuristic stem-cell injections - Daily Star

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Market Report Summary

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The healthcare industry has been focusing on excessive research and development in the last couple of decades to ensure that the need to address issues related to the availability of drugs and treatments for certain chronic diseases is effectively met. Healthcare researchers and scientists at the Li Ka Shing Faculty of Medicine of the Hong Kong University have successfully demonstrated the utilization of human induced pluripotent stem cells or hiPSCs from the skin cells of the patient for testing therapeutic drugs.

The success of this research suggests that scientists have crossed one more hurdle towards using stem cells in precision medicine for the treatment of patients suffering from sporadic hereditary diseases. iPSCs are the new generation approach towards the prevention and treatment of diseases that takes into account patients on an individual basis considering their genetic makeup, lifestyle, and environment. Along with the capacity to transform into different body cell types and same genetic composition of the donors, hiPSCs have surfaced as a promising cell source to screen and test drugs.

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In the present research, hiPSC was synthesized from patients suffering from a rare form of hereditary cardiomyopathy owing to the mutations in Lamin A/C related cardiomyopathy in their distinct families. The affected individuals suffer from sudden death, stroke, and heart failure at a very young age. As on date, there is no exact treatment available for this condition.

This team in Hong Kong tested a drug named PTC124 to suppress specific genetic mutations in other genetic diseases into the iPSC transformed heart muscle cells. While this technology is being considered as a breakthrough in clinical stem cell research, the team at Hong Kong University is collaborating with drug companies regarding its clinical application.

The unique properties of iPS cells provides extensive potential to several biopharmaceutical applications. iPSCs are also used in toxicology testing, high throughput, disease modeling, and target identification. This type of stem cell has the potential to transform drug discovery by offering physiologically relevant cells for tool discovery, compound identification, and target validation.

A new report by Persistence Market Research (PMR) states that the globalinduced pluripotent stem or iPS cell marketis expected to witness a strong CAGR of 7.0% from 2018 to 2026. In 2017, the market was worth US$ 1,254.0 Mn and is expected to reach US$ 2,299.5 Mn by the end of the forecast period in 2026.

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Customization to be the Key Focus of Market Players

Due to the evolving needs of the research community, the demand for specialized cell lines have increased to a certain point where most vendors offering these products cannot depend solely on sales from catalog products. The quality of the products and lead time can determine the choices while requesting custom solutions at the same time. Companies usually focus on establishing a strong distribution network for enabling products to reach customers from the manufacturing units in a short time period.

Entry of Multiple Small Players to be Witnessed in the Coming Years

Several leading players have their presence in the global market; however, many specialized products and services are provided by small and regional vendors. By targeting their marketing strategies towards research institutes and small biotechnology companies, these new players have swiftly established their presence in the market.

Explore Extensive Coverage of PMR`sLife Sciences & Transformational HealthLandscape

Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics and market research methodology to help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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The Induced Pluripotent Stem Cells Market To Witness Fierce Competition Amongst The Key Players - KYT24

Skin Stem Cells Comments Off on The Induced Pluripotent Stem Cells Market To Witness Fierce Competition Amongst The Key Players – KYT24 | November 18th, 2020

What is the value of time? La Prairie has been pondering that question for nearly a century, since founder Dr. Paul Niehans, who earned the sobriquet father of cellular therapy, began experimenting with remedies for longevity in 1931 at the Clinique La Prairie in Montreux, Switzerland.

Over the years, the heritage Swiss luxury house has lived at the forefront of beauty innovation, producing indulgent face creams and serums that introduce science into skincare and incorporate rarefied ingredients such as caviar, gold, and now platinum. The precious metal is the anchor of new the Platinum Rare Haute-Rejuvenation collection, the brands latest fountain-of-youth formula offered in a seven product range.

Housed in an assortment of sculptural, amethyst-shaded vessels with enhanced platinum accents, the velvety creams and elixirsperfumed with La Prairies signature scentshowcase a new science dubbed Haute-Rejuvenation. At the core of it is a cellular renewal process that smooths wrinkles, improves skin moisture, restores volume, and induces a vibrant glow. By invigorating epidermal stem cells, it in effectturns back time to more youthful skin.

La Prairies Exclusive Cellular Complex is a life force for the skin. It uses biotechnological research to give new life and energy back to the very cells where beauty is born. It invigorates and nourishes epidermal stem cells to enable them to resume cellular renewal and functionality similar to that of young skin.

When we age, the skins natural rejuvenating capacity decreases, leading to the appearance of signs of aging, says Dr. Jacqueline Hill, the brands global director of strategic innovation. La Prairies Science of Haute-Rejuvenation seeks to specifically modulate and stimulate the skins natural network of interconnected rejuvenating processes to compensate for the age-related decrease of its performance.

Another pillar of the brands history is art. To celebrate the launch of Platinum RareHaute Rejuvenation, La Prairie commissioned the acclaimed British composer Max Richter and Japanese artist Nobuhiro Nakanishi to collaborate on an immersive installation set to debut at this years West Bund Art & Design in Shanghai (Nov. 12-15). Richter masterminded a score for Nakanishis layer drawing Echo of Time, a sculptural work with a sequential photography series of the Swiss Alps at twilight.

The duo was tasked to consider the essence of time and space, particularly a billion -year-long meteor shower responsible for bringing platinum to earth. For his contribution, Nakanishi traveled to Niederhorn peak in the Swiss Alps where he photographed a vibrant sunrise of blue, red, and purplethe colors that imbue Platinum Rares bottle design. The colors dyed the mountains and at the same time, the sky awakened and became amethyst, Nakanishi says of the scene. The mountainous scenery in Switzerland is the perfect place to illustrate the notion of timeless nature through the clearness of the water, the air, and the reflection of light created by nature itself.

Richters melodic composition begins with pulsating choral strings that give way to an individual acoustic figure meant to stimulate the feeling of entering a new landscape. It provokes a dynamic encounter with a new world and makes you feel alive, he says. To Richter, time is mysterious and doesnt always move at the same speed. This is the kind of thing a piece of music can trigger: it can stop time or speed it up, it can make time feel more intense.

Its a synergetic notion: Manipulating the effects of time is something La Prairie does best.

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La Prairies New Collection Is Inspired by a Platinum Meteor Shower that Lasted 200 Million Years - Surface Magazine

Skin Stem Cells Comments Off on La Prairies New Collection Is Inspired by a Platinum Meteor Shower that Lasted 200 Million Years – Surface Magazine | November 18th, 2020

PARIS, FRANCE - OCTOBER 06: A model walks the runway during the Chanel Womenswear Spring/Summer 2021 ... [+] show as part of Paris Fashion Week on October 06, 2020 in Paris, France. (Photo by Stephane Cardinale - Corbis/Corbis via Getty Images)

In 2020, a symbol of confidence is the perfect companion as the year (thankfully) comes to a close. Americans are turning over a new leaf after being quarantined and pushed forward growing accustomed to a home-hibernated lifestyle. Nowadays, breaking from the tradition has given rise to the public forefront where a socially distant meeting isnt so distant any-longer.

Nonetheless, beauty is a gesture, a symbol of self-assurance that transcends to self-care while remaining true to creating something more modern. The silver lining to 2020, is that given the endless hours spent at home, many Americans came across a new found peace and serenity. In turn, a straight path forward to curate and maintain a healthy lifestyle.

To mark the most memorable moments, home workouts did not go unnoticed. In addition, binge buying had its place to fill a chapter of satisfaction. But what about beauty regimes?Well, that continued to hold its own during this era of self-isolation and wellness. After all, strong willed optimism to return to the once dreaded daily-grind will bestow itself upon us in the near future.

Over the years, innovative treatments in skincare brought forth a fresh new set of revolutionary products and devices that have been entering the market segmentation. For example, Dr. Dennis Gross has pioneered an LED (light emitting diode) device that not only succeeds in its wrinkle reducing and acne fighting purpose, but rather transports you to a world of futuristic rejuvenation as you place this sci-fi mask on your face.

As businesses across the country begin to open their doors again, Dr. Barbara Sturm is providing extensive knowledge and intricate detail into the scientific formulation of serums such as her Anti-Pollution Drops that replenishes skin from HEV blue light, ejected from digital devices; something mankind cannot escape in modern times.

In fact, celebrity makeup artist Marie-Jose Leduc attests that using pure natural oils is the best path forward. Ms Leduc recently launched Odile, a skincare line where the products are a cocktail of active botanicals and devotedly organic. Let go of the harsh chemicals Leduc tells us. Scale it back a little and go gentle. More to the point, Gen Z advocates sustainability, a key factor to the largely lucrative industry.There is a small group of us who look at the big picture. I cant make money knowing that I am harming the environment, Leduc preaches with strength to pave an organic pathway for those that follow.

Now that the world is getting closer and closer, the next chapter is confidence and hope. Americans are rediscovering comfort and security found in beauty and wellness. As tough as 2020 has been, people are feeling refreshed and replenished to take on the next chapter. To help you begin your fresh skincare and wellness regiment, I have reviewed a handful of the best products and services developed to stand the test of time.

Armani Beauty:

Armani beauty Crema Nera Supreme Reviving Cream ($400)

Armani Beauty- Crema Nera Supreme Reviving CreamThe Supreme Revivng Cream is part of a complete Crema Nera skincare ritual that awakens the skin with luxurious, hydrating formulations. The ranges powerful fusion of nature and revolutionary technology imparts both instant results and lasting benefits to the skin. The powerful, exclusive Reviscentalis ingredient defines the Crema Nera collection, and is infused throughout the full range. Prized for its healing and medicinal powers, an extract from the Reviscentalis plant is able to uncover radiant skin and a more youthful appearance. $400

ARTIS:

Perfect for applying foundation, skincare, bronzer and contour with some glam. Its proprietary ... [+] animal-free CosmeFibre can be used with liquids, creams and powders across makeup and skincare formulas.

Artis has created elegance and glamour this holiday season with their limited- edition Elite Oval 7 brushes, each encrusted with a unique design of Swarovski Crystals!The EmeraldCrystal Elite Mirror Oval 7 Brush is adorned with 70 crystalsrichly pigmented soft-green Swarovski crystals, while theThe translucent Crystal Elite Mirror Oval 7 Brush is decorated with 362 translucent-white Swarovski crystals, and the Red Crystal Elite Mirror Oval 7 Brushis filled with 362 ravishing ruby red crystals, all options bring to life a classic holiday color choice thatshines on any bathroom counter. EmeraldCrystal Elite Mirror Oval 7 Brush-$200,Translucent Crystal Elite Mirror Oval 7 Brush$250 andRed Crystal Elite Mirror Oval 7 Brush$250

BABOR:

Babor

DOCTOR BABOR Power Serum Ampoules: This seven day intensive treatment deeply hydrates the skin with four types ofhyaluronic acids of varying weight to plump the skins surface and improve skin elasticity.The Hyaluronic acid + Booster Tripeptides work together to deliver intense hydration and effectively plump the skin. Helps improve skin elasticity with long lasting effects. $49.95

BIOEFFECT:

tk

To celebrate the 10-year anniversary of BIOEFFECT and the brands award-winning, best-selling EGF Serum, BIOEFFECT launched a 50 mL Limited Edition EGF Serum produced in their new patented black barley. Containing only seven ingredients, this serum is three times the size of the original and features double the concentration of EGF proven to reduce the appearance of wrinkles and fine lines as well as plumps skin to increase density and thickness. The unique bottle is custom-sculpted and designed by renowned Icelandic-born, Brooklyn-based artist, Shoplifter, who designed the bottle to show how the magic of nature and science can merge and influence a work of art. $495 USD

Biophile Skin:

Created by maverick creative scientist and award-winning clean beauty pioneer Alison Cutlan, along ... [+] with seasoned business executive Grace Fooden, the biophile brand synthesizes traditional ecological wisdom with modern science in an alchemical process called biofermentation

Biophile is a new generation of biologically advanced, sustainable skincare that works to balance the microbiome, activate the skins regenerative abilities and strengthen skin barrier function. Biophiles breakthrough trio of productsRoot Bionic Refining Essence, Bio-Shroom Rejuvenating Serum, and Bio Barrier Nourishing Oilfeed the skin with probiotic bacteria and botanicals, fungi and superfoods to boost skin immunity and hydration, increase cellular energy, reduce wrinkles and pigmentation, and increase smoothness. Each biophile product is designed to work synergistically to bring skin to life .First, the Root Bionic Refining Essence resurfaces and regenerates to prepare skin for the award-winning Bio-Shroom Rejuvenating Serum. Next, the Bio-Shroom Serum feeds and supports the skin with three powerful mushrooms and age-defying actives and peptides, supporting the skins barrier and microbiome. Finally, the Bio Barrier Nourishing Oil strengthens and fortifies for a plump-and-seal effect. $125

BeautyBio:

BeautyBio

Professional-grade stainless steel, dual-ended Cryo Roller harnesses the natural power of ice-cold temps to depuff, tighten and detoxify skin for a clearer, sculpted, more radiant appearance.USD: $85.00

Dr. Barbara Strum:

Courtesy of Dr. Barbara Sturm Dr. Barbara Sturm Anti-Pollution Drops ($145) strengthen and calm ... [+] skin while also providing protection from damaging HEV blue light.

Dr. Barbara Sturm HEV is a blue light thats emitted by digital devices, and it penetrates deep into the skin making it potentially more dangerous than UV rays. Over time, it can compromise skin barrier function, triggering an inflammation cascade that causes premature aging, uneven tone, loss of firmness, dryness, impaired skin healing, sensitivity and even breakouts. HEV light exposure is a growing danger for our skin. In fact, during quarantine, US-based Internet service providers reported screen time increases of up to 50% as people turn to their phones to stay connected and informed. Dr. Barbara Sturms Anti-Pollution Drops contain a Skin Protect Complex that strengthens the skins defenses, Cocoa Seed Extract that forms a shield to protect against UV rays, and the brands signature ingredient, Purslane, to help calm irritation. Dr. Barbara Sturms propriety blend of Hyaluronic Acid also provides hydration on both deep and surface levels, which is essential to maintaining healthy barrier function. To protect your skin from blue light, apply Dr. Barbara Sturms Anti-Pollution Drops after cleansing and before applying face cream, and reapply as needed throughout the day. $145 USD

Courtesy of Dr. Barbara Sturm

Dr. Barbara Sturm Anti-Pollution Drops ($145) strengthen and calm skin while also providing protection from damaging HEV blue light.

Dr. Dennis Gross Skincare:

Dr. Dennis Gross LED FaceWare Device

Dr. Dennis Gross skincare- This FDA-cleared SpectraLite FaceWare Pro mask is a LED mask offering professional light therapy at the comfort of your home. A combination of 100 light emitting diodes in red mode + 62 LED lights in blue mode work together to smooth wrinkles, diminish discoloration, and clear acne for a beautiful, youthful complexion. Red light emitting diode penetrate deep within skins dermis to boost collagen production. Blue light emitting diode destroy P. acnes bacteria to reduce redness, inflammation, and prevent future breakouts. Within days, see a reduction of acne. In 2 weeks, experience a clearing of mild to moderate acne and fading lines. Optimal skin results occur after a 10 week course of treatment. $435 USD

Dr. Loretta:

Dr. Loretta

This advanced sunscreen protects skin from the four external factors responsible for more than 85% of skin aging pollution, light, climate and irritants. Lipochroman provides antioxidant protection from free radical damage caused by pollution and UV radiation the leading causes of fine lines and age spots. Indian ginseng extract protects skin from HEV light emitted from the sun and electronic devices, while peptides hydrate and firm skin. Zinc oxide protects skin from UVA/UVB and irritants.$50

Franz Skincare USA:

Franz Skincare Premium Microcurrent Facial Dual Mask

The Franz Microcurrent Facial Dual Mask is an award-winning microcurrent facial treatment delivered in a dual-layered mask (set of 2 treatments). The first of its kind, this dual mask system is powered by water energynot batteriesto create tiny waves across skin, letting the masks essences go 6x deeper than the leading face mask* for max results. Price: $50

Garden Apothecary:

Ground facial serum, handmade fresh from our farm

Garden ApothecaryHigher Ground botanical serumis formulated by our in-house botanist, offering the ultimate nourishment with everyday use.With rich phytonutrients, powerful antioxidants, and replenishing peptides, this hydrating serum is dense with healing botanicals, straight from our organic farm. We sustainably grow the saffron that goes into each and every bottle we make here in Half Moon Bay, CA.$108.

GOOPGENES BY GOOP:

GOOPGENES All-In-One Nourishing Face Cream is a luscious treat for the skin and a clinically tested ... [+] supercream that leaves skin looking and feeling soft, smooth, firm, and moisturized for up to 48 hours.

GOOPGENES BY GOOPThis luxuriously rich, all-in-one super-cream melts into skin, leaving it deeply nourished with a unique whipped texture that makes it feel like an invisible second skin. The clinically tested formula is made with seven highly active botanicalsincluding Schisandra fruit, Illipe butter, Caviar lime, and Squalenethat work synergistically to leave skin ultra-moisturized, soft, supple, smooth, firm, and even-toned. A megadose of plant-based ceramides promotes noticeable radiance while smoothing, firming, and hydrating. After just one use, 100% of women experienced significant improvement in hydration. After four weeks of use, 100% showed significant improvement in skin firmness and 94% said their skin appeared brighter. Fragrance-free. $95 USD

iS CLINICAL:

CLINICAL Youth Body Serum

NEW iS CLINICAL Youth Body Serum-This refreshing lightweight serum mist gently absorbs into the skin providing powerful hydration and antioxidant protection against environmental aggressors. The purest form of Hyaluronic Acid, potent extracts of Watermelon, Blue-Micro Algae, Licorice Root and Holy Herb, are combined with essential Vitamin B5, and our proprietary Extremozymes to create a unique and effective formula designed specifically for the body. Much more than a moisturizer, this nourishing treatment leaves skin feeling fresh, soft, and more hydrated. USD$120

KLUR:

Organic hempseed, avocado, and grapeseed oils deliver reparative nutrients to parched areas, while ... [+] providing replenishment and protection against daily moisture loss featuring a comforting aromatic bouquet scent of Neroli Orange Blossom, Bulgarian Rose, and French Lavender.

Klur This uniquely fragrant multi-purpose botanical body oil is formulated to nourish, firm and replenish skin.A comforting aromatic bouquet of Neroli Orange Blossom, Bulgarian Rose, and French Lavender impart a delicate floral yet earthy, gender-fluid aroma. Organic hempseed, avocado, and grapeseed oils deliver reparative nutrients to parched areas, while providing replenishment and protection against daily moisture loss. Thus, transforming skin to its most radiant state. $70 USD

Lancer Skincare:

Lancer Legacy Youth Treatment revitalizes the very look of skin, engineered to promote a ... [+] healthy-looking complexion in five essential functions: supporting rejuvenation, recapturing skin vitality, and providing a moisture barrier, water saturation and antioxidant defense.

Lancer Legacy Youth TreatmentThis luxurious skin rejuvenation treatment saturates the epidermis with moisture and in combination with advanced factors, elicits a fresh, rejuvenated and healthy-looking complexion. A compound of precious saffron and sake help to promote a brighter, more even-looking skin tone. Next generation amino and hyaluronic acids enhance natural moisture retention for supremely supple and renewed skin.Lines appear softer and smoother, skin looks firmer, and the complexion glows with innate vitality. After polishing and cleansing, apply a generous amount to clean, dry skin using upward strokes sweeping onto the entire face, neck and dcollet and pat gently into the skin for one minute. Over 30 ingredients, sourced from around the world, engineered into 5 revolutionary complexes: Youth GF Complex, Firming Mesh Complex, MitoSmooth Compound, Aquadermal Complex, and SativusBright Compound. Price: $1,000

LightStim:

LightStim for Wrinkles is available at major prestige retailers including Sephora, Nordstrom, Neiman ... [+] Marcus, Revolve and more, as well as LightStim.com.

LightStim-The restorative benefits of sunlight have been known for thousands of years, but in more recent history we have become aware of the damage that can be caused by excessive exposure to UV. Often called red light therapy and generally referred to as low-level light therapy or photobiomodulation among researchers and clinicians, this treatment contains no UV and utilizes only clinically proven beneficial wavelengths (or colors) of light to treat the skin. Studies performed over many decades, including those conducted by NASA, have shown that the human body has the ability to absorb light through the skin and other body tissues and convert it into energy. This is important, because as we age our skin loses the energy needed to maintain its plump, youthful appearance. As a result, fine lines and wrinkles form, and skin appears slack. The key to LightStim for Wrinkles' effectiveness is its patented MultiWave technology which allows for a more thorough and comprehensive treatment. The device simultaneously emits 4 different wavelengths of UV-free therapeutic light energy. Amber, deep red, light red and infrared wavelengths nourish the skin from within, filling in fine lines and wrinkles, and over time reducing and even eliminating them all in an easy-to-use, portable hand-held device. $249

Luzern:

Nuit Cleaning Emulsion: Hydrates as it cleans, leaving skin glowing and revitalized

Luzern- Nuit Cleansing EmulsionNuit Cleansing Emulsion. The ultimate pampering and rejuvenating entre' into your evening regimen. Nutrient-rich Alpine extracts are suspended in this ultra-rich cleansing balm.Blended with 6 nourishing oils to help decongest skin without disrupting its delicate protective barrier. Melts on contact with the skin's warmth to dissolve away impurities, makeup, and pollution to prepare it for nighttime renewal. Nuit Cleansing Emulsion: MSRP $135.00

MARA:

MARA's limited edition Sea the Glow Radiance Duo featuring a full-size luxury Universal Face Oil ... [+] and a travel size luxury Algae Retinol Face Oil developed to work in tandem to soften signs of aging, texture and dark spots while delivering fatty acids and phytonutrients for the ultimate hydration and glow.

MaraOur two best selling luxury face oils to hydrate and treat your way to a gorgeous glow this holiday season! This limited edition Sea the Glow Radiance Duo has a full size Universal Face Oil and a travel size Algae Retinol Face Oil so you can treat yourself or someone you love to the gift of good skin this holiday. These two products were developed to work in tandem. Travel size Algae Retinol Face Oil is a nighttime treatment that softens signs of aging, texture and dark spots; Universal Face Oil is filled with fatty acids and phytonutrients for insane hydration and glow. $105 USD

NELI Naturals:

NELI Naturals Skincare Collection

NELI, meaning the truth will be revealed, is an effective, clean skincare line with an attainable price point. Created alongside dermatologists, the cruelty-free (Leaping Bunny Certified), vegan, paraben-free, all-natural ingredient product line consists of a Gentle Facial Cleanser, AHA/BHA Superfruit Hydrating Scrub, Collagen Peptide SPF Daily Moisturizer, 4.25% Retinoid Collagen Night Moisturizer and an Apple Stem Cell Hydrating Eye Cream. The glow boosting, anti-aging collection is enriched with essential ingredients such as collagen, hyaluronic acid and berry antioxidant extracts to improve your skin barrier while maintaining a healthy and hydrated complexion.$102 USD

NON GENDER SPECIFIC:

A luxurious moisturizing face cream with 23 powerful botanicals

Non Gender Specific Everything Cream is a luxurious moisturizing face cream that works to deliver phytonutrients and hydration deep into the skin, thanks to 23 powerful botanicals. This formula works to nourish the skin with natural oils that absorb quickly and are never greasy, leaving skin feeling soft withthe appearance of brighter skin, refined pores andreduced redness.USD$58

PMD Beauty:

The new Personal Microderm Elite Pro is a cordless option for effortless, on-the-go beauty featuring ... [+] an extended range of discs for all your exfoliation needs.

PMD BeuatyThe newly launched Personal Microderm Elite is the brands first microderm device that is wireless and rechargeable. Get rid of dull skin with the revolutionary microdermabrasion tool - on the go. The Elite offers a customizable treatment for your unique skin type. After just one treatment it will reveal smoother, softer skin. Now you can reduce fine lines and wrinkles, increase hydration and even out skin texture at a fraction of an in-spa treatment cost. $299

Phyto-C:

evens-out the appearance of uneven skin tone

PHYTO-CThe new HYPER-C now includes AHAs (Glycolic and Lactic Acid) for even brighter, smoother skin! Formulated with HA technology plus peptides and pure Vitamin C, Hyper-C works to rejuvenate the appearance of dull looking skin by using the highest concentration of Vitamin C (20%) clinically tested to provide the maximum amount of antioxidant benefits to the skin. The unique HA technology, which stands for HYPER absorbing hyaluronic acid delivers essential ingredients where you need them most at the perfect absorption rate. $70

SAINT JANE:

Clean botanicals are paired with rich concentrations of full-spectrum hemp to enhance its benefits, ... [+] making this powerhouse duo the ultimate skin-transforming routine for calm, nourished, and glowing skin

Saint Jane THE IDEAL DUO Layerthese two award-winning skincare powerhousesfor your bestskin days.Start with The C-Drops for 20% active Vitamin C plus soothing hemp extract to resurface and brighten. Follow with Luxury Beauty Serum on top for deepnutrients and intense moisture.They work together to deliver exactly what your skin needs for complete nutrition throughout your day. $200.00

Sunday Riley:

Pink Drink Firming Resurfacing Essence

Sunday Riley A power drink for your skin, this peptide-infused essence resurfaces, balances, and firms the look of your skin (while drenching it in advanced green tea, antioxidant support). Peptides help firm the skin, while fermented honey and botanical extracts balance the skins natural microbiome and resurface the skin. $48.00

Tata Harper:

This limited edition duo is a natural face lift in a bottle, engineered with the most lifting and ... [+] firming technology. Includes the Boosted Contouring Serum and Boosted Contouring Eye Balm.

Tata HarperBoosted Contouring SetThis hyper-potent duo including the Boosted Contouring Serum and Boosted Contouring Eye Balm transforms thelook of mature, sagging skin to restore a youthfully firm, lifted look on both the face, dcollet, and under eye area. Best used for loss of firmness/ elasticity, fine lines & wrinkles, and dryness.$270.00

3LAB:

3LAB Super Cream

Super Cream is a super-powered skin booster with the most advanced technology, targeted delivery system unique to 3LAB.This luxurious, ingredient-rich cream delivers elastin producing peptides and targeted repair in a matter of days. X50 and Intelligent Targeting Device (ITD) deliver antioxidants and peptides directly to the source of the problem, combating fine lines, wrinkles and skin imperfections with quick, dramatic results. Always on the cutting edge of skin care technology, 3LAB prides itself on offering serious skin care solutions that are efficacious and made with the highest quality ingredients.With Super Cream, 3LAB is one of the first to introduce smart technology to skin care.Think of it like a GPS system programmed into your skin cream. Combined with 3LABs signature Bio-Engineered Renewal Complex and Apple Stem Cell Technology, the key ingredients are encapsulated within the cream and when applied, it targets tired, stressed-out, and aged cellsonly targeting the cells that need repair. The concept was adapted from the pharmaceutical industry where smart delivery technology enables medications to target diseased cells.$900 USD

U Beauty:

"U Beauty and Artis Holiday Duo Limited Edition Set

U Beauty and Artis Holiday Duo Limited Edition Set U Beauty, the luxury, clean, science-backed skincare line dedicated to simplifying your skincare routine, and Artis, the beauty brand best known for their innovative makeup and skincare brushes, will launch a limited-edition set for the holiday 2020 season. For Holiday 2020, U Beauty is pleased to present an exclusive, limited-edition gift set in collaboration with Artis. The brands joint offering will pair U Beautys recently launched 50ml The SUPER Smart Hydrator with Artis Palm Brush Mini.Price: $168

Valmont:

A rich replenishing balm created to provide intense nourishment for even the driest skin.

Valmont - PRIMARY POMADEThis ointment immediately and intensely nourishes the skin. Thanks to the latest technology, its incredibly fine texture penetrates the skin at a rapid speed, visibly healing dry or irritated areas. It replenishes lipids, restores the skins protective barrier function, and softens dry skin. The skin is smoother, more supple and comfortable. Retail price: $275

VENeffect:

Veneffect harnesses the power of phytoestrogens to offset the signs of hormonal aging

MoisturizerVeneffect Intensive Moisturizer ($185USD) is a potent blend of plant based phytoestrogens, emollients and peptides to address the effects of hormonal aging on skin.Created by sister duo, Cecil Booth, a beauty industry veteran,and Rebecca Booth, M.D., an OB/GYN specializing in hormonal wellness,their line harnesses their experiences professionally and as women to optimize hormonal vitality throughout the month and as women uniquely age.They call this phenomenon the Venus Effect, thus their brand, Veneffect.$185 USD

VENN Skincare:

ADVANCED MULTI-PERFECTING RED OIL SERUM

VENN Skincare- A multi-correctional face oil serum, strategically formulated using 34 root extracts, botanicals, and essential oils to deliver a category-defining, comprehensive skin benefits. 100% of the formula are efficacy-driven bioactives. Inspired by Korea's traditional herbal first aid ointment, the key ingredients include Lithospermum Erythrorhizon (Gromwell) Root Extract and Angelica Gigas (Korean Angelica) Root Extract that are fermented for 150 hours at low temperature for amplified delivery and performance on the skin. Clinically tested to hydrate skin for up to 24 hours, improve skins elasticity and firmness, and instantly increase skins radiance. $115 USD

Read more here:
The New Generation Of Beauty - Forbes

Skin Stem Cells Comments Off on The New Generation Of Beauty – Forbes | November 18th, 2020

Medical skin care products are used for beautifying or to address some other skin care problems. The cosmetic industry is booming and skin care forms a very huge part of this industry. The aesthetic appearance is so important that people spend a lot on skin care products and treatment. People being more technologically aware of the various new skin care products trending in the market. In addition to the aesthetic application, the medical skin care products are also used to address issues such as acne, pimples or scars.

Medical Skin Care Products Market: Drivers and Restraints

The medical skin care products is primarily driven by the need of natural based active ingredients products which are now trending in the market. Consumers demand medical skin care products which favor health and environment. Moreover, the consumers are updated with the trends so that various companies end up providing such products to satisfy the customers. For instance, a single product face mask has thousands of different variants. This offers consumers different options to select the product depending on the skin type. Moreover, the market players catering to the medical skin care products are offering products with advanced technologies. For instance, Santinov launched the CICABEL mask using stem cell material based on advanced technologies. The stem cells used in the skin care product helps to to protect and activate the cells and promote the proliferation of skin epidermal cells and the anagenesis of skin fibrosis.

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Medical Skin Care Products Market: Segmentation

On the basis of product type the medical skin care products market can be segmented as:

On the basis of application, the medical skin care products market can be segment as:

On the basis of distribution channel, the medical skin care products market can be segment as:

Medical Skin Care Products Market: Overview

Medical skin care products are used to address basic skin problems ranging from acne to scars. There are various advancements in the ingredients used to offer skin care products to the consumers. For instance, the use of hyaluronic acid and retinoids is the latest development in the industry. The anti-aging creams are at the forefront as the help treating issues such as wrinkles, scars, acne, and sun damage. Another, product in demand is the probiotic skincare which include lactobacillus and bifidobacterium.

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Medical Skin Care Products Market: Region-wise Outlook

In terms of geography, medical skin care products market has been divided into five regions including North- America, Asia- Pacific, Middle-East & Africa, Latin America and Europe. North America dominated the global medical skin care products market as international players are acquiring domestic companies to make their hold strong in the U.S. LOral is accelerating its U.S. market by signing a definitive agreement with Valeant Pharmaceuticals International Inc. to acquire CeraVe, AcneFree and Ambi skin-care brands for US$ 1.3 billion. The acquisition is expected LOreal to get hold of the brands in the price-accessible segment. Asia Pacific is expected to be the fastest growing region owing to the increasing disposable income and rising awareness towards the skin care products.

Medical Skin Care Products Market: Key Market Participants

Some of the medical skin care products market participants are Avon Products Inc., Beiersdorf AG, Colgate-Palmolive Company, Kao Corporation, LOral S.A., Procter & Gamble, Shiseido Company, The Estee Lauder Companies Inc., Unilever PLC, Revlon, Clinique Laboratories, llc., Murad, LLC., SkinCeuticals, RMS Beauty, J.R. Watkins and 100% PURE.

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The Medical Skin Care Products Market to personify growth in the next decade - PRnews Leader

Skin Stem Cells Comments Off on The Medical Skin Care Products Market to personify growth in the next decade – PRnews Leader | November 12th, 2020