Bypassing stem cells, mouse skin cells have been converted directly into cells that become the three main parts of the animal's nervous system, according to new research at the Stanford University School of Medicine.

The startling success of this method seems to refute the idea that "pluripotency" -- the ability of stem cells to become nearly any cell in the body -- is necessary for a cell to transform from one cell type to another.

It raises the possibility that embryonic stem cell research, as well as a related technique called "induced pluripotency," could be supplanted by a more direct way of generating cells for therapy or research.

"Not only do these cells appear functional in the laboratory, they also seem to be able to integrate ... in an animal model," said lead author and graduate student Ernesto Lujan.

The study was published online Jan. 30 in the Proceedings of the National Academy of Sciences.

The finding implies that it may one day be possible to generate a variety of neural-system cells for transplantation that would perfectly match a human patient.

While much research has been devoted to harnessing the potential of embryonic stem cells, taking those cells from an embryo and then implanting them in a patient could prove difficult because they would not match genetically.

The Stanford team is working to replicate the work with skin cells from adult mice and humans.

But Lujan emphasized that

much more research is needed before any human transplantation experiments could be conducted.

In the meantime, however, the ability to quickly and efficiently generate cells -- grown in mass quantities in the laboratory, and maintained over time -- will be valuable in disease and drug-targeting studies.

Contact Lisa M. Krieger at 408-920-5565.

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Stanford scientists bypass stem cells to create nervous system cells

Sangeeta Bhatia, MIT professor of health sciences and technology and electrical engineering and computer science

Researchers at MIT and their colleagues said they have devised a way to produce liver-like cells from stem cells, a key step in studying why people respond differently to Hepatitis C.andnbsp;andnbsp;andnbsp;andnbsp;andnbsp;andnbsp;andnbsp;andnbsp;
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An infectious disease that can cause inflammation and organ failure, Hepatitis C has different effects on different people, but no one is sure why, the researchers said in a press release from MIT. Some people are very susceptible to the infection, while others are resistant.

The researchers said that by studying liver cells from different people in the lab, they may determine how genetic differences produce these varying responses. However, liver cells are hard to get and very difficult to grow in a lab dish because they tend to lose their normal structure and function when removed from the body.

The researchers, from MIT, Rockefeller University and the Medical College of Wisconsin, have come up with a way to produce liver-like cells from induced pluripotent stem cells (iPSCs), which are made from body tissues rather than embryos. Those liver-like cells can then be infected with Hepatitis C and help scientists study the varying responses to the infection.

The scientists claim this is the first time an infection has been made in cells derived from iPSCs. Their new technique is described in the Jan. 30 issue of the Proceedings of the National Academy of Sciences. The development, they said, may also eventually enable personalized medicine, in which doctors could test the effect of different drugs on tissues derived from the patient being treated and then customize therapy for that patient.

The new study is a collaboration between Sangeeta Bhatia, professor of health sciences and technology and electrical engineering and computer science at MIT; Charles Rice, professor of virology at Rockefeller; and Stephen Duncan, professor of human and molecular genetics at the Medical College of Wisconsin.

The iPSCs are derived from normal body cells, often skin cells. By turning on certain genes in those cells, the scientists can revert them to an immature state that is identical to embryonic stem cells, which can turn into any cell type. Once the cells become pluripotent, they can be directed to become liver-like cells by turning on genes that control liver development.

The researchers’ goal is to take cells from patients who have unusual reactions to hepatitis C infection, transform them into liver cells and study their genetics to see why people respond as they do. “Hepatitis C virus causes an unusually robust infection in some people, while others are very good at clearing it. It’s not yet known why those differences exist,” Bhatia said in a statement.

Bhatia is a 2009 Mass High Tech Women to Watch honoree.
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Stem cells may shed light on hepatitis, MIT researchers find

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15-01-2012 12:18 http://www.SCRxPlasma.Com Welcome to the 21st Century of Modern Medicine. Recent discovery reveals that it is the umbilical cord lining that is the body's greatest source of undifferentiated stem cells. In a single cord skin, billions of ETHICAL epithelial and mesencymal stems cells can be harvested.

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15-01-2012 00:02 http://www.SCRxPlasma.Com Welcome to the 21st Century of Modern Medicine. Recent discovery reveals that it is the umbilical cord lining that is the body's greatest source of undifferentiated stem cells.

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30-11-2011 11:56 Results after 4 months on Adult Stem Cell growth factors skin serum

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26-11-2011 11:13 Stem cells are the body's repair cells. They have the ability to divide and differentiate into many different types of cells based on where they are needed throughout the body. Stem cells can divide and turn into tissues such as skin, fat, muscle, bone, cartilage, and nerve to name a few

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26-09-2011 18:57 Lean back and learn in just 3 minutes all benefits of our unique biological health care measure. (We) Back-up Your Life! TICEBA is the first private tissue bank worldwide to obtain stem cells from the skin, assess their quality and preserve them.

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Wawa, QC Chemist of Imed Lab Sdn Bhd explains and demo about Glamore Halal Stem Cell Vitalization, built with EverLaSkin as active ingredients, to stimulate dormant stem cells under your skin -- stem cells that are able to regenerate and repair skin tissue, and counterbalance the aging epidermal cells with new and young cells. Imed Lab Sdn Bhd is a manufacturer of halal cosmetic products.

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Israeli researchers have managed for the first time to repair damaged tissue using components produced by embryonic stem cells.

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Dr. Ava discusses stem cell technology for rejuvenating mature skin on ABC7 news

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The Jeunesse Luminesce range of skin care uses the most advanced form of stem cell technology around. By using a cream which contains over 200 adult stem cell particles, these re-activate your skins own stem cells thus helping repair your skin naturally.

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Amazing skin rejuvenation serum made from growth factors of adult stem cells.

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