Ottawa Sun

Tough time: Jonathan Pitre battles kidney complications Ottawa Sun Pitre, 16, was infused two weeks ago with stem-cell rich blood and bone marrow drawn from his mother's hip. The procedure, conducted as part of an ongoing clinical trial at the University of Minnesota Masonic Children's Hospital, is the only treatment ... and more »

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Tough time: Jonathan Pitre battles kidney complications - Ottawa Sun

This weekend the community will be given the chance to save the life of one of its youngest residents. On Friday, April 28, the AmVets Post No. 94 will host a bone marrow registration drive from 3-7 p.m.

Wade Wachter is the son of Adam and Jenni (Duvall) Wachter of Perryville and the grandson of Terri and Lori Duvall, Robyn Roy, and Rodney and Barb Wachter.

On the outside, little Wade is a normal kid though he has been battling a very rare form of bone marrow failure disorder called Schwachman Diamond Syndrome. This dysfunction of the bone marrow requires a lifesaving transplant. He currently takes medication daily and has routine biopsies to monitor for potential leukemia developments in his body.

This disease is so rare that funding is hard to find, which limits the number of possible treatments available. DKMS is the nonprofit group leading the charge to find a bone marrow match for Wachter.

Recent tests show that Wachter will need an immediate transplant for his best chance to have a normal childhood, and according to the DKMS website only 30 percent of patients find a donor inside their families. Nearly 14,000 patients require donations from matched individuals outside of their family line each year. Out of more than 800,000 donors in the U.S., and over 6 million worldwide, 6 out of 10 patients are still unable to find a compatible donor.

We thank DKMS and our community for working with us to help find Wade a bone marrow match, said Jenni Wachter, Wades mother. From the outside, Wade may look like your average 6-year-old child, when really he has been facing a life-threatening battle for years. Our hope is to grow the bone marrow registry to help increase the chances of finding Wade a match so he can move forward towards a healthy and happy life.

Potential donors include anyone who is in good general health between the ages of 18 to 55. Registration is free and only requires filling out a simple form and a quick swab of the inside of each cheek. DKMS covers the $65 registration and processing fee for each supporter, but donations will be accepted to cover costs.

There are two ways to donate once a match has been found. The first method is the Peripheral Blood Stem Cell (PBSC) donation. This is a non-surgical, outpatient procedure that collects blood stem cells via the bloodstream. It takes about 4-8 hours on 1-2 consecutive days. This method is used in 75 percent of all cases. The other donation method is by direct bone marrow procedure. It is a 1-2 hour surgical procedure, done under anesthesia, where a syringe collects marrow cells from the back of the pelvic bone. This method is only used in about 25 percent of the cases, usually when the patient is a child.

Anyone unable to attend the drive that wishes to register as a potential donor may do so online at http://www.dkms.org. The Perryville AmVets Post No. 94 is located at 1203 W. Saint Joseph Street.

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Bone marrow drive set for local youth - Perry County Republic Monitor

This study aimed to explore the role of the transforming growth factor-/mitogen activated protein kinase (TGF-/MAPK) signaling pathway in the effects of bone marrow mesenchymal stem cells (BMSCs) on urinary control and interstitial cystitis in a rat model of urinary bladder transplantation.

A urinary bladder transplantation model was established using Sprague-Dawley rats. Rats were assigned to normal (blank control), negative control (phosphate-buffered saline injection), BMSCs (BMSC injection), sp600125 (MAPK inhibitor injection), or protamine sulfate (protamine sulfate injection) groups. Immunohistochemistry, urodynamic testing, hematoxylin-eosin staining, Western blotting, enzyme-linked immunosorbent assay, and MTT assay were used to assess BMSC growth, the kinetics of bladder urinary excretion, pathological changes in bladder tissue, bladder tissue ultrastructure, the expression of TGF-/MAPK signaling pathway-related proteins, levels of inflammatory cytokines, and the effects of antiproliferative factor on cell proliferation.

Compared with normal, negative control, BMSCs, and sp600125 groups, rats in the PS group exhibited decreased discharge volume, maximal micturition volume, contraction interval, and bladder capacity but increased residual urine volume, bladder pressure, bladder peak pressure, expression of TGF-/MAPK signaling pathway-related proteins, levels of inflammatory cytokines, and growth inhibition rate. Levels of inflammatory cytokines and the growth inhibition rate were positively correlated with the expression of TGF-/MAPK signaling pathway-related proteins.

Our findings demonstrate that the TGF-/MAPK signaling pathway mediates the beneficial effects of BMSCs on urinary control and interstitial cystitis.

American journal of translational research. 2017 Mar 15*** epublish ***

Ya Xiao, Ya-Jun Song, Bo Song, Chi-Bing Huang, Qing Ling, Xiao Yu

Urological Research Institute of PLA, The First Affiliated Hospital, Third Military Medical UniversityChongqing 400037, P. R. China; Department of Urology, The Second Affiliated Hospital, The Third Military Medical UniversityChongqing 400037, P. R. China., Department of Urology, The Second Affiliated Hospital, The Third Military Medical University Chongqing 400037, P. R. China., Urological Research Institute of PLA, The First Affiliated Hospital, Third Military Medical University Chongqing 400037, P. R. China., Department of Urology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology Wuhan 430030, P. R. China.

PubMed http://www.ncbi.nlm.nih.gov/pubmed/28386345

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TGF-/MAPK signaling mediates the effects of bone marrow mesenchymal stem cells on urinary control and interstitial ... - UroToday

Wade Watcher

A Perryville family is organizing a bone-marrow registration drive in hopes of finding a match for their 6-year-old son, who needs a bone-marrow transplant.

Wade Watcher's mother Jenni said for the most part, he's a regular 6-year-old.

"Active and funny and adorable," she said. "He's smart and loves to draw. He likes playing basketball. He's a pretty awesome kid."

But for him to continue leading a normal childhood, Watcher likely would need a bone-marrow transplant.

"We knew that he had a rare disease when he was a baby, and so yearly we have to get a bone marrow biopsy to see if his bone marrow is failing," Watcher said. "It had been fairly normal until December. ... It showed his bone marrow was in the stages of failing and that it was kind of like a waiting game to see if he needs to be sent for a bone marrow transplant or not."

Wade, who suffers from Shwachman-Diamond syndrome, a rare congenital disorder, is stable, but his mother said they don't know for how long.

So they're organizing a registration drive for members of the community to sign up to have their cheek swabbed and see whether they may be a match. The drive will be from 3 to 7 p.m. Friday at the Amvets Post 94 in Perryville.

Watcher said she's not sure how many people are scheduled to participate, but she to register as many people ranging in age from 18 to 55 years old people as possible.

"Anybody that can would be amazing," she said. "It would provide a lot of help for our family as well as other families."

Registration involves filling a form and having a cheek swabbed for about 30 seconds. Donor recruitment coordinator Olivia Haddox said people typically shy away from such drives because they are unsure of what it may mean if they are "matched" with a person in need.

"People are surprised to find how easy it is just to register, but then the next question is always, 'What's going to happen if I get that call?'" she said. "We definitely get that a lot."

There are two ways for the donation to happen if a match is found, she said. About 80 percent of the time, donations are done via peripheral blood stem-cell donation, a four- to eight-hour session in which blood is taken from one arm and filtered through an aphoresis machine to separate the blood from the stem cells. After taking the stem cells, the blood is returned to the donor's body.

"That can kind of be compared to a lengthier platelet or plasma donation," Haddox said. "You don't actually even lose any blood that day; you just lose some stem cells, and you regenerate those in about a week, so what you give you do get back," she said.

People usually watch Netflix while donating, she said, and minor side effects more often come from the series of injections donors receive before the procedure to boost the stem cells. Those injections can cause some fatigue or other side effects.

"Nothing so severe that it might keep anyone out of work," Haddox said. "It's just kind of your body preparing for the donation."

The other, less-common method is an outpatient procedure whereby liquid marrow from the lower back pelvic area is removed.

"And you're actually put under for this procedure, so you're not awake when it happens and you don't feel anything when it happens," Haddox said. "Afterwards, what most people tell me they feel is just a tenderness and a bruising around the site where they removed the marrow. A lot of people equate this to saying, 'I felt like I fell on some ice, and I had a bruise on my hip for a few days.'"

If people can't attend the drive, swab kits can be ordered at dkms.org.

tgraef@semissourian.com

(573) 388-3627

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Perryville family organizing bone-marrow drive Friday for ailing 6-year-old boy - Southeast Missourian

GETTY STOCK IMAGE

The way to the Red Planet and other mysterious worlds is being inspired by the villainous Khan from the blockbuster films, according to new research.

The use of stem cell technology may mean the difference between life and death on any attempt to travel beyond Earth into the wilderness of space.

So the first person to walk on Mars is likely to be selected from the growing group of people whose parents took the step to store their child's stem cells at birth.

Stem cells are 'blank' cells that can be reprogrammed to turn into any other cell in the body, enabling the replacement of damaged cells.

More and more British parents, including TV presenter Natalie Pinkham and dancer Darcey Bussell, are paying more than 2,000 to freeze samples from their babies' umbilical cords at birth.

Stem cells are also found in bone marrow and some body tissue, but the procedure to harvest them from umbilical cords is less risky.

Adventurous Mars pioneers will have to be especially prepared for the dangerous trip, which could expose them to cancer and other diseases, through carefully researched gene therapy.

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We wince at the thought of genetically engineered humans

Mark Hall

Mark Hall, spokesperson for the UK's leading stem cell storage and diagnostics company StemProtect, said: "We wince at the thought of genetically engineered humans.

"And we are not going to create a Khan from Star Trek specifically to get to another planet. Getting humans to Mars and beyond will be both expensive and dangerous.

"But the scientific by-products - such as huge leaps in stem cell medicine - will benefit humanity for centuries to come."

Genetic engineering has featured in two Star Trek movies, and a number of TV episodes.

IG

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This still image strikes an uncanny resemblance to a figure of a woman

Khan, who appeared in Space Seed and Star Trek II: The Wrath of Khan, was modified to make him stronger and to give him greater stamina and intellectual capacity than a regular human.

Mr Hall said: "The first human to walk on Mars may not even be born yet - but that's an advantage."

StemProtect believes advanced medical techniques will be required to cope with the rigours of interplanetary space.

While a trip to Mars may appear "just around the corner" in galactic terms, it is highly possible exposure to radiation along the way could lead to the astronauts developing leukaemia and other cancers even before they arrived.

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This means future travellers will have to be 'immunised' before they leave Earth.

Mr Hall said: "There was an article in The Times suggesting elephants would make ideal Martian travellers because they'd be largely immune to the radiation.

"But those laughing at the ridiculous sounding headline completely missed the point - the fact is scientists are already working on ways of getting humans there and back alive."

Recent research has shown radiation in deep space increase the risk of leukaemia while long term exposure to micro gravity may leave astronauts open to infection.

The three year round trip to Mars would affect humans at the stem cell level, leaving them with a drastically lowered immune system, NASA funded scientists say.

And NASA's own findings say stem cells may be crucial to the future of space travel, particularly how they respond in a low gravity environment.

One study showed stem cells flown in space and then cultured back on Earth had greater ability to self renew and generate any cell type, changing more easily into specialised heart muscle cells, for instance.

Mr Hall said an astronaut will have to be prepared for the journey "quite literally at the stem cell level."

He explained: "That means working with the best and most effective stem cells available to the patient - those harvested from the umbilical cord at birth."

GETTY STOCK IMAGE

The therapies required to 'immunise' humans to space travel are still being researched.

And with most space based science, it can only mean huge benefits to mankind back down on Earth when it comes to fighting otherwise deadly conditions and diseases.

Stem cells have the ability to treat a potentially infinite range of illnesses and diseases.

Stem cell therapy is already being used all over the world to treat some cancers and stroke victims - and there is fast progress being made in many other areas, including Parkinson's and Alzheimer's disease.

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SUPERHUMANS: Mars 'will be colonised by genetically engineered Star Trek-style beings' - Express.co.uk

It was Thursday afternoon, and the little girl from near Cologne, Germany, and the 40-year-old Duluth woman had known each other for less than 24 hours. But it was obvious that Edwards already had bonded with Ina and her little sister Mila.

They were together because the girls' mother had given Edwards a much greater gift: the gift of life.

"By your donation, I still get to be a mom," Edwards told Daniela Halfkann, 30. "(You're) a mom, so you completely understand how important it is to be here with your children."

Edwards, the mother of 15-year-old twin boys and the wife of Duluth Fire Chief Dennis Edwards, is alive because of the stem cell transplant she received at the Mayo Clinic on Oct. 31, 2014. As a result, she said, she is in remission from the rare and aggressive form of leukemia with which she had been diagnosed that June.

All she was told at the time of the transplant was that the donor was a woman from Germany.

Halfkann had registered as a potential stem cell or bone marrow donor at the large insurance company where she works in Cologne, she said. One day she received a call, saying her donation was needed.

After the six-hour procedure, Halfkann was told nothing more than that the recipient was a woman in the United States.

After a two-year waiting period required in Germany, the two women learned each other's identities last October and connected via Facebook.

Their meeting in Duluth was arranged by Amanda Schamper, Midwest donor recruitment coordinator for DKMS, the Germany-based organization that facilitated the donation.

Halfkann made the trip along with husband Stefan and their daughters, leaving their home at 3 a.m. on Tuesday and arriving at the Duluth International Airport at 5 p.m. on Wednesday.

Like Edwards, DKMS wants to raise awareness of the need for people to enter the registry, said Schamper, who also traveled to Duluth for the occasion.

She said 14,000 patients are in need of a peripheral blood stem cell or bone marrow donation, but fewer than half will get one because there's no match on the registry.

"We're looking for a particular protein in our DNA," she explained.

Only in 30 percent of cases are siblings a match. Edwards' brother and sister both had been screened, she said, and neither was a match for her.

Finding a match "is equated to finding your genetic twin, or winning the genetic lottery," Schamper said.

If more people were on the registry a process that only requires taking a swab from your cheek there would be more potential matches. But only 2 percent of eligible Americans are registered, Schamper said.

When the Halfkanns arrived at the gate on Wednesday, Dennis and Merissa Edwards, along with sons Caden and Jaxon, were waiting at the gate.

It was an emotional moment.

"It was hard for me," Merissa Edwards said on Friday, speaking to Daniela Halfkann. "I was crying. I was so emotional, so happy to meet you and hug you."

She wiped away a tear. "I still am."

"It was amazing," Halfkann responded. "I cried at the gate, too."

The Halfkanns, who are staying at the Edgewater, initially focused on recovery from jet lag. But Edwards is making sure they'll get a full taste of Duluth and Minnesota before beginning their return trip to Germany next Saturday. That includes visits to the Mall of America, the Great Lakes Aquarium and a trip up the North Shore.

A "thank-you party," open to the public, is planned on Sunday afternoon. Halfkann also will be recognized on Monday during the Saints Sports Awards ceremony at the College of St. Scholastica, where Edwards is an administrative assistant in the athletics department.

Recovery from the ravages of leukemia has been a long process, Edwards said, but she remains in remission. She gets a PET scan every six months to make sure that's still the case; the next one takes place next week.

Edwards shares her story, she said, not to call attention to herself but to highlight the need for people to take the simple step of registering as a potential donor.

"It's so important for us to help other people keep their families together and save a mother or father or son or daughter," she said. "The more people we can encourage to cheek-swab and get on the registry, the more lives we can help save and help families stay together."

TO LEARN MORE

For more information and to learn how to get on the bone marrow and peripheral blood stem cell registry, visit dkms.org.

IF YOU GO

The thank-you party for Daniela Halfkann will be from 2 to 5 p.m. on Sunday at The Other Place Bar and Grill, 3930 E. Calvary Road.

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Duluth woman meets the German donor whose stem cells saved her ... - WDAZ

The biggest national project to treat patients with cerebral palsy (CP) through injection of stems cells from umbilical cord blood (UCB) into the brain began its trial run in March. The project is jointly undertaken by Royan Institute, Childrens Medical Center (affiliated to Tehran University of Medical Sciences), and the Iran Blood Transfusion Organization (IBTO). In the first phase, it will provide treatment to 130 children with CP between the ages 5-13. The treatment was tested in September 2016 on children with CP in some hospitals, and the results were highly satisfactory. Approximately four in every 1,000 children in Iran have CP while in the developed countries the rate is 2 to 2.5 per 1000 live births. Cerebral palsy is an umbrella term for the effects of damage to a developing brain by various causes. It is connected with a range of symptoms, including muscle weakness and movement problems. The damage to the brain usually occurs early on in its development, either in the baby during pregnancy or during the period soon after birth. Symptoms may include difficulties in walking, balance and motor control, eating, swallowing, speech or coordination of eye movements. Some people affected by CP also have some level of intellectual disability. No two people with cerebral palsy are affected in exactly the same way. The IBTO plans to expand the storage of stems cells from umbilical cord blood to 100,000 samples from the current 80,000, said Ali Akbar Pourfathollah, head of the organization, ILNA reported. Around 75,000 samples have been stored in private banks and 5,000 in public banks, but the number will surpass 100,000 soon, he added.

Valuable Source for Treatment Umbilical blood is a valuable source of hematopoietic stem cells which can be used for treatment of many malignant diseases such as leukemia. Hundreds of transplants have been performed using stem cells from such blood, which is easy and risk free. The use of stem cells reduces the risk of viral diseases transmission and incidence of Graft Versus Host Disease (GVHD). The ability to perform organ transplants is among the benefits of umbilical cord blood transfusion. Using stems cells is also one of the best ways to treat blood diseases since the method has a success rate of 70% worldwide. Storage of stem cells is a valuable investment. So far, 27 cord blood banks have been launched across the country. There are two types: public and private banks for stem cell storage. The former does not charge a fee for storage. But in the latter, the cost of collection and genetic testing is about $645 and the annual charge for storage is $33, according to ISNA. Pourfathollah said the IBTO is looking to store stem cells in medical cases when a patient needs to receive treatment from matched unrelated donors. In the past Iranian year (ended March 20), out of the 8,000 stem cell transplantations in the country, only 100 were from matched unrelated donors and the rest came from sibling (or related) donors. IBTO is also looking to set up coagulation/transfusion and HLA/immunogenetics laboratories in the country on par with international standards. The Immunogenetics and HLA Laboratory provides human leukocyte antigen (HLA) typing, HLA antibody identification and post-transplant engraftment monitoring services. These tests are required for patients undergoing evaluation for organ transplantation, recipients of bone marrow/stem cell transplants, patients requiring platelet transfusions from HLA-matched donors, and patients undergoing evaluation of particular health conditions.

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Treating Cerebral Palsy With UCB Stem Cells - Financial Tribune

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A Lincoln student is set to save someone's life after finding out he was a match for someone who needed a bone marrow transplant.

John-Paul Dickie, the vice-president of academic affairs at the University of Lincoln, said he joined the register after his flatmate told him about it.

He doesn't know the identity of the person whose life he saved, but said he was delighted that he's been able to help someone who was desperate for a transplant.

He said: "My flatmate was involved with Lincoln Marrow, a student-led group trying to sign people up to the British Bone Marrow Register. He was telling me the benefits of it, including the fact it could potentially save someone's life.

READ MORE: Selfless mum marks 50th blood donation with daughter's first

"I signed up in February 2014, so it was a surprise when I heard back earlier this year that I was a potential match. I had some samples taken and eventually I had a date set for the operation in May.

"I'm looking forward to it, as it's an amazing way to help somebody.

"However I'm also a bit hesitant as it will require me to be strapped to a machine for four or five hours. My partner will be there to keep me company and I'll have books and TV to stop me from getting too bored."

When bone marrow is damaged it prevents a person from creating healthy blood cells and transplants like this help to treat the condition.

The transplant requires taking stem cells from the blood or bone marrow of one person and giving them to another.

John-Paul added: "There are two ways to take stem cells. One is taking them out of your back using a needle, which is painful but only 10 per cent of people have. Fortunately, I'm having the more common method in which blood is taken out of one arm, the stem cells are removed and then it is returned in the other arm."

READ MORE: 'Gordon was denied stem cell treatment, but I'll hold him in my heart forever'

Most people who need stem cells will be a match with a close family member. However, if this doesn't work then they will have to wait on the British Bone Marrow Registry.

"It's a great way to contribute and help save someone's life. All you have to do is give a sample of spit to get on the register, the process is so simple and easy. If you're able to do it, I would definitely encourage you to give it a try.

"The procedure is anonymous in case something goes wrong. You can find out their age and sex, but at the moment I don't know anything. After two years, you can apply to find out who they are."

Bone marrow donors need to be aged between 17 and 40 and already registered as a blood donor.

If you meet these criteria interested in signing up to the British Bone Marrow Register, visit their website for more information at: http://www.nhsbt.nhs.uk/bonemarrow/

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'It's amazing!' Student discovers he's a potential life-saving bone marrow match - Lincolnshire Echo

A dad who achieved fame as a bailiff on Channel 5's Can't Pay? We'll Take It Away! has been handed a 'death sentence' unless a donor can be found to rescue him from a terminal blood cancer.

Delroy Anglin, who reached unexpected stardom on the show, has been stricken by an aggressive form of leukaemia which ravages the blood and bones of its sufferers.

The dad-of-six was confined to a hospital bed while undergoing chemotheraphy.

But Delroy, 56, desperately needs a bone marrow transplant so he can beat the debilitating disease.

However, it's proven difficult to find a matching donor because of his minority background, and he has suffered for months since first hearing the news of his deadly illness.

Delroy, from Croydon, told the Croydon Advertiser : "You feel as if someone has pronounced a death sentence.

"Life changed in an instant. When they tell you, you're just hoping someone has made a mistake, but they haven't.

"At the end of the day, unless somebody says differently - I'm terminal."

His condition was first discovered after he requested a check-up because he had been catching more colds than he usually would.

A blood test revealed what was really affecting his usually robust health.

AML affects the stem cells in bone marrow, causing a huge amount of white blood cells to be produced. Less than half of patients can be cured of the rare disease, which causes a dangerous reduction in the number of red blood cells in the body.

"I think I was in denial because I felt so fine," said Delroy, who has been forced to quit his on-screen work.

"Life changed straight away, from diagnosis to entering the hospital was a matter of days.

"Your life just changes instantly. Everything is chaotic and it remains like that for while."

Delroy, now a grandfather, is continuing to battle the disease, which developed with shocking speed, alongside his family.

His children have rallied to support him, and although his 82-year-old mum worries, her home cooking gives him strength.

"You don't want to worry your mum," said Delroy, who is now being treated at the Royal Marsden in Sutton.

"She does worry. She comes from a generation where leukaemia was a death sentence.

"But you get the home cooking from her and build up your strength it's funny how it never changes.

"You don't know how your kids are going to react. Some react well, some become aware of their own mortality a bit, and hate going to hospitals.

"But my family have reacted so well, and I think that's because they've seen my reaction. They've been absolutely amazing."

"It's strange, people don't usually like bailiffs," he said.

"But I have had so much support, from everyone including complete strangers."

The #Match4Delroy appeal is to be led by blood cancer charity the African Caribbean Leukaemia Trust (ACLT) and encourages people to join the donor register.

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Bailiff dad who reached fame on Channel 5's Can't Pay? We'll Take It Away! gets 'death sentence' diagnosis - Mirror.co.uk

BROCKPORT When Chris Cella laced up his boxing gloves last Saturday night in preparation for his war within the squared circle, he was fighting for more than his undefeated fight record.

In front of the sellout crowd in Huntington, W.V., he made quick work of his opponent, working his body hard and knocking him out two minutes into the first round.

After his hand was raised cementing the victory the ring announcer handed Cella the microphone.

It was then that he shared his motivation for the win.

This fight tonight was for a special friend, a little girl named Shea. Shes the toughest warrior of all. This win is for you Shea, said Cella.

The week before the fight, Shea and her parents came out to Cellas gym, BC Boxing, where they wished him luck for his upcoming fight.

I first met Shea when she was five and her aunt brought her to the gym to train. When she came to wish me luck she stole my heart. Her beautiful smile and contagious laugh filled the gym with so much love. Shes been more of an inspiration to me that she will ever know. Shes a fighter and warrior in every sense of the word, and it felt great to get the win in her honor, Cella said.

Shea has been unable to make it to the gym for almost a year now.

Now 8 years old, Shea was diagnosed in August with AML leukemia, a type of cancer of the blood and bone marrow with excess immature white blood cells, weeks before she was to start second grade at DuBois Central Catholic School.

Since her diagnosis, Sheas journey toward being cancer-free hasnt been an easy one.

Shes had adverse reactions to her appendix and gallbladder from the chemotherapy treatments and both had to be removed.

She also had a stem cell transplant this January and struggled with with graft versus host disease of the stomach and skin, which occurs when donor bone marrow or stem cells attack the recipient.

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I know that seems like a lot of bad, but Shea had a positive outlook on this whole experience and is nothing but smiles, Sheas mother Misty McKinney said. We are hoping with in a month or two we can come home for good.

Shea cant wait to come home and have a huge pool party and get back to boxing.

Shea said she felt very special and happy, when Cella dedicated his fight to her. The boxing community at the gym has had the familys back since her diagnosis, even taking up collections of toys and gift cards at Christmastime in an attempt to give the girl a holiday she wouldnt forget.

Shea is one of the biggest inspirations Ive ever met, Cella said. She fights so hard every day, it makes my fight seem meaningless.

To keep up to date on Sheas journey and ways you can help, friend Pray for Shea on Facebook.

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Fight For Shea: Brockport man dedicates bout to DuBois girl with leukemia - The Courier-Express

It was Thursday afternoon, and the little girl from near Cologne, Germany, and the 40-year-old Duluth woman had known each other for less than 24 hours. But it was obvious that Edwards already had bonded with Ina and her little sister Mila.

They were together because the girls' mother had given Edwards a much greater gift: the gift of life.

"By your donation, I still get to be a mom," Edwards told Daniela Halfkann, 30. "(You're) a mom, so you completely understand how important it is to be here with your children."

Edwards, the mother of 15-year-old twin boys and the wife of Duluth Fire Chief Dennis Edwards, is alive because of the stem cell transplant she received at the Mayo Clinic on Oct. 31, 2014. As a result, she said, she is in remission from the rare and aggressive form of leukemia with which she had been diagnosed that June.

All she was told at the time of the transplant was that the donor was a woman from Germany.

Halfkann had registered as a potential stem cell or bone marrow donor at the large insurance company where she works in Cologne, she said. One day she received a call, saying her donation was needed.

After the six-hour procedure, Halfkann was told nothing more than that the recipient was a woman in the United States.

After a two-year waiting period required in Germany, the two women learned each other's identities last October and connected via Facebook.

Their meeting in Duluth was arranged by Amanda Schamper, Midwest donor recruitment coordinator for DKMS, the Germany-based organization that facilitated the donation.

Halfkann made the trip along with husband Stefan and their daughters, leaving their home at 3 a.m. on Tuesday and arriving at the Duluth International Airport at 5 p.m. on Wednesday.

Like Edwards, DKMS wants to raise awareness of the need for people to enter the registry, said Schamper, who also traveled to Duluth for the occasion.

She said 14,000 patients are in need of a peripheral blood stem cell or bone marrow donation, but fewer than half will get one because there's no match on the registry.

"We're looking for a particular protein in our DNA," she explained.

Only in 30 percent of cases are siblings a match. Edwards' brother and sister both had been screened, she said, and neither was a match for her.

Finding a match "is equated to finding your genetic twin, or winning the genetic lottery," Schamper said.

If more people were on the registry a process that only requires taking a swab from your cheek there would be more potential matches. But only 2 percent of eligible Americans are registered, Schamper said.

When the Halfkanns arrived at the gate on Wednesday, Dennis and Merissa Edwards, along with sons Caden and Jaxon, were waiting at the gate.

It was an emotional moment.

"It was hard for me," Merissa Edwards said on Friday, speaking to Daniela Halfkann. "I was crying. I was so emotional, so happy to meet you and hug you."

She wiped away a tear. "I still am."

"It was amazing," Halfkann responded. "I cried at the gate, too."

The Halfkanns, who are staying at the Edgewater, initially focused on recovery from jet lag. But Edwards is making sure they'll get a full taste of Duluth and Minnesota before beginning their return trip to Germany next Saturday. That includes visits to the Mall of America, the Great Lakes Aquarium and a trip up the North Shore.

A "thank-you party," open to the public, is planned on Sunday afternoon. Halfkann also will be recognized on Monday during the Saints Sports Awards ceremony at the College of St. Scholastica, where Edwards is an administrative assistant in the athletics department.

Recovery from the ravages of leukemia has been a long process, Edwards said, but she remains in remission. She gets a PET scan every six months to make sure that's still the case; the next one takes place next week.

Edwards shares her story, she said, not to call attention to herself but to highlight the need for people to take the simple step of registering as a potential donor.

"It's so important for us to help other people keep their families together and save a mother or father or son or daughter," she said. "The more people we can encourage to cheek-swab and get on the registry, the more lives we can help save and help families stay together."

TO LEARN MORE

For more information and to learn how to get on the bone marrow and peripheral blood stem cell registry, visit dkms.org.

IF YOU GO

The thank-you party for Daniela Halfkann will be from 2 to 5 p.m. on Sunday at The Other Place Bar and Grill, 3930 E. Calvary Road.

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Duluth woman meets the German donor whose stem cells saved her life - WDAY

In an autologous BMT procedure, the healthy stem cells from the patient are taken out and preserved

IANS | New Delhi April 21, 2017 Last Updated at 05:00 IST

A team of doctors in New Delhi has successfully treated a 24-year-old girl suffering from Multiple Sclerosis (MS) with bone marrow transplant (BMT).

Kanika Juneja was diagnosed with MS an autoimmune disorder where the body's immune system starts attacking the protective sheet covering the nerve cells in the brain and the spinal cord.

She went through several rounds of treatments but could not be cured. Juneja got another chance at life at Fortis Healthcare where the doctors treated her with BMT.

"In an autologous BMT procedure, the healthy stem cells from the patient are taken out and preserved. Chemotherapy is then administered to reset the body's immunity and then the stem cells are injected back to rescue the person from the side effects of chemotherapy. After the surgery, the patient is kept under isolation for a few months to ensure he/she does not contract any infection," explained Dr Rahul Bhargava, Director, Clinical Hematology and Bone Marrow Transplant, Fortis Memorial Research Institute (FMRI).

Since conventional steroid injections and immune therapy are expensive and don't promise a cure, Bhargava thought of going for a BMT for Juneja.

Juneja is now actively involved in raising awareness about MS amongst the community through social media.

"I had just completed my college education when I was diagnosed with multiple sclerosis. I was lucky because I got diagnosed within a week of my symptoms and could avail treatment options faster," Juneja said.

"In this case, we have proved that bone marrow transplant can be seen as a successful alternate treatment option for multiple sclerosis patients, giving them a fresh shot at life," added Dr Simmardeep Singh Gill, Zonal Director, FMRI, in a statement.

Currently, there are 2.3 million people living with multiple sclerosis worldwide.

A team of doctors in New Delhi has successfully treated a 24-year-old girl suffering from Multiple Sclerosis (MS) with bone marrow transplant (BMT).

Kanika Juneja was diagnosed with MS an autoimmune disorder where the body's immune system starts attacking the protective sheet covering the nerve cells in the brain and the spinal cord.

She went through several rounds of treatments but could not be cured. Juneja got another chance at life at Fortis Healthcare where the doctors treated her with BMT.

"In an autologous BMT procedure, the healthy stem cells from the patient are taken out and preserved. Chemotherapy is then administered to reset the body's immunity and then the stem cells are injected back to rescue the person from the side effects of chemotherapy. After the surgery, the patient is kept under isolation for a few months to ensure he/she does not contract any infection," explained Dr Rahul Bhargava, Director, Clinical Hematology and Bone Marrow Transplant, Fortis Memorial Research Institute (FMRI).

Since conventional steroid injections and immune therapy are expensive and don't promise a cure, Bhargava thought of going for a BMT for Juneja.

Juneja is now actively involved in raising awareness about MS amongst the community through social media.

"I had just completed my college education when I was diagnosed with multiple sclerosis. I was lucky because I got diagnosed within a week of my symptoms and could avail treatment options faster," Juneja said.

"In this case, we have proved that bone marrow transplant can be seen as a successful alternate treatment option for multiple sclerosis patients, giving them a fresh shot at life," added Dr Simmardeep Singh Gill, Zonal Director, FMRI, in a statement.

Currently, there are 2.3 million people living with multiple sclerosis worldwide.

IANS

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Multiple Sclerosis patient successfully treated with bone marrow transplant - Business Standard

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In your biology class, you may have learned that lungs help us breathe while bone marrow, found in flat bones such as the hip bone, produces red and white blood cells through a process called hematopoiesis. Now, a new study conducted by University of California, San Francisco (UCSF) researchers has discovered that in addition to being a crucial part of our respiratory system, lungs also play a major role in the production and storage of blood cells.

Like many medical breakthroughs, the scientists stumbled upon this discovery by accident. The team, led by Professor Mark R. Looney, was trying to observe how platelets (cells that form clots to stop bleeding) circulating in the lungs interact with the immune system in mice. To trace the cells path, the rodents had been genetically modified so that the platelets appeared a glowing green.

To the scientists' astonishment, the lungs were filled with megakaryocytes the cells responsible for producing platelets. Though experts have always known of the existence of these cells inside the lungs, the numbers had been believed to be tiny. Emma Lefranais, who co-wrote the study, says, "When we discovered this massive population of megakaryocytes that appeared to be living in the lung, we realized we had to follow this up."

Further examination revealed that the megakaryocytes in the lungs were producing over 10 million platelets, or more than half the total platelets, produced by a mouse, every hour. The researchers also noticed the large population (1 million per mouse lung) of blood stem cells (which produce red blood cells) as well as megakaryocyte progenitor cells (which generate megakaryocyte cells) on the periphery of the lungs. Looney says, To our knowledge, this is the first description of blood progenitors resident in the lung.

To investigate the significance, the scientists conducted three studies. First, they transplanted lungs from normal mice into the genetically engineered ones to see how the blood stem cells move throughout the body. By following the fluorescent cells, they discovered that megakaryocytes originate in the bone marrow but migrate to the lungs to produce platelets.

To test the practical applications of this discovery and see if it would be useful in the treatment of disorders like lung inflammation, Looneys team injected the fluorescent megakaryocyte progenitor cells into mice with low platelet counts. To their delight, the transplanted cells got to work immediately, restoring the platelet count to normal levels within a short time. What was even more encouraging is that the effect lasted for several months.

Finally, the researchers transplanted healthy lungs in which all the cells had been fluorescently tagged into mice whose bone marrow was not producing blood cells or platelets. The researchers found that the glowing green megakaryocyte progenitor cells instantly migrated from the lungs to the bone marrow, where they helped to produce platelets and other critical blood components, like neutrophils, B cells, and T cells.

While the scientists, who published their findings in the journal Nature on March 22, 2017, still need to test if human lungs are as effective, the findings are being hailed as a major breakthrough. Traci Mondoro from the US National Heart, Lung, and Blood Institute, says, "Looney and his team have disrupted some traditional ideas about the pulmonary role in platelet-related hematopoiesis, paving the way for further scientific exploration of this integrated biology."

Resources: newatlas.com, UCSF.edu

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Lungs Don't Just Help Us Breathe They Produce Blood, Too - DOGOnews

Scientists at the University of California San Francisco have discovered a new function of lungs: They make blood which leads to a new wellspring of stem cells as well.

The astonishing breakthrough comes courtesy of refinement to microscopic video imaging that allows researchers to probe individual cells within blood vessels of a living host's lungs in this case, mice lungs.

The findings have far-reaching implications for human study: Researchers were surprised to find that not only did the lungs produce more blood cells, they did so in volumes that indicated more than half of all platelets in circulation critical for clotting are produced by the lungs.

The significance for the blood stem cells also was compelling. The newly discovered pool of stem cells is capable of restoring blood production when bone marrow stem cells are depleted. This could lead to novel approaches to treating leukemia, a cancer of white blood cells that crowds out red blood cells, and bone cancer, which destroys the body's ability to manufacture red blood cells.

This finding definitely suggests a more sophisticated view of the lungs that theyre not just for respiration but also a key partner in formation of crucial aspects of the blood, said pulmonologist Mark R. Looney, a professor of medicine and of laboratory medicine at the University of California, and the research's senior author. What weve observed here in mice strongly suggests the lung may play a key role in blood formation in humans as well. The report was published online at Nature.com.

The new imaging approach allowed scientists to examine interactions between the immune system and platelets in the lungs. While following the interactions, they discovered a surprisingly large population of cells that produce platelets called megakaryocytes. Though these cells were observed in the lungs previously it was generally though that they exist primarily in bone marrow.

Researchers were baffled and more detailed imaging followed. Once they zeroed in on these cells, they soon realized that they not only took up residence in the lungs, they also were producing 10 million platelets per hour there evidence that more than half of platelet production actually occurs in the lungs (in the mice models).

To be able to track blood stem cells and blood production, researchers transplanted donor lungs to mice with fluorescent-dye-tinted megakaryocytes. They followed the fluorescent cells as they traveled to the new lungs.

In another experiment, scientists wanted to determine if lungs that already had these platelet producers imbedded would spur platelet production in mice with low platelet counts, so they transplanted lungs with fluorescent-tinted megakaryocytes into mice predetermined to have low platelet counts. The transplanted lungs quickly sprung into action and restored normal platelet levels.

In yet another experiment, researchers transplanted healthy lungs with all cells fluorescently tinted into mice without bone marrow blood stem cells. The fluorescent marker cells quickly traveled to the damaged bone marrow and began production of myriad cells including T cells, which are key immune cells.

The exact mechanism behind the bone marrow-lung blood production is not yet known. Its possible that the lung is an ideal bioreactor for platelet production because of the mechanical force of the blood, or perhaps because of some molecular signaling we dont yet know about, said Guadalupe Ortiz-Muoz, a postdoctoral researcher and the researchs co-author. But more research is sure to follow.

Now medical scientists and researchers can zero in on proving in human models that blood components stem cells key among them travel more freely than previously though, which could lead ultimately to advances in treatment options for various blood disorders.

2017 NewsmaxHealth. All rights reserved.

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Surprise - Lungs Make Blood, Too - Newsmax

Oncology Nurse Advisor

Chronic Myeloproliferative Neoplasms Treatment (Fact Sheet) Oncology Nurse Advisor Myeloproliferative neoplasms are a group of diseases in which the bone marrow makes too many red blood cells, white blood cells, or platelets. Normally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. and more »

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Chronic Myeloproliferative Neoplasms Treatment (Fact Sheet) - Oncology Nurse Advisor

April 20, 2017 07:00 ET | Source: David Steenblock, D.O. Inc.

SAN CLEMENTE, Calif., April 20, 2017 (GLOBE NEWSWIRE) -- David Steenblock, an osteopathic physician based in San Clemente, CA, uses stem cells and other therapies to achieve significant and improved lifestyle outcomes for many stroke patients.

Many of our cases have demonstrated improved mobility for stroke victims who received stem cell therapy, along with other therapies, including chelation and hyperbaric oxygen, says Dr. Steenblock.

One patient who suffered a stroke several years ago, came to Dr. Steenblocks clinic to undergo the full stroke program. This included EDTA chelation, a procedure that removes heavy metals from the blood, and hyperbaric oxygen therapy, along with stem cells from his bone marrow to effect healing and restoration.

After having the bone marrow stem cells, the patients eyesight improved, and both of his knees, which hadnt been working well, were back to functioning almost normally. In addition, his hip joint went back to normal function and he believes his balance when walking has improved tremendously.

The EDTA Chelation Therapy, a treatment used to remove heavy metals from the blood, was used with hyperbaric oxygen, which can lead to significant neurologic improvements for stroke patients.

Dr. David Steenblock is a leading-edge physician in many fields of medicine, from stroke care, to acute brain trauma, to generative and cell-based medicine in the treatment of ALS, Cerebral Palsy and other chronic and degenerative diseases. For more information about Dr. Steenblocks work in stem cell therapies, visit http://www.stemcellmd.org

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David Steenblock, D.O., Uses Stem Cells and Other Therapies for Stroke Patients - GlobeNewswire (press release)

A team of researchers in Japan has combined simple agarose with advanced machine learning techniques to study the differentiation of stem cells.

Asian Scientist Newsroom | April 20, 2017 | In the Lab

AsianScientist (Apr. 20, 2017) - Stem cell differentiation can now be seen thanks to a combination of machine learning and microfabrication techniques developed by scientists at the RIKEN Quantitative Biology Center in Japan. The results, published in PLOS ONE, followed the differentiation of human mesenchymal stem cells (MSC) which are easily obtained from adult bone marrow.

MSCs have proven to be important for regenerative medicine and stem cell therapy because they can potentially repair many different types of organ damage. Depending on the way the cells are grown, the results can be quite different, making controlling differentiation is an important goal.

Observing MSC differentiation under different conditions is an essential step in understanding how to control the process. However, this has proved challenging on two fronts. First, the physical space in which the cells are grown has a dramatic impact on the results, causing significant variation in the types of cells into which they differentiate. Studying this effect requires consistent and long lasting spatial confinement. Second, classifying the cell types which have developed through manual observation is time consuming.

Previous studies have confined cell growth with fibronectin on a glass slide. The cells can only adhere and differentiate where the fibronectin is present and are thus chemically confined. However, this procedure requires high technical skill to maintain the confinement for an extended period of time. To overcome this, the first author of the study, Dr. Nobuyuki Tanaka, decided to look for a new way to confine them. Using a simple agarose gel physical confinement system, he found that he could maintain them for up to 15 days.

It was wonderful to be able to do this, because agarose gel is a commonly used material in biology laboratories and can be easily formed into a micro-cast in a PDMS silicone mold, Tanaka said.

The advantage of this system is that once the PDMS molds are obtained the user only needs agarose gel and a vacuum desiccator to create highly reproducible micro-casts.

Tanaka's paper also describes an automated cell type classification system, using machine learning, which reduces the time and labor needed to analyze cells.

Combined together, these tools give us a powerful way to understand how stem cells differentiate in given conditions, he added.

The article can be found at: Tanaka et al. (2017) Simple Agarose Micro-confinement Array and Machine-learning-based Classification for Analyzing the Patterned Differentiation of Mesenchymal Stem Cells.

Source: RIKEN; Photo: Shutterstock. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

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Automatically Observing Stem Cell Differentiation - Asian Scientist Magazine

The Husaini Haematology and Oncology Trust will soon provide facilities of bone marrow transplant and stem cell therapies at its newly established Blood Transfusion Centre and Thalassaemia Centre that was inaugurated by the city director health on Tuesday.

Speaking at the inaugural ceremony, Karachi director health Dr Muhammad Toufique urged the trust officials to share the data of patients undergoing blood transfusions, stem cell therapies and bone marrow transplant.

He said the data would help the Sindh government formulate a plan to establish more such facilities in the future. In addition to the blood screening and storage facilities, the centre is providing blood transfusion service to children suffering from genetic blood disorders as well as diagnostic services related to blood disorders.

This is a state-of-the-art blood transfusion and thalassaemia centre where bone marrow transplant and stem cell therapies would be started very soon, said a renowned haematologist associated with the Husaini Blood Bank, Dr Sarfraz Jaffery, at the inaugural ceremony of the blood transfusion and thalassaemia centre located at Qalandaria Chowk, North Nazimabad.

The head office of the Husaini Haematology and Oncology Trust is equipped with a diagnostic lab, blood bank having storage capacity of around 3,000 blood bags and blood transfusion centre for thalassaemic patients while its management is also planning to introduce bone marrow transplant and stem cell therapy services at the same facility in the near future.

Felicitating the trust officials, the city director health vowed to support them in their services. He said the government was also striving hard for provision of safe blood to thalassaemic children and other patients.

Dr Toufique hoped that institutions like Hussaini would come forward to support the government in establishing such centres in the province. Talking to journalists, the director health said steps were being taken to control the outbreak of Chikungunya in the city.

He said the health department was in contact with the municipal authorities to start fumigation in various areas of Karachi to eliminate the mosquitoes and prevent people from mosquito-borne diseases, including dengue and Malaria.

The Sindh government was planning to merge the Malaria and Dengue Prevention and Control Cells under one project director, who would be utilizing all the resources to eliminate the mosquitoes that were responsible for the deadly infectious diseases in the province, he added.

I would also urge people to take precautionary measures, prevent themselves and their children from mosquitoes by using repellents, improving sanitation conditions in their residential areas and adopt other preventive measures to protect themselves against the mosquitoes, he advised.

Earlier, speaking at a workshop on thalassaemia management held at the same place, noted haematologists of the country stressed the need for promoting the culture of prevention from diseases in the country.

They called for the implementation of laws regarding thalassaemia screening, saying that both the government and private sector could not treat the increasing number of thalassaemic patients.

Senior haematologist from Lahore, Prof Dr Jovaria Mannan, urged the doctors and researchers to use latest research methods in the field of haematology.

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Husaini trust plans to perform bone marrow transplants, stem cell therapy - The News International

SINGAPORE - It was a bone marrow match that defied the odds of one in 20,000 - not once, but twice.

Just months after his first match fell through when the patient withdrew from treatment, Mr Phil Tan, 27, was again identified as a suitable bone marrow donor for another patient.

His donation saved the life of eight-year-old Ryssa, who was diagnosed with a rare blood disease called Myelodysplastic Syndrome about three years ago. Both met for the first time on Wednesday (April 19). Ryssa received the transplant just before her seventh birthday.

Mr Tan was one of 22 Singaporeans who were honoured by Minister for Home Affairs and Law K. Shanmugam for saving the life of a patient through the donation of their bone marrow.

"We celebrate those who have come forward without expecting a benefit, other than making a huge difference in someone else's life. It is the real spirit of giving," said Mr Shanmugam, who is a patron of the Bone Marrow Donor Programme (BMDP).

Bone marrow or blood stem cell transplant is the best treatment option for patients diagnosed with blood diseases such as leukaemia and lymphoma.

At any one time, there are at least 50 patients waiting to find a matching donor.

Siblings of the patient are the first options for a donation, as they have a one in four chance of DNA compatibility for a transplant.

When that fails, the next option would be a match with a volunteer donor registered in the BMDP.

To date, more than 75,000 volunteers have joined the BMDP register, which records the genetic type of each person.

Since 2015, more than 50 Singaporeans have donated their bone marrow to patients in Singapore and overseas, including in the United States, Britain, Canada and France.

The BMDP, which was set up in 1993, aims to increase the size of the local donor register by another 50,000 by next year.

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8-year-old patient surprises her bone marrow donor at their first ... - The Straits Times

April 18, 2017 by Gian Galassi

A research team at University of Wisconsin School of Medicine and Public Health has treated its first patient in an innovative clinical trial using stem cells for the treatment of heart failure that develops after a heart attack.

The trial is taking place at University Hospital, one of three sites nationwide currently enrolling participants. The investigational CardiAMP therapy is designed to deliver a high dose of a patient's own bone-marrow cells directly to the point of cardiac injury to potentially stimulate the body's natural healing response.

The patient experience with the trial begins with a cell-potency screening test. Patients who qualify for therapy are scheduled for a bone-marrow aspiration. The bone marrow is then processed on-site and subsequently delivered directly to the damaged regions in a patient's heart in a minimally invasive procedure.

"Patients living with heart failure experience a variety of negative symptoms that can greatly impact their day-to-day life," said UW Health cardiologist Dr. Amish Raval, associate professor of medicine and one of the principal investigators for the trial. "By being at the forefront of research for this debilitating condition, we look forward to studying the potential of this cell therapy to impact a patient's exercise capacity and quality of life."

The primary outcome to be measured is the change in distance during a six-minute walk 12 months after the initial baseline measurement.

Heart failure commonly occurs after a heart attack, when the heart muscle is weakened and cannot pump enough blood to meet the body's needs for blood and oxygen. About 790,000 people in the U.S. have heart attacks each year. The number of adults living with heart failure increased from about 5.7 million (2009-2012) to about 6.5 million (2011-2014), and the number of adults diagnosed with heart failure is expected to dramatically rise by 46 percent by the year 2030, according to the American Heart Association (AHA).

The CardiAMP Heart Failure Trial is a phase III study of up to 260 patients at up to 40 centers nationwide. Phase III trials are conducted to measure effectiveness of the intervention, monitor side effects and gather information for future use of the procedure. Study subjects must be diagnosed with New York Heart Association (NYHA) Class II or III heart failure as a result of a previous heart attack.

Information about eligibility or enrollment in the trial is available at http://www.clinicaltrials.gov, or through a cardiologist.

Explore further: Stem cell patch shows early promise in treating heart failure

Patching a damaged heart with a patient's own muscle stem cells improves symptoms of heart failure, according to a Phase I clinical trial reported in Journal of the American Heart Association, the Open Access Journal of the ...

In the largest German survey on heart failure to date, investigators found that the overall awareness of heart failure has not increased over the past decade and is not at a satisfactory level.

Heart failure patients who are getting by on existing drug therapies can look forward to a far more effective medicine in the next five years or so, thanks to University of Alberta researchers.

(HealthDay)Patients with rheumatoid arthritis (RA) have increased risk of heart failure, according to a study published in the March 14 issue of the Journal of the American College of Cardiology.

A cardiovascular team at University of Utah Hospital has successfully performed a first-in-the-world heart procedure on a 72-year-old attorney after suffering a large heart attack. Amit N. Patel, M.D. M.S., director of clinical ...

Using a multi-cell therapy called Ixmyelocel, produced from a patient's (autologous) own bone marrow mononuclear cells (BM-MNCs), an ongoing clinical trial named "ixCELL-DCM" is being conducted in various locations in the ...

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have discovered a new mechanism of action of metoprolol, a drug that can reduce the damage produced during a heart attack if administered ...

(Medical Xpress)A team of researchers at the University of Nottingham in the U.K. has found that artificial intelligence systems can be better at gauging a patient's risk of a heart attack than doctors using a standard ...

A team of biomedical engineering researchers, led by the University of Minnesota, has created a revolutionary 3D-bioprinted patch that can help heal scarred heart tissue after a heart attack. The discovery is a major step ...

People who suffer heart attacks or cardiac arrests in the vicinity of an ongoing major marathon are more likely to die within a month due to delays in transportation to nearby hospitals, according to newly published research ...

People living in areas that restrict trans fats in foods had fewer hospitalizations for heart attack and stroke compared to residents in areas without restrictions, according to a study led by a Yale researcher. This finding ...

UCLA scientists have found that conscious sedationa type of anesthesia in which patients remain awake but are sleepy and pain-freeis a safe and viable option to general anesthesia for people undergoing a minimally invasive ...

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First participant treated in trial of stem-cell therapy for heart failure - Medical Xpress