Cardio Round-up: Nanoparticles and Stem Cells in the Spotlight – DocWire News
By daniellenierenberg
This weeks Round-up looks to the future, as nanoparticles and stem cell-derived cardiac muscle cells get a closer look. More good news for lovers of yogurt, and a smelly but effective treatment for atherosclerosis as well.
Using stem cells extracted from the patients own blood and skin cells, this Japanese research team completed the first-in-human transplant of cardiac muscle cells derived from pluripotent stem cells. The team achieved this by reprogramming them, reverting them to their embryonic-like pluripotent initial state. I hope that (the transplant) will become a medical technology that will save as many people as possible, as Ive seen many lives that I couldnt save, Yoshiki Sawa, a professor in the Osaka University cardiovascular surgery unit, said in apress report.
Stem Cell-Derived Heart Muscle Transplanted Into Human for First Time: Researchers
Like something from a sci-fi horror novel, this team of researcher examined the role that nanoparticles that eat dead cells and stabilize atherosclerotic plaque may be able to play in the future of atherosclerosis treatment. We found we could stimulate the macrophages to selectively eat dead and dying cells these inflammatory cells are precursor cells toatherosclerosis that are part of the cause of heart attacks, one of the authors said in press release. We could deliver a small molecule inside the macrophages to tell them to begin eating again. The authors noted that after a single-cell RNA sequencing analysis, they observed that the prophagocytic nanotubes decreased inflammatory gene expression linked to cytokine and chemokine pathways in lesional macrophages, thereby treating the cell from the inside out.
Are Nanoparticles Potential Gamechangers for Treating Clogged Arteries?
In this large analysis of more than 120,000 individuals, the authors reported multivariable-adjusted hazard ratios (95% CI for all) for mortality were reduced in regular (more than four servings per week) consumers of yogurt, and there was an inverse relationship between regular consumption and cancer mortality as well as cardiovascular-related mortality in women. In our study, regular yogurt consumption was related to lower mortality risk among women, the authors wrote. Given that no clear doseresponse relation was apparent, this result must be interpreted with caution.
Yogurt Consumption Associated with Reduced Mortality Risk (Plus a Caveat)
This research teamlooked human microphages and compared them to dying cells in a dish. They observed that macrophages reclaim arginine and other amino acids when they eat dead cells, and then use an enzyme to convert arginine to putrescine. The putrescine, in return, activates a protein (Rac1) that causes the macrophage to eat more dead cells, suggesting to the authors that the problem of atherosclerosis may be, in part, a problem of putrescine. The findings, according to the accompanying press release, suggest that the compound could be use to potentially treat conditions with chronic inflammation, such as Alzheimers disease.
The Nose Knows: Pungent Compound Associated with Improvements in Atherosclerotic Plaque
Read more:
Cardio Round-up: Nanoparticles and Stem Cells in the Spotlight - DocWire News
- 001 Cardiac Stem Cell Therapy [Last Updated On: June 24th, 2011] [Originally Added On: June 24th, 2011]
- 002 Wow! UW Research labs [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- 003 cellalign [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- 004 Cardiac Stem Cells in End-Stage Human Failing Hearts: Are they functional? [Last Updated On: August 25th, 2011] [Originally Added On: August 25th, 2011]
- 005 Designer Life: repair brain, heart with stem cells - Future Health keynote speaker [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 006 Cardiac Stem Cell Therapy at Rostock University [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 007 Stem Cells: Mending a broken heart? [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 008 Cardiovascular Derivatives of Embryonic Stem Cells in Cardiac Repair and Drug Discovery [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 009 Stem Cell Therapy in Cardiac Disease [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 010 Cardiac Recovery Points to Adult Stem Cells [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 011 Oral Surgeon utilizes StemSave to preserve stem cells in wisdom teeth to combat cardiac disease [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 012 Stem Cells and Cardiac Regeneration [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 013 Dr Victor Dzau on Stem Cells for Cardiac Repair. [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 014 Cardiomyogenic differentiation of Mesenchymal Stem cells (KUM2/9-15c) [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 015 Heart Failure Patient After Adult Stem Cell Therapy [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- 016 Stem Cell operation in Cardiac Surgery-Al-Jazeerah [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- 017 Heart Disease Patient Describes His Stem Cell Treatment [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- 018 Cardiovascular Therapies: Spotlight on Stem Cell Research - Douglas Boyd [Last Updated On: September 16th, 2011] [Originally Added On: September 16th, 2011]
- 019 Adult Stem Cell [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- 020 Heart repair using own stem cells after heart attack: Future Health keynote speaker [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- 021 Stem Cell #8 Vas Cath Removal 04/28/11 [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- 022 Adult Stem Cells Used To Rebuild Heart Tissue Video. More at http://www.stemcellfusion.com [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- 023 Davos Question: Stem Cell Answer [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- 024 Did you have a Heart Attack and Need to Recover your Cardiac Muscle? [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- 025 Cardiac Tissue Can Regenerate [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- 026 William F. Testimonial of Treatment Stem Cell [Last Updated On: September 23rd, 2011] [Originally Added On: September 23rd, 2011]
- 027 Stem Cell Heart Surgery must see [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 028 Valentine's Day Stem Cell Wish: Mending Broken Hearts [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 029 Advanced Cell Technology OneMedForum 2011 [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 030 Human 2.0: The Helix of Our Future [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 031 heart cell generation from human ES and iPS cells (embryonic and induced pluripotent stem cells).flv [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 032 Stem Cell Therapy and Stem Cell Treatment with Dell [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 033 UCD Med Student Receives Fulbright Award [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 034 Cardiomyocytes derived from mouse Embryonic stem cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 035 Immune Control of Stem Cell Mobilization [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 036 Better Drugs Through Stem Cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 037 stem cell derived cardiomyocytes [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 038 Stem Cells: Heart cells grown from mouse stem cells [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 039 Patel Stem Cell Heart Failure [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 040 Turning Adult Stem Cells into Medicine - Zannos Grekos, MD [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 041 Kevin's 2 Heart Transplants and Stem Cell Transplant [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 042 Breakthrough in Stem cell technology [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 043 Affordable Stem Cell Therapy in Guatemala (2hrs from Miami) [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- 044 Cadiomyogenesis of human mesenchymal stem cells [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- 045 Mark Mercola: Differentiating embryonic stem cells into adult tissues [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- 046 Cardiomyocytic differentiation of endometrial stem cells. [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- 047 Adult Stem Cell vs Embryonic Stem Cell Research Ethics Video [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- 048 Pt. 1--Dr. Ali Denktas--Stem Cells as Markers after Myocardial Infarctions [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- 049 Repairing Damaged Hearts with Stem Cells [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 050 Mouse GEN cells overexpressing Csx/Nkx2.5 and GATA4 behave like transient amplifying cells [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 051 20100804_axiogenesis.wmv [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 052 Beating Cardiomyocytes from E14 Cells [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 053 Heart cells grown from human embryonic stem cells [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 054 First US Patient In Stem Cell Transplant [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 055 Be still my beating stem cell heart [Last Updated On: October 1st, 2011] [Originally Added On: October 1st, 2011]
- 056 Beating Human Heart Cells from Embryonic Stem Cells [Last Updated On: October 1st, 2011] [Originally Added On: October 1st, 2011]
- 057 Spontaneously and rhythmically beating engineered human heart tissue from pluripotent stem cells [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- 058 Cardiac Stem Cell Therapy - How it works [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- 059 Doctors To Use 'Trained' Stem Cells To Heal Heart [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 060 Beating Heart Stem Cells [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 061 AM RADIO, DR. AMIT PATEL AND STEM CELLS SAVED MY LIFE - Video [Last Updated On: October 14th, 2011] [Originally Added On: October 14th, 2011]
- 062 New heart built with stem cells - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- 063 Adult Stem Cells For Heart Disease: Today's Reality - Video [Last Updated On: October 15th, 2011] [Originally Added On: October 15th, 2011]
- 064 H9 beating stem cells - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 065 Double Blind Trial of Stem Cells for Heart Failure - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 066 Repairing Damaged Hearts with Stem Cells - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 067 Cardiac differentiation of hES cells at 20x - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 068 SPRAY-ON STEM CELLS - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- 069 Stem Cells: A smart use for wisdom teeth - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 070 VistaGen's Stem Cell Derived Cardiomyocytes - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 071 Stem Cell Research [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 072 The Power of Stem Cells - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 073 Beating iCellĀ® Cardiomyocytes - Video [Last Updated On: November 13th, 2011] [Originally Added On: November 13th, 2011]
- 074 SCIPIO: Cardiac stem cells and postinfarction heart failure - Video [Last Updated On: November 15th, 2011] [Originally Added On: November 15th, 2011]
- 075 Beating Cardiomyocytes in Cell Culture - Video [Last Updated On: November 15th, 2011] [Originally Added On: November 15th, 2011]
- 076 Stem Cells Heal Heart Attack Damage. - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
- 077 C2CAM - 2011.11.15 - Dulce Base - Regenerative Medicine - Info - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
- 078 Latest Update on Stem Cell Research at UW - Dr. Timothy Kamp - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
- 079 Coast To Coast AM: Regenerative Medicine / Dulce Base 11-15-2011 Download Link - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
- 080 C2CAM - 2011.11.15 - Dulce Base - Regenerative Medicine - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
