Scientists Rejuvenate Skin Cells by 30 Years, with Pioneering Potential – BioSpace
By daniellenierenberg
As previously reported by BioSpace, a group of scientists from The Babraham Institutein the United Kingdom was able to successfully rejuvenate skin cells by a full 30 years.
The research team published a study in eLife Sciences last month describing their process of using induced pluripotent stem cell (iPSC) reprogramming to reverse aging effects at the cellular level.
Study co-author Ins Milagre told BioSpace that the research process was a team effort. In Lead Author Wolf Reiks lab, she was working on cell reprogramming while a colleague focused on the epigenetic clock.
Milagre came into her research career driven by an early interest in biology. I was fascinated by biology all of my life. I had a very good biology teacher when I was in high school, she said.
She explained that she was also a huge fan of the drama series The X-Files, seeing Gillian Anderson's character, Dana Scully, as a role model. I thought that being a scientist must be very cool. This combination made me decide to go into biology.
The research teams original hypothesis came from knowing that we can easily program cells to be zero years of age. No matter what age they are in the beginning, the cells normally reprogram back to embryonic age, or zero years of age.
Though reprogrammed embryonic cells are free of gradual aging decline, they lack identity and thus function. The research team began to consider what would happen if they could get the cells to only partially rejuvenate.
With embryonic cells, downstream applications can be a problem. We thought that maybe we could just rejuvenate the cells and then coax them back into being the cell of origin, Milagre explained. At first, the idea was casually discussed over happy hour, but then the team found that preliminary experiments yielded promising results.
They utilized Yamanaka factors (Oct4, Sox2, Klf4, c-Myc), which are typically used to differentiate cells into the embryonic stem cell stage. Instead of allowing the full time that it takes for cells to get to the embryonic life stage, we decided to stop the reprogramming process halfway through, Milagre said.
By doing this, we were able to get the cells to a younger age. They were easily reverted back to the original cell type, which in our case, were skin cells. Pausing the process in the middle allowed the cells to become a younger version of the same cell type. The researchers named the novel method maturation phase transient reprogramming (MPTR).
What I find very exciting about this study is that we showed that it's possible to rejuvenate cells, she said. Though the Yamanaka factors have been used in other labs, the Babraham Institute team was the first to rejuvenate cells by a full 30 years.
Courtesy of the Babraham Institute
The scientists observed several benefits of the functionally younger cells. The skin cells were better able to produce collagen, and they were responding better to wound healing sites, Milagre said. The above photo depicts the collagen levels of the skin cells before and after rejuvenation. On the left are the original 53-year-old skin cells, and on the right are the reprogrammed cells. The collagen levels are depicted in red.
Milagre noted that the study is very preliminary, with much more research to be completed before the technology is safe and available. We only tested this in skin cells, so we don't know if this is also possible in other cell types, though we believe that it probably is based on similar work from other groups.
Another element that must be studied is how the technology will work without using the same viral vectors. We need to make a safer technology to do this. As a proof of principle, we showed that it's possible to rejuvenate cells by 30 years. Now, we need to do more research to be able to eventually move this technology into a more clinical setting.
Once the technology is safe and ready, Milagre noted that many downstream applications could be possible. We can think about trying to tackle neurodegenerative and degenerative disorders as well as ameliorating some aging effects. If we can get cells to be functionally younger, even if we don't expand peoples lives, we might be able to give people a better quality of life.
Reik explained in an earlier article that the findings could eventually lead to targeting specific genes that would be able to rejuvenate without any reprogramming. Milagre said that Yamanaka factors are working as pioneers that can start new gene expression programs. If we understand which genes are being activated downstream, we can eventually think about modulating these genes. We can try switching on a minimum number of effector genes. This would be a way to overcome using viral vectors.
Though potential future benefits of the findings are a long way off, the team is still considering the people they may help down the line. We hope the technology will help people live better lives without diseases, or without the consequences of a disease even if they still have it, Milagre said.
See the original post here:
Scientists Rejuvenate Skin Cells by 30 Years, with Pioneering Potential - BioSpace
- 001 Elaine Fuchs discusses research on skin and adult stem cells [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- 002 Skin Stem Cells: Their Biology [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- 003 Come Back Kid [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- 004 Emerge Labs New Anti Aging Swiss Apple Stem Cell Skin Care [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- 005 PhytoCell.mp4 [Last Updated On: June 26th, 2011] [Originally Added On: June 26th, 2011]
- 006 Elaine Fuchs Part 2: Tapping the Potential of Adult Stem Cells, and Summary [Last Updated On: June 28th, 2011] [Originally Added On: June 28th, 2011]
- 007 Elaine Fuchs Part 1: Introduction to Stem Cells [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- 008 Stem Cell Facial At Metamorphosis Day Spa Using Emerge Labs Skin Care [Last Updated On: July 1st, 2011] [Originally Added On: July 1st, 2011]
- 009 A Major Breakthrough in Skin Care and Nutrition [Last Updated On: July 7th, 2011] [Originally Added On: July 7th, 2011]
- 010 The Skin Gun stem cell research [Last Updated On: July 7th, 2011] [Originally Added On: July 7th, 2011]
- 011 The Skin Gun [Last Updated On: July 7th, 2011] [Originally Added On: July 7th, 2011]
- 012 E'shee HBA Global Expo 2011, NYC. Skin Care Anti-Aging Symposium [Last Updated On: July 8th, 2011] [Originally Added On: July 8th, 2011]
- 013 World's 1st Nutricosmetic with Stem Cell Nutrients [Last Updated On: July 15th, 2011] [Originally Added On: July 15th, 2011]
- 014 Stem cells acquired from human skin [Last Updated On: August 22nd, 2011] [Originally Added On: August 22nd, 2011]
- 015 DermaStem Renewal Serum - Stem Cells for Your Skin from STEMTech - New Paradigm in Beauty! [Last Updated On: August 30th, 2011] [Originally Added On: August 30th, 2011]
- 016 Stem Cells Made From Human Skin [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- 017 ReLuma-stemcells- skin rejuvenation [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- 018 Jeunesse Global Business Opportunity with Stem Cell Skin Care Developed by Dr Nathan Newman [Last Updated On: September 5th, 2011] [Originally Added On: September 5th, 2011]
- 019 Dr Nathan Newman- Formulator of Stem Cell Skin Care Line LUMINESCE [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- 020 Luminesce Stem Cell Skin Care - Leaders in Jeunesse [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- 021 Stem Cell Therapy - BioLogic Anti-Aging Skin Cream [Last Updated On: September 7th, 2011] [Originally Added On: September 7th, 2011]
- 022 Isolation and Culture of Adult Epithelial Stem Cells from Human Skin [Last Updated On: September 8th, 2011] [Originally Added On: September 8th, 2011]
- 023 Stem Cell Skin Care- What is the role of stem cells in Luminesce Featuring Dr Nathan Newman [Last Updated On: September 9th, 2011] [Originally Added On: September 9th, 2011]
- 024 Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Patient Advocate [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- 025 Genetic Skin Disease (EB): Optimizing Embryonic Stem Cell Differentiation Protocols [Last Updated On: September 12th, 2011] [Originally Added On: September 12th, 2011]
- 026 Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Introduction [Last Updated On: September 13th, 2011] [Originally Added On: September 13th, 2011]
- 027 The Skin Gun (Stem Cell research to replace burnt off skin. Done in 3 days!) [Last Updated On: September 15th, 2011] [Originally Added On: September 15th, 2011]
- 028 Best natural skin care serum using stem cell technology [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- 029 Stem Cells: Fulfilling the Promise - 2011 CIRM Grantee Meeting [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- 030 Jeunesse Global Opportunity- Stem Cell Skin Care [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- 031 Research on skin cancer: ERC funds studies on stem cells [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- 032 Stem Cell Therapy Skin Repair and Anti-Wrinkle Cream [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- 033 Skin engineering [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- 034 Stem Cell Face Treatment - What People Are Saying | Beverly Hills | Los Angeles [Last Updated On: October 1st, 2011] [Originally Added On: October 1st, 2011]
- 035 How To Use Your Stem Cells For Facial Skin Rejuvenation [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 036 AMAZING - Stem Cell Skin Cream And Liquid Face Lift Revealed [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 037 Dr Nathan Newman MD Stem Cell Face lift on Channel 7 KABC.flv [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 038 Genetic Skin Disease (EB): Spotlight on Stem Cell Research - Welcome [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 039 Dr.Thomas Barnes' PRP Hair Growth and Skin Rejuvenation [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 040 For Damaged Skin - Rejuvenate Your Own Stem Cells [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 041 real food real life - Stemulance stem cell face products [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 042 Dr Amiya Prasad discusses ACell for Hair Regrowth and Skin Rejuvenation with EYES IN Magazine [Last Updated On: October 5th, 2011] [Originally Added On: October 5th, 2011]
- 043 Stem Cell Face Lift - English (Part 5) [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- 044 Cell Reprogramming Transformed [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- 045 Care for Your Skin with Lifeline Skin Care [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- 046 Dr Nathan Newman Repairs Laugh Lines With Stem Cell Face Lift [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- 047 Ellis Martin Report with International Stem Cell Corp [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- 048 Stem Cell Banking: The Perspective of an iPS Donor Family [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- 049 Dr Nathan Newman Stem Cell Face Lift on Entertainment Tonight [Last Updated On: October 8th, 2011] [Originally Added On: October 8th, 2011]
- 050 Elaine Fuchs Part 1: Introduction to Stem Cells English Subtitle [Last Updated On: October 12th, 2011] [Originally Added On: October 12th, 2011]
- 051 Signals Stem Cell Skin Care Anti Aging Skin Care - Video [Last Updated On: October 14th, 2011] [Originally Added On: October 14th, 2011]
- 052 Stem Cell Skin Care - Born Different.mp4 - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- 053 APPLE STEMCELL by SEMCELL - Video [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- 054 Jeunesse Luminesce Stem Cell Skin care Before and After Pictures - Video [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- 055 Stem Cell Therapy -- Reduce Wrinkles,Promote Younger, Healthier Looking Skin - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- 056 Scientists Create Liver from Reprogrammed Human Skin Cells No Stem Cells Needed - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- 057 Vitiligo and Stem Cells: Narrowband UVB Phototherapy in Nonsegmental Vitiligo - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- 058 Dr Nathan Newman MD Stem Cell Face lift on Entertainment Tonight - NewHopeForAging.com - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- 059 Skin Healing And Anti-Aging - Rejuvenate Aging Skin Cells - Video [Last Updated On: October 25th, 2011] [Originally Added On: October 25th, 2011]
- 060 Stem Cell Face Lift - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 061 Stem Cell Therapy Face Cream - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 062 Growing skin in lab with stem cells Video Reuters - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 063 Stem Cells and Their Lineages in Skin - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 064 Stem Cells Rock - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- 065 Stem Cell Therapy: Healing Force of the future - Video [Last Updated On: October 29th, 2011] [Originally Added On: October 29th, 2011]
- 066 Alex Cosmeceuticals - Phyto Stem Cell Technology - Video [Last Updated On: October 29th, 2011] [Originally Added On: October 29th, 2011]
- 067 Reprogramming skin cells into embryonic stem cells - Video [Last Updated On: October 29th, 2011] [Originally Added On: October 29th, 2011]
- 068 Ellis Martin Report with International Stem Cell Corp - YouTube2.flv - Video [Last Updated On: October 30th, 2011] [Originally Added On: October 30th, 2011]
- 069 Dr Lyras Plastic Surgery - Skin Needling 3 - Tv 2011 - Video [Last Updated On: November 5th, 2011] [Originally Added On: November 5th, 2011]
- 070 Donna Queen-Lifeline Skin Care at the CACS - Video [Last Updated On: November 8th, 2011] [Originally Added On: November 8th, 2011]
- 071 Turning Science Into Action with Heather Livingston - Part 1 www.miraclecell.info - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 072 US scientists unveil new cloning method for embryonic stem cells - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 073 A Stem Cell Story - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- 074 Perspectives of a Stem Cell Donor Family - Video [Last Updated On: November 13th, 2011] [Originally Added On: November 13th, 2011]
- 075 Adult Stem Cell Success Stories - Amy Daniels - Video [Last Updated On: November 15th, 2011] [Originally Added On: November 15th, 2011]
- 076 StemCellTV - From National Geographic - The Skin Gun - Healing Burns with Stem Cells - Video [Last Updated On: November 16th, 2011] [Originally Added On: November 16th, 2011]
- 077 Stem Cell Skin Care Jeunesse- Dr Newman FAQ - Video [Last Updated On: November 18th, 2011] [Originally Added On: November 18th, 2011]
- 078 Dr Nathan Newman and Jeunesse Stem Cell Skin Care - Video [Last Updated On: November 26th, 2011] [Originally Added On: November 26th, 2011]
- 079 Apple Stem Cell-Skin aging solution - Video [Last Updated On: November 29th, 2011] [Originally Added On: November 29th, 2011]
- 080 Luminesce rejuvenation serum cellular rejuvenation stem cell skin Products - Video [Last Updated On: November 29th, 2011] [Originally Added On: November 29th, 2011]
