Published February 10, 2015

A British biotech company founded by a Nobel prize winner has raised what it says is a record 691,000 pounds ($1 million) via crowdfunding to help launch a stem cell-based regenerative medicine for use following heart trauma.

Cell Therapy, based in the Welsh capital Cardiff, says the medicine has the potential to reduce scarring of the heart muscle caused by a heart attack or failure.

Chief Executive Ajan Reginald, previously at Roche, said crowd funding was a quick way to raise money for final stage trials or commercial launches.

"It was very fast and very efficient," he told Reuters on Monday. "We have spent 5 percent of our time on fundraising, which enables me to spend 95 percent of my time on the business."

The company, whose founder Martin Evans shared the 2007 Nobel Prize for medicine for groundbreaking stem cell research, used website Crowdcube to raise nearly three times its original target from more than 300 investors.

Reginald said the backers included investment bankers, hedge fund employees and scientists.

"Crowd funding allows investors to look in detail at a company in their own time," he said, adding that some 10,000 investors had seen the pitch.

The company would publish data from clinical trials of the drug, called Heartcel, next month, before final stage trials with a view to a launch in 2016.

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British biotech firm sets crowdfunding record with heart drug

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Freeport, Grand Bahama (PRWEB) March 09, 2015

Okyanos, the leader in cell therapy, launched its next in a series of studies today to determine the emotional impact and lifestyle influence orthopedic conditions such as osteoarthritis and sports-related injuries have had on those affected. The survey focuses on people between the ages of 55 and 75 living with orthopedic health issues and is designed to examine the toll on those afflicted as well as their relationships.

According to Okyanos VP Marketing Carol Montgomery, Millions of people suffer disorders of the joints, bones, muscles and connective ligaments, tendons and cartilage debilitating conditions on a daily basis, ranging from reduced function to crippling pain but have exhausted available methods of treatment. These restrictions affect them in a variety of ways and our ongoing lifestyle surveys measure the effects such chronic conditions have on todays aging population. Many are turning to solutions like adult stem cell therapy for treatment with excellent results.

The Okyanos Lifestyle and Relationship Survey for Heart Disease, of nearly 700 adults, uncovered a staggering 93% were open to alternatives to their existing heart disease treatment plan showing a growing discontent with their current options. A majority 68% were emotionally impacted and felt they were saddled with restrictions imposed by their heart conditions such as chronic fatigue and shortness of breath.

Adult stem cell therapy has emerged as a new treatment alternative for those who are restricted in activities they can no longer do but are determined to live a more normal life. Okyanos cell therapy uses a unique blend of adult stem and regenerative cells derived from a patients own fat tissue, thereby utilizing the bodys own natural biology to heal itself.

Just 50 miles from US shore, Okyanos cell therapy is available to patients suffering with the daily discomfort of orthopedic conditions including osteoarthritis, rheumatoid arthritis, sports-related injuries and spine disease.

Patients with a severe orthopedic condition, interested in participating in the study can go to: https://www.surveymonkey.com/s/ortho_Okyanos

For a copy of the Okyanos Heart Disease Lifestyle Report that reveals the emotional toll and lifestyle impact heart disease has on patients in the United States, visit: Heart Disease Lifestyle Report

Patients can contact Okyanos to learn more and request a free consultation at http://www.Okyanos.com or by calling 1-855-659-2667.

About Okyanos: (Oh key AH nos) Based in Freeport, Grand Bahama, Okyanos brings a new standard of care and a better quality of life to patients with coronary artery disease, tissue ischemia, autoimmune diseases, and other chronic neurological and orthopedic conditions. Okyanos Cell Therapy utilizes a unique blend of stem and regenerative cells derived from patients own adipose (fat) tissue which helps improve blood flow, moderate destructive immune response and prevent further cell death. Okyanos is fully licensed under the Bahamas Stem Cell Therapy and Research Act and adheres to U.S. surgical center standards. The literary name Okyanos, the Greek god of the river Okyanos, symbolizes restoration of blood flow.

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Okyanos Stem Cell Therapy Launches Orthopedic Lifestyle Survey

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CHICAGO (CBS) More than four years after she was close to dying from leukemia, an 8-year-old girl from Mount Prospect is healthy again, and will meet the German man who helped save her life by supplying a stem cell donation.

Sabrina Chahir was diagnosed with leukemia in 2009, and 80 percent of her blood was filled with cancer cells. To survive, she needed a stem cell/bone marrow transplant, but finding a donor was going to be very difficult.

At the beginning, it was we didnt know if we were able to find one, because Sabrina is half Arabic and half Hispanic, and that is not a usual combination, Sabrinas mother, Natalia Wehr said.

Sabrinas DNA match turned out to be 30-year-old Maximilian Eule, a German supermarket manager living in Austria. He quickly agreed to donate

For me, I was close to crying, because it was like a little girl who was almost close to dying, and has no chance without my blood, he said. You give the girl another chance to stay alive.

Sabrinas mother said, thanks to Eules bone marrow donation, her daughter is healthy again, and like any other 2nd grade girl.

This whole thing is like a dream, she said.

Eule said its awesome Sabrina is now happy, healthy, and taking ballet classes and piano lessons. The two will meet for the first time Thursday night.

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Girl With Leukemia To Meet Stem Cell Donor Who Helped Save Her Life

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When it comes to gene expression -- the process by which our DNA provides the recipe used to direct the synthesis of proteins and other molecules that we need for development and survival -- scientists have so far studied one single gene at a time. A new approach developed by Harvard geneticist George Church, Ph.D., can help uncover how tandem gene circuits dictate life processes, such as the healthy development of tissue or the triggering of a particular disease, and can also be used for directing precision stem cell differentiation for regenerative medicine and growing organ transplants.

The findings, reported by Church and his team of researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School in Nature Methods, show promise that precision gene therapies could be developed to prevent and treat disease on a highly customizable, personalized level, which is crucial given the fact that diseases develop among diverse pathways among genetically-varied individuals. Wyss Core Faculty member Jim Collins, Ph.D., was also a co-author on the paper. Collins is also the Henri Termeer Professor of Medical Engineering & Science and Professor in the Department of Biological Engineering at the Massachusetts Institute of Technology.

The approach leverages the Cas9 protein, which has already been employed as a Swiss Army knife for genome engineering, in a novel way. The Cas9 protein can be programmed to bind and cleave any desired section of DNA -- but now Church's new approach activates the genes Cas9 binds to rather than cleaving them, triggering them to activate transcription to express or repress desired genetic traits. And by engineering the Cas9 to be fused to a triple-pronged transcription factor, Church and his team can robustly manipulate single or multiple genes to control gene expression.

"In terms of genetic engineering, the more knobs you can twist to exert control over the expression of genetic traits, the better," said Church, a Wyss Core Faculty member who is also Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. "This new work represents a major, entirely new class of knobs that we could use to control multiple genes and therefore influence whether or not specific genetics traits are expressed and to what extent -- we could essentially dial gene expression up or down with great precision."

Such a capability could lead to gene therapies that would mitigate age-related degeneration and the onset of disease; in the study, Church and his team demonstrated the ability to manipulate gene expression in yeast, flies, mouse and human cell cultures.

"We envision using this approach to investigate and create comprehensive libraries that document which gene circuits control a wide range of gene expression," said one of the study's lead authors Alejandro Chavez, Ph.D., Postdoctoral Fellow at the Wyss Institute. Jonathan Schieman, Ph.D, of the Wyss Institute and Harvard Medical School, and Suhani Vora, of the Wyss Institute, Massachusetts Institute of Technology, and Harvard Medical School, are also lead co-authors on the study.

The new Cas9 approach could also potentially target and activate sections of the genome made up of genes that are not directly responsible for transcription, and which previously were poorly understood. These sections, which comprise up to 90% of the genome in humans, have previously been considered to be useless DNA "dark matter" by geneticists. In contrast to translated DNA, which contains recipes of genetic information used to express traits, this DNA dark matter contains transcribed genes which act in mysterious ways, with several of these genes often having influence in tandem.

But now, that DNA dark matter could be accessed using Cas9, allowing scientists to document which non-translated genes can be activated in tandem to influence gene expression. Furthermore, these non-translated genes could also be turned into a docking station of sorts. By using Cas9 to target and bind gene circuits to these sections, scientists could introduce synthetic loops of genes to a genome, therefore triggering entirely new or altered gene expressions.

The ability to manipulate multiple genes in tandem so precisely also has big implications for advancing stem cell engineering for development of transplant organs and regenerative therapies.

"In order to grow organs from stem cells, our understanding of developmental biology needs to increase rapidly," said Church. "This multivariate approach allows us to quickly churn through and analyze large numbers of gene combinations to identify developmental pathways much faster than has been previously capable."

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Activating genes on demand: Possible?

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