Human Skin Cells: The Next Anti-Aging Frontier?
By daniellenierenberg
Call us biased, but the skincare industry, in particular, is one of our favorites to watch when it comes to technological advancements. From laser zapping to weird-looking at-home devices, the anti-aging sphere is constantly evolving, with new treatments and procedures being launched on the daily. Just 10 years ago, Blackberries (the phone, not the fruit Gisele Bndchen says she avoids) were still the epitome of cool, and no one except makeup artists ever used the word contouring. Ten years from today, will wrinkles, dark spots, and sagging be a thing of the past? Its a slightly exhilarating (and also completely terrifying) thought.
As beauty editors, its our job to stay on top of all thats new in the quest for younger, tauter skin. Right now, were intrigued by a new ingredient trend thats very unexpected (yes, even compared to salmon sperm): human stem cells. Yeah, well let that sink in for a minute. If applying a strangers stem cells on your face sounds creepy or the start of a very niche horror movie, youll want to keep readingthe information ahead might just change your mind. We asked Dr. Hal Simeroth, founder of Stemology skincare and possessor of a Ph.D. in Bioethics, to tell us if human stem cells (and their extracts) are the key to eternal youthor, at the very least, a more prolonged youth. Ready to get really scientific?
Keep scrolling to school yourself on this anti-aging trend.
Everyone likely has a vague notion of what stem cells are, but its probably best to let an expert explain. The term stem cells refers to a rather broad category of cells that participate in tissue generation, regeneration, and renewal, Hal says. In other words, they are the cells that help you, your dog, and the tomatoes in your vegetable garden heal; humans, animals, and plants all have these types of cells. And this is what makes stem cells special: theyre undifferentiated and have the invaluable properties of self-renewal and differentiation, according to Hal. In laymans terms, this means they have the much-coveted ability to divide to make more stem cells, and more stem cells you get the idea. Human stem cells are divided into three primary categories: embryonic, which are the initial stem cells after birth that control the development into a human baby; adult mesenchymel stem cells, which exist in our bodies and are responsible for the repair and renewal of structural tissues; and tissue-specific stem cells, which only repair and rejuvenate specific tissues such as your skin. Remember these, because well touch on them again later.
Before we dive headfirst into human stem cells, lets first talk about plant stem cells. In the skincare industry, theyre the popular crowd: Theyve largely been accepted and welcomed with open arms, touted for their skin-regenerating abilities. The idea is that if this stem cell helps a flower flourish in the freezing temps in some far-off exotic locale, then it must be able to keep your skin dewy and glowing too. But does that logic really make sense? According to Hal, not really. Its false at a primary level, but true at a secondary level, he says. Um, what? The directing of repair and renewal by plant stem cells within the plant is orchestrated by cellular signals that would not be recognized by human cells, he says. Plant stem cell material cannot mimic the activity of our stem cells in the human body in a primary way. There are genetic boundaries that cannot be crossed. So, just because rose stem cells can help a rose grow and flourish doesnt mean it can do the same for your skin. However, Hal does say that some plant stem cells do provide nutrients and metabolites that have been shown to stimulate human epidermal stem cell productionthus, the secondary way he mentions. Either way, he says to always check to see if a plant stem cell material in your skincare product that promises to plump your skin is backed up by scientific research and clinical testing (a quick Google search should yield results).
Now that weve covered plant stem cells, lets dive right into the nitty-gritty and talk human stem cells. Hal mentions adult mesenchymal stem cells (MSC) specifically, citing many research studies and scientific papers published over the last two decades about their ability to be the natural healers of all our bodys structuresmuscle, bone, skin, neural tissue and more. Because of their potent ability to rejuvenate and repair, and also because they do not carry the negative ethical stigma of embryonic stem cells harvested from human embryos, they have been embraced by many for use in potential clinical protocols, Hal explains. Right now, these human stem cells have already been in practice in Europe with success and are currently in FDA-approved testing programs in the U.S. Without getting too technical, heres how these MSCs work. Like a master coordinator, MSCs respond to biochemically transmitted needs from any areas of traumafor example, if you get a cut, scrape, or a more severe injury. Sensing the need, the MSCs begin to multiply and release different biochemical signals to bring on other anti-inflammatory and immune cells, like a commander rallying his troops to fight a battle. Thus, it would be logical to assume that this healing, regenerating ability that works with wound-healing can also apply to overall skin renewal. We can conclude from a large body of scientific evidence that MSCs do their work by releasing messengers and helpers such as growth factors, peptides, and matrix proteins that provide rejuvenating instructions and assistance to the targeted body cells, Hal says. As we age, these "messenger" proteins the MSCs attract might just be the key to helping our skin renew (read: stay wrinkle-free).
Stemologys hero product (and the product that inspired this story) is their Cell Revive Serum Complete ($189), which lists human stem cell-derived conditioned media as the number two ingredient after aloe. Notice how it's a human stem cell-derived mediaand not an actual human stem cell. So, what's the difference? Actual human stem cells can actually be grown outside of the body by stimulating human body conditions, and can create a massive number of cells since theyre self-renewing; a single original MSC can generate large numbers of offspring cultures that grow naturally and are encouraged to secrete the helpers and messengers we mentioned earlier. Those growth factors, cytokinal peptides, matrix proteins, and helper molecules are the human stem cell-derived conditioned media. Under controlled conditions, the MSCs are completely removed, so that there are no actual cellular components, and the harvested small secreted proteins are retained in this conditioned medium, Hal says. This conditioned medium contains all the important, renewing and healing components originally drawn to the human stem cell, which can be integrated into a skincare formula and penetrate the skin. Whewyou still with us?
So, the catch is that as of now, there are no actual human stem cells used in products in the U.S. In fact, Hal says actual human stem cells are not suitable for topical skin care applications since they are fragile and easily destroyed, as well as too large to be absorbed. Instead, brands like Stemology will extract one human stem cell to grow hundreds more, which in turn generates the helper ingredients that plump your skin. The result? More youthful skinat least according to science. Hal cites one published study that confirms the application of topical growth factors from MSC stimulate the repair of facial photo-aging resulting in new collagen synthesis, epidermal thickening, and the clinical appearance of smoother skin with less visible wrinkles.
So, no actual human stem cells are being used in topical skincare (yet). But what about all those self-generating powers and benefits we mentioned earlier? Human stem cell extracts sound great, but what about the real dealthe genuine original? Dr. Christopher Calapai, D.O. and stem cell expert says that actual human stem cells can disrupt the skincare industry, but only under three conditions: theyll need to be from a human who is preferably the one seeking the treatment, alive, and delivered directly to the skin (most likely with an injection). Otherwise, the stem cells are simply too large to penetrate the skins surface, and will just sit there instead of absorbing and encouraging other cells to regenerate (which they'll slowly do less and less of with time).
Until the FDA approves those things, well be giving products with human skincare extracts our attention. And, who knowsthe time when injecting your own stem cells back into your skin might be sooner than you think (a fact we cant decide whether thrills or frightens us).
StemologyCell Revive Serum Complex$189
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Human Skin Cells: The Next Anti-Aging Frontier?
- Colossal Creates Elephant Stem Cells for the First Time in Quest to Revive the Woolly Mammoth - Singularity Hub - March 18th, 2024
- Vitamin A could have a key role in both stem cell biology and wound healing: Study - Medical Dialogues - March 10th, 2024
- A dive into the genetic history of India, and the role of vitamin A in skin repair - Science - March 10th, 2024
- Herbosa: Clinic under probe after skin treatments linked to womans death - Philstar.com - January 22nd, 2024
- These Will Be the Biggest Skin-Care Trends of 2024 - Allure - December 28th, 2023
- Sorry, But These 10 Skincare Products Are A Scam - Refinery29 - December 12th, 2023
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- Spectral Medical Announces CFO Departure - December 4th, 2023
- Are STEM CELL EXOSOMES the secret to a 'snatched' jawline? Discover the products that influencers are claiming - Daily Mail - November 18th, 2023
- Defence Mechanisms: Four ways your body is protecting you every time you fall sick - indulgexpress - May 16th, 2023
- Treat Yourself to a Spa Day With a $100 Deal on $600 Worth of Products From Elemis, 111SKIN, Nest & More - E! NEWS - May 16th, 2023
- INTERNATIONAL STEM CELL CORP MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS (form 10-K) - Marketscreener.com - April 5th, 2023
- Skin Regeneration: The Science and How to Boost It - Healthline - March 9th, 2023
- Treat Yourself to a Spa Day With a $100 Deal on $600 Worth of Products From Elemis, U Beauty, Nest & More - E! NEWS - March 1st, 2023
- 7-year-old vows to find a cure for brother in need of bone marrow transplant - WJLA - February 21st, 2023
- World's most radioactive man 'cried blood' as his skin melted in 83-day nightmare - Times Now - February 4th, 2023
- How old are you, really? The answer is written on your face. - National Geographic UK - February 4th, 2023
- Skin: Layers, Structure and Function - Cleveland Clinic - January 27th, 2023
- Human skin | Definition, Layers, Types, & Facts | Britannica - January 27th, 2023
- Skin Disorders: Pictures, Causes, Symptoms, and Treatment - Healthline - January 27th, 2023
- Skin care: 5 tips for healthy skin - Mayo Clinic - January 27th, 2023
- Skin Care and Aging | National Institute on Aging - January 27th, 2023
- Wrinkles - Symptoms and causes - Mayo Clinic - January 27th, 2023
- Dry skin - Symptoms and causes - Mayo Clinic - January 27th, 2023
- Stem cells: a brief history and outlook - Science in the News - January 3rd, 2023
- Still Drinking Green Tea? Doctor Reveals A Healthier Drink With Proven Benefits For Diabetes, Aging, Oxidative Stress, And Cancer - Revyuh - January 3rd, 2023
- RUDN Physician And Russian Scientists Investigate Long-term Effects Of Treating Diabetic Ulcers With Stem Cells - India Education Diary - December 25th, 2022
- The Use of Stem Cells in Burn Wound Healing: A Review - Hindawi - December 1st, 2022
- FACTORFIVE Skincare The Power of Stem Cells for Skin - December 1st, 2022
- Embryonic Stem Cells - The Definitive Guide | Biology Dictionary - December 1st, 2022
- From pro soccer hopeful to hip hop artist with illness and addiction along the way, Tymaz Bagbani releases debut album - Toronto Star - December 1st, 2022
- Stem Cells | The ALS Association - November 22nd, 2022
- What is a stem cell? YourGenome - October 29th, 2022
- Skin Cell - The Definitive Guide | Biology Dictionary - October 29th, 2022
- Explora Journeys Plans Extensive Fitness And Well-Being Initiatives At Sea, Right On Trend - Forbes - October 29th, 2022
- Ahead of the holiday shopping season, Amazon kicks off second annual Holiday Beauty Haul on Oct. 24 - KXAN.com - October 21st, 2022
- Human skin color - Wikipedia - October 13th, 2022
- Mesenchymal Stem Cells | Properties, Process, Functions, & Therapies - October 13th, 2022
- Skin Grafting, Cryopreservation, and Diseases: A Review Article - Cureus - October 13th, 2022
- Anti-ageing cosmetics: Can they turn back the hands of the clock? - The Sunday Guardian Live - The Sunday Guardian - October 13th, 2022
- Brennand named Elizabeth Mears and House Jameson Professor of Psychiatry - Yale News - October 13th, 2022
- The Switch to Regenerative Medicine - Dermatology Times - October 13th, 2022
- Last Chance to Get The Collagen-Infused Massage Oil That Moisturizes Skin & Diminishes Cellulite For Less Than $20 - msnNOW - October 13th, 2022
- Addison's Disease Explained: Causes, Symptoms, And Treatments - Health Digest - October 13th, 2022
- Stem Cells Therapy for Autism: Does it Work? - October 5th, 2022
- Stem-like CD8 T cells mediate response of adoptive cell ... - PubMed - October 5th, 2022
- 6 Under Eye Products You Need To Have STAT - Grazia India - October 5th, 2022
- CellResearch Corporation (CRC) to present promising new stem cell products for the treatment of chronic diabetic foot ulcers at the world's premier... - September 27th, 2022
- Reprogramming pig cells leads way for new regenerative therapies - National Hog Farmer - September 27th, 2022
- A glimpse into Indian consumers expectations for cosmetic treatments and consumption insights - The Financial Express - September 27th, 2022
- Tajmeel redefines beauty to give its patients the best results - Gulf News - September 27th, 2022
- Here Is Why You Heal Slower As You Age - Health Digest - September 27th, 2022
- Creating stem cells from minipigs offers promise for improved treatments - University of Wisconsin-Madison - September 19th, 2022
- Israeli Biotech Firm Plans to Create Human Embryos to Harvest Organs, Field Experts Say There are Ethical Concerns - CBN.com - September 19th, 2022
- CellResearch Corporation (CRC) announces positive results of Phase I study for CorLiCyte - PR Newswire - September 19th, 2022
- The best CBD and hemp products for pampering your skin this fall - Leafly - September 19th, 2022
- Benjamin Button For Real? Scientists Are Close To Cracking The Code To Reverse Aging - Worldcrunch - September 19th, 2022
- I took an international trip with my frozen eggs to learn about the fertility industry - MIT Technology Review - September 19th, 2022
- Propanc Biopharma Reports Significant Effects of PRP Against the Tumor Microenvironment - Business Wire - September 11th, 2022
- 6 Ingredients to Avoid Putting on Your Skin - Healthline - September 3rd, 2022
- Regenerative Properties of the Newborn Heart Offers Hope for Those With Congenital Heart Disease - The Epoch Times - September 3rd, 2022
- Meet White Orange: The Vitamin C Skin Care Brand For Sensitive Skin - Bustle - September 3rd, 2022
- Rejuvenation Roundup August 2022 - Lifespan.io News - September 3rd, 2022
- To better understand Parkinson's disease, this San Diego expert sent her own cells to space - The San Diego Union-Tribune - August 26th, 2022
- Inside the race to make human sex cells in the lab - MIT Technology Review - August 26th, 2022
- Global Biomaterials Market to Reach Value of $372.7 Billion by 2028 | Demand For Biomaterials in the Healthcare Industry will Grow by 53% Over the... - August 26th, 2022
- A Groovy Guide to Anti-Aging Products With CBD and Mushrooms - Out Magazine - August 26th, 2022
- New milestone organoid synthesis will boost disease and drug development research - RegMedNet - August 10th, 2022
- Victoria Beckham and Kim Kardashian are fans of Augustinus Baders skincare range - and you can get 20% off - The Mirror - August 10th, 2022
- Mutant T Cells That Drive Amyotrophic Lateral Sclerosis (ALS) Progression May React To a Brain Antigen - The Scientist - August 10th, 2022
- Why Glucose Restrictions Are Essential in Treating Cancer - The Epoch Times - August 10th, 2022