New therapeutic approaches for chronic inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis are needed because current treatments are often suboptimal in terms of both efficacy and the risks of serious adverse events. Inhibitor of apoptosis proteins (IAPs) are E3 ubiquitin ligases that inhibit cell death pathways and are themselves inhibited by second mitochondria-derived activator of caspases (SMAC). SMAC mimetics (SMs), small-molecule antagonists of IAPs, are being evaluated as cancer therapies in clinical trials. IAPs are also crucial regulators of inflammatory pathways because they influence both the activation of inflammatory genes and the induction of cell death through the receptor-interacting serine-threonine protein kinases (RIPKs), nuclear factor B (NF-B)inducing kinase, and mitogen-activated protein kinases (MAPKs). Furthermore, there is an increasing interest in specifically targeting the substrates of IAP-mediated ubiquitylation, especially RIPK1, RIPK2, and RIPK3, as druggable nodes in inflammation control. Several studies have revealed an anti-inflammatory potential of RIPK inhibitors that either block inflammatory signaling or block the form of inflammatory cell death known as necroptosis. Expanding research on innate immune signaling through pattern recognition receptors that stimulate proinflammatory NF-B and MAPK signaling may further contribute to uncovering the complex molecular roles used by IAPs and downstream RIPKs in inflammatory signaling. This may benefit and guide the development of SMs or selective RIPK inhibitors as anti-inflammatory therapeutics for various chronic inflammatory conditions.

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SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases - Science

Skin Stem Cells Comments Off on SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases – Science | February 18th, 2020

Going gray is a natural part of getting older. It typically starts with a small streak of white in the hair or beard, a sign that a man has reached a certain level of maturity and is now on that steady, inevitable decline to the grave. Hell, it is even conceivable (and highly likely) that some of you might even pluck one of those pale bastards out of your pube patch one night while trying to determine if the source of a vicious case of crotch itch is the crabs or just dry skin. Listen, all were saying is dont be surprised if, within the next few years, you find yourself staring down at your junk, thinking about how that lustrous man bush of yours is starting to resemble Colonel Sanders with a skinless chicken leg dangling out of his mouth. It happens to the best of us.

But hey, getting old isnt always indicative of a silver coiffure. I knew a guy back in high school who had more gray hair on his head than my 73-year-old father does now. So, it seems that age alone isnt always the culprit. In fact, it has been long since believed that stress also plays a critical role in making some men look distinguished beyond their years. Well, come to find out, the concept of stressful events turning us into gray beasts before we are officially deemed DILFs is probably real. Only science says it really comes down to how our fight or flight response is triggered throughout the years that determine when our manes will be deprived of color.

Researchers at Harvards Stem Cell Institute believe they have found a direct correlation between stress and going gray. They recently published a study in the journal Nature, which shows that three kinds of extreme stress mild, short-term pain, psychological stress, and restricted movement has a way of bringing around the gray quicker than what would happen under natural circumstances. At least that is the conclusion reached by lead researcher Dr. Ya-Chieh Hsu and team after putting a legion of mice through the wringer and watching for their response.

The graying process happens as pigment cells called melanocytes start to fade from our hair follicles. Its just that over time, these cells become less prevalent and we begin brandishing that salt and pepper look popularized by legendary screen stars like Brad Pitt and George Clooney.

Eventually, however, all of those cells fade into extinction and our hair just goes completely white, we start receiving AARP benefits and eating apple sauce with every meal. Yet, researchers say that stress can cause these cells to fade out quicker than theyre supposed to long before we start collecting social security and yelling at the neighborhood kids to get off our lawn.

Without getting overly scientific about it, researchers found that high stress seems to produce elevated levels of a chemical in the brain known as noradrenaline. Its one of the kick-ass substances manufactured by the adrenal gland when a persons fight or flight response starts firing on all cylinders. Thats the real culprit to early aging, researchers concluded. They say that once mice were injected with this chemical, they began losing melanocytes and going gray. And the transformation didnt take long either. It turns out that stress can zap our hair color in a matter of days.

When we started to study this, I expected that stress was bad for the body but the detrimental impact of stress that we discovered was beyond what I imagined, Hsu said in a statement. After just a few days, all of the melanocyte stem cells were lost. Once theyre gone, you cant regenerate pigments anymore. The damage is permanent.

While it might be challenging to manage stress in a way that keeps us looking young forever, there is a silver-lining here, boys. Women, presumably the root of all of that premature grayness in the first place, are especially hot for this look. Seriously, a recent survey from Match.com finds that 72 percent of the women on the dating scene find men with gray hair more attractive than those with darker dos. Other studies on the subject have turned out similar results. The only caveat is that women are really only turned on by the gray as long as it doesnt make the man look old. This has something to do with them wanting to feel like a guy can provide some safety and security without having to worry about changing his diapers down the road.

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Getting Gray Hair Early Actually Can Mean You Are Stressed The F*ck Out - BroBible

Skin Stem Cells Comments Off on Getting Gray Hair Early Actually Can Mean You Are Stressed The F*ck Out – BroBible | February 18th, 2020

The following are the top rated Healthcare stocks according to Validea's Small-Cap Growth Investor model based on the published strategy of Motley Fool. This strategy looks for small cap growth stocks with solid fundamentals and strong price performance.

CORCEPT THERAPEUTICS INCORPORATED (CORT) is a small-cap growth stock in the Biotechnology & Drugs industry. The rating according to our strategy based on Motley Fool is 83% based on the firms underlying fundamentals and the stocks valuation. A score of 80% or above typically indicates that the strategy has some interest in the stock and a score above 90% typically indicates strong interest.

Company Description: Corcept Therapeutics Incorporated is a pharmaceutical company engaged in the discovery, development and commercialization of drugs for the treatment of severe metabolic, psychiatric and oncologic disorders. The Company is developing mifepristone, a compound that modulates the effects of cortisol by acting as a competitive antagonist at the glucocorticoid receptor (GR). As of December 31, 2016, it had discovered three structurally distinct series of selective cortisol modulators, all of which share mifepristone's affinity for GR but, unlike mifepristone, do not bind to the progesterone receptor. It is conducting two clinical trials of its selective cortisol modulator, CORT125134. One trial is investigating CORT125134 as a treatment for patients with Cushing syndrome. The second trial is investigating the combination of CORT125134 and nab-paclitaxel (Celgene Corporation's Abraxane) to treat patients with solid-tumor cancers.

The following table summarizes whether the stock meets each of this strategy's tests. Not all criteria in the below table receive equal weighting or are independent, but the table provides a brief overview of the strong and weak points of the security in the context of the strategy's criteria.

For a full detailed analysis using NASDAQ's Guru Analysis tool, click here

ZYNEX INC. (ZYXI) is a small-cap growth stock in the Medical Equipment & Supplies industry. The rating according to our strategy based on Motley Fool is 83% based on the firms underlying fundamentals and the stocks valuation. A score of 80% or above typically indicates that the strategy has some interest in the stock and a score above 90% typically indicates strong interest.

Company Description: Zynex, Inc. operates through the Electrotherapy and Pain Management Products segment. The Company conducts its business through its subsidiaries and the operating subsidiary is Zynex Medical, Inc. (ZMI). Its other subsidiaries include Zynex Monitoring Solutions, Inc. (ZMS) and Zynex Europe, ApS (ZEU). ZMI designs, manufactures and markets medical devices that treat chronic and acute pain, as well as activate and exercise muscles for rehabilitative purposes with electrical stimulation. ZMS is in the process of developing its blood volume monitoring product for non-invasive cardiac monitoring. ZEU intends to focus on sales and marketing its products within the international marketplace, upon receipt of necessary regulatory approvals. It markets and sells Zynex-manufactured products and distributes private labeled products. Its products include NexWave, NeuroMove, InWave, Electrodes and Batteries. ZMI devices are intended for pain management to reduce reliance on drugs and medications.

The following table summarizes whether the stock meets each of this strategy's tests. Not all criteria in the below table receive equal weighting or are independent, but the table provides a brief overview of the strong and weak points of the security in the context of the strategy's criteria.

For a full detailed analysis using NASDAQ's Guru Analysis tool, click here

INMODE LTD (INMD) is a small-cap growth stock in the Medical Equipment & Supplies industry. The rating according to our strategy based on Motley Fool is 79% based on the firms underlying fundamentals and the stocks valuation. A score of 80% or above typically indicates that the strategy has some interest in the stock and a score above 90% typically indicates strong interest.

Company Description: Inmode Ltd is an Israel-based company. It designs, develops, manufactures and commercializes energy-based, minimally-invasive surgical aesthetic and medical treatment solutions. The Company's proprietary technologies are used by physicians to remodel subdermal adipose, or fatty, tissue in a variety of procedures including fat reduction with simultaneous skin tightening, face and body contouring and ablative skin rejuvenation treatments. Its products target a wide array of procedures including simultaneous fat killing and skin tightening, permanent hair reduction, skin appearance and texture, among others. The Company's products may be used on a variety of body parts, including the face, neck, abdomen, upper arms, thighs and intimate feminine regions. It owns six product platforms: BodyTite, Optimas, Votiva, Contoura, Triton and EmbraceRF. All are market and sell traditionally to plastic and facial surgeons, aesthetic surgeons and dermatologists, among others.

The following table summarizes whether the stock meets each of this strategy's tests. Not all criteria in the below table receive equal weighting or are independent, but the table provides a brief overview of the strong and weak points of the security in the context of the strategy's criteria.

For a full detailed analysis using NASDAQ's Guru Analysis tool, click here

MEDPACE HOLDINGS INC (MEDP) is a mid-cap growth stock in the Biotechnology & Drugs industry. The rating according to our strategy based on Motley Fool is 76% based on the firms underlying fundamentals and the stocks valuation. A score of 80% or above typically indicates that the strategy has some interest in the stock and a score above 90% typically indicates strong interest.

Company Description: Medpace Holdings, Inc. is a clinical contract research organization. The Company provides clinical research-based drug and medical device development services. The Company partners with pharmaceutical, biotechnology, and medical device companies in the development and execution of clinical trials. The Company's drug development services focus on full service Phase I-IV clinical development services and include development plan design, coordinated central laboratory, project management, regulatory affairs, clinical monitoring, data management and analysis, pharmacovigilance new drug application submissions, and post-marketing clinical support. The Company also provides bio-analytical laboratory services, clinical human pharmacology, imaging services, and electrocardiography reading support for clinical trials. The Company's operations are principally based in North America, Europe, and Asia.

The following table summarizes whether the stock meets each of this strategy's tests. Not all criteria in the below table receive equal weighting or are independent, but the table provides a brief overview of the strong and weak points of the security in the context of the strategy's criteria.

For a full detailed analysis using NASDAQ's Guru Analysis tool, click here

CRISPR THERAPEUTICS AG (CRSP) is a mid-cap growth stock in the Biotechnology & Drugs industry. The rating according to our strategy based on Motley Fool is 72% based on the firms underlying fundamentals and the stocks valuation. A score of 80% or above typically indicates that the strategy has some interest in the stock and a score above 90% typically indicates strong interest.

Company Description: CRISPR Therapeutics AG is a Switzerland-based gene-editing company. It focuses on the development of transformative gene-based medicines for serious diseases. The Company develops its products using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 gene-editing platform, which allows for precise directed changes to genomic deoxyribonucleic acid (DNA). The Company has a portfolio of therapeutic programs in a range of disease areas, including hemoglobinopathies, oncology, regenerative medicine and rare diseases. Its lead product candidate is CTX001, an ex vivo CRISPR gene-edited therapy for treating patients suffering from transfusion-dependent beta thalassemia or severe sickle cell disease in which a patient's hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin in red blood cells. The Company has business operations in London and the United Kingdom, as well as research and development operations in the United States.

The following table summarizes whether the stock meets each of this strategy's tests. Not all criteria in the below table receive equal weighting or are independent, but the table provides a brief overview of the strong and weak points of the security in the context of the strategy's criteria.

For a full detailed analysis using NASDAQ's Guru Analysis tool, click here

Since its inception, Validea's strategy based on Motley Fool has returned 625.78% vs. 240.03% for the S&P 500. For more details on this strategy, click here

About Motley Fool: Brothers David and Tom Gardner often wear funny hats in public appearances, but they're hardly fools -- at least not the kind whose advice you should readily dismiss. The Gardners are the founders of the popular Motley Fool web site, which offers frank and often irreverent commentary on investing, the stock market, and personal finance. The Gardners' "Fool" really is a multi-media endeavor, offering not only its web content but also several books written by the brothers, a weekly syndicated newspaper column, and subscription newsletter services.

About Validea: Validea is an investment research service that follows the published strategies of investment legends. Validea offers both stock analysis and model portfolios based on gurus who have outperformed the market over the long-term, including Warren Buffett, Benjamin Graham, Peter Lynch and Martin Zweig. For more information about Validea, click here

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

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Validea's Top Five Healthcare Stocks Based On Motley Fool - 2/16/2020 - Nasdaq

Skin Stem Cells Comments Off on Validea’s Top Five Healthcare Stocks Based On Motley Fool – 2/16/2020 – Nasdaq | February 17th, 2020

Heres the truth about serum: Its the biggest secret to having younger-looking, radiant skin.

You know all the other steps to staying healthyand showing it: wearing SPF, and applying retinol. You stay hydrated and eat healthy foods. You get lots of exercise and plenty of sleep. But, are you applying serums? They can give your skin some of the most immediate and impactful benefits.

Serum seeps into all three layers of your skin to work its magic at deeper levels than moisturizer ever could. Those moisturizing creams merely sit atop your skin. Theyre equally important, and shield skin from toxins, but they do little to reverse dark spots and smooth wrinkles. Serums, on the other hand, can correct hyperpigmentation and puffy eyes.

Serum brightens your skin complexion, and can preserve moisture levels in ways that moisturizers never could (funny, given its name). No two serums are alike in terms of ingredients and overall benefits, but almost all of them brighten your skin and smooth complexion. Here are seven of our favorite serums; apply them to clean, dried skin before moisturizers, SPFs, retinol or night creams.

If your skin suffers from redness or discoloration, then look for a corrective serum. SkinCeuticals gel serum uses thyme and cucumber extract to soothe irritation, as well as mulberry extract to even skin tone and gently hydrate the skin. If most moisturizers make your skin break out, then this is a gentle and top-notch moisturizing alternative.

Vitamin C is one of the best ingredients you can apply to skin for brighter, more even complexion. Glossiers serum is packed with it, along with magnesium, for an instant pick-me-up for tired or dull skin. Use it daily to preserve a fresh face, and to get ahead of the inevitable hangovers or early mornings.

The skin around your eyes is more sensitive than the rest of your face, and is much thinner, too hence why you quickly show signs of tiredness. (Its fluid buildup from a lack of rest, shining through your skin.) So, target the eyes with a special-blend serum that tightens and brightens at the same time. In OSEAs eye serum, hyaluronic acid preserves firmness and moisture levels, grape-seed-derived resveratrol shields this thin skin from toxins, and algae extract plumps and nourishes tired eyes (and alert eyes, if youre plenty rested already everyone benefits). It also prevents and helps reverse fine lines and other signs of aging.

Some serums are best worn during the day those that focus on hydration and pure brightening. Others, like corrective and exfoliating serums, are often best suited for bedtime so that they can sync with your bodys circadian rhythm to boost cellular turnover (and in turn guarantee that you wake up looking rested and more youthful). However, some serums cover both bases: Brickells night serum is ultra-hydrating so much so that its impact is maximized by wearing it overnight. Its loaded with plant stem cells, hyaluronic acid and vitamin C, and promises to magnify the benefits of a full nights sleep. Your friends and colleagues will notice the difference within days. (Assuming you arent pairing it with a lovely binge-drinking or chain-smoking habit.)

Theres an entire family of serums that focuses on exfoliation, by using ingredients that dissolve dead skin cells and reduce hyperpigmentation (dark spots and discoloration). Herbivores serum does so with alpha- and beta-hydroxy acids, all of which are naturally derived, despite their sciencey-sounding names. Theyre extracted from things like willow bark and sugar maple, and in turn leave skin bright, while minimizing pore size and smoothing skin texture.

Its hard to categorize Caudelies skin-brightening serum, since it uses the brands proprietary blend of ingredients (Viniferine, derived from grape vines) but they seem to deliver on their promise to brighten skin 62 times better than Vitamin C. All around the globe, this is what Caudelies spa customers pay top dollar for, and you can enjoy the same complexion-smoothing effects for less than a buck a day (assuming you just use a couple drops daily).

If your skin texture needs attention just as much as your skin tone, then look for a corrective and smoothing serum. This one from PCA Skin is pumped with peptides, and it waxes poetic on your skin to undo signs of aging (like the appearance of fine lines, wrinkles, dark spots and acne spots). It also helps skin retain moisture thanks to the inclusion of hyaluronic acid, rice bran extract, squalene, ensuring firmness and brightness.

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The Best Serums to Brighten and Refresh Dull, Tired Skin - gearpatrol.com

Skin Stem Cells Comments Off on The Best Serums to Brighten and Refresh Dull, Tired Skin – gearpatrol.com | February 17th, 2020

Stephanie Singleton for BuzzFeed News

Do you miss being a scientist? some people ask.

Sometimes.

When people talk about science, they usually mean people in white lab coats doing things, like solving equations on the board or preparing solutions in beakers. What they mean is science as this crude mechanism of discovery by which humans refine over decades and centuries a small kernel of knowing. What they mean is grant dollars. What they mean is wild hair. What they mean is clean, aseptic, analytical. Brainy little robot people. White.

I try to be honest about my time in science about the feeling of satisfaction I had when I plotted all of my confocal data and there was a beautiful curve depicting the drop-off in signal as one moved further down the tissue of the gonad. I think about the calculations we did on scraps of paper to check the ratios of inheritance of the genes we introduced. I think of the little side room where we took our coffee and bagels. I think of the feeling of friendship and family that comes with being in a big lab, where everyone has a place, a role, an expertise, a skill. I remember the surprise I felt when people started to come to me because I knew something, because I could help. And how rare that was for me.

For the better part of several years, I saw my labmates every day. For hours and hours. Every holiday, every break, we stayed. We worked. We supported each other. We fought. We feuded. We gossiped. We threw parties for each other. We celebrated. We said goodbye at graduations and retirements. There were people who supported me and cherished me and looked after me. People who treated me like I mattered. A lab is a family. In a way.

Science was beautiful and it was wild and it was unknowable. Science was spending days and weeks on a single experiment with no way to know if it would work and no real way to tell if it had worked. Science was like trying to find your way to a dark forest only to realize that you had always been inside of the forest and that the forest is inside of another, greater, darker forest. Science was laughing with my labmates about television the night before, about the song of the summer, about tennis, about the unruly nature of mold growing on our plates, about cheap wings at Buffalo Wild Wings. Science was being taught to think. Taught to speak. Science was a finishing school. Science was a brutal education. Science made me ruthless. Science made me understand the vast beauty of the world.

But science was also working 15 hours a day for weeks or months. Science was working weekends and holidays. Science was being called lazy for taking a break. Science was the beat of doubting silence after I answered a question put to me. Science was being told that racism was not racism. Science was being told that I was fortunate that I had running water while growing up and that I was actually privileged because there are some places that do not. Science was being told that I was mistaken for a waiter at a party because I had worn a black sweater. Science was being told that I had to work harder despite working my hardest. Science was being told that I talked too much. Science was being told that I was too loud. Science was being told that I was behind, always behind. Science was being told that I had failed but had been gifted a pass by virtue of who you are. Science was being told that I had never once been to class despite attending every session and office hour because I was mistaken for someone else.

Science was being the only black person in the program for four years. Science was saying nothing because I was tired of being corrected about the particulars of my own experience. Science was being told that I should consider moving to the other side of town where more black people live. Science was someone suggesting that I find a church in order to find community. Science was having my hair stroked and touched. Science was being told that I was articulate. Science was watching peoples eyes widen slightly in surprise when I told them what program I was in. Science was the constant humiliation of wondering if I had justified my presence or if I had made it harder for the next black person to get admitted. Science was having to worry about that in the first place.

Science was a place I ultimately left, not so much because I wanted to, but because I had to. Science is not being able to say that because I reflexively feel the rebuttal waiting on the other end of that sentence: You could have made it work if you wanted it enough. Science is not knowing whether I wanted it enough.

Does science influence your writing?

Oh, sure. I guess.

Do you write science fiction?

No, I write domestic realism.

After the above exchange, people sometimes look at me like Im joking and at any moment will drop the faade to reveal that I do in fact write and love science fiction, after all.

But no, I do not write science fiction. I think that if people knew more scientists and spent significant time in their company, they would understand that the worst possible preparation for a career as a science fiction writer is an intensive science education. My training as a scientist makes it difficult to absent myself in the way I need to in order to write good fiction. I can never turn off the part of my brain that knows about protein folding or microscopy or tissue preparation or stem cells or physics or chemistry. Writing science fiction would be an extended exercise in pedantry.

People presume that science and writing are quite different. But they are both ways of knowing. They are ways of understanding the greater mystery of the world. They are systems of knowledge and inquiry. I do not understand something until I have written it, or more accurately put, until I have written my way through it.

Science was being the only black person in the program for four years. Science was saying nothing because I was tired of being corrected about the particulars of my own experience.

I think in many ways, the best preparation for a writer is a period of prolonged and rigorous thought about a difficult and complicated question. You learn to assemble your resources. You learn to fight with yourself. You learn to quarrel on the page with your worst ideas and with the ones you hold dearest. You treat your expectations with suspicion. You demand proof. You demand evidence. You think hard about the alternate hypothesis or other explanations, and you devise strategies to root these out. You learn to live with doubt. You try to prove yourself wrong. You look for places where you have been too soft. Too vague. You eliminate language that contains falsehoods. You eliminate language that can mislead your reader. You ask questions. You pursue answers with all the energy you can muster. You try to put language to what it is you observe. You develop a stamina for iteration. You develop a thick skin. You learn to seek criticism. You treat criticism like kindness. You churn the raw material of life into something that can be understood, and when you fail, you marvel at the mystery of things.

Do you miss science?

Yes. No. Yes. No.

Sometimes, when I dont feel well, I consider the question of how to derive an expression for the degradation of a molecular species in a particular tissue under a given set of circumstances. Old calculus. I turn to YouTube lectures from MIT about thermodynamics. I think of my first winter in Madison, Wisconsin.

The first snowfall was in October. It had been a hot, rainy summer, so much so that the weather seemed to turn all at once with very little warning. I was either in the middle or at the start of my second rotation as a biochemistry graduate student, working in a biophysical chemistry lab and spending most of my day in the windowless instrument facility in the basement. My project was to deduce the effect of protein concentration on the ability of a polymer of DNA to wind itself. I spent a lot of time pipetting various liquids into each other in little cuvettes, slotting them into a machine, and then waiting for the reading. It was the kind of work to which I felt ideally suited, and I could have gone on that way forever. I had recently moved to the Midwest from Alabama to pursue a PhD, and it seemed as likely as anything else that I would go on pipetting and measuring the effect of things like DNA polymer length and protein concentration on DNA winding. It was as removed from the circumstances of my previous life as anything else, and so I didnt have a compelling reason to doubt that this would be the shape my life held.

But I remember sitting down at the desk in the lab and looking out the broad window. There was a large tree at the center of the courtyard that had recently turned yellow. Fall was there in name, but not in temperature. The labs were kept quite cold, and so I wore a sweater indoors and shucked it as soon as I got outside. But that day, I looked out of the window and saw snow drifting down. The flakes were thick and fluffy, and they seemed almost fake. It was the first time I had seen snow in years, and I was totally enamored by it. The other people in the lab were on edge because snow in October portended something dark and awful a hard winter, a long, brutal freeze. Where they saw inconvenient travel and slushy roads, I saw something beautiful if frivolous, a minor novelty. Winter came early that year, and it didnt end until the very beginning of the following summer. When I went to the lake on my birthday in early June, there was still ice in the water.

People presume that science and writing are quite different. But they are both ways of knowing.

When people ask me about my time in science, it is this day which presents itself to me in jewel-like clarity. It is the day something about my life altered irrevocably. Or perhaps it is that the snow has accumulated, the way all such moments do in life, the weight of meaning, of prophecy. Inevitability is an artifact of retrospection. It is because the snow represented a stark deviation from the previous course of events in my life, at the precise moment when my life was changing so wildly, that I remember it. It is not that the snow changed me, but it came at a point when I was starting not to resemble myself. I cannot use the snow to explain to people what my life was like in science. It has the whiff of superstition, folklore. It feels too much like a memory and not enough like an answer. I do not tell them about the snow or how it seemed a benediction at the outset of something I needed desperately to work.

It was only later that I realized this was wishful thinking, and that the snow was just snow.

Do you think youd ever go back to science?

That part of my life is over now.

Ive come to understand that what people want in such a situation is to have their own conceptions of the world confirmed. That is, they want me to say that when you leave science because you have written a novel and a book of stories and have decided to attend an MFA program in creative writing, you are doing something that is antithetical to science. People presume that it is akin to picking up and leaving your home in the middle of the night under great duress, never to return. What they want is the spectacle of the forgotten treasured item, the confirmation that something has been lost, perhaps forever.

I think if people knew what it was that I left, then theyd know better than to ask. It would be like asking someone if they were sad to have left their home with no prospect of returning. It would be like asking someone if they were sad to have left their faith behind. It would be like asking someone if they were sad to have given up some fundamental idea about who they are. It would be like asking someone if they were sad to have watched their life burn to the ground. It would be like asking someone if they were sad to have left their family and friends.

They would mind their own business if they knew.

But they do not know, and so they say things like Science, wow, thats so cool, like, do you miss it?

And I smile because that is what I have learned to do. Because explaining is too hard. Too messy. There is no clean or easy or simple way to make it known to others that I left because I had to, because it was necessary to leave that I do miss it, but I also dont because Im still that person but not that person, that every day I remind myself less of the person I was then. Its sad, like losing a memory of myself, and all those years are lost to me now, all the little tricks and habits of home dropping down and away, as I become this other person known for this other thing, and its too much in the moment to say that I miss it both more and less every day, that I become a person more capable of appreciating what is lost in the grand scheme of things but less a person who knows what it is Ive actually lost, and that there is some painful, brutal, awful misalignment in the scale of those two losses.

When people ask if I miss science, the only answer available to me is an incomplete solution to the problem: Yes. No. Sometimes. Its over now.

Brandon Taylor is the senior editor of Electric Literatures Recommended Reading and a staff writer at Literary Hub. His writing has earned him fellowships from Lambda Literary Foundation, Kimbilio Fiction, and the Tin House Summer Writer's Workshop. He holds graduate degrees from the University of Wisconsin-Madison and the University of Iowa, where he was an Iowa Arts Fellow at the Iowa Writers Workshop in fiction. Learn more about his first novel Real Life here.

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Working In Science Was A Brutal Education. Thats Why I Left. - BuzzFeed News

Skin Stem Cells Comments Off on Working In Science Was A Brutal Education. Thats Why I Left. – BuzzFeed News | February 17th, 2020

Marie Antoinette, the last queen of France, is best remembered for her reckless extravagance and her tragic death. French revolutionaries executed her with a guillotine in 1793 for treason. Popular belief is that her hair turned grey the night before her death.

There are other stories and anecdotes like this which suggest that stressful experiences are correlated with the phenomenon of hair greying. Now, for the first time, Harvard University scientists have found the real mechanism behind it.

Published in the journal Nature, the study was initiated with the aim of analysing the effect of stress on various tissues. Hair and skin are the tissues that are visible from outside. So, the researchers started with effects of stress on hair colour.

Their initial hypothesis was that stress initiates an immune attack on pigment-producing cells in the hair follicles. However, when they tested it on mouse, they found those lacking immune cells (nude mouse) also exhibited hair greying. Then, their attention turned to a hormone called cortisol. It is responsible for regulating a wide range of processes through the body, including metabolism and the immune response. In response to stress, extra cortisol is released to help the body to respond appropriately. Surprisingly, when the researchers removed the adrenal gland from the miceto prevent production of cortisol-like hormone aldosteroneand triggered stress, their hair still turned grey.

Finally, the researchers tested the sympathetic nerves that branch out to each hair follicle. The sympathetic nerve system is responsible for the bodys fight-or-flight response. They found that in a stressful condition, the sympathetic nerves release a chemical called norepinephrine, which is taken up by certain stem cells in the hair follicle. Stem cells act as a reservoir for pigment-producing cells. During hair regeneration, some of these stem cells are converted into pigment-producing cells to give colour to new hair strands.

When these stem cells take norepinephrine, they are activated excessively and all of them get converted into pigment-producing cells. This would prematurely deplete the reservoir for pigment-producing cells. Once all of them are consumed, pigment regeneration would stop, resulting in permanent damage. The fight-or-flight response has been traditionally viewed as beneficial. But now it is proved that it has its own detrimental effects, too.

The study established how neurons interact at the cellular and molecular level to link stress with hair greying. The findings are expected to put light on the broader effects of stress on various body parts. The scientists will initiate new studies that seek to modify or block the damaging effects of stress.

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The ghost behind grey - THE WEEK

Skin Stem Cells Comments Off on The ghost behind grey – THE WEEK | February 16th, 2020

People usually start gradually greying in their thirties. Once across the age of 50, one will be hard-pressed to successfully disguise ones white hair without paying monthly visits to a hairdresser.

However, medical reports suggest the process of hair colour loss, which scientists call canities or achromotrichia, can be greatly accelerated by persistent acute stress or severe trauma.

Some historians have speculated that the French Queen Marie Antoinettes hair turned white when she heard she was to be guillotined at the height of the French Revolution in 1793.

For the longest time, its been said that stress makes the hair turn white, but until now, there was no scientific basis for this belief.

Our study proved that the phenomenon does indeed occur and we identified the mechanisms involved.

In addition, we discovered a way of interrupting the process of hair colour loss due to stress, said Thiago Mattar Cunha, a researcher affiliated with the Center for Research on Inflammatory Diseases (CRID) a Research, Innovation and Dissemination Center funded by FAPESP and hosted by the University of So Paulos Ribeiro Preto Medical School in Brazil.

The study was conducted in partnership with a group led by Hsu Ya-Chieh, a professor of regenerative biology at Harvard University in the United States.

According to Cunha, the results, published recently in the journal Nature, were partly serendipitous.

We were conducting a study on pain using black C57 mice, a dark-furred laboratory strain, he said.

In this model, we administered a substance called resiniferatoxin to activate a receptor expressed by sensory nerve fibres and induce intense pain.

Some four weeks after systemic injection of the toxin, a PhD student observed that the animals fur had turned completely white.

The experiment was repeated several times until the CRID researchers concluded that the phenomenon was indeed due to the application of resiniferatoxin, a naturally-occurring chemical found in resin spurge (Euphorbia resinifera), a cactus-like plant native to Morocco.

We set out to check the hypothesis that the loss of fur colour resulted from pain-induced stress, Cunha said.

We designed a very simple experiment to see if the phenomenon was dependent on activation of sympathetic nerve fibres.

He explained that the sympathetic nervous system is directly affected by stress.

This division of the autonomic nervous system consists of nerves that branch from the spine and run throughout the body.

It controls the organisms fight or flight response to imminent danger, triggering the release of adrenaline and cortisol to make the heart beat faster, blood pressure rise, respiration accelerate and the pupils dilate, among other systemic effects.

After injecting resiniferatoxin into the mice, we treated them with guanethidine, an anti-hypertensive capable of inhibiting neurotransmission via sympathetic fibres.

We observed that the process of fur colour loss was blocked by the treatment, Cunha said.

In another experiment, neurotransmission was interrupted by the surgical removal of sympathetic fibres.

In this case too, fur colour was not lost in the weeks following pain induction.

These and other experiments conducted by our group demonstrated the participation of sympathetic innervation in achromotrichia and confirmed that pain is a powerful stressor in this model.

But it remained to detail the mechanisms involved, he explained.

Maturing too quickly

Cunha spent a period at Harvard as a visiting professor in 2018-19 with a scholarship from the joint programme Harvard holds with CAPES, the Brazilian Education Ministrys Office for Faculty Development.

In conversations with colleagues, he heard that a Harvard group had made similar discoveries to those of his group at So Paulo, and that their findings were also partly accidental.

Professor Hsu Ya-Chieh invited me to join a project in which the phenomenon was being investigated in more detail.

Shes a leading researcher on processes that control skin stem cell differentiation, Cunha said.

His group already knew by then that pain-related stress was somehow making the melanocyte stem cells in the hair follicle bulb mature too soon.

These cells are responsible for yielding melanin-producing cells. Melanin is the pigment primarily responsible for skin and hair colour.

In a young individual, the cells are undifferentiated like all stem cells, but with ageing, they gradually differentiate.

Once the process is complete, they stop producing the melanocytes that produce melanin, Cunha explained.

We used various methodologies to show that intense sympathetic activity speeds up differentiation significantly.

In our model therefore, pain accelerated the ageing of melanocyte stem cells.

When we started to study this, I expected that stress was bad for the body but the detrimental impact of stress that we discovered was beyond what I imagined, Prof Hsu said.

After just a few days, all of the pigment-regenerating stem cells were lost. Once theyre gone, you cant regenerate pigment anymore. The damage is permanent.

Study lead author and postdoctoral fellow Zhang Bing added: Acute stress, particularly the fight-or-flight response, has been traditionally viewed to be beneficial for an animals survival.

But in this case, acute stress causes permanent depletion of stem cells.

Other systems in the organism are probably affected by intense stress in a similar manner to the hair follicle bulb.

We dont know for sure what the implications are, Cunha said.

Im currently working with other researchers on an investigation of the effects of sympathetic activity in other stem cell subpopulations.

Altered gene expression

RNA (ribonucleic acid) sequencing was one of the methodologies used to explore the mechanisms that promote melanocyte stem cell differentiation.

The researchers used this technology to compare the gene expression profiles of mice that received the injection of resiniferatoxin developing pain, stress and fur colour loss with those of mice injected with a placebo.

We looked for genes whose expression was most altered after stress induction, and one caught our attention: the gene that encodes a protein called CDK (cyclin-dependent kinase).

This is an enzyme that participates in cell cycle regulation, Cunha said.

When the researchers repeated the pain induction procedure and treated the mice with a CDK inhibitor, they found that melanocyte stem cell differentiation was prevented, as was fur colour loss.

This finding shows that CDK participates in the process and could, therefore, be a therapeutic target, he said.

Its too soon to know whether it will actually become a target someday in clinical practice, but its worth exploring further.

In another experiment, the researchers demonstrated that when the sympathetic system is robustly activated, the fibres that innervate hair follicle bulbs release noradrenaline very near the melanocyte stem cells.

We showed that melanocyte stem cells express the protein ADRB2 (beta-2 adrenergic receptor), which is activated by noradrenaline, and we discovered that the stem cells differentiate when this receptor is activated by noradrenaline, Cunha said.

To confirm the finding, the researchers repeated the experiment using mice that had been genetically modified so as not to express ADRB2.

As suspected, their fur did not turn white after they were injected with resiniferatoxin.

In another test, we injected noradrenaline directly into the skin of the mouse.

As a result, the fur around the site of the injection turned white, Cunha said.

Finally, the group treated a primary culture of human melanocytes (melanin-producing cells obtained directly from the skin of a volunteer) with noradrenaline, which as noted earlier, is released by the sympathetic nerve fibres in hair follicles.

The result was an increase in expression of CDK similar to that observed in mice.

According to Cunha, the researchers do not yet know if there will be future aesthetic applications for their findings, such as the development of a drug that prevents the hair colour loss associated with ageing.

It would be necessary to see if a CDK inhibitor has side effects, and if so, whether they would be outweighed by the aesthetic benefit, he said. Agncia FAPESP

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What makes your hair turn white faster - The Star Online

Skin Stem Cells Comments Off on What makes your hair turn white faster – The Star Online | February 15th, 2020

Clumsy robots have been offered hope of improving their coordination after MIT researchers found a new way to help them find their bearings.

The systemgives soft robots a greater awareness of their movements by analysing motion and position data through a sensorized skin.

It works by collecting feedback fromsensors on the robots body.A deep learning model then analyses the data to estimate the robots 3D configuration.

[Read:Scientists used stem cells to create a new life-form: Organic robots]

The sensors are comprised of conductive silicone sheets, which the researchers cut into patterns inspired by kirigami a variation of origami that that involvescutting as well as folding paper. These patterns make the material sufficiently flexible and stretchable to be applied to soft robots.

A deep neural network then captures signals from sensorsto predict the best configuration for the robot.

The system aims to overcome the problem of controlling soft robots that can move in countless direction by giving themproprioception an awareness of their position and movements.It could eventually make artificial limbs better at handling objects.

The researchers used the system to teach an elephant trunk-shaped robot to predict its own position as it rotated and extended.

We want to use these soft robotic trunks, for instance, to orient and control themselves automatically, to pick things up and interact with the world, said MIT researcherRyan Truby, who co-wrote a paper describing how the system works. This is a first step toward that type of more sophisticated automated control.

Truby admits that the system can not yet capture subtle or dynamic motion. But it could at least reduce the clumsiness that has embarrassed robotkind for decades.

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Published February 13, 2020 17:10 UTC

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Sensorized skin helps robots understand where the hell they are - The Next Web

Skin Stem Cells Comments Off on Sensorized skin helps robots understand where the hell they are – The Next Web | February 14th, 2020

When Lt. Col. Jason Barnhill traveled to Africa last summer, he took with him not only the normal gear of an Army officer, but also a 3D printer.Barnhill, who is the life science program director at the U.S. Military Academy, traveled to Africa to study how 3D printers could be used for field medical care. Barnhills printer was not set up to print objects made out of plastics as the printers are frequently known for. Instead, his printer makes bioprinted items that could one day be used to save Soldiers injured in combat.The 3D bioprinting research has not reached the point where a printed organ or meniscus can be implanted into the body, but Barnhill and a team of cadets are working to advance the research in the field.Twenty-six firsties are doing bioprinting research across seven different projects as their capstone this year. Two teams are working on biobandages for burn and field care. Two teams are working on how to bioengineer blood vessels to enable other bioprinted items that require a blood source, such as organs, to be viable. One team is working on printing a viable meniscus and the final team is working on printing a liver.The basic process of printing biomaterial is the same as what is used to print a plastic figurine. A model of what will be printed is created on the computer, it is digitally sliced into layers and then the printer builds it layer by layer. The difference is the ink that is used.Instead of heating plastic, 3D bioprinting uses a bioink that includes collagen, a major part of human tissue, and cells, typically stem cells.A lot of this has to do with the bioink that we want to use, exactly what material were using as our printer ink, if you will, Class of 2020 Cadet Allen Gong, a life science major working on the meniscus project, said. Once we have that 3D model where we want it, then its just a matter of being able to stack the ink on top of each other properly.Cadets are researching how to use that ink to create a meniscus to be implanted into a Soldiers injured knee or print a liver that could be used to test medicine and maybe one day eliminate the shortage of transplantable organs.The research at West Point is funded by the Uniformed Services University of Health Science and is focused on increasing Soldier survivability in the field and treating wounded warriors.Right now, cadets on each of the teams are in the beginning stages of their research before starting the actual printing process. The first stage includes reading the research already available in their area of focus and learning how to use the printers. After spring break, they will have their first chance to start printing with cells.For the biobandage, meniscus and liver teams, the goal is to print a tangible product by the end of the semester, though neither the meniscus or liver will be something that could be implanted and used.There are definitely some leaps before we can get to that point, Class of 2020 Cadet Thatcher Shepard, a life science major working on the meniscus project, said of actually implanting what they print. (We have to) make sure the body doesnt reject the new bioprinted meniscus and also the emplacement. There can be difficulties with that. Right now, were trying to just make a viable meniscus. Then, well look into further research to be able to work on methods of actually placing it into the body.The blood vessel teams are further away from printing something concrete because the field has so many unanswered questions. Their initial step will be looking at what has already been done in the field and what questions still need to be answered. They will then decide on the scope and direction of their projects. Their research will be key to allowing other areas of the field to move forward, though. Organs such as livers and pancreases have been printed, so far, they can only be produced at the micro level because they have no blood flow.Its kind of like putting the cart before the horse, Class of 2020 Cadet Michael Deegan, a life science major working on one of the blood vessel projects, said. Youve printed it, great, but whats the point of printing it if its not going to survive inside your body? Being able to work on that fundamental step thats actually going to make these organs viable is what drew me and my teammates to be able to do this.While the blood vessel, liver and meniscus projects have the potential to impact long-term care, the work being done by the biobandage teams will potentially have direct uses in the field during combat. The goal is to be able to take cells from an injured Soldier, specifically one who suffers burns, and print a bandage with built in biomaterial on it to jumpstart the healing process.Medics would potentially be deployed with a 3D printer in their Humvee to enable bandages to be printed on site to meet the needs of the specific Soldier and his or her exact wound. The projects are building on existing research on printing sterile bandages and then adding a bioengineering element. The bandages would be printed with specialized skin and stem cells necessary to the healing process, jumpstarting healing faster.Were researching how the body actually heals from burns, Class of 2020 Cadet Channah Mills, a life science major working on one of the biobandage projects, said. So, what are some things we can do to speed along that process? Introducing a bandage could kickstart that healing process. The faster you start healing, the less scarring and the more likely youre going to recover.The meniscus team is starting with MRI images of knees and working to build a 3D model of a meniscus, which they will eventually be able to print. Unlike a liver, the meniscus doesnt need a blood flow. It does still have a complex cellular structure, though, and a large part of the teams research will be figuring out how and when to implant those cells into what theyre printing.Of the 26 cadets working on bioprinting projects, 17 will be attending medical school following graduation from West Point. The research they are doing gives them hands-on experience in a cutting-edge area of the medical field. It also enabled them to play a role in improving the care for Soldiers in the future, which will be their jobs as Army doctors.Being on the forefront of it and just seeing the potential in bioengineering, its pretty astounding, Gong said. But it has also been sobering just to see how much more complicated it is to 3D print biomaterials than plastic.The bioprinting projects will be presented during the academys annual Projects Day April 30.

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Cadets research bioprinting to improve Soldier care in the future - Pointer View

Skin Stem Cells Comments Off on Cadets research bioprinting to improve Soldier care in the future – Pointer View | February 14th, 2020

The research report presents a detailed competitive analysis of the Non-Melanoma Skin Cancer Market 2019 market Share, Size, and Future scope 2026. This research report classifies the market by manufacturers, region, type, and applications.

The data presented in the graphical format gives a thorough understanding of the major players of Non-Melanoma Skin Cancer . The restraints and growth, industry plans, innovations, mergers, and acquisitions are covered in this report. The market is segmented based on key industry verticals like the product type, applications, and geographical regions.

Get a Sample Copy of the Report @ https://www.reportspedia.com/report/life-sciences/global-non-melanoma-skin-cancer-market-report-2019,-competitive-landscape,-trends-and-opportunities/28562 #request_sample

Key Players of Non-Melanoma Skin Cancer Report are:

OncothyreonVarian Medical SystemsLEO PharmaAqua PharmaceuticalsMedaIRX TherapeuticsMoberg PharmaEli Lilly and Co.Cannabis ScienceMylan PharmaceuticalMerck & Co.Boehringer IngelheimCellceutix Corp.Bristol Myers Squibb Co.BiofronteraElektaICADValeant PharmaceuticalsSun Pharma IndustriesGaldermaAlmirallGENEXTRAF. Hoffmann-la RocheNovartis International

Short Description of Non-Melanoma Skin Cancer Market 2019-2026:

The Non-Melanoma Skin Cancer market was valued t XX Million US$ in 2019 and is projected to reach XX Million US$ by 2026, at a CAGR of XX% during 2019-2026. The research report gives historic report from 2013-2018.

The market is segmented into below points:

Market by Type/Products:

Type 1Type 2Type 3

Market by Application/End-Use:

Application 1Application 2Application 3

Enquire or share your questions if any before the purchasing this report @ https://www.reportspedia.com/report/life-sciences/global-non-melanoma-skin-cancer-market-report-2019,-competitive-landscape,-trends-and-opportunities/28562 #inquiry_before_buying

Outline of the data covered in this study:

The market study covers the forecast Non-Melanoma Skin Cancer information from 2019-2026 and key questions answered by this report include:

In this study, the years considered to estimate the market size of Non-Melanoma Skin Cancer are as follows:

Historic Period: 2015-2019.

Base Year: 2019.

Estimated Year: 2020.

Forecast Year 2020 to 2026.

Significant Features that are under Offering and Key Highlights of the Reports:

Table of contents:

For More TOC Content Continued,

Get A Sample Pdf Copy Of Table Of Content Describing Current Value And Volume Of The Market With All Other Essential Information @ https://www.reportspedia.com/report/life-sciences/global-non-melanoma-skin-cancer-market-report-2019,-competitive-landscape,-trends-and-opportunities/28562 #table_of_contents

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Global Stem Cells Types, Technologies And Therapeutics Market Is Estimated To Expand At a Healthy CAGR in Upcoming year 2020-2026 - Jewish Life News

Skin Stem Cells Comments Off on Global Stem Cells Types, Technologies And Therapeutics Market Is Estimated To Expand At a Healthy CAGR in Upcoming year 2020-2026 – Jewish Life News | February 14th, 2020

Tresor Rare is French for rare treasure. Thebrand goes well beyond the luxury perfume industry: it is a statement ofelegance; a philosophy to carry with you through life; and an aura surroundingyou that will make the world cherish you.

While the market is constantly bombarded with innumerable kinds of cosmetics and brands popping up every other day, few actually possess quality ingredients. In order for any cosmetic product to be safe and effective, you have to make sure that it incorporates potent, vitalizing ingredients that are also safe and well-known for their beneficial qualities. From added vitamins and minerals to precious metals like gold, these constituents give your skin, hair, and body a radiant appearance whilst providing a dose of nourishment to your bodys largest organ.

Tresor Rare formulated products with the rarest ingredients collected from different regions of the world. They are utilizing a perfect mix of natural ingredients including plant stem cells, pearls, gemstones dust, etc. which are capable of rejuvenating and healing the skin. Tresor Rare is using the secret of ancient skincare when these rare ingredients were a part of regular skincare routines. The developed products that reduces the signs of fatigue and the appearance of fine lines and wrinkles, promotes skin elasticity and collagen production. We reviewed for you Tresor Rare top collections

The enhanced skin treatment for elixirnourishes your skin completely, revitalizing it to give you a radiance and glowthat you could never have dreamt of. Give your face a natural life by using theelixir luxe mask treatment and enjoy a deep and rich skin nourishing. Are youtoo stressed from work or fatigued from trying to stick to your rigorousschedule? This work of art brings you antioxidant protection to keep you freshand rejuvenated.

This powerful, richly prepared serum battles the appearance of aging that gets concentrated in the eye area, like fine lines, puffiness, dark circles, and sagging lids. Appy before treatment and enjoy results like never before. This wonderful product has gotten rave reviews ever since it was launched to a diverse market. If you want to fend off the aging process while remaining natural and bringing out your inner beauty, this is the perfect choice for you.

For women, this aromatic collection of 5,000numbered bottles is a dream come true. A blend of floral and oriental notescomes in an unmistakable fragrance that lingers like a pure expression ofmajesty, an aroma that is a treat to the senses.

As enchanting as it is outright irresistible,this perfume is the embodiment of exquisite feminine beauty, with notes oforange, peach, vanilla, and white musk coming together to soothe your senses.Tresor Rares customer base is wide and varied, but one common factor bindsthem together: their love for pure beauty, a certain richness of aroma.

This lovely product from Tresor Rare is amajestic combination of the rare blend and pearl powder, which helps inconditioning, relaxing, and revitalizing the skin. For a softer, fresher andrejuvenated look, this unique blend works like a charm, with de-pollutingeffects to instantly take away the dry areas of the skin. Use this along withTresor Rares unique perfumes and bring out the most wonderful aspects of yourvibrant personality.

Its easy to fall back on the unanimouspraise, acclaim, and the great reviews that have been bestowed on Tresor Rareproducts, but try it for yourself once and youll see what everyone is talkingabout. The brand isnt just a collection of beauty products it is a philosophyof beauty, bringing you a unique aroma, fragrance, and effect, with each ofthem.

Beautifully crafted from gold, sapphire,diamond dust, rare pearls, and rich, organic liposomes, Tresor Raresdefinitive statement on natural beauty comes to life with every one of itsproducts, bringing you a youthful glow that lasts a long time. These arentreally products, even: they are fine works of art, the only difference beingthat your admirers wont need atrained eye to recognize it!

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Exploring the Wonderful World of Tresor Rare - VIVA GLAM MAGAZINE - vivaglammagazine.com

Skin Stem Cells Comments Off on Exploring the Wonderful World of Tresor Rare – VIVA GLAM MAGAZINE – vivaglammagazine.com | February 14th, 2020

INDIANAPOLIS (WISH)A near north side representative called for a crackdown on crime along the 38th Street corridor, between Capitol Avenue and Meridian Street, weeks after a News 8 report highlighted a string of incidents at an area McDonalds.

The restaurant, located at 37 W 38th St, shares a facility with a BP gas station convenience store.

Drivers and restaurant regulars described shootings, stabbings, fights and an attack on the McDonalds franchise owner near 38th and Illinois streets.

Annually, there are hundreds of [police] runs to this area, city-county council member John Barth said Sunday night in a Tweet. Historically, many runs have been attributed to the BP/McDonalds.

In the six-part Tweet thread, Barth detailed plans to hold monthly neighborhood meetings, review data-driven crime research and combat addiction-related issues.

Conversations with community leaders and police officers led him to believe substance abuse and addiction were significant contributing factors to violent crime along 38th Street, he told News 8.

I did a ride-along with the IMPD and spent 8 hours driving all around this area, Barth said Wednesday. And what I hear, over and over, is an increasing concern about substance abuse and the need for enhanced treatment options.

Some community members pointed to a disconnect between what they described as city hall narratives and real neighborhood needs.

Talk to the people and really get their point of view, said Diamond Taylor, a Chicago native who relocated to the near north side of Indianapolis. Everybody in this area is not homeless. Everybody in this area is not on drugs. They are not alcoholics. Theyre very good, hardworking people that live here [and] require assistance from the higher-ups; and they havent been getting it.

Lavorah Brady, a longtime resident, said she believed increased business investments and youth programs would be more beneficial to the community than an anti-drug campaign.

A lot of the people dont have good examples to follow, Brady told News 8. If [city leaders] could do more in the communitymaybe open up more community centers where the people have positive things to doI think it would make a world of difference.

There are a variety of causes for the crime along [the 38th Street] corridor, Barth acknowledged.

Drugs and violence were not contained within the corridor. Residential areas throughout his district had been impacted by rising crime rates, including the Crown Hill, Butler Tarkington and Meridian-Kessler neighborhoods, he said.

Members of the Butler Tarkington Neighborhood Association collaborated with gas station and restaurant franchise owners to implement new security measures following Januarys assault.

I am thankful that there are so many people in my district who want to focus on these issues and work together at the grass-roots level, Barth Tweeted.

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Makeup artist shares her FOUR favorite eye creams that you CANNOT buy in a store - WISHTV.com

Skin Stem Cells Comments Off on Makeup artist shares her FOUR favorite eye creams that you CANNOT buy in a store – WISHTV.com | February 13th, 2020

In the rush to get ready for work or kick back in front of Netflix at night, its easy to forget to look after your skin. But as winter bites, its time to step up your skincare routine, or risk developing dry, flaky and uncomfortable skin.

Of course, everyones skin is different and one mans rich moisturiser is anothers potential acne, but from vitamin-infused face washes, to SPF and face oil, weve got something to keep everyones skin looking its best.

(Image credit: Mr Porter)

The best mist to keep your skin juicy

+Great for freshening up+Contains hyaluronic acid

If you work in a highly heated or air-conditioned office and you have dry or dehydrated skin, youll need a little something to keep you skin happy. Face mists are brilliant because you can spritz and go without any mess or a mirror. Dr Barbara Sturms hydrating face mist is infused with hyaluronic acid which is great for hydrating dry and dehydrated skin, as well as purslane extract to nourish skin while protecting cells from free radicals. If thats not enough, its also packed with detoxifying extracts such as lemon, aloe vera and broccoli to minimise the effects of pollution and stress.

(Image credit: Mr Porter)

The best SPF to block harmful rays

+SPF 50+Great price

Whether youre whooshing down ski slopes or going for a wintery walk, an SPF is essential to block harmful rays and to keep you looking younger for longer. Jaxon Lanes Rain or Shine moisturising sunscreen is designed to shield your skin from UVA and UBV rays and offers SPF 50+ protection. Lightweight and non-greasy, it's infused with vitamin E, hyaluronic acid, green tea, liquorice root and ginseng so it not only protects but moisturises and enlivens your skin too.

(Image credit: Mr Porter)

Best deep-cleaning cleanser

+Great price point+Deep cleaning power of charcoal+Suitable for all face types

Washing your face in the winter isnt always the most pleasurable experience if your bathroom is cold. But a nice face wash can help. Clinque for Mens charcoal face wash harnesses the deep-cleaning power of charcoal, which is great for all skin types, especially those with slightly greasy complexions. The detoxifying gel formula is designed to work into a foam and draw out dirt, oil and impurities but isnt drying. Like all Clinque products its non-scented, which makes it a winner for sensitive skin too.

(Image credit: Mr Porter)

Best for the winter sports

+Hydrating, soothing solution+Designed to protect

Gliding down ski slopes and playing in powdery snow may fun, but a dry, red face blasted by the wind and sun isnt, so you definitely dont want to go off-piste with your skincare. If youre going skiing or are spending lots of time in the great but freezing outdoors, try Dr Barbara Sturms aptly-named Ski Cream. Its definitely not cheap, but it does promise a lot, acting as a protective shield against wind and extreme climates. Suitable for all skin types, the cream contains balloon vine, blackcurrant oil and purslane to soothe skin and reduce redness, while shea butter and jojoba oil lock in moisture.

(Image credit: Mr Porter)

The best moisturising serum

+Natural ingredients+Lighter than creams+Beautiful packaging

-Empty List

Aesop may be a favourite on Instagram thanks to its seriously stylish packaging, but the skincare brands parsley seed range packs a botanical punch. The anti-oxidant serum is a lighter alternative to creams and can be used daily after cleaning. The aloe-vera based formula contains other botanical extracts, such as parsley and grape seed oils to soften and moisturise. Plus, its designed to give skin strength and flight of environmental aggressors, which is ideal for winter months and city living alike. Its a stylish skincare solution that wont break the bank.

(Image credit: Mr Porter)

Best for brightening the complexion

+Exfoliates and brightens in one+Can help with pigmentation problems+A good multitasker

You remember to eat your five a day, but vitamin-infused skincare is great for keeping your face looking good too. 111SKINs vitamin C brightening cleanser is a great multitasker, tackling lots of issues in the time it takes to wash your face. A great addition to your morning routine during the winter months, its packed with radiance-boosting vitamin C to help reduce hyper-pigmentation, age spots and uneven skin tone. The exfoliating formula promises leaves your complexion looking clear, even and illuminated, which isnt bad for a quick scrub. Its not cheap, but it might just work miracles.

(Image credit: Mr Porter)

The best anti-ageing moisturiser

+High tech formula+Free from parabens, sulphates and gluten+For all skin types

Not all moisturisers are created equal. Sure, some are a couple of quid and do a little to keep your skin soft, but others, like MALIN + GOETZ advanced renewal moisturiser do much more. Of course, all this comes at a cost and the stylish brands high-tech daily moisturiser is pretty expensive. But its blended with antioxidant-rich meadowfoam seed oil and a combination of sugar molecules, barley and sodium hyaluronate to reduce the appearance of fine lines and wrinkles. Meanwhile, linseed extract, which is rich in Omega-3 fatty acids, trap water molecules to make your skin look healthier and plumper, and apple stem cell protects against harsh environments, which is ideal in winter.

(Image credit: Mr Porter)

Best moisturiser for dry and sensitive skin

+Hypoallergenic and gentle+Good for everyday use+Also has some anti-ageing benefits

Everyones skin needs a little extra TLC in the colder months, but those with dry and sensitive complexions can really suffer as chilly winds and harsh heating take their toll. But, PERRICONE MDs hypoallergenic nourishing moisturiser can help. Designed for specifically for dry and sensitive skin, its hypoallergenic and paraben-free, and harnesses the antioxidant properties of vitamin E along with with nourishing olive polyphenols. Gentle enough for everyday use, the brand also claims its good for keeping fine lines and wrinkles at bay.

(Image credit: Mr Porter)

Best lip balm for outdoors

+SPF 30+Water-resistant+Contains natural oils

If youre hitting the slopes or spend a lot of time outside, its important to protect your lips from the elements to avoid them becoming chapped, or sunburnt if theres snow around. Shiseidos Suncare UV Lip Color Splash SPF30 may be a bit of a mouthful, but it will protect your lips admirably. The balm is infused with natural oils to lock in moisture, as well as that all-important SPF protection. It costs considerably more than the likes of Carmex, but its water resistant, you wont need to apply it too often.

(Image credit: Mr Porter)

Best scrub for exfoliating

+Soothing and brightening+Uses sand for exfoliation

-Empty List

Regular exfoliation helps keeps skin healthy and clear, and when done before shaving can reduce bumps and irritation. While its important all year round, its great for preventing patches of dry skin building up and blocking pores in the winter and can make your complexion look brighter. Anthonys facial scrub is formulated with boro boro sand to remove dead cells, as well as soothing aloe vera, algae and chamomile. Antioxidant-rich Vitamin C is also included to protect from environmental stressors and brighten the complexion. The scrub is a handy multitasker and offers a lot of bang for its buck.

(Image credit: Mr Porter)

The best luxury hand cream

+Trendy fragrance+Easily absorbed formula+Luxe packaging

Its not just your face you need to look after in the cold and a hand cream is essential. Byredos Tulipmania hand cream is one of the trendiest options out there. Named after the infamous "tulip mania" period during the Dutch Golden Age when the flowers were in high demand, the cream is lightly fragranced with notes of Freesia and Blond Woods. Byredos hand cream is formulated with moisturising ingredients and has a gel-like consistency that's quick-drying and absorbent, which is a big selling point for busy men and women alike.

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Winter skincare routine: products to protect your face from cold weather - T3

Skin Stem Cells Comments Off on Winter skincare routine: products to protect your face from cold weather – T3 | February 13th, 2020

Penn State researchers have received a $2.8 million grant to investigate 3D bioprinting tissue for facial reconstructions, according to a Penn State news release.

The grant, from the National Institutes of Healths National Institute of Dental and Craniofacial Research, funds five years of research exploring methods for bioprinting face, mouth and skull tissue directly into patients during surgery, with the ultimate goal of developing a bioprinting technology, according to the release.

Craniomaxillofacial reconstruction currently presents challenges for doctors because it requires precisely stacking several different types of tissue. Penn States researchers hope to solve this problem by bioprinting the tissue directly into the subject, according to the release. Researchers will also be investigating the use of stem cells, biomaterials and differentiation factors in this process.

The team of researchers that received the grant includes professors of plastic surgery, biomedical engineering, and orthopedics and rehabilitation.

The researchers plan to investigate printing each type of tissue necessary for craniomaxillofacial reconstruction bone, fat and skin tissue individually, then study composite tissues that include all three of these layers. They hope that this will help them better understand how vascularization occurs in each type of tissue.

Ultimately, researchers hope to learn how different types of tissue interact and how bioprinting tissue directly into subjects will affect the facial reconstruction process.

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Penn State receives grant to study bioprinting tissue for facial reconstructions - The Daily Collegian Online

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Liposuction is a surgical procedure to remove extra fat from your body. It started in the 1980s and has become one of the most popular plastic surgeries in the US. An estimated 258,000 Americans got it in 2018.

Today, you can expect to pay around $3,500 for liposuction and most health insurance plans won't cover the cost. But if you're willing to pay the price, liposuction is a relatively safe and quick procedure that can help you shed fat that diet and exercise can't.

Here's what you need to know about how liposuction works and why it's not a weight-loss tool.

Liposuction is a 1-to2-hour-long procedure where fat cells are permanently removed from your body, usually for cosmetic reasons. People who get liposuction don't do it to lose large amounts of weight but rather to help sculpt the shape of their body.

Some of the most common places to have fat removed are the belly, thighs, buttocks, arms, back, the upper neck just under the chin, and jawline/jowls.

Depending on where you're getting the procedure, doctors will either provide a local anesthetic to numb the area of operation or they will give you a general anesthetic so you're unconscious during the procedure.

Then, surgeons will often inject into the area of operation a solution containing a mix of saline solution, a numbing medicine, and medicine the decreases bleeding. This is to help the skin and fat separate from important structures like muscles and blood vessels so they aren't damaged during the suctioning process.

After that, the surgeon inserts a long metal instrument called a cannula under your skin. The cannula then vacuums out your fat. During this process, surgeons may also use a smaller microcannula to remove fat in nearby areas to achieve a more natural, smoother contour.

Once the fat is removed through liposuction it can be discarded or it can be injected back into your body to enhance features like breasts, buttocks, or face. Or, more recently, in the last decade or so, liposuction has also been used to retrieve stem cells a type of cell that can form other specialized cells in the body for laboratory research.

After liposuction, your surgeon will likely recommend you wear a temporary band or brace over the area of operation to help the skin heal. The band or brace also helps prevent fluid from building up in the area of operation where the fat was removed, between the skin and deeper structures like muscles and blood vessels.

Whether you are awake or asleep during liposuction, you shouldn't feel any pain during the procedure, says Marco A. Pelosi II, MD, a cosmetic surgeon with experience performing liposuction procedures. The recovery, also, should be a relatively mild process.

After getting liposuction, you will feel soreness similar to a muscle ache. "The level of this soreness is typically a 2 or 3 out of 10 for a few weeks," says Pelosi, adding that you should be able to go back to work in 2 to 3 days.

Ongoing pain near the area where the cannula was inserted is a risk of liposuction, and if the pain grows or pain killers don't help, you should tell your surgeon.

According to the Cleveland Clinic, you should not use liposuction as a weight loss alternative. It recommends that if you want to lose weight, you should first try diet and exercise, then use liposuction to take care of more stubborn areas like the chin or belly fat.

Moreover, research shows that people who keep up other weight loss practices like a healthy diet and exercise will see better results after liposuction and keep fat from returning to a particular area.

This is because while liposuction permanently removes fat cells from your body, there is nothing to stop the remaining fat cells from getting bigger if you gain more weight.

There are some important safety tips to look for when choosing a liposuction provider.

First, look for a facility that meets national safety requirements. You can verify if a facility is accredited on the American Society of Plastic Surgeons' website here.

Pelosi says that doctors should also do blood work testing and medical clearances before a liposuction procedure to ensure your safety. These tests are to make sure you can safely undergo general anesthesia without complication. If, for example, you have an infection or are pregnant, you may not qualify for the surgery.

Last, but not least, is to look for a surgeon who is board-certified in performing these types of procedures and also has extensive experience with liposuction procedures so you know that they are well versed in the technique. To find out more about a practitioner's experience with liposuction, you can check the American Society of Plastic Surgeons' website.

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What is liposuction? How the procedure works and how painful it is - Insider - INSIDER

Skin Stem Cells Comments Off on What is liposuction? How the procedure works and how painful it is – Insider – INSIDER | February 13th, 2020

The defense for Joseph Sentore Coleman Jr. rested their case Wednesday with witnesses who contradicted previous statements by the prosecutions witnesses.

Both sides of the aisle are expected to make their closing statements today, before the jury is let out to deliberate the verdict in the case against Coleman, 38.

Coleman, who allegedly robbed and murdered Christopher Wilkins on Aug. 30, 2016, at 505 Park Ave., is already serving two life sentences for a double homicide on Halloween 2016.

Previously unknown to the jury, Louis Martin, frequent visitor of the Park Avenue residence, was called by Jeana Longo, Colemans attorney.

As Coleman and James Rooks allegedly entered the Park Avenue home with the intention of robbing the known drug dealers, Wilkins and Savoy Jennings, Martin said he was just waking up in Jeff Greenes adjacent bedroom from a long night of doing drugs and watching movies.

I was sitting in a chair, just closing my eyes, said Martin, when he heard shouts from the second bedroom.

I aint got nothing, I aint got nothing,' he said a voice shouted.

Then a pop it was a gunshot, said Martin.

Peering out from inside the room, he said two masked people came out of the room and looked at the body of Wilkins before running out.

One was short, slim and was built, he said. One was taller with really dark skin neither of them had dreadlocks.

Martin said he was familiar with Coleman from passing him in the street, but was not a friend of his.

However, Martin said he was familiar enough with Coleman that if his face were covered in a mask that he would know.

When they left, I waited two to three seconds. I see Chris on the floor, he said. I shook him, but Wilkins didnt move.

Martin said he alerted Jeff Greene before he left. The situation had traumatized him.

Ill be honest, I needed a drink to calm down, so I went to the bar, he said.

Later that day in initial police interviews, Martin told police that he drank about a six-pack of beer.

Martin gave a description of the men he thought murdered Wilkins for sketches to be made of their faces after police insisted, he said.

You cant make out their features, but I know what I saw, he said.

Martin said he suspected that one of the masked men was Jamal Brown, who previously testified to have given Coleman the layout of the building and advice on the chances of a successful robbery.

The defense also called John Greene, brother of Jeff Greene, and who lived in the second floor apartment of 505 Park Ave.

He too said he doubted Coleman committed the crime.

(Coleman) had been there plenty of times, he said, and didnt need help figuring out the layout of the home.

John Greene testified that he had seen Brown a native of New York wearing a hat similar to the one found at the scene. Namely, a Brooklyn Dodgers baseball hat.

Although Wilkins killer is still legally unproven, Dr. Barbara Bollinger, the forensic pathologist who conducted the autopsy on Wilkins, said she knew the man died immediately from the gunshot.

The projectile entered Wilkins brain near his left earlobe, passed through his cerebellum and brain stem, which collectively control balance, coordinating movement and breathing.

I think this would have incapacitated him within the span of seconds, she said.

Additionally, the gunshot caused stippling, she said, or abrasions from unburned gunpowder or debris, which typically indicates the gun was 12 inches to three feet away.

Colemans DNA was found on both the hat and a cut-off pant leg, which were used as disguises in the crime and discarded at the scene, said Regina Kuzero and Brittney Lenig, forensic scientists with the Pennsylvania State police, and Jennifer Bracamontes, a data analyst.

Though up to five peoples DNA was found on the two articles, Bracamontes said using a supercomputer to allow her to identify Coleman as the major contributor. This method does not allow anyone to learn when or how the DNA, which is typically obtained through skin cells, was rubbed into the masks.

The trial resumes at 10 a.m. today in courtroom three before Judge Marc F. Lovecchio.

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Defense presents witnesses on day 3 of trial | News, Sports, Jobs - Williamsport Sun-Gazette

Skin Stem Cells Comments Off on Defense presents witnesses on day 3 of trial | News, Sports, Jobs – Williamsport Sun-Gazette | February 13th, 2020

The market analysis and insights included in the Cosmetic Skin Care market report presents key statistics on the market status of global and regional manufacturers and is an essential source of guidance which provides right direction to the companies and individuals interested in the industry. To prosper in this competitive market place, businesses are highly benefited if they adopt innovative solutions such as this Cosmetic Skin Care market research report. This wide-ranging market research report acts as a backbone for the success of business in any sector. The market drivers and restraints have been explained in the report with the use of SWOT analysis.

Global cosmetic skin care marketis set to witness a substantial CAGR of 5.5% in the forecast period of 2019- 2026. The report contains data of the base year 2018 and historic year 2017. Increasing self-consciousness among population and rising demand for anti- aging skin care products are the factor for the market growth.

Global Cosmetic Skin Care Market By Product (Anti-Aging Cosmetic Products, Skin Whitening Cosmetic Products, Sensitive Skin Care Products, Anti-Acne Products, Dry Skin Care Products, Warts Removal Products, Infant Skin Care Products, Anti-Scars Solution Products, Mole Removal Products, Multi Utility Products), Application (Flakiness Reduction, Stem Cells Protection against UV, Rehydrate the skins surface, Minimize wrinkles, Increase the viscosity of Aqueous, Others), Gender (Men, Women), Distribution Channel (Online, Departmental Stores and Convenience Stores, Pharmacies, Supermarket, Others), Geography (North America, Europe, Asia-Pacific, South America, Middle East and Africa) Industry Trends and Forecast to 2026 ;

Complete report on Global Cosmetic Skin Care Market Research Report 2019-2026 spread across 350 Pages, profiling Top companies and supports with tables and figures

Market Definition: Global Cosmetic Skin Care Market

Cosmetic skin care is a variety of products which are used to improve the skins appearance and alleviate skin conditions. It consists different products such as anti- aging cosmetic products, sensitive skin care products, anti- scar solution products, warts removal products, infant skin care products and other. They contain various ingredients which are beneficial for the skin such as phytochemicals, vitamins, essential oils, and other. Their main function is to make the skin healthy and repair the skin damages.

Key Questions Answered in Global Cosmetic Skin Care Market Report:-

Our Report offers:-

Top Key Players:

Market Drivers:

Market Restraints:

Key Developments in the Market:

Customize report of Global Cosmetic Skin Care Market as per customers requirement also available.

Market Segmentations:

Global Cosmetic Skin Care Market is segmented on the basis of

Market Segmentations in Details:

By Product

By Application

By Gender

By Distribution Channel

By Geography

North America

Europe

Asia-Pacific

South America

Middle East & Africa

Competitive Analysis: Global Cosmetic Skin Care Market

Global cosmetic skin care market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of cosmetic skin care market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

About Data Bridge Market Research:

Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

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COSMETIC SKIN CARE MARKET ENHANCEMENT AND ITS GROWTH PROSPECTS FORECAST 2019 TO 2026 - Reporting 99

Skin Stem Cells Comments Off on COSMETIC SKIN CARE MARKET ENHANCEMENT AND ITS GROWTH PROSPECTS FORECAST 2019 TO 2026 – Reporting 99 | February 13th, 2020

10 February 2020

A study, published in Cell Reports, investigating when and how human stem cells develop into egg and sperm cells could one day help generate lab-grown gametes to treat infertility.

Human pluripotent stem cells can evolve into germ cells, which are the precursor cells for gamete development. By growing these human germ cells in vitro, the theory is that gametes engineered in a laboratory setting could someday be used, instead of natural eggs and sperm, in IVF treatment.

The research conducted within the Eli and Edythe Broad Centre of Regenerative Medicine and Stem Cell Research at University of California, Los Angeles (UCLA) provides great hope for those who are unable to produce gametes naturally,including thosewhose fertility has been affected by injury, illness or medical treatment.

'With donated eggs and sperm, the child is not genetically related to one or both parents. To treat patients who want a child who is genetically related, we need to understand how to make germ cells from stem cells, and then how to coax those germ cells into eggs or sperm'Dr Amander Clark, lead author of the study at UCLA, explained.

'Right now, if your body doesn't make germ cells, then there's no option for having a child that's biologically related to you. What we want to do is use stem cells to be able to generate germ cells outside the human body so that this kind of infertility can be overcome.'

In previous studies, scientists have been able to grow similarinduced pluripotent stem calls (iPS cells), and develop them into human skin cells and blood cells. The researchers, in collaboration with Massachusetts Institute of Technology, analysed the hundreds of thousands of genes active when both human embryonic stem cells and iPS cells transition to germ cells.

The data obtained allowed the researchers to firstly formulate when the germ cells are likely to form, which was between 24-48 hours after starting differentiation, and secondly which lineages of the differentiating stem cells give rise to the germ cells.

They also found that the activation and manifestation of germ cells was identical when developed from embryonic stem cells and iPS cells. This information was essential as they needed to ensure that the in vitro environment they had created was mimicking the molecular signals of the testis and ovaries to give hope for successful sperm and egg cell development.

Dr Clark stated: 'This tells us that the approach we're using to begin the process of making germ cells is on the right track. Now we're poised to take the next step of combining these cells with ovary or testis cells.'

Although current research is far from generating gametes, the end goal is that one day scientists are able to use a patient's skin cells to form stem cells, which can be programmed into egg or sperm cells to be used in fertility treatment.

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Lab-grown eggs and sperm a step closer - BioNews

Skin Stem Cells Comments Off on Lab-grown eggs and sperm a step closer – BioNews | February 11th, 2020

In our regular feature #TheBrand, Bazaars beauty team look into an exciting and efficacious brand taking the beauty industry by storm. This time, its an under-the-radar skincare line gaining traction for its transformative effects.

The latest brand making beauty editors fawn is surprisingly buzz-free. Theres no celebrity founder, attention-seeking packaging, or heavily filtered Instagram account. The brands website is unassuming, and stockists are scarce. So, why is everyone clamouring for iS Clinical, and is it worth the search? Here, we reveal the story behind beautys quietest game-changer.

Founded in 2002 by biochemist Bryan Johns and Alec Call and still privately owned iS Clinical is part of the Innovative Skincare umbrella, which creates products focused on pure, pharmaceutical-grade ingredients. The transformative effects of these meticulously created products made the brands professional treatments an awards-circuit mainstay, yet the buzz didnt quite reverberate across the pond.

Warming Honey Cleanser

30.99

Reparative Moisture Emulsion

66.99

Youth Complex

31.99

Cleansing Complex

29.99

Cue a few choice (not paid-for) endorsements from some enviably glossy influencers think Rosie Huntington-Whiteley, January Jones and celebrity facialist Shani Darden and iS Clinical has become the under-the-radar skincare line of the moment.

iS Clinical doesnt look like the type of brand to be touting buzzwords such as botanical and natural. In fact, it looks veritably like something youd only expect to find lining the white walls of a dermatologists office.

But the formulas in these gimmick-free blue bottles are actually a force of nature, combining highly active, plant-derived extracts (and omitting fragrance and parabens), to directly tackle specific skin concerns.

The brands skincare ethos comprises four steps: cleanse, treat, hydrate and protect, and the range offers products in each category for a variety of specific skin types. Every one is conceptualised and produced in-house, with no third-party involvement, meaning you wont' find a 'dupe' or replica anywhere else.

High-grade ingredients think plant-derived acids, vitamins A to E, stem cells and ceramides are combined to deliver the most notable results in the least amount of time. Users of the brands star serum (more on that later) have reported visible improvements in a matter of days.

The brands scientific approach is founded on the biological principle of xenohormesis: the concept that stressed plants produce bioactive compounds, which pass on stress-resistance and survival benefits to the people who consume (or apply) them.

While the brand offers a specific range for each skin type, theres one hero product that has made more waves than most. Praised in particular by those with acne and rough skin texture, the Active Serum is widely hailed as the product to solve the most persistent of breakouts, while fading scars and hyperpigmentation.

According to Dr. Charlene DeHaven M.D, clinical director of iS Clinical, the cult following is due to the unique combination of four naturally occurring acids that do more than just treat blemishes.

Sugar cane (a source of glycolic acid) and bilberry fruit extract (a source of lactic acid) both encourage gentle exfoliation of the outer layers of the epidermis, without dehydrating the skin. Willow bark extract (containing salicylic acid) deep-cleanse the pores, while kojic-acid rich mushroom extract has powerful antibacterial and antimicrobial properties, she explains. The addition of arbutin makes this serum a powerful tool in fading pigmentation, too combined with the kojic acid, it inhibits melanin-producing enzymes, therefore fading post-inflammatory pigmentation.

Active Serum

63.99

C Eye Advance+

44.99

Youth Serum

134.99

Pro-Heal Serum Advance+

15.00

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#TheBrand | iS Clinical Skincare Reviews - harpersbazaar.com

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Photo: Yulia Gorbachenko

BEST ACNE-REDUCING FACIALRejuran Healer+ Laser Peel$737 for 60 minutes, Priv ClinicAt the heart of this facial is polynucleotide, a biopolymer molecule highly compatible with the human body. Delivered into the skin via a series of micro injections, it reportedly helps repair damaged skin cells, boost collagen synthesis, reduce sebum production and even out the skins moisture-oil balance. The miniscule punctures in the skin also trigger its natural wound-healing response, boosting cellular turnover. Some light swelling may appear post-treatment, but it goes away within 24 hours. Meanwhile, skin is visibly suppler, and looks smoother and healthier.

BEST ANTI-AGEING FACIALInstant Youth ProgrammeFrom $260 for 75 minutes, EstheClinicBehold the ultimate helping hand to counter the signs of mature skin. Each treatment is uniquely tailored to your specific skin type and needs, with subsequent sessions building on and enhancing the effects of prior treatments to maximise collagen production for firmer skin. By using the latest in aesthetic technology alongside EstheClinics specially selected cosmeceutical products, the signs of ageing are thus tackled from the inside out, with effects continuing to last up to four months after completing the programme.

BEST ANTI-BLEMISH FACIALTetra+ $398 per session, The Aesthetics Medical ClinicThis four-in-one treatment features a symphony of lasers with varying wavelengths to tackle multiple issues in just one sitting. A pigment wavelength breaks down melanin clusters to improve discoloration; a custom fractional laser refines texture; a superficial wavelength zaps clogged pores clean; and a long-pulse wavelength stimulates collagen production. Expect minimal to no downtimeand a smoother complexion in no time at all.

BEST BRIGHTENING FACIALRejuvenation Laser and Stem Cell Infusion$1,888 for five sessions, The Aesthetics Medical ClinicCombining two laser machinesQ Switch and yellow laserthat work in tandem to give you radiant, glowy skin, this also removes dirt, dead skin cells, oil and superficial hair, so skin is not only brightened, but also clearer and cleaner. The laser also helps to regulate oil production and reduce pigmentation, while the potent 80percent stem cell-derived serum delivers proteins, growth factors and cytokines intoskin to help boost regeneration and repair.

BEST CLEANSING FACIALJet Set$129 for 30 minutes, EPIONIdeal as a maintenance facial for time-strapped individuals, this express purifying solution rejuvenates weary skin in 30 minutes. A highpressure aqua jet peel gently sweeps away any build-up of dry and dead skin, before an ultrasonic deep cleanse purges pores of dirt, sebum and impurities. Jet technology is then used to infuse skin with potent actives with intense hydrating and brightening benefits.

Related article:BAZAAR Spa Awards 2020: Best Face Therapies To Transform And Pamper Your Skin

BEST DETOXIFYING FACIALVitamin C Infusion$288 for 45 minutes, Simply AestheticsBid adieu to skin woes such as open pores, blemishes, pigmentation and dullness with a super-potent dose of medical-grade vitamin C, which smooths and revitalises the skin. Besides getting rid of pore-clogging impurities that can make the skin appear dull or lacklustre, the facial also stimulates the dermal cells to actively produce collagen in order to regain that plump, fresh-faced radiance.

BEST EXPRESS FACIALIDS Electro Infusion (IEI)$280 for 45 minutes, IDS AestheticsGreat as a lunchtime facial, this uses a combination of electronic-magnetic pulses and LED light to brighten and firm skin. Designed to tackle various skin conditionspigmentation, fine lines, wrinkles, dryness, dullnessthis quickie facial is deemed a universal beauty enhancer and works its magic in less than an hour.

BEST EYE LIFT TREATMENTSygmaLift Eyes$670 for 60 minutes, Clifford AestheticsWhether its eyebags or dark circles that no concealer can hide, the root causes of your undereye issues are sussed out with a consultation in order to tailor an effective treatment. SygmaLift therapy, which utilises high-intensity focused ultrasound technology, is then applied to the under-eye area to contract the connective tissues deep within to tighten and smooth skin. The end resulta marked improvement in the appearance of under-eye bags, sagginess, discoloration and linestakes years off your face!

BEST HYDRATING FACIALHydraFacial$250 for 35 minutes, Dr Kevin Chua Medical & AestheticsThis all-in-one treatment starts off with a deep cleanse, and an exfoliating cocktail of salicylic and glycolic acids to break up pore-clogging impurities, allowing the HydraPeel Tip to essentially vacuum out sebum, product build-up, blackheads and dirt, before infusing skin with intensive serums to replenish hydration levels and provide antioxidant protection.

BEST LIFTING & FIRMING FACIALThermage FLX$5,350 for 90 minutes, Priv ClinicWant to reduce the look of fine lines, wrinkles, sagging skin and other signs of ageing, or simply delay their dreaded appearance? Promising just that is the Thermage FLX, which uses radio frequency to stimulate cell regeneration and collagen production. This newgen treatment is optimised for improved comfort and more controlled delivery, and the results from one session is said to last for months.

BEST PORE-REFINING FACIAL3D Deep Pore Cleansing Facial$588 for 90 minutes, Aesthetics Central ClinicFlawless skin can now be had with this signature treatment that utilises a patented device called 50 Micron Jet Technology, where high-pressure micro-jets of water gently push out the sebum and impurities trapped in pores. As the pores are being cleaned out, the machine delivers a serum, designed to lift and tighten skin while encouraging microcirculation, deep into the skin.

BEST REJUVENATING FACIALPicoWay RESOLVE $650 for 30 minutes, Dr Kevin Chua Medical & AestheticsSo named for the technology where laser pulses are delivered in picosecondsa unit of measurement that refers to one trillionth of a seconda PicoWay facial sends small bursts of intense laser energy deep into the skin to stimulate its natural healing abilities. The short pulsations mean that less heat is emitted during the procedure, so you neednt worry about post-treatment burns. Benefits of the treatment, which is suitable for most skin types, include plumper, suppler skin with improved tone and texture.

Related article:Spa Awards 2020 Best Rejuvenating Facial: PicoWay RESOLVE

BEST RESURFACING FACIALPico Fractional Laser Treatment$300 for 60 minutes, Calvin Chan Aesthetic & Laser ClinicVia short but intense pulses of laser energy delivered deep into the dermis, the skin is transformed from the inside out as new collagen and elastin is produced to significantly improve the appearance of pitted acne scars, pigmentation and wrinkles. And if youre worried about downtime, dont. The surface of the skin is left intact while the deep tissue heals, which means theres no recovery time involved.

BEST SHAPING & TIGHTENING FACIALBiologique Recherche Remodeling Face $380 for 90 minutes, Freia AestheticsThis kicks off with a 60-minute booster customised to your skins needs, followed by a proprietary massage that promotes blood flow and stimulates the lymph nodes for a detoxifying effect. The Remodelling Face machine then uses a bespoke blend of electric, galvanic and high-frequency currents to enhance the benefits of the preceding steps, and deliver product actives deeper and more efficiently into skin for a supreme lifting, tightening and plumping effect.

BEST SOOTHING FACIALSeriously Soothing $209 for 90 minutes, EPIONLiving up to its name, this hydrates and calms thirsty skin with a side of sensitivity. Ultrasonic energy is first used to give skin a deep cleanse. This is followed by a dose of much-needed hyaluronic acid and the application of a soothing face mask. The final step: LED red light therapy to help stimulate collagen production and reduce redness or inflammation.

Related article:Cindy Crawford Shows How She Stays Fabulous At Every Age In Our February Issue

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Spa Awards 2020: Best Specialised Solutions Tackle Every Skin Concern - Harper's Bazaar Singapore

Skin Stem Cells Comments Off on Spa Awards 2020: Best Specialised Solutions Tackle Every Skin Concern – Harper’s Bazaar Singapore | February 11th, 2020